Author: tianli

Xiao, Cong published the artcileLight-promoted nickel catalysis: etherification of aryl electrophiles with alcohols catalyzed by Ni (II)/aryl complex, Recommanded Product: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, the publication is Youji Huaxue (2020), 40(9), 3004-3006, database is CAplus.

In this paper, a highly efficient photo promoted nickel catalyzed C-O bond coupling reaction was realized. The reaction uses air stable Ni (II) – aryl halide as catalyst and DBU as base without external photosensitizer.

Youji Huaxue published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H15NO, Recommanded Product: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Fan, Xuanzi published the artcileNeutral-Eosin-Y-Photocatalyzed Silane Chlorination Using Dichloromethane, Formula: C6H16OSi, the publication is Angewandte Chemie, International Edition (2019), 58(36), 12580-12584, database is CAplus and MEDLINE.

Chlorosilanes are versatile reagents in organic synthesis and material science. A mild pathway is now reported for the quant. conversion of hydrosilanes to silyl chlorides under visible-light irradiation using neutral eosin Y as a hydrogen-atom-transfer photocatalyst and dichloromethane as a chlorinating agent. Stepwise chlorination of di- and trihydrosilanes was achieved in a highly selective fashion assisted by continuous-flow micro-tubing reactors. The ability to access silyl radicals using photocatalytic Si-H activation promoted by eosin Y offers new perspectives for the synthesis of valuable silicon reagents in a convenient and green manner.

Angewandte Chemie, International Edition published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Formula: C6H16OSi.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Xing published the artcileProperties of Multiblock Sulfonated Poly(arylene ether sulfone)s Synthesized by Precise Controllable Post-sulfonation for Proton Exchange Membranes, Recommanded Product: 4,4′-Sulfonyldiphenol, the publication is Chinese Journal of Polymer Science (2022), 40(7), 754-763, database is CAplus.

A series of multiblock sulfonated poly(arylene ether sulfone)s (SPAES) with various block lengths and predictable ion exchange capacity were synthesized from 4,4′-difluorodiphenyl sulfone, 4,4′-dihydrodiphenyl sulfone and 4,4′-biphenol by one-pot and two-pot polymerization 1H-NMR and FTIR spectra confirmed the structure that sulfonic acid groups were introduced precisely on the poly(arylene ether sulfone)s by post-sulfonation which resulted in controllable sulfonation degree. The proton exchange membranes (PEMs)-based SPAES displayed excellent dimensional, thermal, antioxidant stability, proton conductivity and mech. properties (maximum tensile stress >35 MPa). Thermogravimetric anal. indicated the prepared SPAES began to degrade above 310°C. The effects of polymerization processes, those were, one-pot hydrophobic segment process, one-pot hydrophilic segment process and two-pot process, on the properties of polymers were investigated. The proton conductivity and microphase separation of SPAES PEMs increased in order of those prepared by one-pot hydrophobic segment process, two-pot process and one-pot hydrophilic segment process. The highest conductivities of SPAES synthesized by the above processes under 80°C and 100% relative humidity were 213 (MS4), 297 (MB3) and 360 mS·cm^-1 (MQ2), resp.

Chinese Journal of Polymer Science published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Recommanded Product: 4,4′-Sulfonyldiphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nie, Aihua published the artcileDrug discovery based on structure of FKBP52: design and synthesis of 2-azabicyclo[2.2.1]hept-5-ene-3-carboxylic acid derivatives and determination of their activity as neuroimmunophilin ligands, Synthetic Route of 101-98-4, the publication is Zhongguo Yaowu Huaxue Zazhi (2006), 16(6), 323-330, database is CAplus.

A method for the synthesis of the title compounds is reported here. One such 2-aza-bicyclo[2.2.1]hept-5-ene-3-carboxy derivatives were investigated for their activity as neuroimmunophilin ligands. SYBYL/Composer was used for homol. modeling the structure of domain 1 (D1) of FKBP52 (a member of the FK506-binding family of immunophilins). Based on the structure of FKBP52D1, CADD (computer-aided drug design) was employed to design and virtually screen such novel 2-azabicyclo[2.2.1]hept-5-ene-3-carboxy derivatives These compounds were synthesized by liquid-phase synthetic method. Cultured chick DRGs (dorsal root ganglion sensory neurons) was applied to evaluate neurotrophic activity of these target compounds Novel 2-azabicyclo[2.2.1]hept-5-ene-3-carboxy derivatives were designed based on the structure of FKBP52 and 21 target compounds were synthesized. In cultured chick DRGs, one compound produced potent neurotrophic effects and promoted neurite outgrowth in vitro.

Zhongguo Yaowu Huaxue Zazhi published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Synthetic Route of 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nie, AiHua published the artcileDrug discovery based on the structure of FKBP12: Design, synthesis and evaluation of L-1,4-thiazane-3-carboxylic acid derivatives as neuroimmunophilin ligands, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol, the publication is Science in China, Series B: Chemistry (2007), 50(3), 405-417, database is CAplus.

By choosing neuroimmunophilin FKBP12 as a therapeutical target, the authors have attempted to discover a new structural drug for treating neurodegenerative disease. This drug should possess neurotrophic activity and not affect the immune system. Based on the crystal structure of FKBP12, FK506 and Calcineurin complex, small organic mols. were designed. These mols. were to have the ability of binding to FKBP12 in a virtual screening. By using a solution parallel synthetic method, these compounds were synthesized. The neuroprotective and neuroregenerative activities of these compounds were evaluated by binding assays, PC12 cells survival and neurite outgrowth model, chick dorsal root ganglion cultures (DRG) and 6-OHDA lesioned mice sympathetic nerve endings model. The evaluation results of these compounds showed that (2S)-2-[[[(3R)-4-(4-toluenesulfonyl)thiomorpholin-3-yl]carbonyl]amino]-4-methylpentanoic acid Et ester (N308) has great promise as a candidate for a neuroprotective and neuroregenerative agent.

Science in China, Series B: Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nie, Ai Hua published the artcileDrug discovery based on the structure of FKBPs: design, synthesis and evaluation of L-1,4-thiazane-3-carboxylic acid derivatives as neuroimmunophilin ligands, Quality Control of 101-98-4, the publication is Chinese Chemical Letters (2005), 16(2), 163-166, database is CAplus.

Based on the structure of FK506, FKBP12 and calcineurin complex and the interactive characteristics of small mol. ligands with FK-506-binding proteins (FKBPs), a series of L-tetrahydro-1,4-thiazine-3-carboxylic acid derivatives I [X = O, R = PhCH₂NMeCH₂CH₂, PhCH:CHCH₂, 3-cyclohexylpropyl, 4-O₂NC₆H₄CH₂, etc.; X = NH, R = Me₂CHCH₂CH(CO₂Et), PhCH₂CH(CO₂CH₂Ph), etc.] was designed and synthesized as neuroimmunophilin ligands. The results of evaluation show that I [X = O; R = (PhCH₂OCH₂)₂CH] (N308) has a great promise as a candidate of neuroprotective and neuroregenerative agent.

Chinese Chemical Letters published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Quality Control of 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liao, Yan-ling published the artcileClinical efficacy of midazolam and dezocine for hemabate-induced side effects during caesarean section, Product Details of C25H47NO8, the publication is Hainan Yixue (2014), 25(1), 35-37, database is CAplus.

The clin. efficacy of midazolam and dezocine for hemabate (carboprost tromethamine injection) induced side effects in the patients undergoing caesarean section was explored. Forty patients used hemabate during saesarean section were randomly divided into two groups, each with twenty cases. Before hemabate intrauterine injection, the patients in the control group were given normal saline 3 mL i.v., while those in the exptl. group were given midazolam 2 mg and dezocine 5 mg i.v. Respiratory function, circulatory function and side effects were observed before and after hemabate medication. The changes of MAP, HR, RR and SpO₂ in the exptl. group were fewer than those in the control group at any time point (P<0.05). The incidence of side effects in exptl. group was lower than that in the control group (P<0.05). Midazolam and dezocine could be used effectively and safely for bemabate-induced side effects during caesarean section.

Hainan Yixue published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Product Details of C25H47NO8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shen, Haigen published the artcileCopper-Catalyzed Radical Bis(trifluoromethylation) of Alkynes and 1,3-Enynes, Safety of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, the publication is Synlett (2020), 31(1), 41-44, database is CAplus.

The copper-catalyzed radical bis(trifluoromethylation) of alkynes ArCCH [Ar = 4-tert-butylphenyl, phenanthren-9-yl, 2-methyl-1,3-benzothiazol-6-yl, [4-([[(1R,2S,5R)-5-methyl-2-(propan-2- yl)cyclohexyl]oxy]carbonyl)phenyl], etc.] and 1,3-enynes R¹CCC(=CH₂)R² (R¹ = 4-bromophenyl, 9-oxo-9H-fluoren-2-yl, 3-[(benzenesulfonyl)oxy]propyl, etc.; R² = H, Me) is described. With Cu(CH₃CN)₄BF₄as the catalyst, the reaction of arylalkynes with Togni reagent II and (bpy)Zn(CF₃)₂ at room temperature affords the corresponding 1,2-bis(trifluoromethylated) alkenes ArC(CF₃)=CHCF₃ in good yields with excellent E-stereoselectivity. Under similar conditions, the reaction of 1,3-enynes provides the corresponding 1,4-bis(trifluoromethylated) allenes R¹C(CF₃)=C=C(CH₂CF₃)R² exclusively in satisfactory yields. The protocol exhibits broad substrate scope and excellent functional group compatibility.

Synlett published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H10O4S, Safety of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ou, Wei published the artcileRoom-Temperature Palladium-Catalyzed Deuterogenolysis of Carbon Oxygen Bonds towards Deuterated Pharmaceuticals, Category: alcohols-buliding-blocks, the publication is Angewandte Chemie, International Edition (2021), 60(12), 6357-6361, database is CAplus and MEDLINE.

Site-specific incorporation of deuterium into drug mols. to study and improve their biol. properties is crucial for drug discovery and development. Herein, we describe a palladium-catalyzed room-temperature deuterogenolysis of carbon-oxygen bonds in alcs. and ketones with D₂ balloon for practical synthesis of deuterated pharmaceuticals and chems. with benzyl-site (sp³ C-H) D-incorporation. The highlights of this deoxygenative deuteration strategy are mild conditions, broad scope, practicability and high chemoselectivity. To enable the direct use of D₂O, electrocatalytic D₂O-splitting is adapted to in situ supply D₂ on demand. With this system, the precise incorporation of deuterium in the metabolic position (benzyl-site) of ibuprofen is demonstrated in a sustainable and practical way with D₂O.

Angewandte Chemie, International Edition published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Spielmann, Kim published the artcileDirect Conversion of Primary Alcohols to 1,2-Amino Alcohols: Enantioselective Iridium-Catalyzed Carbonyl Reductive Coupling of Phthalimido-Allene via Hydrogen Auto-Transfer, HPLC of Formula: 83706-94-9, the publication is Journal of the American Chemical Society (2019), 141(36), 14136-14141, database is CAplus and MEDLINE.

The first catalytic enantioselective carbonyl (α-amino)allylations are described. Phthalimido-allene and primary alcs. engage in hydrogen auto-transfer-mediated carbonyl reductive coupling by way of (α-amino)allyliridium-aldehyde pairs to form vicinal amino alcs. with high levels of regio-, anti-diastereo-, and enantioselectivity. Reaction progress kinetic anal. and isotopic labeling studies corroborate a catalytic cycle involving turnover-limiting alc. dehydrogenation followed by rapid allene hydrometalation.

Journal of the American Chemical Society published new progress about 83706-94-9. 83706-94-9 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethylated Building Blocks, name is (E)-4,4,4-Trifluorobut-2-en-1-ol, and the molecular formula is C7H13NO2, HPLC of Formula: 83706-94-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts