Author: tianli

Farnejad, Soudeh published the artcileObtaining of Chickpea Protein Isolate and its Application as Coating Enriched with Essential Oils from Satureja Hortensis and Satureja Mutica in Egg at Room Temperature, COA of Formula: C10H18O, the publication is International Journal of Food Science and Technology (2022), 57(1), 400-407, database is CAplus.

Eggs are one of the most nutritious products on a daily basis. The objective of present research is to investigate the impact of coatings on improving storage time and internal quality of eggs. Coating treatments included control (C), coated with chickpea protein isolate (CPI), coated with PI containing Satureja hortensis (CPISH), coated with PI containing Satureja mutica (CPISM). Internal quality was assessed by air cell depth, shell strength, weight loss, haugh unit, yolk and albumen pH, yolk index, microbial evaluation and scanning electron microscope. The weight loss increased during storage and its highest value was 6.12%. Edible coatings (CPI, CPISH, CPISM) preserved internal quality according to the haugh unit, yolk index and pH over 4 wk (20°C) compared with C. Haugh unit (5.04), yolk index (0.31), albumen (9.51) and yolk pH (7.04) were detected in C after 7 wk. CPISH and CPISM protected shell is observed by scanning electron microscope and these coatings affected the internal quality and were appropriate alternatives to extend storage.

International Journal of Food Science and Technology published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, COA of Formula: C10H18O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mitsudome, Takato published the artcileSupported gold nanoparticle catalyst for the selective oxidation of silanes to silanols in water, Recommanded Product: Triisopropylsilanol, the publication is Chemical Communications (Cambridge, United Kingdom) (2009), 5302-5304, database is CAplus and MEDLINE.

Hydroxyapatite-supported gold nanoparticles (AuHAP) can act as highly efficient and reusable catalysts for the oxidation of diverse silanes into silanols in water; this is the first catalytic methodol. for the selective synthesis of aliphatic silanols using water under organic-solvent-free conditions.

Chemical Communications (Cambridge, United Kingdom) published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Recommanded Product: Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Naidu, Priya S. R. published the artcileNovel Hydrophilic Copolymer-Based Nanoparticle Enhances the Therapeutic Efficiency of Doxorubicin in Cultured MCF-7 Cells, Recommanded Product: 2-Morpholinoethanol, the publication is ACS Omega (2019), 4(17), 17083-17089, database is CAplus and MEDLINE.

Nanoparticle drug delivery applications have predominantly focused on the entrapment and delivery of hydrophobic mols. with poor water solubility However, benefits can also be obtained from nanoparticle-based delivery of hydrophilic therapeutics. This study reports on the development of a p(HEMA-ran-GMA)-based nanoparticle synthesized via a spontaneous water-in-oil inverse nanoemulsion to deliver doxorubicin, a water-soluble chemotherapeutic. High drug loading efficiency and sustained release of doxorubicin from Cy5-functionalized p(HEMA-ran-GMA) nanoparticles enabled effective inhibition of the MCF-7 human breast cancer derived cell line. Direct comparative analyses with a hydrophobic PGMA nanoparticle demonstrated enhanced capabilities of the p(HEMA-ran-GMA)-based nanoparticle in vitro. The results suggest that p(HEMA-ran-GMA)-based nanoparticles, which are better suited for hydrophilic drug loading and delivery, may have the potential for the improved therapeutic effect in vivo by enhanced permeation and retention of the nanoparticles by avoidance of off-site side effects of the chemotherapeutic.

ACS Omega published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Recommanded Product: 2-Morpholinoethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Leroux, Yves published the artcileReaction of magnesium with γ- and δ-halogenated ketones; synthesis of cyclanols, COA of Formula: C5H10O, the publication is Comptes Rendus des Seances de l’Academie des Sciences, Serie C: Sciences Chimiques (1967), 265(25), 1472-4, database is CAplus.

The reaction of Mg with γ- and δ-halo ketones in tetrahydrofuran (THF) was investigated. Treatment of γ-chlorinated ketones with Mg in THF followed by hydrolysis gave the corresponding pinacols. Similar treatment of γ-brominated ketones at 25° gave the corresponding I (R, R1, R2 and m.p. of phenylurethane derivative given): Me, H, H, 140°; Me, Me, H, 110°; Me, Et, H, 81°; Me, H, Me, 110°; Et, H, H, 125°; Pr, H, H, 99°; Bu, H, H, 95°; pentyl, H, H, 74°. The second alc. above was 60:40 cis-trans mixture and the fourth was practically pure cis isomer. Similar treatment of a δ-bromo ketone, e.g. 1-bromo-5-hexanone, gave 65% 1-methyl-1-cyclopentanol, as well as small amounts of pinacol and non-brominated ketones. The reaction is pictured as involving a radical cleavage of C-halogen bond and a reduction of the carbonyl group to an anion radical.

Comptes Rendus des Seances de l’Academie des Sciences, Serie C: Sciences Chimiques published new progress about 20117-47-9. 20117-47-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic cyclic hydrocarbon,Alcohol, name is 1-Methylcyclobutan-1-ol, and the molecular formula is C5H10O, COA of Formula: C5H10O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dracheva, Elena published the artcileIn Silico Identification of Potential Thyroid Hormone System Disruptors among Chemicals in Human Serum and Chemicals with a High Exposure Index, Category: alcohols-buliding-blocks, the publication is Environmental Science & Technology (2022), 56(12), 8363-8372, database is CAplus and MEDLINE.

Data on toxic effects are at large missing the prevailing understanding of the risks of industrial chems. Thyroid hormone (TH) system disruption includes interferences of the life cycle of the thyroid hormones and may occur in various organs. In the current study, high-throughput screening data available for 14 putative mol. initiating events of adverse outcome pathways, related to disruption of the TH system, were used to develop 19 in silico models for identification of potential thyroid hormone system-disrupting chems. The conformal prediction framework with the underlying Random Forest was used as a wrapper for the models allowing for setting the desired confidence level and controlling the error rate of predictions. The trained models were then applied to two different databases: (i) an inhouse database comprising xenobiotics identified in human blood and (ii) currently used chems. registered in the Swedish Product Register, which have been predicted to have a high exposure index to consumers. The application of these models showed that among currently used chems., fewer were overall predicted as active compared to chems. identified in human blood. Chems. of specific concern for TH disruption were identified from both databases based on their predicted activity.

Environmental Science & Technology published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Biessen, Erik A. L. published the artcileLysine-based cluster mannosides that inhibit ligand binding to the human mannose receptor at nanomolar concentration, Formula: C13H15NO6S, the publication is Journal of Biological Chemistry (1996), 271(45), 28024-28030, database is CAplus and MEDLINE.

In search of synthetic high affinity ligands for the mannose receptor, a series of lysine-based oligomannosides were synthesized containing two (M₂L) to six (M₆L₅) terminal α-D-mannose groups that are connected with the backbone by flexible elongated spacers (16 Å). The synthesized cluster mannosides were all able to displace binding of biotinylated RNase B and tissue-type plasminogen activator to isolated human mannose receptor. The affinity of these cluster mannosides for the mannose receptor was continuously enhanced from 18-23 μM to 0.5-2.6 nM, with mannose valencies increasing from two to six. On average, expansion of the cluster mannoside with an addnl. α-D-mannose group resulted in a 10-fold increase in its affinity for the mannose receptor. M₃L₂ to M₆L₅ displayed neg. cooperative inhibition of ligand binding to the mannose receptor, suggesting that binding of these mannosides involves multiple binding sites. The nanomolar affinity of the most potent ligand, the hexamannoside M₆L₅ makes it the most potent synthetic cluster mannoside for the mannose receptor yet developed. As a result of its high affinity and accessible synthesis, M₆L₅ not only is a powerful tool to study the mechanism of ligand binding by the mannose receptor, but it is also a promising targeting device to accomplish cell-specific delivery of genes and drugs to liver endothelial cells or macrophages in bone marrow, lungs, spleen, and atherosclerotic plaques.

Journal of Biological Chemistry published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, Formula: C13H15NO6S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chang, Jae Won published the artcileA Potent and Selective Inhibitor of KIAA1363/AADACL1 that Impairs Prostate Cancer Pathogenesis, Application of 4-(1H-Pyrrol-1-yl)phenol, the publication is Chemistry & Biology (Cambridge, MA, United States) (2011), 18(4), 476-484, database is CAplus and MEDLINE.

Summary: Cancer cells show alterations in metabolism that support malignancy and disease progression. Prominent among these metabolic changes is elevations in neutral ether lipids (NELs). We have previously shown that the hydrolytic enzyme KIAA1363 (or AADACL1) is highly elevated in aggressive cancer cells, where it plays a key role in generating the monoalkylglycerol ether (MAGE) class of NELs. Here, we use activity-based protein profiling-guided medicinal chem. to discover a highly potent and selective inhibitor of KIAA1363, the carbamate JW480. We show that JW480, and an shRNA probe that targets KIAA1363, reduce MAGEs and impair the migration, invasion, survival, and in vivo tumor growth of human prostate cancer cell lines. These findings indicate that the KIAA1363-MAGE pathway is important for prostate cancer pathogenesis and designate JW480 as a versatile pharmacol. probe for disrupting this pro-tumorigenic metabolic pathway.

Chemistry & Biology (Cambridge, MA, United States) published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Application of 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Terao, Yoshito published the artcilePalladium-catalyzed dehydroarylation of triarylmethanols and their coupling with unsaturated compounds accompanied by C-C bond cleavage, Related Products of alcohols-buliding-blocks, the publication is Journal of Organic Chemistry (2004), 69(20), 6942-6944, database is CAplus and MEDLINE.

Triarylmethanols were effectively dehydroarylated and reacted with some unsaturated compounds by using an appropriate palladium catalyst system such as Pd(OAc)₂-P(1-Nap)₃ to give the corresponding arenes and hydroarylation products, e.g., I, resp., along with diaryl ketones.

Journal of Organic Chemistry published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C6H10N2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Okuma, Kentaro published the artcileReaction of Benzyne with Salicylaldehydes: General Synthesis of Xanthenes, Xanthones, and Xanthols, Category: alcohols-buliding-blocks, the publication is Organic Letters (2009), 11(1), 169-171, database is CAplus and MEDLINE.

The reaction of salicylaldehydes with benzyne prepared from o-trimethylsilylphenyl triflate and CsF gave xanthenes and xanthones. When the reaction was carried out under basic conditions, 9-hydroxyxanthenes (xanthols) were obtained in good yields.

Organic Letters published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Drouet, Fleur published the artcileA Convenient Method for the Asymmetric Synthesis of Fluorinated α-Amino Acids from Alcohols, Synthetic Route of 2240-88-2, the publication is European Journal of Organic Chemistry (2014), 2014(6), 1195-1201, database is CAplus.

Due to their numerous applications, fluorinated amino acids have recently attracted significant attention. The preparation of fluorine-containing phenylalanines and aliphatic fluorinated amino acids using Mitsunobu-Tsunoda alkylation of a chiral nucleophilic glycine equivalent with readily available alc. substrates is described. The reaction proceeds in high yields and with excellent diastereoselectivity. This method provides an efficient synthetic route to fluorinated amino acids for which asym. approaches are scarce.

European Journal of Organic Chemistry published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Synthetic Route of 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts