Author: tianli

Sudhakar, Sekar published the artcileBiodistribution and pharmacokinetics of thiolated chitosan nanoparticles for oral delivery of insulin in vivo, Application In Synthesis of 7575-23-7, the main research area is thiolated chitosan nanoparticle insulin oral delivery pharmacokinetics; Bioavailability; Chitosan; Insulin; Mucoadhesion; Oral delivery.

To improve the quality of life of diabetic patients, oral delivery of insulin would be better than s.c. injection, and the encapsulation of insulin for its oral delivery is a promising alternative one. In this study, we prepared an oral insulin delivery system using thiolated chitosan nanoparticles (TCNPs) loaded with insulin (Ins) and tested under in vitro and in vivo systems. TCNPs prepared from CS and pentaerythritol tetrakis (3-mercaptopropionate) (PETMP) at 4:1 ratio showed 220 ± 4 nm, 2.3 ± 1 mV, and 119 ± 4μmol g-1 in their size, charge and sulfhydryl content, resp . There was a sustained release of insulin from the TCNPs at pH 5.3. TCNPs treatment did not alter cell viability in vitro and oral administration of TCNPs reached over the tip of the microvilli near the intestinal mucosa in vivo. There were increased and decreased the levels of insulin and glucose in the blood, resp. when Ins-TCNPs were orally administered in the diabetes induced rats. Thus, our results suggested that the insulin stays significantly for a prolonged period to make bio-distribution and bioavailability due to its interaction with the mucus of the intestine, thus offering a better oral insulin delivery system for diabetic patients.

International Journal of Biological Macromolecules published new progress about Bioavailability. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Application In Synthesis of 7575-23-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wright, JaLessa N. published the artcileAcute increases in O-GlcNAc indirectly impair mitochondrial bioenergetics through dysregulation of LonP1-mediated mitochondrial protein complex turnover, Application of (S)-2-hydroxysuccinic acid, the main research area is OGlcNAc LonP dysregulation mitochondrial protein bioenergetics; LonP1; Thiamet-G; bioenergetics; mitochondria; protein -GlcNAcylation; protein turnover.

The attachment of O-linked β-N-acetylglucosamine (O-GlcNAc) to the serine and threonine residues of proteins in distinct cellular compartments is increasingly recognized as an important mechanism regulating cellular function. Importantly, the O-GlcNAc modification of mitochondrial proteins has been identified as a potential mechanism to modulate metabolism under stress with both potentially beneficial and detrimental effects. This suggests that temporal and dose-dependent changes in O-GlcNAcylation may have different effects on mitochondrial function. In the current study, we found that acutely augmenting O-GlcNAc levels by inhibiting O-GlcNAcase with Thiamet-G for up to 6 h resulted in a time-dependent decrease in cellular bioenergetics and decreased mitochondrial complex I, II, and IV activities. Under these conditions, mitochondrial number was unchanged, whereas an increase in the protein levels of the subunits of several electron transport complex proteins was observed However, the observed bioenergetic changes appeared not to be due to direct increased O-GlcNAc modification of complex subunit proteins. Increases in O-GlcNAc were also associated with an accumulation of mitochondrial ubiquitinated proteins; phosphatase and tensin homolog induced kinase 1 (PINK1) and p62 protein levels were also significantly increased. Interestingly, the increase in O-GlcNAc levels was associated with a decrease in the protein levels of the mitochondrial Lon protease homolog 1 (LonP1), which is known to target complex IV subunits and PINK1, in addition to other mitochondrial proteins. These data suggest that impaired bioenergetics associated with short-term increases in O-GlcNAc levels could be due to impaired, LonP1-dependent, mitochondrial complex protein turnover.

American Journal of Physiology published new progress about Bioaccumulation. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Application of (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reifenrath, William G. published the artcilePercutaneous Absorption of an Insect Repellent p-Menthane-3,8-DIOL: A Model for Human Dermal Absorption, Recommanded Product: 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, the main research area is menthanediol insect repellent skin absorption swine model solvent.

P-Menthane-3,8-diol(38DIOL) was recently introduced as a natural topical insect repellent in the com. product “”OFF! Botanicals”” lotion. The objective of this study was to provide an estimate of the potential for 38DIOL systemic absorption in humans. 14C 38DIOL formulated in the lotion and in an EtOH solution was applied to excised swine skin in an in vitro flow-through test system predictive of skin absorption in humans. Twenty-four hours after application, radiolabel recovered from the dermis and receptor fluid was summed to determine % absorption. At a dose of approx. 80 μg/cm2 of 38DIOL in the lotion, a value of 3.5 ± 0.8% of applied dose was obtained with swine skin. The corresponding value for 38DIOL in EtOH (90 μg/cm2) was not significantly different (3.0 ± 1.2%). Most of the applied dose of 38DIOL was found to evaporate from swine skin (77 ± 8% for the lotion and 87 ± 1% for EtOH solution), thus limiting percutaneous absorption values. For reference purposes, the swine skin absorptions of piperonyl butoxide (PBO) at 100 μg/cm2 in isopropanol, N,N-diethyl-m-toluamide (DEET) at 500 μg/cm2 in EtOH, and neat isododecane at 650 μg/cm2 (in order of increasing volatility) were 15 ± 6%, 23 ± 3%, and 0.09 ± 0.05% of applied dose resp. Isododecane was lost almost exclusively from the skin surface by evaporation For addnl. reference, absorptions of PBO, DEET, and 38DIOL were found to be higher with excised rat skin.

Journal of Toxicology and Environmental Health, Part A: Current Issues published new progress about Bioaccumulation. 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, Recommanded Product: 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Losada-Perez, Patricia published the artcileAsymmetric liquid-liquid criticality in the ideal volumetric mixing approximation, Product Details of C5H12O, the main research area is nitromethane pentanol liquid criticality volumetric mixing.

We address the question on the validity of the ideal volumetric mixing approximation, a customarily used approach to analyze liquid-liquid phase transitions. Thus, liquid-liquid coexistence curves for the binary mixture composed by nitromethane and 3-pentanol were obtained from direct single-phase mass d. measurements as a function of temperature A reasonable agreement with previously reported data obtained from refractive index measurements has been found, indicating that assuming ideal mixing is rather reasonable. Furthermore, the implications of the ideal volumetric mixing approximation on asym. liquid-liquid criticality are explored in the framework of complete scaling formulation, with emphasis on the coexistence curves in the mole fraction-temperature and volume fraction-temperature planes as well as on the behavior of the isobaric heat capacity per particle and per unit volume and the associated Yang-Yang-type anomalies.

Journal of Chemical Thermodynamics published new progress about Binary mixtures. 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Product Details of C5H12O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Khedri, Zohrab published the artcileKirkwood-Buff integrals and structure factor for binary mixtures of ionic liquid with 1-alkanol, Safety of n-Octanol, the main research area is alkanol Kirkwood Buff integral binary mixture ionic liquid.

In this paper, we have tried to describe the factors affecting mol. interactions and structure of binary systems including 1-Hexyl-3-methylimidazolium Nitrate ([Hmim][NO3]) and 1-alkanol (1-hexanol, up to 1-decanol) using Kirkwood-Buff (KB) integrals and structure factor. Obtained results indicate that unlike mols. tend to form favorable interactions via forming hydrogen bonds or dipolar interactions and stay alongside, while an increase in the carbon chain of 1-alkanols reduces the strength of bonds and tendency of the unlike mols. to stay together. Moreover, the structure of mixtures was studied using the concentration-concentration structure factor, SCC(0). Results from the application of this parameter show that in all binary mixtures, heterocoordination is predominant, ordering occurs in solutions and fluctuations are less than random orientation. In addition, the chem. short-range order parameter α’, which is an important function to understand the complex formation and phase segregation in the liquid mixtures, was calculated and discussed for mentioned mixtures For current binary mixtures, exptl. data and theor. investigations are novel and reported for the first time.

Journal of Molecular Liquids published new progress about Binary mixtures. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Safety of n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Almasi, Mohammad published the artcileCohesive energy density and internal pressure of benzene and 1-alkanol binary mixtures, Recommanded Product: n-Octanol, the main research area is benzene alkanol binary mixture cohesive energy density internal pressure.

The internal pressure (Pint), cohesive energy d. (ced), and free volume (vf) for liquid mixtures of benzene with (C6 to C10) 1-alkanol are calculated at 303.15 K and atm. pressure. Flory’s statistical theory was employed to drive the internal pressure of five binary mixtures The conductor-like screening model for real solutions (COSMO-RS), in combination with exptl. densities was applied to calculate the cohesive energy d. of the binary systems. The ‘structuredness’ of the fluids above was studied using the Pint/ced ratio. The values are between 0.7 and 1.2, as is the case for non-associated mol. liquids, and demonstrates the non-chem. dispersions and repulsion types for binary liquids The variations of these parameters with mole fraction and length of alkyl chain in the studied 1-alkanol were explained from the perspective of intermol. interactions. It is observed that increase in the Me groups of alc. creates addnl. steric hindrances, loosens the structural packing, and reduces the order of interactions in these mixtures Also, exptl. densities and viscosities at various temperatures were reported for liquid mixtures to verify the existing interactions among unlike mols.

Journal of Molecular Liquids published new progress about Binary mixtures. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Recommanded Product: n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Almasi, Mohammad published the artcileStudy of interactions in binary mixtures containing normal alkanols; KB integrals and structure factor, Recommanded Product: n-Octanol, the main research area is binary mixture normal alkanol Kirkwood Buff integral structure factor.

In this paper, the investigation on the structure and mol. interactions in the binary systems containing aniline and 1-alkanol (1-pentanol up to 1-decanol) was performed in the framework of Kirkwood-Buff (KB) integrals and exptl. techniques. The interpretation of obtained parameters shows that in binary mixtures with shorter chain alcs., unlike mols. tend to form strong interactions, while increasing in the carbon atom of 1-alkanols reduces the strength of bonds and tendency of the heterogeneous mols. to stay along side. Mixtures structure was studied using the concentration-concentration structure factor, . Results from the application of this parameter show that the heterocoordination occurs in solutions involving 1-pentanol up to 1-heptanol, while for mixtures containing 1-octanol to 1-decanol, homocoordination is predominant. Also, the chem. short-range order parameter, α’which is an important function to understand the complex formation and phase segregation in the liquid mixtures was obtained and discussed for mentioned mixtures

Physics and Chemistry of Liquids published new progress about Binary mixtures. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Recommanded Product: n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nagababu, P. published the artcileInvestigation of molecular interactions in binary mixtures of homologous series of aliphatic alcohols with 2-methoxyaniline at various temperatures, Recommanded Product: n-Octanol, the main research area is methoxyaniline binary mixture aliphatic alc mol interaction.

Thermodn. and transport properties (excess molar volume, excess isentropic compressibility and deviation in viscosity) are calculated from the exptl. d., speed of sound and viscosity. The results are analyzed in terms of rupture of hydrogen-bonded chain as the dipolar interaction between 2-methoxyaniline and 1-alkanol (1-hexanol, 1-heptanol and 1-octanol) exceeds the intermol. interaction through dipole-dipole and hydrogen bonding between these unlike mols. The VE results are analyzed in the light of Prigogine-Flory-Patterson theory. Anal. of each of the three contributions viz. interactional, free volume and P* to VE has shown that interactional contribution are pos. for all systems, the free volume effect and P* contribution are neg. for all the mixtures

Physics and Chemistry of Liquids published new progress about Binary mixtures. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Recommanded Product: n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mirheydari, Seyyedeh Narjes published the artcileComparison of models for correlation of drug solubility in ethanol + water binary mixtures, Synthetic Route of 64519-82-0, the main research area is ethanol water binary mixture drug solubility computational model.

The ability of a number of common models for correlating the collected solubility data of drugs in ethanol + water mixtures (the number of data sets is 43) was tested. The selected models are classified within three groups, (1) λ-h, van’t Hoff and Apelblat models with temperature dependency, and modified Wilson with solvent composition dependency, (2) Jouyban-Acree, Jouyban-Acree-van’t Hoff and Jouyban-Acree-Apelblat (linear models) and NRTL, Wilson and UNIQUAC (nonlinear models) with both temperature and solvent composition dependencies, (3) UNIFAC, Yalkowsky, log-linear model of Yalkowsky, Jouyban-Acree-Abraham and Jouyban-Acree-Hansen predictive models. Of the models in group 1, the Apelblat model has the lowest overall %ARD and Jouyban-Acree-van’t Hoff and Jouyban-Acree-Apelblat models in group 2 performed best in correlations. Moreover, predictions using Jouyban-Acree-Abraham and Jouyban-Acree-Hansen models in group 3 have the lowest %ARDs in this group.

Journal of Solution Chemistry published new progress about Binary mixtures. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Synthetic Route of 64519-82-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ashraf Uddin, M. published the artcileViscometric studies of molecular interactions in binary mixtures of ethylbenzene with (C4 to C8) Alkan-1-ols, SDS of cas: 111-87-5, the main research area is ethylbenzene butanol electron transfer density functional theory.

Dynamic viscosities (ηexp) for binary mixtures of ethylbenzene with butan-1-ol, pentan-1-ol, hexan-1-ol, heptan-1-ol, and octan-1-ol were measured at varying temperatures (298.15-323.15 K; interval, 5 K) and atm. pressure. Viscosity deviations (Δη) across the entire range of mole fractions were derived from ηexp and were correlated using a Redlich-Kister type polynomial expression. The ηexp were compared with those calculated, ηcal, in terms of the pure components and the adjustable interaction parameters derived from ηexp using Arrhenius, Kendall-Monroe, Grunberg-Nissan, Teja-Rice, and Andrade/DIPPR models to evaluate the validity of the predictive and correlative approaches. The temperature-induced variations in ηexp were discussed considering the impact of the increasing chain-length of alkanols, including mol. interactions among the component mols. in the binary mixtures A computational quantum mech. modeling approach, d.-functional theory, was used to explore the dimensions in interactions among the binary mixture components.

Journal of Molecular Liquids published new progress about Binary mixtures. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, SDS of cas: 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts