Author: tianli

Grimster, Neil P. published the artcileAlkynes to (E)-enolates using tandem catalysis: stereoselective anti-aldol and syn-[3,3]-rearrangement reactions, Computed Properties of 17877-23-5, the publication is Tetrahedron (2010), 66(33), 6429-6436, database is CAplus.

A new tandem catalysis strategy that transformed alkyne derivatives to (E)-enol-equivalent followed by either stereoselective anti-selective aldol coupling or syn-selective [3,3]-rearrangement transformations was reported. The mechanism was thought to proceed through an interchanging series of Lewis acid and Bronsted acid catalyzed reactions via the intermediacy of a ketiminum ion species. For example, the scandium(III) triflate-catalyzed reaction of alkyne I with Me₂CHCHO and triphenylsilanol afforded adduct II in 73% yield and dr >95:5, while zinc triflate-catalyzed reaction of (E)-PhCH:CHCH₂OH with I gave III in 88% yield and dr >95:5.

Tetrahedron published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Computed Properties of 17877-23-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Yiding published the artcileAn Aryne-Based Route to Substituted Benzoisothiazoles, Product Details of C6H9N3O2S, the publication is Organic Letters (2015), 17(19), 4786-4789, database is CAplus and MEDLINE.

The combination of arynes, generated using fluoride from the corresponding 2-(trimethylsilyl)aryl triflates, and 3-hydroxy-4-aminothiadiazoles leads to the selective formation of 3-amino-substituted benzo[d]isothiazoles. Variation of the substitution pattern of the aryne precursor, and of the thiadiazole, is possible, with the target heterocycles being obtained in good to excellent yields. In all cases, use of 3-hydroxy-4-aminothiadiazoles leads to incorporation of the amino-substituent in the product heterocycle.

Organic Letters published new progress about 30165-97-0. 30165-97-0 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Thiadiazole,Alcohol, name is 4-Morpholino-1,2,5-thiadiazol-3-ol, and the molecular formula is C6H9N3O2S, Product Details of C6H9N3O2S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sherwood, Alexander M. published the artcileModular Approach to pseudo-Neoclerodanes as Designer κ-Opioid Ligands, SDS of cas: 57044-25-4, the publication is Organic Letters (2017), 19(19), 5414-5417, database is CAplus and MEDLINE.

Informed by previous semisynthetic work on salvinorin A, a modular total synthesis has been developed capable of producing novel compounds targeting the κ-opioid receptor. The strategy has permitted the deliberate simplification and introduction of functionality about the target mol. to provide access to mol. features on salvinorin A otherwise unattainable by semisynthesis. Using this approach, a potent pseudo-neoclerodane κ-opioid receptor ligand (I) has been realized.

Organic Letters published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C8H5F3N4, SDS of cas: 57044-25-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kleinmans, Roman published the artcilePhotoredox-enabled 1,2-dialkylation of α-substituted acrylates via Ireland-Claisen rearrangement, Safety of 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, the publication is Chemical Science (2021), 12(8), 2816-2822, database is CAplus and MEDLINE.

The 1,2-dialkylation of simple feedstock acrylates RC(=CH₂)C(O)OR¹ [R = H, Me, F, i-Pr, naphthalen-1-yl, etc.; R¹ = prop-2-en-1-yl, 4-ethenyloxan-4-yl, 2-chloroprop-2-en-1-yl, 2-(4-oxocyclohexylidene)ethyl, etc.] for the synthesis of valuable tertiary carboxylic acids R²CH₂C(R)(R³)C(O)OH [R² = cyclohexyl, oxan-4-yl, 5-(2,5-dimethylphenoxy)-2-methylpentan-2-yl, etc.; R³ = prop-2-en-1-yl, 2-(oxan-4-ylidene)ethyl, 2-chloroprop-2-en-1-yl, etc.] by merging Giese-type radical addition with an Ireland-Claisen rearrangement have been reported. Key to success is the utilization of the reductive radical-polar crossover concept under photocatalytic reaction conditions to force the [3,3]-sigmatropic rearrangement after alkyl radical addition to allyl acrylates. Using readily available alkyl boronic acids as radical progenitors, this redox-neutral, transition-metal-free protocol allows the mild formation of two C(sp³)-C(sp³) bonds, thus providing rapid access to complex tertiary carboxylic acids in a single step. Moreover, this strategy enables the efficient synthesis of highly attractive α,α-dialkylated γ-amino butyric acids (GABAs) R⁴(CH₂)₂C(CH₃)(CH₂CH=CH₂)C(O)OH [R⁴ = dibutylaminyl, morpholin-4-yl, 4-[2-(morpholin-4-yl)-2-oxoethyl]piperazin-1-yl, etc.] when α-silyl amines R⁴CH₂Si(CH₃)₃ are used as radical precursors – a structural motif that was still inaccessible in related transformations. Depending on the nature of the radical precursors and their inherent oxidation potentials, either a photoredox-induced radical chain or a solely photoredox mechanism is proposed to be operative.

Chemical Science published new progress about 608534-44-7. 608534-44-7 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic,Boronic acid and ester,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C15H21BO2, Safety of 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Radzki, Dominik published the artcileA Fresh Look at Mouthwashes-What Is Inside and What Is It For?, Quality Control of 70445-33-9, the publication is International Journal of Environmental Research and Public Health (2022), 19(7), 3926, database is CAplus and MEDLINE.

Mouthwashes are a very popular addnl. oral hygiene element and there are plenty of individual products, whose compositions are in a state of flux. The aim of our study was to investigate the compositions of mouthwashes and their functions, as well as to discuss their effectiveness in preventing and curing oral diseases and side effects. We searched for mouthwashes available on the market in Poland. We identified 241 individual mouthwash products. The extraction of compositions was performed and functions of the ingredients were assessed. Then, anal. was performed. The evaluation revealed that there are plenty of ingredients, but a typical mouthwash is a water-glycerin mixture and consists of addnl. sweetener, surfactant, preservative, and some colorant and flavoring agent, as well as usually having two oral health substances, anticaries sodium fluoride and antimicrobial essential oils. The effectiveness or side effects of several substances of mouthwashes were thoroughly discussed. We recommend not multiplying individual mouthwash products and their ingredients beyond medical or pharmaceutical necessity, especially without scientific proof.

International Journal of Environmental Research and Public Health published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Quality Control of 70445-33-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ebner, A. published the artcileFunctionalization of AFM Tips and supports for molecular recognition force spectroscopy and recognition imaging, Related Products of alcohols-buliding-blocks, the publication is Methods in Molecular Biology (New York, NY, United States) (2019), 117-151, database is CAplus and MEDLINE.

Linking of sensor mols. (e.g., antibodies) to an AFM tip converts it into a biosensor by which single target mols. (e.g., antigens) can be detected and localized on the sample surface. Moreover, the mechanism of interaction can be studied by force spectroscopy if purified target mols. are linked to an ultra-flat surface, such as mica or silicon (nitride). Rapid imaging of the binding sites and force spectroscopy studies are greatly facilitated if 6-10 nm long polyethylene glycol (PEG) chains are used as flexible tethers between the sensor mol. and the tip. Here, we describe a set of methods by which a variety of proteins, oligonucleotides, or small mols. can be tethered to silicon (nitride) tips or to mica. Methods are included which afford site-specific and oriented coupling of the sensor mols.

Methods in Molecular Biology (New York, NY, United States) published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shugars, Diane C. published the artcileBiophysical characterization of recombinant proteins expressing the leucine zipper-like domain of the human immunodeficiency virus type 1 transmembrane protein gp41, Synthetic Route of 70539-42-3, the publication is Journal of Virology (1996), 70(5), 2982-91, database is CAplus and MEDLINE.

Envelope oligomerization is thought to serve crucial functions during the life cycle of human immunodeficiency virus type 1 (HIV-1). We recently reported that virus entry requires coiled-coil formation of the leucine zipper-like domain of the HIV-1 transmembrane envelope glycoprotein gp41. To determine the oligomeric state mediated by this region of the envelope, we have expressed the zipper motif as a fusion partner with the monomeric maltose-binding protein of Escherichia coli. The biophys. properties of this protein were characterized by velocity and equilibrium sedimentation, size exclusion chromatog., light scattering, and chem. crosslinking analyses. Results indicate that the leucine zipper sequence from HIV-1 is capable of multimerizing much larger and otherwise monomeric proteins into extremely stable tetramers. Recombinant proteins containing an alanine or a serine substitution at a critical isoleucine residue within the zipper region were also generated and similarly analyzed. The alanine- and serine-substituted proteins behaved as tetrameric and monomeric species, resp., consistent with the influence of these same substitutions on the helical coiled-coil structure of synthetic peptide models. On the basis of these findings, we propose that the fusogenic gp41 structure involves tetramerization of the leucine zipper domain which is situated ∼30 residues from the N-terminal fusion peptide sequence.

Journal of Virology published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H12FN, Synthetic Route of 70539-42-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Ye published the artcileInfluence of the Electronic Properties of the Ligand on the Photoelectrochemical Behavior of Au₂₅ Nanocluster-Sensitized TiO₂ Photoanode, Category: alcohols-buliding-blocks, the publication is Journal of Physical Chemistry C (2022), 126(4), 1778-1784, database is CAplus.

Atomically precise metal nanoclusters (NCs) have recently emerged as a new class of bifunctional (photoactive and catalytically active) photosensitizers in light energy conversion applications. Despite the size and alloy effects of NCs, no effort has been made to elucidate how the protecting ligand affects the photoelectrochem. of the NC-sensitized photoelectrodes. With a nanoporous TiO₂ array as model support, Au₂₅ NCs protected by various thiol-bearing ligands have been used to prepare four different photoanodes. It is revealed that a subtle change of the ligand from an alkanethiol to an aromatic thiol facilitates the charge transfer between the NC and TiO₂, which in turn improves the photoelectrochem. performance of the corresponding photoanode by at least 6 times. This new insight highlights the importance of the electronic properties of the ligand on the design of more efficient NC-sensitized photoelectrodes.

Journal of Physical Chemistry C published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pein, Wesley L. published the artcileNickel-Catalyzed Ipso-Borylation of Silyloxyarenes via C-O Bond Activation, Application In Synthesis of 27292-49-5, the publication is Organic Letters (2021), 23(12), 4588-4592, database is CAplus and MEDLINE.

The conversion of silyloxyarenes to boronic acid pinacol esters via Ni catalysis is described. In contrast to other borylation protocols of inert C-O bonds, the method is competent in activating the C-O bond of silyloxyarenes in isolated aromatic systems lacking a directing group. The catalytic functionalization of benzyl silyl ethers was also achieved under these conditions. Sequential cross-coupling reactions were achieved by leveraging the orthogonal reactivity of silyloxyarenes, which could then be functionalized subsequently.

Organic Letters published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Application In Synthesis of 27292-49-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Singh, Rajeeva published the artcileComparisons of rate constants for thiolate-disulfide interchange in water and in polar aprotic solvents using dynamic proton NMR line shape analysis, Category: alcohols-buliding-blocks, the publication is Journal of the American Chemical Society (1990), 112(3), 1190-7, database is CAplus.

The rate constants for representative thiolate-disulfide interchange reactions are larger in DMSO and DMF than in water by a factor of ∼2300 at 24°. The log of the rate constant is directly proportional to the mole fraction of D₂O in mixtures of DMSO and D₂O, even at small mole fractions of D₂O. This linear proportionality suggests that thiolate anion is not specifically solvated by water and that hydrogen bonding is relatively unimportant in stabilizing this species. The values of ΔS^⧧ for thiolate-disulfide interchange are ∼-10 cal/(deg mol), presumptively because of loss in the entropy of the reactants in going from ground to transition state, partially compensated by a gain in entropy from solvent release. Introduction of a hydroxy group β to the C-S bond slows the reaction by a factor of 2-15; the introduction of Me groups β to the C-S bond slows the rate by factors of 3-20.

Journal of the American Chemical Society published new progress about 73303-88-5. 73303-88-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Alcohol, name is 2-Methyl-2-sulfanylpropan-1-ol, and the molecular formula is C23H20BN, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts