Author: tianli

Zhu, Yuanzhao published the artcileEffect of weak intermolecular interactions in micro/nanoscale polyphosphazenes and polyethylene terephthalate composites on flame retardancy, Recommanded Product: 4,4′-Sulfonyldiphenol, the publication is Polymers for Advanced Technologies (2022), 33(7), 2231-2243, database is CAplus.

This study investigates the effects of weak intermol. interactions on the flame retardancy of a poly(ethylene terephthalate) (PET) and polyphosphazene flame retardant. Monodispersed poly-(cyclotriphosphazene-co-4,4′-sulfonyldiphenol) (PZS) microspheres with different diameters were synthesized by controlling the reactant concentration Simulation studies revealed that the weak intermol. interactions between PZS and PET predominantly include strong hydrogen bonding and π-π interactions. The weak intermol. interactions imparted high thermal stability, even in the molten state, and PZS microspheres with smaller diameters achieved stronger hydrogen bonds and π-π interactions with PET. The diameter of the PZS microspheres influenced the limiting oxygen index value and UL-94 rating. Increasing the carbon residue alone was insufficient to promote the flame retardancy, and the weak intermol. interactions played an important role. Thus, stronger weak-intermol.-interactions are beneficial for realizing a material with superior flame retardancy and anti-dropping performance.

Polymers for Advanced Technologies published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C13H9FO2, Recommanded Product: 4,4′-Sulfonyldiphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lin, Wen-Hsing published the artcileIdentification of a Multitargeted Tyrosine Kinase Inhibitor for the Treatment of Gastrointestinal Stromal Tumors and Acute Myeloid Leukemia, Application In Synthesis of 622-40-2, the publication is Journal of Medicinal Chemistry (2019), 62(24), 11135-11150, database is CAplus and MEDLINE.

Gastrointestinal stromal tumors (GISTs) are prototypes of stem cell factor receptor (c-KIT)-driven cancer. Two receptor tyrosine kinases, c-KIT and fms-tyrosine kinase (FLT3), are frequently mutated in AML patients, and these mutations are associated with poor prognosis. In this study, the authors discovered a multitargeted tyrosine kinase inhibitor, (6-(4-ethylpiperazin-1-yl)-2-methylpyrimidin-4-yl)(5-pyridin-4-ylthiazol-2-yl)amine Hydrochloride [2581827-29-2] (15a), with potent inhibition against single or double mutations of c-KIT developed in GISTs. Moreover, crystal structure anal. revealed the unique binding mode of (15a) with c-KIT and may elucidate its high potency in inhibiting c-KIT kinase activity. (15A) inhibited cell proliferation and induced apoptosis by targeting c-KIT in c-KIT-mutant GIST cell lines. The antitumor effects of (15a) were also demonstrated in GIST430 and GIST patient-derived xenograft (PDX) models. Further studies demonstrated that (15a) inhibited the proliferation of c-KIT- and FLT3-driven AML cells in vitro and in vivo. The results of this study suggest that (15a) may be a potential anticancer drug for the treatment of GISTs and AML.

Journal of Medicinal Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Application In Synthesis of 622-40-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Xin published the artcileN-Bridged Pincer Iridium Complexes for Highly Efficient Alkane Dehydrogenation and the Relevant Linker Effects, Quality Control of 14703-69-6, the publication is ACS Catalysis (2020), 10(11), 6475-6487, database is CAplus.

Ir complexes (RPOCR’NP)-HCl (4-HCl) and (RPSCR’NP)Ir-HCl (5-HCl) (R = substituent on P; R’ = substituent on N) supported by N-linked pincer ligands, with the other linker of being O- or S-atom, were synthesized. Among them, complexes with phosphino-iPr substituents (iPrPOCR’NP)Ir (4b, 4e, 4g) exhibit very high catalytic activity for transfer dehydrogenation (TD) of both cyclic and linear alkanes. In the prototypical TD reaction of cyclooctane (COA) with tert-butylethylene (TBE), for example, 4g affords 14720 turnovers at 200°, which are >2-fold of that obtained by the most efficient catalyst reported so far. Also, these complexes are highly effective for acceptorless dehydrogenation of 1,2,3,4-tetrahydronaphthalene, giving a turnover frequency of 8.8 min-1 for H₂ production within the 1st 4 h. The effects of the linkers at the positions ortho to the Ir center were elucidated by a systematic comparison of electronic and steric properties of these O/N- and S/N-linked pincer systems to those of C/C-linked iPrPCP, O/O-linked iPrPOCOP, and S/O-linked iPrPSCOP systems. Examination of the structure-activity relations reveals that alkane C-H bond addition to the 14e (pincer)Ir fragment (the rate-determining step in the TD reaction) is more favored by iPrPOCR’NP relative to other pincers, largely due to strong N-linker C(aryl) -donation. Compared to the parent iPrPOCOP complex with similarly -donating O-linkers, the energy of the alkene-bound out-of-cycle resting state is raised by iPrPOCR’NP primarily due to steric factors. Consequently, the incorporation of N-linker exerts an overall favorable effect on the catalytic rates. The authors found the thermal stability of these catalysts with different linker-combinations differs significantly.

ACS Catalysis published new progress about 14703-69-6. 14703-69-6 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Phenol, name is 3-(Methylamino)phenol, and the molecular formula is C11H23NO3, Quality Control of 14703-69-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Linhua published the artcileTargeted Codelivery of an Antigen and Dual Agonists by Hybrid Nanoparticles for Enhanced Cancer Immunotherapy, Application of (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, the publication is Nano Letters (2019), 19(7), 4237-4249, database is CAplus and MEDLINE.

Among approaches of current cancer immunotherapy, a dendritic cell (DC)-targeted vaccine based on nanotechnol. could be a promising way to efficiently induce potent immune responses. To enhance DC targeting and vaccine efficiency, we included imiquimod (IMQ), a toll-like receptor 7/8 (TLR 7/8) agonist, and monophosphoryl lipid A (MPLA), a TLR4 agonist, to synthesize lipid-polymer hybrid nanoparticles using PCL-PEG-PCL and DOTAP (IMNPs) as well as DSPE-PEG-mannose (MAN-IMNPS). The spatiotemporal delivery of MPLA (within the outer lipid layer) to extracellular TLR4 and IMQ (in the hydrophobic core of NPs) to intracellular TLR7/8 can activate DCs synergistically to improve vaccine efficacy. Ovalbumin (OVA) as a model antigen was readily absorbed by pos. charged DOTAP and showed a quick release in vitro. Our results demonstrated that this novel nanovaccine enhanced cellular uptake, cytokine production, and maturation of DCs. Compared with the quick metabolism of free OVA-agonists, the depot effect of OVA-IMNPs was observed, whereas MAN-OVA-IMNPs promoted trafficking to secondary lymphoid organs. After immunization with a s.c. injection, the nanovaccine, especially MAN-OVA-IMNPs, induced more antigen-specific CD8⁺ T cells, greater lymphocyte activation, stronger cross-presentation, and more generation of memory T cells, antibody, IFN-γ, and granzyme B. Prophylactic vaccination of MAN-OVA-IMNPs significantly delayed tumor development and prolonged the survival in mice. The therapeutic tumor challenge indicated that MAN-OVA-IMNPs prohibited tumor progression more efficiently than other formulations, and the combination with an immune checkpoint blockade further enhanced antitumor effects. Hence, the DC-targeted vaccine codelivery with IMQ and MPLA adjuvants by hybrid cationic nanoparticles in a spatiotemporal manner is a promising multifunctional antigen delivery system in cancer immunotherapy.

Nano Letters published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C44H28ClFeN4, Application of (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Yanru published the artcilePoly(1,5-pentylene-co-2,2,4,4-tetramethyl cyclobutylene terephthalate) copolyesters with high T_g and improved ductility and thermal stability, Related Products of alcohols-buliding-blocks, the publication is Polymer (2021), 124152, database is CAplus.

Poly(1,5-pentylene-co-2,2,4,4-tetramethyl cyclobutylene terephthalate) (PPecBT) random copolyesters glass transition temperature up to 136°C were synthesized through two-step melting polycondensation of di-Me terephthalate (DMT) or terephthalic acid (TPA), 2,2,4,4-tetramethyl-1,3-cyclobutanediol (CBDO) and 1,5-pentanediol (PeDO). They were characterized and assessed with intrinsic viscosity, ¹H NMR, DSC, TGA, tensile and impact testing as well as melt foaming observation. Using PeDO as a diol comonomer was helpful to depress CBDO sublimation and pipeline blocking, and to reduce the composition and cis-trans ratio deviations between monomer and copolymer. The presence of PeT repeat unit in PPecBT was beneficial to improve the thermal stability of PPecBT and to reduce undesired melt foaming and volume expansion during melt processing. The T^g of these amorphous copolymers is determined by intrinsic viscosity, copolymer composition and cis-cB unit fraction, and a quant. relationship among them is established. Futhermore, these PPecBTs showed superior tensile ductility as well as strength and modulus.

Polymer published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liang, Dongjun published the artcileA real-time, click chemistry imaging approach reveals stimulus-specific subcellular locations of phospholipase D activity, Application of (R)-Oxiran-2-ylmethanol, the publication is Proceedings of the National Academy of Sciences of the United States of America (2019), 116(31), 15453-15462, database is CAplus and MEDLINE.

The fidelity of signal transduction requires spatiotemporal control of the production of signaling agents. Phosphatidic acid (PA) is a pleiotropic lipid second messenger whose modes of action differ based on upstream stimulus, biosynthetic source, and site of production How cells regulate the local production of PA to effect diverse signaling outcomes remains elusive. Unlike other second messengers, sites of PA biosynthesis cannot be accurately visualized with subcellular precision. Here, we describe a rapid, chemoenzymic approach for imaging physiol. PA production by phospholipase D (PLD) enzymes. Our method capitalizes on the remarkable discovery that bulky, hydrophilic trans-cyclooctene-containing primary alcs. can supplant water as the nucleophile in the PLD active site in a transphosphatidylation reaction of PLD’s lipid substrate, phosphatidylcholine. The resultant trans-cyclooctene-containing lipids are tagged with a fluorogenic tetrazine reagent via a no-rinse, inverse electron-demand Diels-Alder (IEDDA) reaction, enabling their immediate visualization by confocal microscopy in real time. Strikingly, the fluorescent reporter lipids initially produced at the plasma membrane (PM) induced by phorbol ester stimulation of PLD were rapidly internalized via apparent nonvesicular pathways rather than endocytosis, suggesting applications of this activity-based imaging toolset for probing mechanisms of intracellular phospholipid transport. By instead focusing on the initial 10 s of the IEDDA reaction, we precisely pinpointed the subcellular locations of endogenous PLD activity as elicited by physiol. agonists of G protein-coupled receptor and receptor tyrosine kinase signaling. These tools hold promise to shed light on both lipid trafficking pathways and physiol. and pathol. effects of localized PLD signaling.

Proceedings of the National Academy of Sciences of the United States of America published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Application of (R)-Oxiran-2-ylmethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kang, Yuxuan published the artcilePreparation of Kushui Rose (Rosa setate x Rosa rugosa) essential oil fractions by double molecular distillation: Aroma and biological activities, Safety of cis-3,7-Dimethyl-2,6-Octadien-1-Ol, the publication is Industrial Crops and Products (2022), 114230, database is CAplus.

Kushui Rose (Rosa setate x Rosa rugosa, KR) is a distinctive Chinese rose variety. Its extracts, especially essential oil (EO), showed various biol. activities. In this study, double mol. distillation was used to sep. different fractions from KREO. GC-MS was used to detect the composition of volatile components in different fractions. The aroma anal. of different fractions was carried out by a professional sensory evaluation team. D1 (the light phase in the first stage) and R2 (the heavy phase in the second stage) showed better biol. activities, with a lower IC50 value on antioxidant ability and a higher capacity for antimicrobial. Furthermore, D1 and R2 also effectively prevented the oxidation of sunflower oil. The antimicrobial mechanism was explored by relative conductivity, the content of protein and reducing sugar, and SEM on Escherichia coli. In all, mol. distillation could be considered an effective way to improve the aroma and biol. activity for KREO.

Industrial Crops and Products published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, Safety of cis-3,7-Dimethyl-2,6-Octadien-1-Ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

He, Zhen published the artcileMicrobiota in mesenteric adipose tissue from Crohns disease promote colitis in mice, Application of 3-Hydroxyphenylacetic acid, the publication is Microbiome (2021), 9(1), 228, database is CAplus and MEDLINE.

Mesenteric adipose tissue (mAT) hyperplasia, known as creeping fat is a pathol. characteristic of Crohns disease (CD). The reserve of creeping fat in surgery is associated with poor prognosis of CD patients, but the mechanism remains unknown. Mesenteric microbiome, metabolome, and host transcriptome were characterized using a cohort of 48 patients with CD and 16 non-CD controls. Multidimensional data including 16S rRNA gene sequencing (16S rRNA), host RNA sequencing, and metabolome were integrated to reveal network interaction. Mesenteric resident bacteria were isolated from mAT and functionally investigated both in the dextran sulfate sodium (DSS) model and in the Il10 gene-deficient (Il10-/-) mouse colitis model to validate their pro-inflammatory roles. Mesenteric microbiota contributed to aberrant metabolites production and transcripts in mATs from patients with CD. The presence of mAT resident microbiota was associated with the development of CD. Achromobacter pulmonis (A. pulmonis) isolated from CD mAT could translocate to mAT and exacerbate both DSS-induced and Il10 gene-deficient (Il10-/-) spontaneous colitis in mice. The levels of A. pulmonis in both mAT and mucous layer from CD patients were higher compared to those from the non-CD group. This study suggests that the mesenteric microbiota from patients with CD sculpt a detrimental microenvironment and promote intestinal inflammation.

Microbiome published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Application of 3-Hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Zhi-mei published the artcileEffect of carboprost tromethamine on amount of bleeding in cesarean section at different time points of high risk parturients, Application of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Zhongguo Yaofang (2014), 25(4), 336-338, database is CAplus.

The aim of this paper is to observe the effects of carboprost tromethamine on the amount of bleeding in cesarean section of high risk parturients at different time points. The clin. data of 180 high risk parturients with postpartum hemorrhage tendency in cesarean section were retrospectively analyzed and divided into treatment group and control group according to the duration of carboprost tromethamine treatment. Treatment group was given intrauterine injection of carboprost tromethamine 250 μg and i.v. dripping of oxytocin 10 u after the delivery of fetus; control group was given intrauterine injection of carboprost tromethamine 250 μg if the amount of bleeding increased because uterine inertia and uterine massage was invalid, following intrauterine injection of oxytocin 10 u i.v. after the delivery of fetus. Both groups were given carboprost tromethamine continuously, depending on the situation. The amounts of bleeding and adverse drug reactions were recorded in 2 groups. The incidence of postpartum hemorrhage in treatment group was 17.7%, which was significantly lower than in control group(28.7%); the amounts of bleeding in treatment group 2 h and 24 h after operation were significantly lower than in control group; there was statistical significance(P<0.05). Adverse drug reaction of 2 groups was slight and recovered spontaneously. The application of carboprost tromethamine in advance could effectively decrease postpartum hemorrhage in high risk parturients with postpartum hemorrhage tendency, and it’s safety.

Zhongguo Yaofang published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C9H8O4, Application of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Sheng published the artcileA high-throughput screening assay for identification of chemicals with liver tumor promoting potential using a transgenic zebrafish line, Name: 4,4′-Sulfonyldiphenol, the publication is Chemosphere (2022), 134169, database is CAplus and MEDLINE.

Traditional high-throughput methods for identification of chems. with liver tumor promotion potentials are based on established cancer cell lines, and rapid and cost-effective high-throughput screening assays in whole organisms are presently lacking. In this study, a transgenic zebrafish liver cancer model was employed to develop a method that could be used to identify chems. with liver tumor promotion effect quickly and accurately. The method consisted of three parts, including exposure preparation, exposure process and image acquisition. In brief, after chem. exposure for 7 days, 96-well plate exposure system for zebrafish larvae was assessed by microplate reader. Then, the liver cancer promoting potential chems. were evaluated by field area and field average intensity of fluorescence. The results were further validated by conducting histopathol. examination Our data demonstrated that the high-throughput screening assay developed in this study was reproducible and could be used to rapidly screen chems. with liver tumor promoting potentials by using tris-(2-chloropropyl)-phosphate (TDCIPP) as a pos. control. Furthermore, some other pos. chems. found in previous studies and environmental compounds were assessed using the established method. Results indicated that 86.7% of the pos. chems. and five environmental compounds out of seventeen compounds could enhance liver tumor progression.

Chemosphere published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Name: 4,4′-Sulfonyldiphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts