Author: tianli

Yano, Yohko F. published the artcilePeriodic Elastic Motion in a Self-Assembled Monolayer under Spontaneous Oscillations of Surface Tension: Molecules in a Scrum Push Back a Marangoni Flow, Name: n-Octanol, the main research area is self assembled monolayer surface tension Marangoni effect.

Regularly recurring phenomena are a common and important part of life. Such rhythmic behaviors are often seen in nonliving systems under far-from-equilibrium conditions. The study of simple nonliving systems provides clues for improving our understanding of the origin of biol. rhythms. Here, we focus on the spontaneous oscillation of surface tension associated with an intermittent Marangoni convective flow generated by two types of surfactants, those that are partially soluble (long chain alcs.) and insoluble (lipids) in water. In this system, we find that the collective motions of two surfactants interact with each other in a systematic manner to control a stable periodic motion: the alc. mols. (donor) produce a Marangoni flow, and the lipid mols. (acceptor) in a monolayer push the flow back. The shape of the surface tension oscillation can be explained by the viscoelastic properties of the acceptor surfactant, whereas the period of the surface tension oscillation has been explained by the phys. properties of the donor surfactant. A recently developed time-resolved X-ray surface scattering technique enables the dynamic structure of the water surface under flow to be determined We have repeatedly observed that lipid mols. at the air-water interface become regularly oriented normal to the surface at every onset of the Marangoni convective flow.

Journal of Physical Chemistry Letters published new progress about Convective flow. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Name: n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lura, Ard published the artcileTableting of mini-tablets in comparison with conventionally sized tablets: A comparison of tableting properties and tablet dimensions, COA of Formula: C12H24O11, the main research area is minitablet property tablet dimension; Compaction simulator; Direct compression; Functionalized excipients; Mini-tablets; Tablet properties; Tablets.

Mini-tablets are solid dosage forms with increasing interest for pharmaceutical industry due to clin. and biopharmaceutical benefits. But technol. aspects on mini-tableting are not fully investigated. Therefore, the impact of punch size and tableting pressure for industrially relevant excipients like microcrystalline cellulose, lactose, isomalt and Ludiflash are investigated using 8 and 11.28 mm punches for conventionally sized tablets and 1,2 and 3 mm punches for mini-tablets. For evaluation of the effect of tablet size on deformation behavior and mech. properties, compressibility, compactibility and tabletability plots are created and evaluated. Deformation behavior is analyzed by In-Die Heckel plot and modified Weibull function. Further, specific plastic energy (SPE) profiles are generated out of force-displacement plots. The effect of the adjustment of the aspect ratio towards 1 as in conventionally sized tablets on deformation behavior and tabletability is analyzed. The effect of tablet size on deformation behavior mainly showed lower yield pressures for conventionally sized tablets, whereas comparable SPEs were obtained with all tablet sizes. Furthermore, mini-tablets indicate better compactibility, as (depending on the excipient) higher tensile strengths were obtained at lower solid fractions. However, no superior tabletability properties are obtained for mini-tablets compared to conventionally sized tablets.

International Journal of Pharmaceutics: X published new progress about Compressibility. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, COA of Formula: C12H24O11.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sune-Negre, Josep M. published the artcileApplication of the SeDeM Diagram and a new mathematical equation in the design of direct compression tablet formulation, Name: (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is SeDeM diagram excipient Kleptose Plasdone S630.

Application of the new SeDeM Method is proposed for the study of the galenic properties of excipients in terms of the applicability of direct-compression technol. Through exptl. studies of the parameters of the SeDeM Method and their subsequent math. treatment and graphical expression (SeDeM Diagram), six different DC diluents were analyzed to determine whether they were suitable for direct compression (DC). Based on the properties of these diluents, a math. equation was established to identify the best DC diluent and the optimum amount to be used when defining a suitable formula for direct compression, depending on the SeDeM properties of the active pharmaceutical ingredient (API) to be used. The results obtained confirm that the SeDeM Method is an appropriate system, effective tool for determining a viable formulation for tablets prepared by direct compression, and can thus be used as the basis for the relevant pharmaceutical development.

European Journal of Pharmaceutics and Biopharmaceutics published new progress about Compressibility. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Name: (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ilic, Ilija published the artcileDeformation properties of pharmaceutical excipients determined using an in-die and out-die method, Name: (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is deformation pharmaceutical excipient compressibility.

This study investigated deformation mechanisms of some commonly used pharmaceutical fillers, such as microcrystalline cellulose, lactose, dicalcium phosphate, isomalt and cornstarch, using a combination of the in-die and out-die method with the Heckel and Walker models. The tableting mixtures contained of 98.5% (weight/weight) filler, the rest consisted of dry binder and an antiadhesive agent. Our results showed that plasticity and elasticity may be considered independent deformation properties as highly plastic materials (microcrystalline cellulose, cornstarch) also exhibited high elasticity. Particular emphasis was placed on explaining the differences observed between the in-die and out-die method-comparison revealed that the differences are a consequence of the material’s elastic properties. Larger error of in-die results can be expected for more elastic materials, and thus in-die Heckel should be used with some considerations. In contrast, the Walker model was found to be more robust and smaller differences were observed between the two methods. We consider the most correct results to have been obtained by the out-die approach, which excludes the elastic properties of the material evaluated. An excellent correlation between elastic determination at the single-particle level and multiple-particle scale was demonstrated, suggesting a great potential of nanoscale determination of a material’s mech. properties for better elucidation of deformation mechanisms.

International Journal of Pharmaceutics (Amsterdam, Netherlands) published new progress about Compressibility. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Name: (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rangamani, Adithya published the artcileEffect of backbone and end-group regioisomerism on thermomechanical properties of vanillin-based polyurethane networks, Application In Synthesis of 7575-23-7, the main research area is vanillin polyurethane network thermomech property.

Monomer composition, crosslink d., and crosslink distribution are the primary determinants of material properties in thermosetting networks. Here, we investigate the effect of regioisomerism and composition in polymeric networks via a recently developed scalable sequence-defined polyurethane macromer (SD-PUM) platform. The iterative, support-free SD-PUM platform facilitates the assembly of macromers with tunable backbones and pendant groups at the gram-scale. A series of SD-PUMs made with different end-groups and vanillin positional isomers were synthesized and crosslinked into thermosetting networks via multivalent thiol crosslinkers. The results show that the thermomech. properties of the ensuing networks are sensitive to the choice of regioisomer embedded in the SD-PUM backbone as well as the type of macromer end-group. When a crosslinker with higher functionality is employed, regioisomeric differences result in more pronounced changes in material properties. This work showcases the robustness of the SD-PUM platform and its use of backbone and end-group regioisomers to modulate material properties.

Polymer Chemistry published new progress about Complex modulus. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Application In Synthesis of 7575-23-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Galla, E. A. published the artcileRIM catalysis and coating interaction, Recommanded Product: N2-(2-Hydroxyethyl)-N1,N1,N2-trimethyl-1,2-ethylenediamine, the main research area is polyurethane reaction injection molding; catalyst polyurethane molding coating; amine catalyst polyurethane molding; triethylenediamine catalyst polyurethane molding.

The use of high-solids Durethane Elastomeric Enamel and Dabco  [280-57-9] catalyst (≤0.15 phr) enables the reaction-injection molding (RIM) of polyurethanes with no adverse effects on the coating. Other amine catalysts, e.g. Dabco T  [2212-32-0], can be added at ≤0.5 phr as cocatalyst with Dabco and Bu2Sn dilaurate [77-58-7]. Moldings catalyzed with >15 phr Dabco were successfully coated by subjecting the part to a high-temperature water rinse or by adding a small amount of acid to the primer.

Proceedings of the S.P.I. Annual Urethane Division Technical Conference published new progress about Coating process. 2212-32-0 belongs to class alcohols-buliding-blocks, name is N2-(2-Hydroxyethyl)-N1,N1,N2-trimethyl-1,2-ethylenediamine, and the molecular formula is C7H18N2O, Recommanded Product: N2-(2-Hydroxyethyl)-N1,N1,N2-trimethyl-1,2-ethylenediamine.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Galla, E. A. published the artcileRIM catalysis and coating interaction, Formula: C7H18N2O, the main research area is polyurethane molding coating; polymerization catalyst polyurethane coating; triethylenediamine polyurethane coating; molding reaction injection polyurethane.

Reaction-injection molded (RIM) polyurethanes containing ≤0.5 phr triethylenediamine (I) [280-57-9] catalyst and Sn cocatalysts can be coated with com. high-solids coatings (e.g. Durethane 300) or water-based coatings. With an exptl. high-solids Durethane Elastomeric Enamel, I can be used at ≤0.15 phr with no adverse effect, and reactive amine cocatalysts [e.g. Me2NCH2CH2N(Me)CH2CH2OH [2212-32-0]] can be added at 0.5 phr. Parts containing >0.15 phr I can be coated after rinsing with H2O or adding a small amount of acid to the primer. An additive which reacts with I during curing, thus preventing interference with coating without affecting curing rate, can be added to parts containing ≤1.0 phr I.

Journal of Elastomers & Plastics published new progress about Coating process. 2212-32-0 belongs to class alcohols-buliding-blocks, name is N2-(2-Hydroxyethyl)-N1,N1,N2-trimethyl-1,2-ethylenediamine, and the molecular formula is C7H18N2O, Formula: C7H18N2O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lopes, Diogo Gomes published the artcileImproving the granule strength of roller-compacted ibuprofen sodium for hot-melt coating processing, Synthetic Route of 64519-82-0, the main research area is ibuprofen granule coating strength excipient; Hot-melt coating; Multiparticulate system; Roller compaction; Sodium ibuprofen dihydrate; Sorbitol hydrate; Taste-masking.

Solvent-free hot-melt coating processing is a novel and cost-efficient approach to manufacturing taste-masked multiparticulate systems. However, most API powders are fine and cohesive and not processable by hot-melt coating. The aim of this study was to produce dense and abrasion-resistant granules with high drug content (>80%) via roller compaction for hot-melt coating process optimization. The selected API was ibuprofen sodium dihydrate, a salt of ibuprofen with improved bioavailability and poor intrinsic compactibility. The formulation and roller compaction process were developed for the production of granules with 94%w/w of API and low friability (∼30%), using sorbitol and isomalt as excipients. The strong bonding mechanism relied on powder jamming prior to the rollers and was investigated via SEM, differential scanning calorimetry and small and wide angle X-ray scattering. It was shown that sorbitol crystals are solubilized during roller compaction and recrystallize as sorbitol hydrate, acting as strong solid bridges. The robustness of the roller compaction process and the re-compaction of fines were investigated. A statistical design of experiments was conducted to evaluate the hot-melt coating process for taste masking of ibuprofen sodium granules. Taste masking required coating ratios higher than 40%w/w of granule batch, emphasizing the need for high-drug-content and abrasion-resistant granules.

International Journal of Pharmaceutics (Amsterdam, Netherlands) published new progress about Coating process. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Synthetic Route of 64519-82-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Aghofack-Nguemezi, Jean published the artcileEffects of bio-based coatings on the ripening and quality attributes of tomato (Solanum lycopersicum) fruits, Recommanded Product: 3-(Methylthio)propan-1-ol, the main research area is Solanum fruit ripening quality bio based coating; Solanum lycopersicum; by-products; cocoa; coffee; quality; shelf life.

BACKGROUND : Postharvest conservation of tomatoes is a major current challenge for growers and traders. Edible coatings constitute a pertinent alternative to existing conservation methods. RESULTS : Control tomatoes were fully ripe 3 days after harvesting, whereas fruits dipped in solutions containing extracts from cocoa pods (T1), cocoa leaves (T2) or coffee hulls (T3) reached full ripeness 14 days after treatment (DAT). Fruits treated by dipping in a solution containing an extract from coffee leaves (T4) were fully ripe 21 DAT. The visual assessment was confirmed by alterations in the level of chlorophyll a. Treatments induced a significant inhibition of chlorophyll a breakdown, especially during the first week after their application, T4 being the most efficacious. Weight loss increased significantly throughout the exptl. period and was accelerated by treatments. Some quality-related parameters of ripe tomato fruits were in most cases not significantly influenced by treatments. In a few cases, however, there were improvements in quality traits of ripe fruits. On 21 DAT, T4 induced significant increases in levels of β-carotene and 6-methyl-3,5-heptadien-2-ol, whereas T2 led, especially, to higher levels of volatile compounds CONCLUSION : Edible coatings based on extracts from coffee or cocoa leaves induced improvements in the shelf life and quality of tomato fruits.

Journal of the Science of Food and Agriculture published new progress about Coating process. 505-10-2 belongs to class alcohols-buliding-blocks, name is 3-(Methylthio)propan-1-ol, and the molecular formula is C4H10OS, Recommanded Product: 3-(Methylthio)propan-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kumar, Anil published the artcileRotational Diffusion of Medium Sized 7-[Diethylamino]-2H-1-Benzopyran-2-One Molecule in Alcohols: Study of Temperature and Solvent Viscosity Effect, Related Products of alcohols-buliding-blocks, the main research area is diethylamino benzopyranone dipole moment dielec relaxation rotational diffusion fluorescence; Hydrodynamic theories; Laser dye; Point dipole dielectric theories; Reorientation times; Super slip.

The rotational re-orientations times of the 7-[diethylamino]-2H-1-benzopyran-2-one (7-DHB) dye mol. have been examined in ethanol and octanol solvents when macroscopic solvent viscosity parameter is varied by varying the temperature, by employing the steady-state fluorescence depolarisation and Time-Correlated Single Photon Counting (TCSPC) techniques. Exptl. observation shows that 7-DHB probe is experiencing higher friction in octanol compared to ethanol and rotates slower by a factor of 7.3. The hydrodynamic Stokes Einstein’s Debye theory (SED) with a stick, slip boundary conditions parameters, quasi-hydrodynamic models (Dote-Kivelson-Schwartz and Geirer-Wirtz) were used to determine mech. friction and found an interesting towards super slip trend. Dielec. frictional theories of point dipole, Nee-Zwanzig and van der Zwan-Hynes both models fail to describe exptl. observe dielec. friction trends. Evidently, both hydrodynamic and dielec. models failed to explain the examined behavior, even in the qual. way in alcs.

Journal of Fluorescence published new progress about C-N bond length. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts