Author: tianli

Wu, Xiaoyun published the artcileBisphenol A Analogs Induce Cellular Dysfunction in Human Trophoblast Cells in a Thyroid Hormone Receptor-Dependent Manner: In Silico and In Vitro Analyses, Category: alcohols-buliding-blocks, the publication is Environmental Science & Technology (2022), 56(12), 8384-8394, database is CAplus and MEDLINE.

Bisphenol A (BPA) and its analogs are frequently detected in human daily necessities and environmental media. Placental thyroid hormone plays an important role in fetal development. Herein, we followed the adverse outcome pathway (AOP) to explore the toxic mechanisms of BPA and its analogs toward placental thyroid hormone receptor (TR). First, the TOX21 database was used, and the interactions between BPA analogs and the ligand-binding domains (LBDs) of two subtypes of TR (TRα and TRβ) were subjected to in silico screening using mol. docking (MD) and mol. dynamics simulation (MDS). Fluorescence spectra and CD showed that BPA and its analogs interfere with TRs as a mol. initiation event (MIE), including static fluorescence quenching and secondary structural content changes in TR-LBDs. Key events (KEs) of the AOP, including the toxicity induced in placental chorionic trophoblast cells (HTR-8/SVneo) by an inverted U-shaped dose effect and changes in ROS levels, were tested in vitro. BPA, BPB, and BPAF significantly changed the expression level of TRβ, and only BPAF significantly downregulated the expression level of TRα. In conclusion, our study contributes to the health risk assessment of BPA and its analogs regarding placental adverse outcomes (AOs).

Environmental Science & Technology published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C18H23N3O4S, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cao, Jilei published the artcileMetal-free hydrogen evolution cross-coupling enabled by synergistic photoredox and polarity reversal catalysis, Computed Properties of 597-52-4, the publication is Green Chemistry (2021), 23(22), 8988-8994, database is CAplus.

A synergistic combination of photoredox and polarity reversal catalysis enabled a hydrogen evolution cross-coupling of silanes with H₂O, alcs., phenols, and silanols, which afforded the corresponding silanols, monosilyl ethers, and disilyl ethers, resp., in moderate to excellent yields. The dehydrogenative cross-coupling of Si-H and O-H proceeded smoothly with broad substrate scope and good functional group compatibility in the presence of only an organophotocatalyst 4-CzIPN and a thiol HAT catalyst, without the requirement of any metals, external oxidants and proton reductants, which is distinct from the previously reported photocatalytic hydrogen evolution cross-coupling reactions where a proton reduction cocatalyst such as a cobalt complex is generally required. Mechanistically, a silyl cation intermediate is generated to facilitate the cross-coupling reaction, which therefore represents an unprecedented approach for the generation of silyl cation via visible-light photoredox catalysis.

Green Chemistry published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Computed Properties of 597-52-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cao, Jilei published the artcileMetal-free hydrogen evolution cross-coupling enabled by synergistic photoredox and polarity reversal catalysis, HPLC of Formula: 17877-23-5, the publication is Green Chemistry (2021), 23(22), 8988-8994, database is CAplus.

A synergistic combination of photoredox and polarity reversal catalysis enabled a hydrogen evolution cross-coupling of silanes with H₂O, alcs., phenols, and silanols, which afforded the corresponding silanols, monosilyl ethers, and disilyl ethers, resp., in moderate to excellent yields. The dehydrogenative cross-coupling of Si-H and O-H proceeded smoothly with broad substrate scope and good functional group compatibility in the presence of only an organophotocatalyst 4-CzIPN and a thiol HAT catalyst, without the requirement of any metals, external oxidants and proton reductants, which is distinct from the previously reported photocatalytic hydrogen evolution cross-coupling reactions where a proton reduction cocatalyst such as a cobalt complex is generally required. Mechanistically, a silyl cation intermediate is generated to facilitate the cross-coupling reaction, which therefore represents an unprecedented approach for the generation of silyl cation via visible-light photoredox catalysis.

Green Chemistry published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, HPLC of Formula: 17877-23-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhu, X. published the artcileInfluence of Saccharomyces cerevisiae autochthonous MQ3 strain on terpenes during the alcoholic fermentation of Chardonnay dry white wine, COA of Formula: C10H18O, the publication is Australian Journal of Grape and Wine Research (2022), 28(1), 41-49, database is CAplus.

Terpenes are major varietal aroma compounds significantly contributing to wine quality and style. Autochthonous microbial starters can promote the formation and release of the terpenes and thus highlight the terroir typicality of wines. This study compared the physicochem. parameters, changes in the terpene concentration, β-D-glucosidase activity and sensory attributes of Chardonnay wines fermented individually by the Saccharomyces cerevisiae autochthonous MQ3 strain isolated from spontaneous fermented grape must and by three com. S. cerevisiae strains. The evolution of terpenes during alc. fermentation was followed with ultrasound-assisted liquid-liquid extraction combined with GC. The physicochem. parameters of wine fermented by the MQ3 strain were significantly different from those of the wines fermented by other yeasts. The pattern of the terpenes detected, including linalool, α-terpineol, farnesol, geraniol, nerol and citronellol, varied during alc. fermentation The MQ3 strain induced greater accumulation of terpenes with increased concentration of α-terpineol, geraniol and (E,E)-farnesol. Besides, the MQ3 strain exhibited an enhanced ability to produce β-D-glucosidase compared to that of the other three strains. With the exception of α-terpineol and (E,E)-farnesol, there was no significant correlation between the concentration of the other terpenoids and β-D-glucosidase activity as shown by Pearson’s correlation anal. Wine produced with the MQ3 strain was characterised by a distinctive complex flavor with enhanced floral and fruity aromas. Conclusions : The autochthonous MQ3 strain had a pos. effect on the varietal aroma and sensory quality of the wines. Significance of the Study : Due to its aroma enhancing ability, the MQ3 strain could be applied to produce quality Chardonnay wine with terroir typicality.

Australian Journal of Grape and Wine Research published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C15H20BNO3, COA of Formula: C10H18O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yang, Bo published the artcileEnantioselective Silylation of Aliphatic C-H Bonds for the Synthesis of Silicon-Stereogenic Dihydrobenzosiloles, Name: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, the publication is Angewandte Chemie, International Edition (2020), 59(49), 22217-22222, database is CAplus and MEDLINE.

A Rh(I)-catalyzed enantioselective silylation of aliphatic C-H bonds for the synthesis of Si-stereogenic dihydrobenzosiloles is demonstrated. This reaction involves a highly enantioselective intramol. C(sp³)-H silylation of dihydrosilanes, followed by a stereospecific intermol. alkene hydrosilylation leading to the asym. tetrasubstituted silanes. A wide range of dihydrosilanes and alkenes displaying various functional groups are compatible with this process, giving access to a variety of highly functionalized Si-stereogenic dihydrobenzosiloles in good to excellent yields and enantioselectivities.

Angewandte Chemie, International Edition published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C19H21N, Name: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Ting-Sheng published the artcileEffects of mesopore introduction on the stability of zeolites for 4-iso-Propylphenol dealkylation, Name: 4-Propylphenol, the publication is Catalysis Today (2021), 40-49, database is CAplus.

Low rank coal- and biomass-derived liquids generally contain a mixture of alkylphenols, which can be dealkylated over zeolites into phenol as a basic chem. Zeolites with different pore structures were evaluated for the dealkylation of 4-iso-propylphenol as a model alkylphenol, among which HZSM-5 and HMCM-22 displayed the highest phenol selectivity above 96%. However, HZSM-5 deactivated fastest among the catalysts due to coke deposition. Thus, mesopores were introduced by desilication into HZSM-5 catalysts to improve the catalytic stability. The mesopore incorporation enhanced the connectivity of the micropores with the crystal surface, and shortened the diffusion lengths. Coke location anal. revealed that micropore occlusion by the coke shell occurred on the parent HZSM-5, whereas the acid sites in the desilicated catalysts were more accessible for fully utilization, even though the coke mainly deposited in the micropores. Furthermore, the coke on the desilicated HZSM-5 displayed a lower graphitization degree.

Catalysis Today published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Name: 4-Propylphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mandlaa published the artcileTwo-helper-strain co-culture system: a novel method for enhancement of 2-keto-L-gulonic acid production, COA of Formula: C6H10O7, the publication is Biotechnology Letters (2013), 35(11), 1853-1857, database is CAplus and MEDLINE.

A novel two-helper-strain co-culture system (TSCS) was developed to enhance 2-keto-L-gulonic acid (2-KLG) productivity for vitamin C production Bacillus megaterium and B. cereus (with a seeding culture ratio of 1:3, volume/volume), used as helper strains, increased the 2-KLG yield using Ketogulonigenium vulgare compared to the conventional one-helper-strain (either B. cereus or B. megaterium) co-culture system (OSCS). After 45 h cultivation, 2-KLG concentration in the TSCS (69 g l^-1) increased by 8.9 and 7 % over that of the OSCS (B. cereus: 63.4 g l^-1; B. megaterium: 64.5 g l^-1). The fermentation period of TSCS was 4 h shorter than that of OSCS (B. cereus). The increased cell numbers of K. vulgare stimulated by the two helper strains possibly explain the enhanced 2-KLG yield. The results imply that TSCS is a viable method for enhancing industrial production of 2-KLG.

Biotechnology Letters published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, COA of Formula: C6H10O7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mandlaa published the artcileL-sorbose is not only a substrate for 2-keto-L-gulonic acid production in the artificial microbial ecosystem of two strains mixed fermentation, Name: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Journal of Industrial Microbiology & Biotechnology (2015), 42(6), 897-904, database is CAplus and MEDLINE.

The co-culture system of the fermentation process of vitamin C can be regarded as an artificial microbial ecosystem (AME). To extend our understanding of this AME, an investigation of the relationship between strains, substrate and product was carried out in this study. The results showed that both Ketogulonicigenium vulgare and 2-keto-L-gulonic acid (2-KLG, the precursor of vitamin C) can inhibit the growth of the helper strain, while the helper strain promoted the growth of K. vulgare and 2-KLG production Moreover, L-sorbose is not only a substrate for 2-KLG production in the AME, but also a promoter of K. vulgare and an inhibitor of the helper strain. In the earlier stage of fermentation, the inhibition of L-sorbose on the helper strain’s growth is a key factor for ensuring an efficient fermentation In the condition of adding the extra helper strain (OD: 0.57, ratio of inoculation: 2 %), the yields of 2-KLG is increased by 9 % in the 14 % L-sorbose medium. To the best of our knowledge, this is the first report about the inhibition of substrate in the AME of 2-KLG production

Journal of Industrial Microbiology & Biotechnology published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Name: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liao, Liangkun published the artcileAnti-inflammatory effect of essential oil from Amomum Tsaoko Crevost et Lemarie, Quality Control of 106-25-2, the publication is Journal of Functional Foods (2022), 105087, database is CAplus.

Amomum Tsaoko Crevost et Lemarie is a kind of spices and traditional Chinese medicines with great com. value. Traditional treatment often uses essential oils from Amomum Tsaoko in aromatherapy. In this study, researchers analyzed the composition of steam-distilled essential oil from Amomum tsaoko (ATEO) and evaluated its potential antioxidant and anti-inflammatory activity. GC-MS identified a total of 33 volatile compounds, the majority of which were alc. (1,8-cineole and nerol) and aldehyde ((2E)-2-decenal) compounds Addnl., ATEO showed great anti-inflammatory activity in LPS-induced RAW 264.7 macrophages. ATEO markedly inhibited the nitric oxide (NO) release, and decreased the expression level of TNF-α, IL-1β, IL-6 and monocyte chemotactic protein-1 (MCP-1) in a dose-dependent manner. Furthermore, ATEO significantly reduced the expression of iNOS, COX-2, NF-κB p-p65 and p-ERK. These results suggested that ATEO has great anti-inflammatory activity in LPS-induced RAW 264.7 cells, which will facilitate the development of ATEO as a functional food.

Journal of Functional Foods published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, Quality Control of 106-25-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Guo, Dengkang published the artcileModification mechanism of plantation wood via grafting epoxy monomers onto cell walls, Computed Properties of 645-56-7, the publication is Wood Science and Technology (2022), 56(3), 813-831, database is CAplus.

The range of application for fast-growing plantation wood is limited by its dimensional instability, susceptibility to biodegradation and low mech. strength. In this study, a novel method based on in situ reaction of a hydrophilic epoxy monomer (1,4-butanediol diglycidyl ether) in the wood cell walls was proposed to improve the performance of plantation wood. The effects of curing agent on the reaction mechanism and performance of treated wood were discussed in detail. The results demonstrated that after curing using Me hexahydro phthalic anhydride (MHHPA), an epoxy oligomer with a higher mol. weight and superior water resistance was formed inside the wood cell wall compared to curing with the 2-methylimidazole (2-MI). Moreover, the epoxy group was able to react with alc. and phenolic hydroxyl in wood through 2-MI catalysis resulting in a higher grafting ratio. After the modification reaction, notable improvements were observed in the dimensional stability (anti-swelling efficiency of more than 65%), fungal (Gloeophyllum trabeum) decay resistance (weight loss of < 6%) and compressive strength (increased by 17%) of the wood.

Wood Science and Technology published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Computed Properties of 645-56-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts