Author: tianli

Ghosh, Pranab published the artcilePerformance evaluation of polymeric blend of vinyl acetate and acrylate-based copolymers in lubricating oil, Application of n-Octanol, the main research area is polymeric blend vinyl acetate acrylate lubricating oil.

Polymer modification processes like blending has attracted much attention as an easy, cost-effective and less time-consuming method for developing new polymeric materials enriched with versatile com. application. Polymer blends are supposed to carry better thermal and mech. properties compared to their parent polymers. In this view we have prepared a polymer blend of two copolymers- one of vinyl acetate and octyl acrylate and another of Me methacrylate and dodecyl acrylate and characterized them by FT-IR and NMR spectroscopy. The mol. weight was determined by Gel Permeation Chromatog. (GPC). We represented here a comparative study of their mech. property as well as their performance as flow improver.

Petroleum Science and Technology published new progress about Lubricating oils. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Application of n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Berthon, Laurence published the artcileHow Phase Modifiers Disrupt Third-phase Formation in Solvent Extraction Solutions, Recommanded Product: n-Octanol, the main research area is solvent extraction neodymium mol dynamics.

The structure of complex organic solutions based on N,N,N,N-tetraoctyldiglycolamide (TODGA) used in actinide separation processes were characterized after water and neodymium extraction The organic phases were characterized using FTIR spectroscopy, ESI-MS spectrometry, Small and Wide Angle X-ray Scattering (SWAXS) and mol. dynamic simulations. The role of the “”phase modifier”” like 1-octanol (used in the innovative SANEX process) or the “”co-extractant”” like DMDOHEMA (used, for example, in the EURO-GANEX process) added to the organic phase to avoid third-phase formation was investigated at mol. and supramol. scales. Without metallic cations in 0.2 mol/L TODGA solution in n-heptane, TODGA mols. are organized in monomers and small aggregates containing mainly two or three TODGA mols. After Nd(NO3)3 extraction, complexes or aggregates are formed in which each neodymium cation is surrounded in average by 2 to 4 TODGA, 3 nitrate ions and 1 to 2 water mols. Polymetallic species (aggregates) may also be formed. Adding 5%Vol 1-octanol or 0.5 mol/L DMDOHEMA to 0.2 mol/L TODGA solution in n-heptane leads to the formation of mixed aggregates containing TODGA and octanol mols. or TODGA and DMDOHEMA mols. These mols. both interact directly with the extracted metallic cation in the organic phase, modifying the structure of the neodymium species, and improving their solubility in this organic phase. At least one TODGA mol. remains in the cation first coordination sphere in both cases and preserves its significant role in the complexation/selectivity of the cations. But it is clear that both 1-octanol and DMDOHEMA have a role in the speciation of the cations in the organic phase: 1-octanol replaces water mols. in the first coordination sphere of Nd, acting as a co-surfactant; DMDOHEMA drives the organization and DMDOHEMA mols. partially replace TODGA in the first coordination sphere of Nd.

Solvent Extraction and Ion Exchange published new progress about Lattice dynamics. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Recommanded Product: n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wu, Mengqi published the artcileStructural elucidation and immunomodulatory activity of a neutral polysaccharide from the Kushui Rose (Rosa setate x Rosa rugosa) waste, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is structural immunomodulatory activity neutral polysaccharide Kushui waste WSRP1b; Immunomodulatory; Kushui Rose (Rosa setate x Rosa rugosa) waste; Polysaccharide; Structure.

In this present study, the structure and immunomodulatory activity of a novel polysaccharide (WSRP-1b) from Kushui rose (Rosa setate x Rosa rugosa) waste were investigated. Structure characterization demonstrated that WSRP-1b had a weight-average mol. weight of 1.11 × 104 Da and consisted of glucose (42.6%), mannose (21.4%), arabinose (9.9%), xylose (2.2%), and galactose (23.9%). Its backbone was composed of 1, 4-linked α-Glcp, 1, 4-linked β-Glcp, and 1, 4-linked β-Manp, with branches of 1, 4-linked α-Glcp and 1, 4-linked β-Manp substituted at C-6 by 1, 6-linked β-Galp. The branches mainly contained 1, 5-linked Araf, terminal arabinose and terminal glucose. Bioactivity assays showed that WSRP-1b had immunomodulatory activity by enhancing phagocytosis of macrophages, increasing production of ROS, NO, cytokines (IL-6, TNF-α), and activating NF-κB signaling pathway. These results suggested that it could be developed as a potential and safe immunomodulatory agent in fields of pharmacol. or functional foods.

Carbohydrate Polymers published new progress about Immunomodulators. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Baro-Montel, Nuria published the artcileScrutinising the relationship between major physiological and compositional changes during ‘Merrill O’Henry’ peach growth with brown rot susceptibility, Category: alcohols-buliding-blocks, the main research area is ethylene Monilinia respiration peach growth brown rot susceptibility; Citric; Monilinia spp.; Prunus persica; ethylene; fruit development.

In the present work, the major physiol. and compositional changes occurring during ‘Merrill O’Henry’ peach growth and its relationship with susceptibility to three strains of Monilinia spp. at 49, 77, 126 and 160 days after full bloom were explored. Results of disease incidence indicated wide differences among phenol. stages, being 49 and 126 days after full bloom the moment when peaches showed significantly lower susceptibility to brown rot (40 and 23% of rotten fruit, resp., for strain ML8L). Variation in brown rot susceptibility among different growth stages was also strain-dependent. Lower fruit susceptibility to ML8L at 49 and 126 was accompanied by noticeable changes in the fruit ethylene and respiration patterns, and also in sugars and organic acids content. By employing a partial least squares regression model, a strong neg. relationship between citric acid, and a pos. association of ethylene with peach susceptibility to Monilinia spp. at diverse phenol. stages were observed The results obtained herein highlight that the content of certain compounds such as citrate, malate and sucrose; the respiratory activity and the fruit ethylene production may mediate in a coordinated manner the fruit resistance to Monilinia spp. at different phenol. stages of peach fruit.

Food Science and Technology International (London, United Kingdom) published new progress about Fungi, brown rot. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Erkang published the artcileTransient absorption spectroscopy and imaging of redox in muscle mitochondria, Category: alcohols-buliding-blocks, the main research area is muscle mitochondria imaging transient absorption spectroscopy.

Mitochondrial redox is an important indicator of cell metabolism and health, with implications in cancer, diabetes, aging, neurodegenerative diseases, and mitochondrial disease. The most common method to observe redox of individual cells and mitochondria is through fluorescence of NADH and FAD+, endogenous cofactors serve as electron transport inputs to the mitochondrial respiratory chain. Yet this leaves out redox within the respiratory chain itself. To a degree, the missing information can be filled in by exogenous fluorophores, but at the risk of disturbed mitochondrial permeability and respiration. Here we show that variations in respiratory chain redox can be detected up by visible-wavelength transient absorption microscopy (TAM). In TAM, the selection of pump and probe wavelengths can provide multiphoton imaging contrast between non-fluorescent mols. Here, we applied TAM with a pump at 520nm and probe at 450nm, 490nm, and 620nm to elicit redox contrast from mitochondrial respiratory chain hemeproteins. Experiments were performed with reduced and oxidized preparations of isolated mitochondria and whole muscle fibers, using mitochondrial fuels (malate, pyruvate, and succinate) to set up physiol. relevant oxidation levels. TAM images of muscle fibers were analyzed with multivariate curve resolution (MCR), revealing that the response at 620nm probe provides the best redox contrast and the most consistent response between whole cells and isolated mitochondria.

Biomedical Optics Express published new progress about Flash photolysis. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dias, Patricia published the artcile3-Hydroxyphenylacetic Acid: A Blood Pressure-Reducing Flavonoid Metabolite, HPLC of Formula: 621-37-4, the publication is Nutrients (2022), 14(2), 328, database is CAplus and MEDLINE.

Regular intake of polyphenol-rich food has been associated with a wide variety of beneficial health effects, including the prevention of cardiovascular diseases. However, the parent flavonoids have mostly low bioavailability and, hence, their metabolites have been hypothesized to be bioactive. One of these metabolites, 3-hydroxyphenylacetic acid (3-HPAA), formed by the gut microbiota, was previously reported to exert vasorelaxant effects ex vivo. The aim of this study was to shed more light on this effect in vivo, and to elucidate the mechanism of action. 3-HPAA gave rise to a dose-dependent decrease in arterial blood pressure when administered i.v. both as a bolus and infusion to spontaneously hypertensive rats. In contrast, no significant changes in heart rate were observed In ex vivo experiments, where porcine hearts from a slaughterhouse were used to decrease the need for laboratory animals, 3-HPAA relaxed precontracted porcine coronary artery segments via a mechanism partially dependent on endothelium integrity. This relaxation was significantly impaired after endothelial nitric oxide synthase inhibition. In contrast, the blockade of SKCa or IKCa channels, or muscarinic receptors, did not affect 3-HPAA relaxation. Similarly, no effects of 3-HPAA on cyclooxygenase nor L-type calcium channels were observed Thus, 3-HPAA decreases blood pressure in vivo via vessel relaxation, and this mechanism might be based on the release of nitric oxide by the endothelial layer.

Nutrients published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, HPLC of Formula: 621-37-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ho, Angel published the artcileAcid-Catalyzed Intramolecular Ring-Opening Reactions of Cyclopropanated Oxabenzonorbornadienes with Carboxylic Acid Nucleophiles, Related Products of alcohols-buliding-blocks, the publication is Synthesis (2022), 54(5), 1422-1430, database is CAplus.

The present work demonstrates the ability of carboxylic acid tethered cyclopropanated oxabenzonorbornadienes (CPOBDs) to undergo ring-opening reactions in mild acidic conditions. The optimized reaction conditions involve the use of pTsOH in DCE at 90°C. Two regioisomers are formed but the reactions are highly regioselective towards type 3 ring-opened products. It was observed that substitution at the C5 and aryl positions of CPOBD significantly hinders the ring-opening reactions leading to decreased yields of ring-opened products, although high regioselectivity for the Type 3 ring-opened products is still maintained. Herein, the first examples of acid-catalyzed intramol. ring-opening reactions of CPOBD with carboxylic acid nucleophiles are reported.

Synthesis published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Michnova, Hana published the artcileBioactivity of methoxylated and methylated 1-hydroxynaphthalene-2-carboxanilides: comparative molecular surface analysis, Product Details of C11H8O3, the publication is Molecules (2019), 24(16), 2991, database is CAplus and MEDLINE.

A series of twenty-six methoxylated and methylated N-aryl-1-hydroxynaphthalene-2-carboxanilides was prepared and characterized as potential anti-invasive agents. The mol. structure of N-(2,5-dimethylphenyl)-1-hydroxynaphthalene-2-carboxamide as a model compound was determined by single-crystal X-ray diffraction. All the analyzed compounds were tested against the reference strain Staphylococcus aureus and three clin. isolates of methicillin-resistant S. aureus as well as against Mycobacterium tuberculosis and M. kansasii. In addition, the inhibitory profile of photosynthetic electron transport in spinach (Spinacia oleracea L.) chloroplasts was specified. In vitro cytotoxicity of the most effective compounds was tested on the human monocytic leukemia THP-1 cell line. The activities of N-(3,5-dimethylphenyl)-, N-(3-fluoro-5-methoxy-phenyl)- and N-(3,5-dimethoxyphenyl)-1-hydroxynaphthalene-2-carbox-amide were comparable with or even better than the commonly used standards ampicillin and isoniazid. All promising compounds did not show any cytotoxic effect at the concentration >30 μM. Moreover, an in silico evaluation of clogP features was performed for the entire set of the carboxamides using a range of software lipophilicity predictors, and cross-comparison with the exptl. determined lipophilicity (log k), in consensus lipophilicity estimation, was conducted as well. Principal component anal. was employed to illustrate noticeable variations with respect to the mol. lipophilicity (theor./exptl.) and rule-of-five violations. Addnl., ligand-oriented studies for the assessment of the three-dimensional quant. structure-activity relationship profile were carried out with the comparative mol. surface anal. to determine electron and/or steric factors that potentially contribute to the biol. activities of the investigated compounds

Molecules published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Product Details of C11H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nechitailo, N. A. published the artcileDihydric phenols as stabilizers for irradiated polypropylene, COA of Formula: C14H22O2, the publication is Plasticheskie Massy (1966), 37-41, database is CAplus.

Polypropylene (I) of mol. weight 390,000 after addition of 0.1 mmol of stabilizer/g. was irradiated with ⁶⁰Co γ-rays at an intensity of 1.0-1.5 megarads/h. in vacuo with a dose of 160 megarads or in air with a dose of 40 megarads. After irradiation, the fraction insoluble in o-xylene and intrinsic viscosity (in Decalin at 135°) of I were determined As stabilizers hydroquinone (II), 2-methylhydroquinone (III), 2-tert-butylhydroquinone (IV), 2-tert-octylhydroquinone (V), 2,5-di-tert-butylhydroquinone (VI), pyrocatechol (VII), 4-methylpyrocatechol (VIII), 4-tert-butylpyrocatechol (IX), 4-tert-octylcatechol (X), and 3,5-di-tert-butylpyrocatechol (XI) were used. The oxidation of I with air was determined by DTA and ir anal. γ-rays caused fission of chains and a decrease in mol. weight and softening temperature; simultaneously, crosslinking took place and an insoluble gel was formed. In the absence of air, no oxidation took place and only IX, X, and XI decreased the destruction of I; the amount of gel formed in I without stabilizers was 77.5%, and with II 68.0%, III 54.8%, IV 50.3%, V 43.7%, VI 67.0%, VII 40%, VIII 15.0%, IX 14.2%, X 71.0%, and XI 8.7%. Dihydric phenols shifted the temperature of the oxidation initiation to higher temperatures; the effect of alkyl derivatives of VII containing tert-Bu groups was especially strong. Oxidation of I irradiated in the presence of air was weakened by the addition of several phenols (no formation of a gel fraction, strong diminution of absorption by OH groups in the ir spectrum). The intrinsic viscosity of I irradiated in the presence of air was 0.13 for pure I (before irradiation 3.2), for II 0.11, III 0.23, IV 0.13, V 0.22, VI 0.13, VII 0.31, VIII 0.31, IX 0.20, X 0.11, and XI 0.17.

Plasticheskie Massy published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, COA of Formula: C14H22O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Taeufer, Tobias published the artcilePalladium-Catalyzed Synthesis of N,N-Dimethylanilines via Buchwald-Hartwig Amination of (Hetero)aryl Triflates, Product Details of C10H9NO, the publication is Journal of Organic Chemistry (2020), 85(11), 7097-7111, database is CAplus and MEDLINE.

This work delineates the synthesis of N,N-dimethylaniline derivatives from dimethylamines and aryl triflates. The palladium-catalyzed C-N bond formation proceeds in excellent yields, using an unsophisticated catalytic system, a mild base, and triflates as electrophiles, which are readily available from inexpensive phenols. N,N-Dimethylanilines are multifunctional reaction partners and represent useful but underutilized building blocks in organic synthesis.

Journal of Organic Chemistry published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C14H17BF2O2, Product Details of C10H9NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts