Author: tianli

Cope, Stephen published the artcileSweeteners, SDS of cas: 64519-82-0, the main research area is sweetener solubility sweetness review.

Bulk sweeteners provide both bulk and sweetness to a food product and exhibit similar properties to sucrose and are often used as direct substitutes. Sweetness is a key element in perception of product taste and quality. It represents an obvious factor in determining the appeal of sugar free products. Consumers demand the same sweet taste associated with sugar-sweetened products, without any unpleasant after-taste. The solubility of a sweetener can greatly influence the perception of sweetness. Highly soluble sweeteners result in a finished product which exhibits a rapid sweetness onset and impact, while poorly soluble sweeteners can provide mild, prolonged background sweetness. All bulk sweeteners exhibit excellent chem. and thermal stability, are largely non-reactive and exhibit excellent heat and acid stability in comparison to sucrose. Bulk sweeteners such as lactitol and xylitol allow manufacturers the opportunity to produce healthier products with a variety of nutritional claims, while exploiting new market opportunities. The relative risk of phys. health problems associated with obesity due to sweeteners are discussed.

NutraCos published new progress about Food solubility. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, SDS of cas: 64519-82-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Padilha, Carlos Eduardo de Araujo published the artcileSeparation and concentration of bioactive phenolic compounds by solvent sublation using three-liquid-phase system, Computed Properties of 111-87-5, the main research area is bioactive phenolic compound solvent sublation liquid phase system.

The present work investigated the SS performance with focus on the addition of second collecting phase to intensify the separation of vanillin and eugenol. First, experiments were performed with only n-octanol as the only collecting phase and the effects of solutes concentration and pH of the bottom phase were evaluated on the separation efficiency (E%). Then, the SS process was performed in a three-liquid-phase system formed by n-octanol/PEG 400/(NH4)2SO4 and the results were evaluated based on E%, distribution coefficient (D) and vanillin selectivity (RVAN/EUG) values. When compared to single component experiments, the presence of another solute had little effect on the E% values of vanillin and eugenol, regardless of the range of the initial concentration Moreover, in SS with n-octanol/acetate buffer it was possible to reach the highest values of E% for vanillin (53.83%) and eugenol (85.37%) in experiments with pH equal to 4.5. On the other hand, the three-liquid-phase system achieved selectivity at least twice as high as two-liquid-phase systems and D values higher than 25 for vanillin in the PEG 400-rich phase. Thus, SS using three-liquid-phase system appears as an alternative to solve multicomponent separation problems involving bioactive compounds

Food and Bioproducts Processing published new progress about Food processing. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Computed Properties of 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Libo published the artcileUltrasonic-assisted enzymatic extraction and characterization of polysaccharides from dandelion (Taraxacum officinale) leaves, HPLC of Formula: 59-23-4, the main research area is polysaccharide ultrasonic enzymic extraction leaf Taraxacum; Dandelion; Polysaccharides; Simulated digestion; Structural characterization; Ultrasonic-assisted enzymatic extraction.

Ultrasonic-assisted enzymic extraction (UAEE) technol. was employed to extract the polysaccharides from dandelion leaves (DLP). The extraction conditions were optimized by response surface method (RSM) and Box-Behnken design (BBD). The polysaccharide yield (14.05 ± 0.95%), which well matched with the predicted value of 14.27%, was obtained under the optimum parameters: ultrasound power 500 W, ultrasound time 42 min, cellulase amount 4.90%, and particle size 80 mesh. After purification by AB-8 Macroporous Resin and Sephadex G-100 column, a novel polysaccharide (DLP-I) was isolated and its mol. weight was estimated to be 87,000 g/mol by high performance liquid chromatog. (HPLC). Gas chromatog. (GC) anal. showed that DLP-I was composed of rhamnose, arabinose, mannose, galactose and glucose in the molar ratio of 1.14:1.00:1.05:4.76:1.52. 1D and 2D NMR spectra confirmed that the backbone of DLP-I was mainly consisted of →4)-α-D-Galp-(1→, →4)-β-D-Manp-(1→, →4)-α-D-Glcp-(1→, →2,4)-α-L-Rhap-(1→, and α-L-Araf-(1→ with branching at O-2 and O-4 of →2,4)-α-L-Rhap-(1→. In addition, the digestion results showed DLP-I could keep its stability during the simulated digestive juices.

International Journal of Biological Macromolecules published new progress about Food processing. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, HPLC of Formula: 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shao, Huimin published the artcileComposition and rheological properties of polysaccharide extracted from tamarind (Tamarindus indica L.) seed, Computed Properties of 59-23-4, the main research area is Tamarindus seed polysaccharide rheol; chemical composition; pH-resistance; rheological properties; tamarind seed polysaccharide; thermo-stability.

A polysaccharide was extracted in high yield from tamarind (Tamarindus indica L.) seed (TSP) by acidic hot water extraction and ethanol precipitation It was composed of 86.2% neutral polysaccharide, 5.4% uronic acid and 1.3% protein. The mol. weight of TSP was estimated to be about 1735 kDa, with glucose, xylose, and galactose in a molar ratio of 2.9:1.8:1.0 as the major monosaccharides. The steady shear and viscoelastic properties of TSP aqueous solutions were investigated by dynamic rheometry. Results revealed that TSP aqueous solution at a concentration above 0.5% (w/v) exhibited non-Newtonian shear-thinning behavior. Dynamic oscillatory anal. revealed that 10% (w/v) TSP showed as a “”weak gel”” structure. Apparent viscosities and viscoelastic parameters of TSP solutions decreased drastically in an alk. solution of pH > 10, but slightly influenced by acidic solution, high temperature and the presence of salt ions and sucrose. These results indicated that TSP possessed excellent pH-resistance and thermo-stability, which might be suitable for applications in acidic beverages and high-temperature processed foodstuffs.

Molecules published new progress about Food processing. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Computed Properties of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wedel, M. published the artcileSynthesis of metalloporphyrins and metallochlorins for immobilization on electrode surfaces, Safety of 3-(1H-Pyrrol-1-yl)propan-1-ol, the main research area is metalloporphyrin pendant pyrrole phosphonate preparation; metallochlorin pendant pyrrole phosphonate preparation; immobilization metalloporphyrinoid electrode surface.

New metalloporphyrinoid complexes functionalized with two pyrrole groups and bearing two phosphonate residues were synthesized starting from readily accessible deuterioporphyrin derivatives The functional pyrrole groups gave metalloporphyrinoid films on electrodes by oxidative electropolymerization However, the phosphonate functionalities could be used to immobilize the metalloporphyrinoids on polycrystalline TiO2 electrodes. Electrodes modified by immobilization of the metalloporphyrinoid complexes are useful for electrocatalysis and as electrochem. sensors.

European Journal of Organic Chemistry published new progress about Film electrodes. 50966-69-3 belongs to class alcohols-buliding-blocks, name is 3-(1H-Pyrrol-1-yl)propan-1-ol, and the molecular formula is C7H11NO, Safety of 3-(1H-Pyrrol-1-yl)propan-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhu, Hu published the artcileIdentification of Activators of Human Fumarate Hydratase by Quantitative High-Throughput Screening, Safety of (S)-2-hydroxysuccinic acid, the main research area is fumarate hydratase antioxidant hereditary leiomyomatosis renal cell cancer; automation; enzyme assays; enzyme kinetics; fluorescence methods; robotics; ultra-high-throughput screening.

Fumarate hydratase (FH) is a metabolic enzyme that is part of the Krebs cycle and reversibly catalyzes the hydration of fumarate to malate. Mutations of the FH gene have been associated with fumarate hydratase deficiency (FHD), hereditary leiomyomatosis and renal cell cancer (HLRCC), and other diseases. Currently, there are no high-quality small-mol. probes for studying human FH. To address this, we developed a quant. high-throughput screening (qHTS) FH assay and screened a total of 57,037 compounds from inhouse libraries in dose-response. While no inhibitors of FH were confirmed, a series of phenyl-pyrrolo-pyrimidine-diones were identified as activators of human FH. These compounds were not substrates of FH, were inactive in a malate dehydrogenase counterscreen, and showed no detectable reduction-oxidation activity. The binding of two compounds from the series to human FH was confirmed by microscale thermophoresis. The low hit rate in this screening campaign confirmed that FH is a “”tough target”” to modulate, and the small-mol. activators of human FH reported here may serve as a starting point for further optimization and development into cellular probes of human FH and potential drug candidates.

SLAS Discovery published new progress about Enzyme kinetics. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Safety of (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jang, Eun Ha published the artcileInvestigation of the effects of materials and dry granulation process on the mirabegron tablet by integrated QbD approach with multivariate analysis, COA of Formula: C12H24O11, the main research area is dry granulation mirabegron tablet QbD.

The purpose of this study was to evaluate the relationship among numerous variables to enhance the understanding of the effects of materials and process parameters on drug product quality. The study consisted of two stages: the first stage involved exptl. designing to optimize formulation and process parameters, and the second stage involved assessing the relationship between intermediate quality attributes (IQAs) and critical quality attributes (CQAs) by multivariate anal. (MVA). Initial risk assessment was conducted to select critical material attributes (CMAs) and critical process parameters (CPPs), which have a high effect on CQAs and IQAs. The correlation between IQAs and CQAs was confirmed via Pearson correlation anal. and principal component anal. The robustness of the correlation was verified using a wide range of variables. Therefore, the study suggests that risk in the development of drug products can be reduced via an integrated quality by design (QbD) approach employing MVA.

Powder Technology published new progress about Dry granulation. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, COA of Formula: C12H24O11.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Bo published the artcileVisible light-promoted dihydroxylation of styrenes with water and dioxygen, Category: alcohols-buliding-blocks, the main research area is visible light promoted dihydroxylation styrene water dioxygen; vicinal alc preparation.

An efficient visible light promoted metal-free dihydroxylation of styrenes with water and dioxygen was developed for the construction of vicinal alcs. The protocol was operationally simple with a broad substrate scope. The mechanistic studies demonstrated that one of the hydroxyl groups came from water and the other one came from mol. oxygen. Addnl., the β-alkyoxy alcs. could also be obtained using a similar strategy.

Chemical Communications (Cambridge, United Kingdom) published new progress about Dihydroxylation. 92093-23-7 belongs to class alcohols-buliding-blocks, name is 1-(4-Bromophenyl)ethane-1,2-diol, and the molecular formula is C8H9BrO2, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jacobs, Jeffrey W. published the artcileDiscovery of Tenapanor: A First-in-Class Minimally Systemic Inhibitor of Intestinal Na+/H+ Exchanger Isoform 3, Computed Properties of 110-99-6, the main research area is tenapanor inhibitor intestine sodium hydrogen exchanger isoform 3 NHE3.

We present herein the design, synthesis, and optimization of gut-restricted inhibitors of Na+/H+ exchanger isoform 3 (NHE3). NHE3 is predominantly expressed in the kidney and gastrointestinal tract where it acts as the major absorptive sodium transporter. We desired minimally systemic agents that would block sodium absorption in the gastrointestinal tract but avoid exposure in the kidney. Starting with a relatively low-potency highly bioavailable hit compound (1), potent and minimally absorbed NHE3 inhibitors were designed, culminating with the discovery of tenapanor (28). Tenapanor has been approved by the U.S. Food and Drug Administration (FDA) for the treatment of irritable bowel syndrome with constipation in adults.

ACS Medicinal Chemistry Letters published new progress about Digestive tract. 110-99-6 belongs to class alcohols-buliding-blocks, name is 2,2′-Oxydiacetic acid, and the molecular formula is C4H6O5, Computed Properties of 110-99-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Luhn, Oliver published the artcileDissolution profile of novel composite pellet cores based on different ratios of microcrystalline cellulose and isomalt, Category: alcohols-buliding-blocks, the main research area is dissolution composite pellet microcrystalline cellulose isomalt Eudragit.

There is a growing interest towards the application of inert cores as starting materials for pharmaceutical pellet manufacturing They serve as alternatives to develop and adapt a relatively simple manufacturing technol. compared with an extrusion/spheronization process. The major objective of this study was to investigate the effect of the compositions of core materials on the drug release profile. Pure microcrystalline cellulose (MCC), isomalt and different types of novel composite MCC-isomalt cores were layered with model drug (sodium diclofenac) and were coated with acrylic polymer. The effect of the osmolality in the gastrointestinal tract was simulated using glucose as osmotically active agent during in vitro dissolution tests. The results demonstrated the dependence of drug dissolution profile on the ratio of MCC and isomalt in the core and the influence of osmotic properties of the dissolution medium. Isomalt used in the composite core was able to decrease the vulnerability of the dissolution kinetics to the changes in the osmotic environment. © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci.

Journal of Pharmaceutical Sciences published new progress about Digestive tract. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts