Author: tianli

Chateauneuf, John E. published the artcileAn investigation of Friedel-Crafts alkylation reactions in super- and subcritical CO₂ and under solventless reaction conditions, Application of 9-Phenyl-9H-xanthen-9-ol, the publication is ACS Symposium Series (2002), 136-150, database is CAplus.

A symposium report. The Friedel-Crafts alkylation reaction of triphenylmethanol with methoxybenzene in supercritical and subcritical carbon dioxide, and under solventless reaction conditions was investigated. The reaction was initiated using trifluoroacetic acid to produce triphenylmethlycarbocation as the reaction intermediate. Isolated product yields of the Friedel-Crafts product, p-methoxytetraphenylmethane, are reported. The possibility of using the above reaction as an alternative synthesis in an undergraduate organic laboratory to teach some of the tenets of green chem. was also investigated. Addnl., the use of benzhydrol, 9-hydroxyxanthene and 9-phenylxanthen-9-ol as potential carbocation sources for supercritical carbon dioxide synthesis was studied and preliminary results are reported.

ACS Symposium Series published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Application of 9-Phenyl-9H-xanthen-9-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ren, Shen published the artcileDesign, synthesis and evaluation of 2,2-dimethyl-1,3-dioxolane-4,5-dicarboxylic acid derivatives as neuroimmunophilin ligands, Quality Control of 101-98-4, the publication is Zhongguo Yaowu Huaxue Zazhi (2007), 17(1), 1-7, 12, database is CAplus.

A method for the synthesis of the title compounds is reported here. Both, the sequence and conformation of the FK506-binding site in FKBPs (FK506 binding proteins) family are highly conserved. According to this characteristic of FKBPs and the structural feature of ligands binding to FKBP12, CADD (computer-aided drug design) was employed to design and virtually screen novel 2,2-dimethyl-1,3-dioxolane-4,5-5-dicarboxylic acid derivatives These compounds were synthesized by a liquid-phase synthetic method. A model of chick embryos dorsal root ganglion (DRG) cultures free of serum and a model of NG108-15 cell injured by H₂O₂ were applied to evaluate neurotropic activity of these target compounds Thus, 27 target compounds were synthesized. In cultured chick DRGs, N-[[(4R,5R)-5-[[(cyclohexyl)amino]carbonyl]-2,2-dimethyl-1,3-dioxolan-4-yl]carbonyl]-L-aspartic acid di-Et ester produced a little neurotrophic effect and promoted neurite outgrowth in vitro. In the model of H₂O₂-induced NG108 cell damage, N-[[(4R,5R)-2,2-dimethyl-5-[[(phenylmethyl)amino]carbonyl]-1,3-dioxolan-4-yl]carbonyl]-L-serine Et ester showed a significantly protective effect on an NG 108 cell.

Zhongguo Yaowu Huaxue Zazhi published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Quality Control of 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Halloran, Matthew W. published the artcileSmall molecule plasticizers for improved migration resistance: Investigation of branching and leaching behaviour in PVC blends, Synthetic Route of 111-29-5, the publication is Materials Today Communications (2021), 102874, database is CAplus.

The influence of branching on plasticizer effectiveness and migration behavior of heptyl-succinate plasticizers blended with poly(vinyl chloride) (PVC) was evaluated. An increase of branching led to a decrease in migration of the plasticizers into both hexanes and vegetable oil medias. Addnl., a quant. ¹H NMR method was used to identify plasticizer concentration in the leachates and compared to a gravimetric standard test method. Overall, the quant. ¹H NMR method proved to be a more direct method to assess leaching. In comparison to com. plasticizer di(2-ethylhexyl) phthalate (DEHP) and alternative plasticizer diheptyl succinate (DHPS), all of the branched species displayed superior migration resistance into hexanes (two to ten-fold). The glass transition temperatures and stress at break data indicated that the plasticizers comprised of up to three branches functioned as well as, or better than DEHP and DHPS. However, there was a decrease in plasticizer efficiency with compounds comprised of four or more branches.

Materials Today Communications published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Synthetic Route of 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pourafshar, Shirin published the artcileUrine and plasma metabolome of healthy adults consuming the DASH (dietary approaches to stop hypertension) diet: a randomized pilot feeding study, HPLC of Formula: 621-37-4, the publication is Nutrients (2021), 13(6), 1768, database is CAplus and MEDLINE.

We aimed to identify plasma and urine metabolites altered by the Dietary Approaches to Stop Hypertension (DASH) diet in a post-hoc anal. of a pilot feeding trial. Twenty adult participants with un-medicated hypertension consumed a Control diet for one week followed by 2 wk of random assignment to either Control or DASH diet. Non-missing fasting plasma (n = 56) and 24-h urine (n = 40) were used to profile metabolites using untargeted gas chromatog./mass spectrometry. Linear models were used to compare metabolite levels between the groups. In urine, 19 identifiable untargeted metabolites differed between groups at p < 0.05. These included a variety of phenolic acids and their microbial metabolites that were higher during the DASH diet, with many at false discovery rate (FDR) adjusted p < 0.2. In plasma, eight identifiable untargeted metabolites were different at p < 0.05, but only gamma-tocopherol was significantly lower on DASH at FDR adjusted p < 0.2. The results provide insights into the mechanisms of benefit of the DASH diet.

Nutrients published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, HPLC of Formula: 621-37-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sun, Yang published the artcileTheoretical study on the mechanisms of the decomposition of nitrate esters and the stabilization of aromatic amines, Related Products of alcohols-buliding-blocks, the publication is Journal of Molecular Modeling (2019), 25(12), 346, database is CAplus and MEDLINE.

The nitrate esters are important components of double-base propellants. Aromatic amines are recommended as the stabilizers to delay the decomposition of nitrate esters and increase their storage time. The decomposition mechanisms of alkyl, alkoxy dinitrate, and poly-fluoride nitrate esters and the stabilizing effect of aromatic amines including new designed phenols are studied at the level of B3LYP/6-31G**. Alkyl and alkoxyl dinitrate esters are likely to be transformed by hydrogen abstraction, which is consistent with that of mononitrate and trinitrate esters. However, for poly-fluoride nitrate esters, NO₂ catalyzed self-decomposition is preferred. In addition, comparing with mononitrate and trinitrate esters, the order of their stability is mononitrates > dinitrates > trinitrates. Poly-fluoride nitrate esters have a poorer stability than non-fluorinated nitrate esters. Comparing with parent nitrate esters, the stability of new designed poly-fluoride oxygen-containing nitrate esters is slightly improved. Aromatic amines including new designed phenols are effective stabilizers of nitrate esters, especially when introduced hydroxyl in the para position, can enhance the effects of stabilizers. The rate constants for the decomposition of nitrate esters and the bimol. reaction between stabilizers and NO₂ are calculated by using traditional transition state theory.

Journal of Molecular Modeling published new progress about 14703-69-6. 14703-69-6 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Phenol, name is 3-(Methylamino)phenol, and the molecular formula is C24H20Ge, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Meng, Charles Q. published the artcileCarboxylated, Heteroaryl-Substituted Chalcones as Inhibitors of Vascular Cell Adhesion Molecule-1 Expression for Use in Chronic Inflammatory Diseases, Related Products of alcohols-buliding-blocks, the publication is Journal of Medicinal Chemistry (2007), 50(6), 1304-1315, database is CAplus and MEDLINE.

Starting from a simple chalcone template, structure-activity relationship (SAR) studies led to a series of carboxylated, heteroaryl-substituted chalcone derivatives as novel, potent inhibitors of vascular cell adhesion mol.-1 (VCAM-1) expression. Correlations between lipophilicity determined by calculated logP values and inhibitory efficacy were observed among structurally similar compounds of the series. Various substituents were found to be tolerated at several positions of the chalcone backbone as long as the compounds fell into the right range of lipophilicity. The chalcone α,β-unsaturated ketone moiety seemed to be the pharmacophore required for inhibition of VCAM-1 expression. Compound 19 (I) showed significant antiinflammatory effects in a mouse model of allergic inflammation, indicating that this series of compounds might have therapeutic value for human asthma and other inflammatory disorders.

Journal of Medicinal Chemistry published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Williamson, Alice E. published the artcileRapid Generation of Complex Molecular Architectures by a Catalytic Enantioselective Dearomatization Strategy, Application In Synthesis of 6346-09-4, the publication is Synlett (2016), 27(1), 116-120, database is CAplus.

A catalytic enantioselective dearomatization strategy can be used to convert readily assembled phenols into complex polycyclic architectures. By combining oxidative dearomatization of phenols bearing a pendent nucleophile with enantioselective secondary amine catalysis, high enantiomeric excesses were obtained for the natural product-like products.

Synlett published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C17H14F3N3O2S, Application In Synthesis of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hoang, Van-Hai published the artcileDiscovery of Conformationally Restricted Human Glutaminyl Cyclase Inhibitors as Potent Anti-Alzheimer’s Agents by Structure-Based Design, Recommanded Product: 2-Morpholinoethanol, the publication is Journal of Medicinal Chemistry (2019), 62(17), 8011-8027, database is CAplus and MEDLINE.

Alzheimer’s disease (AD) is an incurable, progressive neurodegenerative disease whose pathogenesis cannot be defined by one single element but consists of various factors; thus, there is a call for alternative approaches to tackle the multifaceted aspects of AD. Among the potential alternative targets, we aim to focus on glutaminyl cyclase (QC), which reduces the toxic pyroform of β-amyloid in the brains of AD patients. On the basis of a putative active conformation of the prototype inhibitor 1, a series of N-substituted thiourea, urea, and α-substituted amide derivatives were developed. The structure-activity relationship analyses indicated that conformationally restrained inhibitors demonstrated much improved QC inhibition in vitro compared to nonrestricted analogs, and several selected compounds demonstrated desirable therapeutic activity in an AD mouse model. The conformational anal. of a representative inhibitor indicated that the inhibitor appeared to maintain the Z-E conformation at the active site, as it is critical for its potent activity.

Journal of Medicinal Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Recommanded Product: 2-Morpholinoethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gnanakumar, Edwin S. published the artcilePlasma-Assisted Synthesis of Monodispersed and Robust Ruthenium Ultrafine Nanocatalysts for Organosilane Oxidation and Oxygen Evolution Reactions, Application of Triethylsilanol, the publication is ChemCatChem (2017), 9(22), 4159-4163, database is CAplus and MEDLINE.

A facile and general approach for preparing ultrafine Ru nanocatalysts by using a plasma-assisted synthesis at <100° is reported. The resulting Ru nanoparticles are monodispersed (typical size 2 nm) and remain that way upon loading onto C and TiO₂ supports. This gives robust catalysts with excellent activities in both organosilane oxidation and the O evolution reaction.

ChemCatChem published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Application of Triethylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Guo-Ying published the artcileApplication of Fragment-Based Drug Discovery against DNA Gyrase B, SDS of cas: 23351-09-9, the publication is ChemPlusChem (2015), 80(8), 1250-1254, database is CAplus and MEDLINE.

Bacterial resistance to antibiotics remains a serious threat to global health. The gyrase B enzyme is a well-validated target for developing antibacterial drugs. Despite being an attractive target for antibiotic development, there are currently no gyrase B inhibitory drugs on the market. A fragment screen using 1,800 compounds identified 14 fragments that bind to Escherichia coli (E. coli) gyrase B. The detailed characterization of binding is described for all 14 fragments. With the aid of X-ray crystallog., modifications on a low-affinity fragment (K_D=253 μΜ, IC₅₀=634 μΜ) has led to the development of a new class of potent Ph aminopyrazole inhibitors against E. coli gyrase B (IC₅₀=160 nΜ). The study presented here combines the use of a set of biophys. techniques including differential scanning fluorimetry, NMR, isothermal titration calorimetry, and X-ray crystallog. to methodically identify, quantify, and optimize fragments into new chem. leads.

ChemPlusChem published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, SDS of cas: 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts