Author: tianli

Norris, Marie K. published the artcileTutorial: Triheptanoin and Nutrition Management for Treatment of Long-Chain Fatty Acid Oxidation Disorders, Recommanded Product: (S)-2-hydroxysuccinic acid, the main research area is triheptanoin nutrition management treatment long chain fatty acid oxidation; anaplerotic; carnitine-acylcarnitine translocase deficiency; fatty acid oxidation disorder; medical nutrition therapy; triheptanoin; very long-chain acyl-CoA dehydrogenase deficiency.

Patients with severe long-chain fatty acid oxidation disorders (LC-FAODs) experience serious morbidity and mortality despite traditional dietary management including medium-chain triglyceride (MCT)-supplemented, low-fat diets. Triheptanoin is a triglyceride oil that is broken down to acetyl-CoA (CoA) and propionyl-CoA, which replenishes deficient tricarboxylic acid cycle intermediates. We report the complex medical and nutrition management of triheptanoin therapy initiated emergently for 3 patients with LC-FAOD. Triheptanoin (Ultragenyx Pharmaceutical, Inc, Novato, CA, USA) was administered to 3 patients with LC-FAOD on a compassionate-use basis. Triheptanoin was mixed with non-MCT-containing low-fat formula. Patients were closely followed with regular cardiac and laboratory monitoring. Cardiac ejection fraction normalized after triheptanoin initiation. Patients experienced fewer hospitalizations related to metabolic crises while on triheptanoin. Patient 1 has tolerated oral administration without difficulty since birth. Patients 2 and 3 experienced increased diarrhea. Recurrent breakdown of the silicone gastrostomy tube occurred in patient 3, whereas the polyurethane nasogastric tube for patient 2 remained intact. Patient 3 experiences recurrent episodes of elevated creatine kinase levels and muscle weakness associated with illness. Patient 3 had chronically elevated C10-acylcarnitines while on MCT supplementation, which normalized after initiation of triheptanoin and discontinuation of MCT oil. Triheptanoin can ameliorate acute cardiomyopathy and increase survival in patients with severe LC-FAOD. Substituting triheptanoin for traditional MCT-based treatment improves clin. outcomes. MCT oil might be less effective in carnitine-acylcarnitine translocase deficiency patients compared with other FAODs and needs further investigation.

JPEN, Journal of Parenteral and Enteral Nutrition published new progress about Cardiomyopathy. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Recommanded Product: (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Vazquez-Martinez, Olivia published the artcileMitochondrial Oxidation of the Cytoplasmic Reducing Equivalents at the Onset of Oxidant Stress in the Isoproterenol-Induced Rat Myocardial Infarction, Synthetic Route of 97-67-6, the main research area is myocardial infarction mitochondrial oxidation cytoplasm NADH oxidant stress; cardiac infarction; isoproterenol; malate-aspartate shuttle; oxidative stress; sequential alterations.

We have developed and characterized a model of isoproterenol (ISO)-induced myocardial necrosis, identifying three stages of cardiac damage: a pre-infarction (0-12 h), infarction (24 h), and post-infarction period (48-96 h). Using this model, we have previously found alterations in calcium homeostasis and their relationship with oxidant stress in mitochondria, which showed deficient oxygen consumption and coupled ATP synthesis. Therefore, the present study was aimed at assessing the mitochondrial ability to transport and oxidize cytoplasmic reducing equivalent (NADH), correlating the kinetic parameters of the malate-aspartate shuttle, oxidant stress, and mitochondrial functionality. Our results showed only discreet effects during the cardiotoxic ISO action on the endogenous malate-aspartate shuttle activity, suggesting that endogenous mitochondrial NADH oxidation capacity (Nohl dehydrogenase) was not affected by the cellular stress. On the contrary, the reconstituted system showed significant enhancement in maximal capacity of the malate-aspartate shuttle activity only at later times (post-infarction period), probably as a compensatory part of cardiomyocytes′ response to the metabolic and functional consequences of the infarcted tissue. Therefore, these findings support the notion that heart damage associated with myocardial infarction suffers a set of sequential biochem. and metabolic modifications within cardiomyocytes, where mitochondrial activity, controlling the redox state, could play a relevant role.

Antioxidants published new progress about Cardiac injury. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Synthetic Route of 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wong, S. published the artcileCatalysis in competing isocyanate reactions, HPLC of Formula: 2212-32-0, the main research area is butanol phenylisocyanate reaction model polyurethane; chromatog butanol phenylisocyanate reaction; catalysis isocyanate reaction; water phenylisocyanate reaction model polyurethane.

High-performance liquid chromatog. was used to determine the products given by the reaction of phenyl isocyanate  [103-71-9] with butanol  [71-36-3], and the reaction was a model for the main and side reactions occurring in the preparation of polyurethanes. The reaction in the presence of dibutyltin dilaurate  [77-58-7] gave only Bu N-phenylcarbamate (I) [1538-74-5], but PhNHCONPhCO2Bu [21367-12-4] was detected in very early stages of the reaction. The reaction in the presence of N,N’,N”-tris(3-dimethylaminopropyl)hexahydrotriazine  [15875-13-5] gave I and N,N’,N”-triphenylisocyanurate (II) [1785-02-0] simultaneously, but the reaction in the presence of N,N,N’-trimethylaminoethyl ethanolamine  [2212-32-0] gave I and II in sequence. The reaction of Ph isocyanate with water gave mainly PhNHCONHPh [26763-63-3], with 5% PhNHCONPhCO2Bu and PhNHCONPhCONHPh [2645-39-8].

Polymeric Materials Science and Engineering published new progress about Carbamoylation. 2212-32-0 belongs to class alcohols-buliding-blocks, name is N2-(2-Hydroxyethyl)-N1,N1,N2-trimethyl-1,2-ethylenediamine, and the molecular formula is C7H18N2O, HPLC of Formula: 2212-32-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Huiying published the artcileMultivariate relationships among sensory attributes and volatile components in commercial dry porcini mushrooms (Boletus edulis), Name: 3-(Methylthio)propan-1-ol, the main research area is porcini mushroom sensory characterization multivariate analysis; Aroma characteristic; Dry porcini mushroom; Hedonic rating; Multivariate analysis; Relative odor activity value; Volatile compound.

The present research investigated the relationships among sensory attributes and volatile components in dry porcini mushrooms by multivariate statistical analyses. The sensory characteristics were based on quant. descriptive anal. and consumer hedonic assessment. The volatile compounds were extracted by solid-phase microextraction, then were identified using gas chromatog.-mass spectrometry and gas chromatog.-olfactometry. The results showed that the high hedonic rating of porcini mushrooms was due in part to its aroma notes such as seasoning-like, roasted, cacao-like and smoky. High hedonic liking and pos. aromas of porcini mushrooms could be responsible for the volatiles including 3-(methylthio)propanal, 3-(methylthio)propanol, pyrazines, phenolic and furanone components. On the other hand, raw mushroom-like, cardboard-like, as well as sweaty attributes were attributed to the relatively low hedonic liking of porcini mushrooms, which correlated with high contents of 1-octen-3-ol, octanal, 2-pentylfuran and 3-methylbutanoic acid. The information reported here could be important for the quality control of com. porcini mushrooms by providing an approach to strengthen the interpretation of sensory data by showing how they were affected by the chem. properties.

Food Research International published new progress about Boletus edulis. 505-10-2 belongs to class alcohols-buliding-blocks, name is 3-(Methylthio)propan-1-ol, and the molecular formula is C4H10OS, Name: 3-(Methylthio)propan-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Huiying published the artcileMultivariate relationships among sensory attributes and volatile components in commercial dry porcini mushrooms (Boletus edulis), Quality Control of 111-87-5, the main research area is porcini mushroom sensory characterization multivariate analysis; Aroma characteristic; Dry porcini mushroom; Hedonic rating; Multivariate analysis; Relative odor activity value; Volatile compound.

The present research investigated the relationships among sensory attributes and volatile components in dry porcini mushrooms by multivariate statistical analyses. The sensory characteristics were based on quant. descriptive anal. and consumer hedonic assessment. The volatile compounds were extracted by solid-phase microextraction, then were identified using gas chromatog.-mass spectrometry and gas chromatog.-olfactometry. The results showed that the high hedonic rating of porcini mushrooms was due in part to its aroma notes such as seasoning-like, roasted, cacao-like and smoky. High hedonic liking and pos. aromas of porcini mushrooms could be responsible for the volatiles including 3-(methylthio)propanal, 3-(methylthio)propanol, pyrazines, phenolic and furanone components. On the other hand, raw mushroom-like, cardboard-like, as well as sweaty attributes were attributed to the relatively low hedonic liking of porcini mushrooms, which correlated with high contents of 1-octen-3-ol, octanal, 2-pentylfuran and 3-methylbutanoic acid. The information reported here could be important for the quality control of com. porcini mushrooms by providing an approach to strengthen the interpretation of sensory data by showing how they were affected by the chem. properties.

Food Research International published new progress about Boletus edulis. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Quality Control of 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Zhangbao published the artcileCharacterization and immunological activities of polysaccharides from Polygonatum sibiricum, Product Details of C6H12O6, the main research area is Polygonatum polysaccharides cytokines immunomodulatory; Polygonatum sibiricum polysaccharide; characterization; immunological activity.

We investigated the physicochem. properties and composition of monosaccharides from Polygonatum sibiricum. Simultaneously, we explored the in vivo and in vitro immunomodulatory activity and mechanism of Polygonatum sibiricum polysaccharide (PSP) activity by monitoring changes in immune organs, immune cells, and cytokines. The average mol. weight (Mw) of PSP was 9.514 x 104 Da. The monosaccharide components of PSP were galactose, rhamnose, arabinose, mannose, and glucose at a molar ratio of 11.72:1.78:4.15:1.00:2.48. PSP increased thymus and spleen indexes, enhance the proliferative responses of splenocytes, and increased the phagocytosis of mononuclear macrophages. Simultaneously, PSP could recover the body mass of immunosuppressed mice, and increased blood erythrocyte counts in the sera of cyclophosphamide (Cy)-treated and normal mice, while blood leukocytes and platelet counts of Cy-treated mice recovered. PSP elevated the CD4+/CD8+ ratio is a dose-dependent manner and increased the levels of interleukin-2 (IL-2) and tumor necrosis factor-a (TNF-α) in the sera of Cy-treated mice. PSP further enhanced the expression of IL-2 and TNF-α in spleen lymphocytes. Addnl., PSP treatment accelerated the recovery of natural killer cell activity in a dose-dependent manner. Taken together, PSP not only regulated the immune function of normal mice, but participated in the protection against immunosuppression in Cy-treated mice, highlighting its potential as an immunostimulant.

Biological & Pharmaceutical Bulletin published new progress about Blood platelet. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Product Details of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Parvin Shahdousti published the artcileSimultaneous Determination of Lamotrigine and Carbamazepine in Plasma Using Ultrasound-Assisted Emulsification Microextraction-High Performance Liquid Chromatography, Synthetic Route of 111-87-5, the main research area is lamotrigine carbamazepine ultrasound assisted emulsification microextraction HPLC.

A simple, fast and efficient method based on ultrasound-assisted emulsification microextraction (USAEME) followed by HPLC has been developed for simultaneous determination of Carbamazepine (CBZ) and Lamotrigine (LTG) in biol. samples. The influence of different parameters affecting the USAEME procedure was evaluated to optimize the efficiency of the process. At these conditions, validation of the proposed method was performed based on European medicines agency guidelines. The proposed method showed good linearity in plasma samples ranging from 0.25 to 6μg/mL and 0.13 to 6μg/mL (R2 ≥ 0.99) for CBZ and LTG, resp. The precision of the proposed method was evaluated for repeatability which was ≤12% (n = 5). The detection limits of 0.06 and 0.05μg/mL were obtained for CBZ and LTG, resp. The proposed method can be applied as an effective technique for therapeutic drug monitoring of CBZ and LTG in plasma of epileptic patients.

Journal of Analytical Chemistry published new progress about Blood analysis. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Synthetic Route of 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhu, Quan-Fei published the artcileIn-Depth Annotation Strategy of Saturated Hydroxy Fatty Acids Based on Their Chromatographic Retention Behaviors and MS Fragmentation Patterns, Application of 17-Hydroxyheptadecanoic acid, the main research area is hydroxy fatty acid annotation LC MS.

Hydroxy fatty acids are a class of bioactive compounds in a variety of organisms. The identification of hydroxy fatty acids in biol. samples has still been a challenge because of their low abundance, high structural similarity, and limited availability of authentic hydroxy fatty acid standards Here, we present a strategy for the annotation of saturated monohydroxyl fatty acids (OH-FAs) based on the integration of chromatog. retention rules and MS2 fragmentation patterns. Thirty-nine authentic OH-FA standards were used to investigate their retention behavior on a reversed-phase stationary phase (C18) of liquid chromatog., and we found that their retention simultaneously follows two kinds of “”carbon number rules””. Using the “”carbon number rules””, the retention index (RI) of all OH-FAs that contain carbon numbers from 8 to 18 (C8-18) can be predicted. Addnl., by studying the MS2 fragmentation of OH-FAs under collision-induced dissociation, we found that the intensity ratio (IR) of the characteristic fragment ions ([M + H]+-63 and [M + H]+-45) is closely related to the position of the hydroxyl group on the OH-FA structure, which is helpful to further identify and confirm the OH-FA isomers. As a result, 97 of 107 potential OH-FAs detected in honey, human serum, and rice seedling by chem. isotope labeling-assisted liquid chromatog.-mass spectrometry were annotated upon the RI matching and IR confirming. Furthermore, in order to simplify the annotation process of OH-FAs, we constructed an OH-FA library to facilitate the annotation of OH-FAs. Overall, this study provides a new and promising tool for the in-depth annotation of OH-FA isomers.

Analytical Chemistry (Washington, DC, United States) published new progress about Blood analysis. 13099-34-8 belongs to class alcohols-buliding-blocks, name is 17-Hydroxyheptadecanoic acid, and the molecular formula is C17H34O3, Application of 17-Hydroxyheptadecanoic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yuvali, Donay published the artcileAn environment-friendly and rapid liquid-liquid microextraction based on new synthesized hydrophobic deep eutectic solvent for separation and preconcentration of erythrosine (E127) in biological and pharmaceutical samples, Product Details of C8H18O, the main research area is liquid microextraction hydrophobic deep eutectic solvent erythrosine; Blood; Deep eutectic solvent; Erythrosine; Liquid-liquid microextraction; Pharmaceutical samples; Urine.

A new deep eutectic solvent (DES) consist of tetrabuthylammonium bromide (TBABr) and 1-octanol at 1:2 M ratio was prepared for the first time and characterized by FTIR spectroscopy (FTIR), proton NMR (1H NMR) and carbon NMR (13C NMR) techniques. The new DES was used as an extraction solvent in the ultrasound assisted liquid-liquid microextraction (UA-LLME) of Erythrosine (E127) in blood, urine, pharmaceutical tablet and syrup samples. Accurate and sensitive determination of erythrosine was accomplished with the combination use of DES-UA-LLME and UV-visible spectrophotometric detection. Before applying UA-LLME, while protein precipitation was applied to blood samples, pharmaceutical tablets were homogenized and dissolved in methanol. The proposed DES-UA-LLME/UV-visible procedure was applied directly to urine, syrup sample and supernatant of blood and tablet samples with high recoveries in range of 90% and 100%. Erythrosine in the aqueous sample phase was extracted into 200μL hydrophobic DES phase at pH 7.0. The effect of important anal. variables such as pH of sample solution, mol ratio of DES components, volume of DES, ultrasonic-based extraction time, sample volume and salt effect were optimized. The preconcentration factor (PF), limit of detection (LOD), intra-day and inter-day relative standard deviations (relative standard deviation, %) for the developed procedure were found as 40, 3.75μg·L-1, 2.6% and 4.6%, resp.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about Blood analysis. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Product Details of C8H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fashi, Armin published the artcileAn analytical strategy based on the combination of ultrasound assisted flat membrane liquid phase microextraction and a smartphone reader for trace determination of malondialdehyde, Name: n-Octanol, the main research area is ultrasound assisted flat membrane liquid phase microextraction malondialdehyde; Biological samples; Derivatization; Membrane extraction; Preconcentration; RGB analysis; Sugaring out.

A new cleanup process entitled ultrasonic assisted flat membrane liquid phase microextraction (UA-FM-LPME) was introduced. The UA-FM-LPME procedure in two phase format was applied for the extraction-preconcentration of malondialdehyde (MDA) as an analyte model from the biol. samples after a derivatization reaction. In the designed extraction setup, the simultaneous use of two flat sheet membranes and the application of ultrasonic radiation provided the efficient mass transfer of MDA into the acceptor phase in a short extraction time (2 min). The collected organic phase was then analyzed through Red-Green-Blue (RGB) image anal. and HPLC coupled with UV-visible spectroscopy (HPLC-UV/visible) as detection methods. The key parameters affecting the extraction process were studied and optimized. The effect of the sugaring out on the partition of MDA into the extraction phase was examined for the first time. Under optimal conditions, linearity was observed in the concentration range of 8-1000 ng mL-1 for HPLC, and 10-1000 ng mL-1 for RGB anal., with the coefficient of determination (R2) values >0.9973. The introduced method also offered satisfactory relative standard deviations (RSDs) <4.0%. In order to examine the reliability of the technique in complicated matrixes, three different biol. samples (urine, saliva and blood plasma) were analyzed and the acceptable results in terms of relative recoveries (89.7-102.4%) were obtained. The designed setup in combination with RGB anal. will provide a low-cost alternative technique for rapid determination of MDA in clin. diagnosis or biochem. anal. without the need to complex, time consuming and expensive anal. instruments. Talanta published new progress about Blood analysis. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Name: n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts