Author: tianli

Zhang, Ping published the artcileAdvanced continuous flow platform for on-demand pharmaceutical manufacturing, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol, the publication is Chemistry – A European Journal (2018), 24(11), 2776-2784, database is CAplus and MEDLINE.

As a demonstration of an alternative to the challenges faced with batch pharmaceutical manufacturing including the large production footprint and lengthy time-scale, we previously reported a refrigerator-sized continuous flow system for the on-demand production of essential medicines. Building on this technol., herein we report a second-generation, reconfigurable and 25% smaller (by volume) continuous flow pharmaceutical manufacturing platform featuring advances in reaction and purification equipment. Consisting of two compact [0.7 (L)×0.5 (D)×1.3 m (H)] stand-alone units for synthesis and purification/formulation processes, the capabilities of this automated system are demonstrated with the synthesis of nicardipine hydrochloride and the production of concentrated liquid doses of ciprofloxacin hydrochloride, neostigmine methylsulfate and rufinamide that meet US Pharmacopeia standards

Chemistry – A European Journal published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C12H17NO2, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hsin, Ling-Wei published the artcileSynthesis and biological activity of fluoro-substituted pyrrolo[2,3-d]pyrimidines: the development of potential positron emission tomography imaging agents for the corticotropin-releasing hormone type 1 receptor, COA of Formula: C8H19NO, the publication is Bioorganic & Medicinal Chemistry Letters (2000), 10(8), 707-710, database is CAplus and MEDLINE.

A series of fluoro-substituted 4-(dialkylamino)pyrrolo[2,3-d]pyrimidines was synthesized and their binding affinity for corticotropin-releasing hormone type 1 receptor (CRHR₁) was investigated. Thus, N-ethyl-N-(4-fluorobutyl)-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine and N-(4-fluorobutyl)-2,5,6-trimethyl-N-propyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine possessed very high CRHR₁ affinity (K_i=3.5, 0.91 nM, resp.). They are promising candidates for the development of ¹⁸F-containing non-peptide PET radioligands for CRHR₁.

Bioorganic & Medicinal Chemistry Letters published new progress about 4543-95-7. 4543-95-7 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 4-(Butylamino)butan-1-ol, and the molecular formula is C8H19NO, COA of Formula: C8H19NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shenghur, Abraham published the artcileTheoretical Study of the Hydrogen Abstraction of Substituted Phenols by Nitrogen Dioxide as a Source of HONO, Application of 3-(Methylamino)phenol, the publication is Journal of Physical Chemistry A (2014), 118(46), 11002-11014, database is CAplus and MEDLINE.

The mild yet promiscuous reactions of nitrogen dioxide (NO₂) and phenolic derivatives to produce nitrous acid (HONO) have been explored with d. functional theory calculations The reaction is found to occur via four distinct pathways with both proton coupled electron transfer (PCET) and hydrogen atom transfer (HAT) mechanisms available. While the parent reaction with phenol may not be significant in the gas phase, electron donating groups in the ortho and para positions facilitate the reduction of nitrogen dioxide by electronically stabilizing the product phenoxy radical. Hydrogen bonding groups in the ortho position may addnl. stabilize the nascent resonantly stabilized radical product, thus enhancing the reaction. Catechol (ortho-hydroxy phenol) has a predicted overall free energy change ΔG⁰ = -0.8 kcal mol^-1 and electronic activation energy E_a = 7.0 kcal mol^-1. Free amines at the ortho and para positions have ΔG⁰ = -3.8 and -1.5 kcal mol^-1; E_a = 2.3 and 2.1 kcal mol^-1, resp. The results indicate that the hydrogen abstraction reactions of these substituted phenols by NO₂ are fast and spontaneous. Hammett constants produce a linear correlation with bond dissociation energy (BDE) demonstrating that the BDE is the main parameter controlling the dark abstraction reaction. The implications for atm. chem. and ground-level nitrous acid production are discussed.

Journal of Physical Chemistry A published new progress about 14703-69-6. 14703-69-6 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Phenol, name is 3-(Methylamino)phenol, and the molecular formula is C9H10N2O, Application of 3-(Methylamino)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gao, Fang published the artcileFragmentation of Lignin Samples with Commercial Pd/C under Ambient Pressure of Hydrogen, Name: 2-Phenoxy-1-phenylpropane-1,3-diol, the publication is ACS Catalysis (2016), 6(11), 7385-7392, database is CAplus.

We report the reagentless cleavage of prevalent β-O-4 linkages in lignin model compounds, as well as the cleavage of several types of organosolv lignins, catalyzed by com. available Pd/C. Such lignin fragmentation occurred without added reagent if the indigenous double bonds were reduced first or it occurred under conditions in which just 1 atm of hydrogen was added to the system to reduce C=C bonds of the original lignin sample in situ prior to fragmentation. A detailed view of the sites of cleavage of lignin samples from various sources was gained by HSQC NMR experiments Complex model compounds were prepared and shown to form simpler arenes and substituted phenols under catalytic conditions without added reagents. The hydrogen generated in situ from alc. functionalities provides the reductant for concomitant hydrogenolysis of C-O bonds in β aryl ethers. Decarbonylation of primary alcs. also occurred, and this process resulted in significant amounts of aromatic products containing substituents bearing one fewer carbon atom than the original linkages in lignin. The fragmentations of synthetic lignin and several organosolv lignins derived from Miscanthus giganteus and pine tree were conducted. Because the lignins contain alkenes that accept the hydrogen, two procedures involving reduction of the alkenes prior to C-O bond cleavage were developed. The first procedure involves reduction of the alkenes, followed by catalytic cleavage of C-O bonds after saturation of the C-C bonds; a second involves cleavage of lignin samples in the presence of 1 atm of hydrogen to saturate the alkenes before cleavage in situ. These protocols convert solid lignin to monomeric phenolic compounds with 20 mol % catalyst or to an oil (with 5 mol % Pd/C loading) having favorable viscosity parameters upon blending with a renewable organic solvent.

ACS Catalysis published new progress about 70110-65-5. 70110-65-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Alcohol,Ether,Benzene Compounds, name is 2-Phenoxy-1-phenylpropane-1,3-diol, and the molecular formula is C15H16O3, Name: 2-Phenoxy-1-phenylpropane-1,3-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rybicka-Jasinska, Katarzyna published the artcilePorphyrins as Promising Photocatalysts for Red-Light-Induced Functionalizations of Biomolecules, Recommanded Product: 2-Phenylethanethiol, the publication is ACS Organic & Inorganic Au, database is CAplus.

Red-light enables deeper material penetration, which is important for biol. applications and has consequences for chem. synthesis. Therefore, the search for new photocatalysts that absorb in this region is crucial. Despite the undeniable utility of porphyrins in blue- and green-light-induced energy- and electron-transfer processes, they are also perfectly suited for red-light applications. Herein, we describe free-base porphyrins as photoredox catalysts for red-light-induced organic transformations. They can act as both photooxidants and photoreductants and can accomplish the synthesis of biaryls once merged with Pd-catalysis. The developed methodol. holds promise for broader applications, as the heme-based protoporphyrin is used as a photocatalyst and reactions can be realized in aqueous conditions.

ACS Organic & Inorganic Au published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Recommanded Product: 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Habtemariam, Abraha published the artcileControl of aminophosphine chelate ring-opening in Pt(II) and Pd(II) complexes: potential dual-mode anticancer agents, Formula: C10H15NO, the publication is Journal of the Chemical Society, Dalton Transactions (2001), 1306-1318, database is CAplus.

Bis(aminophosphine) complexes [M(R¹R²N(CH₂)_nPPh₂)₂]²⁺, M = Pt(II) or Pd(II), can exist in chelate ring-closed and ring-opened forms both in the solid state and in aqueous solution The equilibrium between them in solution can be controlled by the nature of the groups R¹ and R² (H, Me, Bz, cyclohexyl), by the bridge length n, and by the pH and Cl^– concentration X-ray crystal structures are reported for the ring-closed complexes cis-[Pt(H₂N(CH₂)₂PPh₂-P,N)₂]Cl₂, cis-[Pt(H₂N(CH₂)₃PPh₂-P,N)₂]Cl₂, and cis-[Pt(Me(H)N(CH₂)₂PPh₂-P,N)₂]Cl₂, the mono-ring-opened complex cis-Pd[(Me₂N(CH₂)₂PPh₂-N,P)Cl(Me₂NH(CH₂)₂PPh₂-P)](NO₃)₂, the di-ring-opened complex cis-[Pt(Me₂N(CH₂)₃PPh₂-P)₂Cl₂], and, for comparison, the monochelate cis-[Pd(Me₂N(CH₂)₃PPh₂-N,P)]Cl₂. These square-planar complexes exhibit varying degrees of distortion and variable M-N bond lengths dependent not only on the trans influence of P but also on steric effects within the complex. PH-induced chelate ring-opening of cis-[Pt(Me₂N(CH₂)₂PPh₂-P,N)₂]Cl₂ had an associated pK value of 6.9. In contrast, [M(R¹R²N(CH₂)_nPPh₂)₂]²⁺ complexes with R¹ and R² = H, n = 2 or 3 or R¹ = H and R² = Me, n = 2, are more difficult to ring-open. Thus cis-[Pt(Me(H)N(CH₂)₂PPh₂-P,N)₂]Cl₂ and cis-[Pt(H₂N(CH₂)₃PPh₂-P,N)₂]Cl₂ had associated pK values of 2.1 and 2.9, resp. These aminophosphine complexes may exhibit anticancer activity by two mechanisms: by disrupting mitochondrial membrane potentials as bis-chelated (ring-closed) lipophilic cations, or by direct binding to DNA bases as ring-opened complexes.

Journal of the Chemical Society, Dalton Transactions published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Formula: C10H15NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nakamura, Shohei published the artcileDevelopment and application of functional powder coated by perfluoropolyoxypropylene (PFPOP) derivative, Application of 3-((2-Ethylhexyl)oxy)propane-1,2-diol, the publication is Fragrance Journal (2017), 45(3), 38-41, database is CAplus.

For cosmetic ingredients, the surface treated clay powders are well used. Especially perfluoroalkyl derivatives are widely used for their water or sebum proof properties. We developed a novel perfluoropolyoxypropylene derivative and used as a surface treatment agent. Surface treated clay powders had much higher water and oil repellency and better smoothness. We confirmed its long lasting effect by applying it to powder foundation formulation with 30wt% surface treated powder.

Fragrance Journal published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Application of 3-((2-Ethylhexyl)oxy)propane-1,2-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Norcum, Mona T. published the artcileStructural analysis of the multienzyme aminoacyl-tRNA synthetase complex: a three-domain model based on reversible chemical crosslinking, Formula: C18H20N2O12, the publication is Protein Science (1998), 7(1), 79-87, database is CAplus and MEDLINE.

A subset of eukaryotic aminoacyl-tRNA synthetases (a-RS) are contained in a multienzyme complex for which little structural detail is known. Three reversible chem. crosslinking reagents have been used to investigate the arrangement of polypeptides within this particle as isolated from rabbit reticulocytes. Identification of the crosslinked protein pairs was accomplished by two-dimensional SDS diagonal gel electrophoresis. Seventeen neighboring protein pairs have been identified. Eight are seen with at least two reagents: K-RS:p38, D-RS:K-RS, R-RS dimer, K-RS dimer, K-RS:Q-RS, E/P-RS:K-RS, E/P-RS:I-RS, and Q-RS with one of the nonsynthetase proteins. Nine more are observed with one reagent: D-RS dimer, R-RS:p43, D-RS:Q-RS, D-RS:M-RS, K-RS:L-RS, I-RS:R-RS, D-RS:E/P-RS, I-RS:Q-RS, I-RS:L-RS. One trimeric association is seen: E/P-RS:I-RS:L-RS. The observed neighboring protein pairs suggest that the polypeptides within the aminoacyl-tRNA synthetase complex are distributed in three structural domains of similar mass. These can be arranged in a U-shaped particle in which each “arm” is considered a domain and the third forms the “base” of the structure. The arms have been termed domain I (D-RS, M-RS, Q-RS) and domain II (K-RS, R-RS), with domain III (E/P-RS, I-RS, L-RS) assigned to the base. The smaller proteins (p38, p43) may bridge the domains. This proposed spatial relationship of these domains, as well as their compositions, are consistent with earlier studies. Thus, this study provides an initial three-dimensional working model of the arrangement of polypeptides within the multienzyme aminoacyl-tRNA synthetase complex.

Protein Science published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Formula: C18H20N2O12.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Owczarek, Katarzyna published the artcileValidated GC-MS method for determination of bisphenol a and its five analogues in dietary and nutritional supplements, SDS of cas: 80-09-1, the publication is Microchemical Journal (2022), 107643, database is CAplus.

Bisphenol A (BPA) and its analogs showing structural and functional similarity to BPA are commonly applied in various industrial applications and thus are becoming ubiquitous in the environment. At the same time there is increasing scientific evidence that exposure to these chems. may lead to adverse health effects in human and wildlife. In recent years dietary and nutritional supplements dedicated for athletes have become more popular and are widely used even by people who are not professionals. This study presents the development, optimization and validation of an anal. procedure for determination of six bisphenol analogs in dietary supplements using gas chromatog. – mass spectrometry technique. All validation parameters met the established acceptance criteria in accordance with international guidelines. The method was linear within the tested range of 50-1000 ng/mL, the limit of quantitation was set as the lowest calibration point 50 ng/mL, detection limit for each bisphenol was calculated as standard estimation error on the basis of the linearity testing and was in the range of 8.73-15.44 ng/mL. Method trueness, accuracy (within and between runs) and precision were also verified and were in the range of 78.8 – 100.4%, 94.3 – 103.1%,0.5 – 9.6% resp. The developed procedure was successfully applied for real samples anal., namely for fifteen sport supplements of different composition and designated for various purposes, i.e. for increasing effectiveness, promoting muscle recovery and endurance, reducing tiredness and fatigue or increasing immune ability. For the majority of samples, bisphenols were either not detected or detected at the LOD level except bisphenol A which was quantitated in few samples at LOQ level or higher (in the range 0.852-2.892 ng/mg). The field of bisphenol analogs analytics has increased in recent years due to law regulations becoming more strict, thus the development of new anal. tools for quality control of dietary products is needed and fully justified.

Microchemical Journal published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, SDS of cas: 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jiang, Biwei published the artcileApplication of carboprost tromethamine combined with modified patch suture in placenta previa postpartum hemorrhage, Application of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Zhongguo Jiceng Yiyao (2013), 20(4), 533-535, database is CAplus.

The effect of carboprost tromethamine (hemabate) combined with modified patch suture in placenta previa postpartum hemorrhage was observed Sixty-two patients with placenta previa were divided into the control group (30 cases) and treatment group (32 cases). The control group was treated with hemabate, and the treatment group was treated with hemabate combined with modified patch suture. The two groups of intraoperative, postpartum 2 h, 24 h postpartum were compared in bleeding volume and Hb changes. The intraoperative bleeding volume [(321.9±67.8) ml vs (435.9±83.3) ml] and 2h, 24h postpartum bleeding volume [(417.7±68.0) ml vs (539.6±70.4) ml and (485.3±68.5) ml vs (621.0±81.3) ml] of the treatment group were significant less than that of the control group (t=5.926, 6.938, 7.133, all P<0.05). Significant difference in changes of Hb level was also observed between the two groups, though postpartum level was not significantly reduced in the treatment group compared with the control group [(5.0±6.5) g/L vs (-4.0±6.8) g/L] (t=-3.662, P<0.05). Hemabate combined with modified patch suture can be more effective in the prevention of postpartum hemorrhage in placenta previa.

Zhongguo Jiceng Yiyao published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Application of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts