Author: tianli

Martin-Montero, Raul published the artcileNi-catalyzed Reductive Deaminative Arylation at sp³ Carbon Centers, Category: alcohols-buliding-blocks, the publication is Organic Letters (2019), 21(8), 2947-2951, database is CAplus and MEDLINE.

A Ni-catalyzed reductive deaminative arylation at unactivated sp³ carbon centers is described. This operationally simple and user-friendly protocol exhibits excellent chemoselectivity profile and broad substrate scope, thus complementing existing metal-catalyzed cross-coupling reactions to forge sp³ C-C linkages. These virtues have been assessed in the context of late-stage functionalization, hence providing a strategic advantage to reliably generate structure diversity with amine-containing drugs.

Organic Letters published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wan, Peter published the artcileAdiabatic photodehydroxylation of 9-phenylxanthen-9-ol. Observation of carbocation fluorescence in neutral aqueous solution, Safety of 9-Phenyl-9H-xanthen-9-ol, the publication is Journal of Organic Chemistry (1985), 50(16), 2881-6, database is CAplus.

The photobehavior of the title compound (I) is examined in aqueous solution and organic solvents. Aqueous I undergoes adiabatic photodehydroxylation (the first example of a new class of adiabatic photochem. reactions). The reaction is not observed in MeCN and 95% aqueous EtOH. The photogenerated carbocation is trapped by MeOH in aqueous MeOH. The photobehavior of I is due to the enhanced basicity (as measured by the ionization constant pK_R⁺ of the mol. in S₁ relative to that of the ground state (S₀). The enhanced electron-donating effect of the ortho atom of I in the excited singlet state is responsible for this effect.

Journal of Organic Chemistry published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C15H14Cl2S2, Safety of 9-Phenyl-9H-xanthen-9-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Morino, Yusuke published the artcileCu/N-Oxyl-catalyzed aerobic oxidative esterification to oxalic acid diesters from ethylene glycol via highly selective intermolecular alcohol oxidation, Name: 3,3,3-Trifluoropropan-1-ol, the publication is Green Chemistry (2022), 24(5), 2017-2026, database is CAplus.

One of the ideal green esterification reactions is aerobic oxidative esterification using only a stoichiometric amount of different alcs. via intermol. selective alc. oxidation followed by hemiacetal formation by the addition of the other alc. and hemiacetal oxidation to esters. However, oxalic acid diester synthesis via oxidative esterification has not been reported to date, possibly owing to the difficulty of selectivity control of intermol. alc. oxidation and the chelating effects of ethylene glycol-derived alcs./hemiacetals on inhibiting oxidation catalysts. Herein, using a CuCl/tetramethylethylenediamine/1,5-dimethyl-9-azanoradamantane N-oxyl catalyst, authors describe a highly efficient aerobic oxidative esterification reaction of ethylene glycol to various oxalic acid diesters via selective oxidation of ethylene glycol-derived alcs./hemiacetals even in the presence of other aliphatic primary alcs. Notably, the green reaction works well using an ideal stoichiometric ratio of ethylene glycol and primary/secondary alcs. Thorough exptl. investigation and theor. calculations revealed that highly selective oxidative esterification is enabled by the preferential bidentate coordination of ethylene glycol-derived alcs./hemiacetals to the Cu(II) species, followed by efficient two-electron/one-proton transfer.

Green Chemistry published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Name: 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ferraris, John P. published the artcileGrafting of buckminsterfullerene onto polythiophene: novel intramolecular donor-acceptor polymers, Application of Thiophen-3-ol, the publication is Optical Materials (Amsterdam) (1998), 9(1-4), 34-42, database is CAplus.

Conjugated polymer-fullerene composites have shown efficient photoinduced charge transfer. The attachment of a fullerene moiety to the conducting polymer backbone is expected to lead to materials with more intimate association of the donor/acceptor sites. Two approaches to the attachment of fullerenes onto polythiophene derivatives were explored. In the first case, C₆₀ fullerene was bonded to a bithiophene derivative which can be electropolymerized In the second, solvent-processable polythiophene copolymers were prepared and functionalized with fullerene. Both these systems exhibit electrochem. and optoelectrochem. properties for fullerene and the conducting polymer, as seen in cyclic voltammograms and UV-visible spectra.

Optical Materials (Amsterdam) published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C4H4OS, Application of Thiophen-3-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Diaw, A. K. D. published the artcileSynthetic routes, characterization, electrochemical and spectral properties of p-substituted N-phenylpyrroles, HPLC of Formula: 23351-09-9, the publication is ARKIVOC (Gainesville, FL, United States) (2008), 122-144, database is CAplus.

A series of p-substituted N-phenylpyrroles, including 4-(1H-pyrrol-1-yl)phenol, 1-(4-methoxyphenyl)-1H-pyrrole, 1,1′-benzene-1,4-diylbis(1H-pyrrole), 1,1′-biphenyl-4,4′-diylbis(1H-pyrrole), and 1-(4-bromophenyl)-1H-pyrrole (I), was prepared by means of a modified Clauson-Kaas method. Two new sym. and asym. end-capped pyrrole thiophenes, namely 1-[4-(thiophen-2-yl)phenyl]-1H-pyrrole and 1,1′-(bithiophen-5,5”-diyldibenzene-4,1-diyl)bis(1H-pyrrole), were synthesized by using I as a building block and the Stille method as cross-coupling reaction. For both methods, the chem. yields ranged from 36 to 81% and the desired products were characterized by ¹H and ¹³C NMR, IR, and mass spectrometry. Electrochem. properties and UV-visible absorption spectra were also investigated in order to evaluate the substituent electron-donor effects on the physicochem. parameters.

ARKIVOC (Gainesville, FL, United States) published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, HPLC of Formula: 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ambreen, Samina published the artcileNovel degradation pathways for Chlorpyrifos and 3, 5, 6-Trichloro-2-pyridinol degradation by bacterial strain Bacillus thuringiensis MB497 isolated from agricultural fields of Mianwali, Pakistan, Name: 4-Propylphenol, the publication is Pesticide Biochemistry and Physiology (2021), 104750, database is CAplus and MEDLINE.

Over use of organophosphate pesticides including Chlorpyrifos (CPF) has led to contamination of soil and water resources, resulting in serious health problems in humans along with other non-target organisms. The current study was aimed to investigate Chlorpyrifos as well as 3, 5, 6-Trichloro-2-pyridinol (TCP) biodegradation tendency of bacterial strain Bacillus thuringiensis MB497 isolated from wheat/cotton fields of Dera Saleemabad, Mianwali, Pakistan, having a history of heavy Organophosphate pesticides application. HPLC anal. revealed almost 99% degradation of the spiked CPF (200 mg L^-1) in M-9 broth, soil slurry and soil microcosm by MB497 after 9 days of incubation. Strain MB497 was also able to degrade and transform TCP (28 mg L^-1), up to 90.57% after 72 h of incubation in M-9 broth. A novel compound Di-iso-Pr methanephosphonate along with known products of 3, 5, 6-Trichloro-2-pyridinol (TCP), Di-Et thiophospsphate and Phosphorothioic acid were detected as metabolites of CPF by GCMS anal. Three novel metabolites of TCP (p-Pr phenol, 2-Ethoxy-4, 4, 5, 5-tetramethyloxazoline and 3-(2, 4, 5-Trichlorophenoxy)-1-propyne) were identified after 72 h. Based on these metabolites, new/amended metabolic pathways for CPF and TCP degradation in these bacteria has been suggested.

Pesticide Biochemistry and Physiology published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Name: 4-Propylphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yu, Lili published the artcileEfficacy of Electroacupuncture Combined with Tropisetron in Treating Carboprost Tromethamine-Induced Nausea and Vomiting during Cesarean Section under Lumbar Anesthesia., Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Complementary medicine research (2021), 28(6), 516-522, database is MEDLINE.

OBJECTIVE: We evaluated the efficacy of electroacupuncture combined with tropisetron in treating carboprost tromethamine-induced nausea and vomiting during cesarean section under lumbar anesthesia. METHODS: A total of 264 patients aged 22-40 years were enrolled, who received carboprost tromethamine and suffered nausea and vomiting during cesarean section under lumbar anesthesia. The patients were divided randomly into the control group, electroacupuncture group, tropisetron group, and electroacupuncture + tropisetron group. RESULTS: Compared to the control group, the nausea and vomiting scores decreased at T3 in both the electroacupuncture and electroacupuncture + tropisetron groups, and decreased at T4 in the electroacupuncture group, tropisetron group, and electroacupuncture + tropisetron group; the motilin, gastrin, and 5-hydroxytryptamine (5-HT) levels decreased at T5 in the other 3 groups. Compared to the electroacupuncture + tropisetron group, the nausea and vomiting scores increased at T3 in the control and tropisetron groups, and increased at T4 in the other 3 groups; the motilin, gastrin, and 5-HT levels increased at T5. CONCLUSIONS: Our study suggested that electroacupuncture combined with tropisetron could effectively relieve carboprost tromethamine-induced nausea and vomiting during cesarean section under lumbar anesthesia. The effect was better than its single application, and the reduced 5-HT, motilin, and gastrin levels might be involved in the underlying mechanism.

Complementary medicine research published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C11H22N2O4, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Yitao published the artcileDesign, synthesis, and biological evaluation of phenyloxadiazole derivatives as potential antifungal agents against phytopathogenic fungi, Recommanded Product: 4-Propylphenol, the publication is Monatshefte fuer Chemie (2021), 152(1), 121-135, database is CAplus.

A novel series of picarbutrazox-inspired oxadiazole hybrids I (R = 4-cyanophenyl, 3,5-dibromophenyl, 3,5-dichloro-4-(3-methoxyphenoxy)phenyl, etc.) was synthesized and the derivatives’ biol. activity against phytopathogenic fungi was investigated. The mols. were designed by retaining the active fragment of tetrazolyl phenyloxime ether of lead compound picarbutrazox, while introducing the potentially active oxadiazole-derived fragment I. Bioassay results revealed that some of the title compounds showed potent in vivo antifungal activities to control cucumber downy mildew. Therefore, this novel oxadiazole phenyloxadiazole derivative I can be used as a potential antifungal agent to control cucumber downy mildew and other phytopathogenic fungi for crop protection.

Monatshefte fuer Chemie published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Recommanded Product: 4-Propylphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Qiu, Qian published the artcileEffect of ergometrine combined with carboprost tromethamine on preventing postpartum hemorrhage in patients with scar uterus after cesarean section and its effect on GSH-Px SOD MDA and postpartum lactation, Category: alcohols-buliding-blocks, the publication is Hebei Yixue (2021), 27(11), 1901-1907, database is CAplus.

Objective: To investigate the effect of the combination of Ergometrine and Carboprost Tromethamine Injection in preventing postpartum hemorrhage in patients with scarred uterus re-cesarean section and its influence on glutathione peroxidase (GSH-px), superoxide dismutase (SOD), malondialdehyde (MDA) and postpartum lactation. Methods: A total of 92 patients with scarred uterus re-cesarean section in our hospital from Feb. 2018 to Apr. 2020 were selected as the research objects. They were divided into observation group and control group by simple randomization method, with 46 cases in each group. The control group was treated with Carboprost Tromethamine Injection to prevent postpartum hemorrhage, and the observation group was treated with Ergometrine combined with Carboprost Tromethamine Injection to prevent postpartum hemorrhage. The efficacy, postpartum hemorrhage, recovery, lactation, and adverse reactions, coagulation function indexes [activated partial thromboplastin time (APTT), prothrombin time (PT), fibrinogen (FIB), D-dimer (DD)], serum GSH-px, SOD, MDA levels before and 24 h after the operation of the two groups were compared. Results: After treatment, the total effective rate of the observation group was 93.48% higher than that of the control group 76.09% (P<0.05). The bleeding volume and rate of postpartum hemorrhage at 2 h and 24 h in the observation group were lower than those in the control group, the duration of lochia and hospital stay were shorter than those in the control group, and the uterine fundus declined faster than the control group (P<0.05). The levels of APTT, PT, FIB, DD, and serum MDA in the two groups aT24 h after surgery were lower than those before the operation, and the observation group was lower than the control group, and the serum GSH-px and SOD levels were higher than those before operation, and the observation group was higher than the control group (P<0.05). The lactation initiation time of the observation group was shorter than that of the control group, and the lactation volume scores of the 1 and 2 d postpartum were higher than those of the control group (P<0.05); there was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: The combined application of Ergometrine and Carboprost Tromethamine Injection to prevent postpartum hemorrhage in patients with scarred uterus re-cesarean section can significantly improve the preventive effect, reduce postpartum hemorrhage, and promote the recovery of patients, improve coagulation function and lactation, reduce serum GSH-px, SOD, MDA levels, reduce oxidative stress, and have good safety.

Hebei Yixue published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ling, Zhang published the artcileEffect of carboprost tromethamine in prevention of postpartum hemorrhage in cesarean section, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Pakistan Journal of Pharmaceutical Sciences (2018), 31(5), 2257-2262, database is CAplus.

Carboprost tromethamine is a synthetic prostaglandin derivative, which can effectively promote law contraction of the uterus and significantly reduce the amount of bleeding during and after delivery. In this study, we explored the effect of carboprost tromethamine on the prevention of postpartum hemorrhage after cesarean section and the effect on coagulation function and hemodynamics. At the same time, the effects of oxytocin and carboprost tromethamine were studied in different groups. The results showed that the amount of 2h bleeding (256.7 ± 65.21) mL and the amount of 24h hemorrhage (308.3 ± 78.3) after the operation were significantly decreased, and the difference was statistically significant (P<0.05). After the operation, the levels of APTT, TT and Fib in the two groups were significantly lower than those before the operation. The levels of SBP (119.4 ± 8.24) mmHg and DBP (79.6 ± 6.21) mmHg in the exptl. group were significantly higher than those of the control group. In summary, carboprost tromethamine has a significant effect on the prevention of postpartum hemorrhage in cesarean section, and has a significant effect on improving the state of hypercoagulable blood and maintaining the stable hemodynamic state, which has clin. a value.

Pakistan Journal of Pharmaceutical Sciences published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts