Author: tianli

Shon, Jong Cheol published the artcileThe impact of phenanthrene on membrane phospholipids and its biodegradation by Sphingopyxis soli, Related Products of alcohols-buliding-blocks, the publication is Ecotoxicology and Environmental Safety (2020), 110254, database is CAplus and MEDLINE.

The direct interactions of bacterial membranes and polycyclic aromatic hydrocarbons (PAHs) strongly influence the biol. processes, such as metabolic activity and uptake of substrates due to changes in membrane lipids. However, the elucidation of adaptation mechanisms as well as membrane phospholipid alterations in the presence of phenanthrene (PHE) from α-proteobacteria has not been fully explored. This study was conducted to define the degradation efficiency of PHE by Sphingopyxis soli strain KIT-001 in a newly isolated from Jeonju river sediments and to characterize lipid profiles in the presence of PHE in comparison to cells grown on glucose using quant. lipidomic anal. This strain was able to resp. utilize 1-hydroxy-2-naphthoic acid and salicylic acid as sole carbon source and approx. 90% of PHE (50 mg/L) was rapidly degraded via naphthalene route within 1 day incubation. In the cells grown on PHE, strain KIT-001 appeared to dynamically change profiles of metabolite and lipid in comparison to cells grown on glucose. The levels of primary metabolites, phosphatidylethanolamines (PE), and phosphatidic acids (PA) were significantly decreased, whereas the levels of phosphatidylcholines (PC) and phosphatidylglycerols (PG) were significantly increased. The adaptation mechanism of Sphingopyxis sp. regarded mainly the accumulation of bilayer forming lipids and anionic lipids to adapt more quickly under restricted nutrition and toxicity condition. Hence, these findings are conceivable that strain KIT-001 has a good adaptive ability and biodegradation for PHE through the alteration of phospholipids, and will be helpful for applications for effective bioremediation of PAHs-contaminated sites.

Ecotoxicology and Environmental Safety published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C2H8Cl2N4S2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sutili, Felipe K. published the artcileLipase immobilized in microemulsion based organogels (MBGs) as an efficient catalyst for continuous-flow esterification of protected fructose, COA of Formula: C12H20O6, the publication is RSC Advances (2015), 5(47), 37287-37291, database is CAplus.

Sugar-based organogels are important esters for the cosmetic, food and pharmaceutical industries due to their intrinsic properties. Chem. routes to obtain these mols. suffer from low yields and undesirable side products. In this way, biocatalysis can be an interesting and efficient alternative, which meets the green chem. principles. Herein we report our results on the development of a continuous flow process for the production of sugar-based surfactants mediated by immobilized enzymes in microemulsion based organogels, leading to the desired product in high productivities (66.8 to 88.1 g of ester per h per g of lipase).

RSC Advances published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C17H19N3O7S, COA of Formula: C12H20O6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kuge, Souichi published the artcileIdentification of peptide fragments chemically cross-linked in cytochrome c oxidase from thermophilic Bacillus PS3, Application of Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, the publication is Biochemistry and Molecular Biology International (1996), 38(1), 181-188, database is CAplus and MEDLINE.

In order to study steric arrangement of subunits in cytochrome c oxidase isolated from thermophilic Bacillus PS3, we developed a simple procedure including chem. crosslinking, two consecutive runs of electrophoresis, proteolytic digestion, and peptide sequencing for simultaneous identification of two cross-linked fragments. By this procedure, the cytochrome c domain of subunit 2 was found cross-linked to the C-terminal region of subunit 1 including two hydrophobic transmembrane segments, suggesting that these two regions were located close each other. The present simple procedure might be applicable to proteins whose crystal structures are not revealed.

Biochemistry and Molecular Biology International published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Application of Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhu, Qilei published the artcileCatalytic C(β)-O Bond Cleavage of Lignin in a One-Step Reaction Enabled by a Spin-Center Shift, Related Products of alcohols-buliding-blocks, the publication is ACS Catalysis (2021), 11(22), 14181-14187, database is CAplus.

A challenge to the utilization of lignin as a feedstock for aromatic fine chems. lies in selective cleavage of copious β-O-4 linkages. A photocatalytic strategy for the selective cleavage of the C(β)-O bonds of model substrates and natural lignin extracts is achieved by a redox-neutral, catalytic cycle that does not require stoichiometric reagents. Mechanistic studies reveal the generation of a thiyl radical, which is derived from a cystine-derived H-atom transfer catalyst, initiates a spin-center shift (SCS) that leads to C(β)-O bond cleavage. The SCS reactivity is reminiscent of the C(β)-O bond cleavage chem. that occurs in the active site of ribonucleotide reductase.

ACS Catalysis published new progress about 70110-65-5. 70110-65-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Alcohol,Ether,Benzene Compounds, name is 2-Phenoxy-1-phenylpropane-1,3-diol, and the molecular formula is C20H28B2O4S2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cherkasov, Rafael A. published the artcileThiophosphorylation of Pharmacophoric Phenols, Diols, and Triols, Recommanded Product: 4-(1H-Pyrrol-1-yl)phenol, the publication is Phosphorus, Sulfur and Silicon and the Related Elements (2013), 188(1-3), 24-26, database is CAplus.

Novel organyldithiophosphonic and bis(aryldithiophosphonic) acids were obtained by the reaction of 2,4-diorganyl 1,3,2,4-dithiadiphosphetane-2,4-disulfides with paracetamol, 4-(1H-pyrrol-1-yl)phenol, ethambutol dihydrochloride, vitamin B₆, and its acetonide derivatives

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Recommanded Product: 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Feng published the artcileSynthetic studies towards atkamine, Product Details of C8H19NO2, the publication is Chinese Chemical Letters (2021), 32(2), 668-671, database is CAplus.

Atkamine (I) is a complex marine pyrroloiminoquinone alkaloid that comprises a heptacyclic scaffold bearing five different heterocycles and four contiguous stereocenters, and therefore it is a highly challenging target for synthetic chemists. We herein reported a modular synthetic strategy toward this alkaloid, featuring a formal [5 + 2] annulation and an asym. Michael addition The efficient synthesis of the long-chain aliphatic aldehyde and chiral amino acetal fragments have been achieved. A simplified tetracyclic intermediate bearing the core structure of atkamine has been successfully constructed through the formal [5 + 2] annulation.

Chinese Chemical Letters published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H8O2, Product Details of C8H19NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yang, Ling published the artcileThe pH-influenced PET processes between pyronine and different heterocycles, Related Products of alcohols-buliding-blocks, the publication is Organic & Biomolecular Chemistry (2017), 15(39), 8402-8409, database is CAplus and MEDLINE.

The OFF-ON and ON-OFF type pH probes based on rosamine were designed by using the relative electron densities between pyronine and various linked heterocycles. Probe 1a with an indole-pyronine skeleton gave an OFF-ON pH response (pK_a = 1.41) with decreasing pH, and the relative fluorescence intensity increased 15-fold, while probe 1b with an imidazole-pyronine skeleton did not give an ON-OFF response to different pH values. When pyronine was connected with a quinolinyl group, i.e., probes 1c-d, the red emission (around 575-800 nm) gave a monotonous ON-OFF pH response (pK_a = 3.26 and 2.62, resp.) with decreasing pH. The relative fluorescence intensities decreased 263- and 46-fold, resp. Changes in the electron donating abilities of the nitrogen containing heterocycles were used to explain variations in PET processes within the probes, and their pH-dependent PET mechanisms were verified using time-dependent d. functional theory calculations Confocal fluorescence imaging was also used to evaluate the potential biomedical application of probes 1a-d. Ultimately, probe 1d (I) with an appropriate pK_a value and good biocompatibility showed lysosome targeting ability.

Organic & Biomolecular Chemistry published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C11H21BF4N2O2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dahlin, Jayme L. published the artcilePAINS in the Assay: Chemical Mechanisms of Assay Interference and Promiscuous Enzymatic Inhibition Observed during a Sulfhydryl-Scavenging HTS, COA of Formula: C18H14BrNO5S2, the publication is Journal of Medicinal Chemistry (2015), 58(5), 2091-2113, database is CAplus and MEDLINE.

Significant resources in early drug discovery are spent unknowingly pursuing artifacts and promiscuous bioactive compounds, while understanding the chem. basis for these adverse behaviors often goes unexplored in pursuit of lead compounds Nearly all the hits from our recent sulfhydryl-scavenging high-throughput screen (HTS) targeting the histone acetyltransferase Rtt109 were such compounds Herein, we characterize the chem. basis for assay interference and promiscuous enzymic inhibition for several prominent chemotypes identified by this HTS, including some pan-assay interference compounds (PAINS). Protein mass spectrometry and ALARM NMR confirmed these compounds react covalently with cysteines on multiple proteins. Unfortunately, compounds containing these chemotypes have been published as screening actives in reputable journals and even touted as chem. probes or preclin. candidates. Our detailed characterization and identification of such thiol-reactive chemotypes should accelerate triage of nuisance compounds, guide screening library design, and prevent follow-up on undesirable chem. matter.

Journal of Medicinal Chemistry published new progress about 518303-20-3. 518303-20-3 belongs to alcohols-buliding-blocks, auxiliary class Apoptosis,Bcl-2, name is 2-((4-(4-Bromophenylsulfonamido)-1-hydroxynaphthalen-2-yl)thio)acetic acid, and the molecular formula is C18H14BrNO5S2, COA of Formula: C18H14BrNO5S2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sakti, Aditya Wibawa published the artcileRigorous pK_a Estimation of Amine Species Using Density-Functional Tight-Binding-Based Metadynamics Simulations, Quality Control of 622-40-2, the publication is Journal of Chemical Theory and Computation (2018), 14(1), 351-356, database is CAplus and MEDLINE.

Predicting pK_a values for different types of amine species with high accuracy and efficiency is of critical importance for the design of high performance and economical solvents in carbon capture and storage with aqueous amine solutions In this study, we demonstrate that d.-functional tight-binding (DFTB) metadynamics simulations are a promising approach to calculate the free energy difference between the protonated and neutral states of amines in aqueous solution with inexpensive computational cost. The calculated pKa values were in satisfactory agreement with the exptl. values, the mean absolute deviation being only 0.08 pK_a units for 34 amines commonly used in CO₂ scrubbing. Such superior reproducibility and correlation compared to estimations by static quantum mech. calculations highlight the significant effect of dynamical proton transfer processes in explicit solvent mols. for the improvement of the estimation accuracy. Note that the accuracy of the estimated pK_a might be dependent on the adopted systems, due to the limitation of the DFTB parameter.

Journal of Chemical Theory and Computation published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Quality Control of 622-40-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Maeda, Allyn H. published the artcileChemical and genomic analyses of polycyclic aromatic hydrocarbon biodegradation in Sphingobium barthaii KK22 reveals divergent pathways in soil sphingomonads, Product Details of C11H8O3, the publication is International Biodeterioration & Biodegradation (2020), 104993, database is CAplus.

Polycyclic aromatic hydrocarbons (PAHs) are hazardous pollutants that are biodegraded by soil bacteria and the soil sphingomonads are thought to be major contributors to PAH biodegradation To predict PAH environmental fates it is necessary to understand the chem. and genetics of PAH biodegradation by sphingomonads. When the soil sphingomonad Sphingobium barthaii KK22 was exposed to low mol. weight (LMW) PAHs and biotransformation products were investigated by comprehensive chem. analyses, at least twenty products were identified by different techniques and both intradiol- and extradiol-aromatic ring cleavage pathways were found to be active in this organism. Sphingomonads, a large and diverse group, have been studied in regard to PAH biodegradation, however intradiol-ring cleavage of LMW PAHs has never been reported. Whole genome sequencing and prediction of S. barthaii KK22 functional genes revealed sets of aromatic ring-hydroxylating oxygenases and PAH biotransformation genes. Combined with chem. analyses results, novel, near complete PAH biotransformation pathways for soil sphingomonads were constructed. In conjunction with quant. assays, a comprehensive view of PAH biodegradation was obtained that revealed divergent downstream pathways that advanced our understanding of the PAH biotransformation capabilities of these versatile soil bacteria and shall aid in predictions of PAH environmental fate during soil bioremediation.

International Biodeterioration & Biodegradation published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Product Details of C11H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts