Author: tianli

Wei, Yuming published the artcileImproving the flavor of summer green tea (Camellia sinensis L.) using the yellowing process, Recommanded Product: cis-3,7-Dimethyl-2,6-Octadien-1-Ol, the publication is Food Chemistry (2022), 132982, database is CAplus and MEDLINE.

Summer green tea (SGT) has poor flavor due to its high levels of bitterness and astringency. The present study aimed to improve the flavor of SGT using the yellowing process. The results showed that after the yellowing process, the sweetness and overall acceptability increased, and the content of gallated catechins and flavonol glycosides decreased by 30.2% and 27.4%, resp., as did the bitterness and astringency of SGT. Yellowing caused a decrease in the concentration of some aroma compounds, such as (z)-3-hexen-1-ol, 1-hexanol, pentanal, heptanal and 1-octanol, which caused grassy, floral and fruity aromas. In contrast, the concentrations of 1-octen-3-ol, benzene acetaldehyde and β-ionone increased, which have mushroom and sweet aromas. Meanwhile, the sweetness and umami of SGT were enhanced by the addition of selected aroma compounds (1-octen-3-ol, benzene acetaldehyde and β-ionone), demonstrating that the yellowing process improves the flavor of SGT through odor-taste interactions.

Food Chemistry published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C40H36O4P2, Recommanded Product: cis-3,7-Dimethyl-2,6-Octadien-1-Ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Rui published the artcilePreparation and pyrolysis of two Amadori analogues as flavor precursors, Computed Properties of 20880-92-6, the publication is Journal of Analytical and Applied Pyrolysis (2021), 105357, database is CAplus.

Amadori compounds, produced during Maillard reaction, are considered as precursors of flavor compounds On the basis of Amadori compounds, herein two Amadori analogs, di-O-isopropylidene-2,3:4,5-β-D-fructopyranosyl alanine ester (A-ARP) and di-O-isopropylidene-2,3:4,5-β-D-fructopyranosyl proline ester (P-ARP), were chem. synthesized and their possibility as flavor precursors was evaluated by thermogravimetry (TG), derivative thermogravimetry (DTG), differential scanning calorimetry (DSC), and pyrolysis gas chromatog.-mass spectrometry (Py-GC/MS). TG-DTG analyses indicated that the samples were stable at room temperature, and the largest mass-loss rates (T_p) were at 208 and 278 °C, resp. Upon thermal pyrolysis, the major flavor substances were butan-2-one, Et propionate, furfural, and DL-limonene for A-ARP, while 2,5-dimethylfuran, heptan-2-one, acetophenone, and 1H-pyrrole for P-ARP. The flavor profiles are different from that of corresponding Amadori compounds, and are influenced by pyrolytic temperatures These results provide one method to regulate the species and amounts of the degraded flavor products. Finally, the possible mechanisms of the pyrolytic processes are proposed.

Journal of Analytical and Applied Pyrolysis published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Computed Properties of 20880-92-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xiao, Meng published the artcileEffect of hydroxypropyl-β-cyclodextrin on the cometabolism of phenol and phenanthrene by a novel Chryseobacterium sp., Application of 1-Hydroxy-2-naphthoic acid, the publication is Bioresource Technology (2019), 56-62, database is CAplus and MEDLINE.

Cometabolic degradation is an effective method to remove the polycyclic aromatic hydrocarbons (PAHs) with phenol as growth substrate from coal chem. wastewater (CCW). Unfortunately, the toxicity and low solubility of PAHs always restrict their degradation In this study, Chryseobacterium sp. H202 was firstly isolated from the aerobic segment of CCW. Then, to improve the cometabolic degradation of PAHs, the effects of hydroxypropyl-β-cyclodextrin (HPCD) were investigated. Phenanthrene removal was accelerated in the presence of phenol; however, the degradation of phenol was inhibited because of the toxicity of phenanthrene. Addition of 50 mg/L HPCD accelerated the degradation of phenol and effectively improved the phenanthrene removal rate by about 55%. Inclusion of HPCD appeared to increase the apparent solubility and reduce the toxicity of phenanthrene, thereby improving the cometabolic degradation of phenol and phenanthrene. Therefore, HPCD can enhance the degradation of phenanthrene with phenol as the growth substrate during CCW treatment.

Bioresource Technology published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C4H6N2, Application of 1-Hydroxy-2-naphthoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Gang published the artcileStructure-activity relationship studies on Bax activator SMBA1 for the treatment of ER-positive and triple-negative breast cancer, Safety of 2-Morpholinoethanol, the publication is European Journal of Medicinal Chemistry (2019), 589-605, database is CAplus and MEDLINE.

In an effort to develop novel Bax activators for breast cancer treatment, a series of diverse analogs have been designed and synthesized based on lead compound SMBA1 through several strategies, including introducing various alkylamino side chains to have a deeper access to S184 pocket, replacing carbon atoms with nitrogen, and reducing the nitro group of 9H-fluorene scaffold. Compounds 14 (CYD-2-11, I) and 49 (CYD-4-61, II) have been identified to exhibit significantly improved antiproliferative activity compared to SMBA1, with IC₅₀ values of 3.22 μM and 0.07 μM against triple-neg. breast cancer MDA-MB-231 and 3.81 μM and 0.06 μM against ER-pos. breast cancer MCF-7 cell lines, resp. Mechanism of action studies of II indicated that it can activate Bax protein to induce cytochrome c release and regulate apoptotic biomarkers, leading to cancer cell apoptosis. Further in vivo efficacy studies of I and II in nude mice bearing MDA-MB-231 tumor xenografts demonstrated that these drug candidates can significantly suppress tumor growth, indicating their therapeutic potential for the treatment of breast cancer.

European Journal of Medicinal Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Safety of 2-Morpholinoethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Guo, Jielong published the artcileThe influence of oxygen on the metabolites of phenolic blueberry extract and the mouse microflora during in vitro fermentation, Safety of 3-Hydroxyphenylacetic acid, the publication is Food Research International (2020), 109610, database is CAplus and MEDLINE.

The elevated intestinal oxygen in certain unhealthy conditions (e.g., mucosa injury) enhances the expansion of aerobic/facultative anaerobic bacteria (mainly Proteobacteria) in gut microbiota (GM) and is strongly linked to various diseases. The alteration of GM, influenced by oxygen, may affect the bioavailability of dietary polyphenols. In vitro digestion, dialysis and fermentation of phenolic blueberry extract (BE) were performed here using the GM of mice under different oxygen conditions. Oxygen delayed the degradation of the main phenolic components, including quercetin, kaempferol and their rutinose-conjugates, in BE during in vitro fermentation In addition, the metabolites of BE were also influenced by oxygen. Oxygen skewed the production of 3-hydroxyphenylacetatic acid to 4-hydroxyphenylacetatic acid. Moreover, oxygen also blunted hippuric, 3-phenylpropionic, and 3-hydroxycinnamic acids production Furthermore, oxygen enhanced the expansion of Salmonella and Escherichia belonging to phylum Proteobacteria and suppressed the proliferation of the anaerobic bacteria Clostridium and Bacteroides belonging to phyla Firmicutes and Bacteroidetes, resp., which was reversed by BE supplementation.

Food Research International published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Safety of 3-Hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

He, Chunbai published the artcileMultifunctional polymeric nanoparticles for oral delivery of TNF-α siRNA to macrophages, Quality Control of 96345-79-8, the publication is Biomaterials (2013), 34(11), 2843-2854, database is CAplus and MEDLINE.

Oral delivery of therapeutic siRNA is an appealing strategy for the treatment of many diseases, however poses numerous challenges to escort siRNA from the site of administration to the cytoplasm of the target cells. Mannose-modified tri-Me chitosan-cysteine (MTC) conjugate nanoparticles (NPs) were developed via ionic gelation and performed as highly effective polymeric vehicles for oral delivery of TNF-α siRNA. The chitosan backbone as well as tri-Me, thiol, and mannose groups of MTC NPs could be activated at proper time and location to overcome the extracellular and intracellular barriers to oral siRNA delivery, thereby promoting gene silencing efficiency. MTC NPs effectively improved siRNA integrity in physiol. environment, enhanced siRNA permeation across the intestinal epithelium, facilitated siRNA uptake by macrophages through clathrin-independent endocytosis, and promoted cytoplasmic siRNA release. At equivalent TNF-α siRNA dose, MTC NPs notably outperformed Lipofectamine2000 in terms of in vitro knockdown of TNF-α production in macrophages. Orally delivered MTC NPs containing low amount of TNF-α siRNA (3.75 nm/kg) inhibited TNF-α production in macrophages in vivo, which protected mice with acute hepatic injury from inflammation-induced liver damage and lethality. This study could provide broad insights into the rational design of oral siRNA vehicles for the treatment of inflammatory diseases.

Biomaterials published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, Quality Control of 96345-79-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Guo, Yi-lin published the artcileStudy on the characteristic of β-O-4 lignin polymer model compound fast pyrolysis catalyzed by K⁺, Ca²⁺, Fe²⁺, HPLC of Formula: 645-56-7, the publication is Gongcheng Rewuli Xuebao (2021), 42(12), 3073-3082, database is CAplus.

In order to reveal the mechanism of the influence of C_α functional groups and metal ions on the pyrolysis process of lignin, this study synthesized two β-O-4 type lignin polymer model compounds (Ca connected to carbonyl and hydroxyl functional groups resp.), and carried out Py-GC-MS fast pyrolysis experiment catalyzed by acetate at different temperatures (500°C, 650°C, 800°C) and different metal ions(K⁺, Ca²⁺, Fe²⁺). The exptl. results show that the C_β-O bond is easier to break than the C_α-C_β bond. The homolytic reaction produces more phenolic compounds; the addition of K⁺, Ca²⁺, Fe²⁺ metal ions can reduce the temperature required during pyrolysis, promote the generation of phenolic products, inhibited the formation of anisyl (aldehyde) and acetophenyl products.

Gongcheng Rewuli Xuebao published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, HPLC of Formula: 645-56-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yao, Yuhang published the artcileStrong Fluorescent Lanthanide Salen Complexes: Photophysical Properties, Excited-State Dynamics, and Bioimaging, Quality Control of 14703-69-6, the publication is Inorganic Chemistry (2019), 58(3), 1806-1814, database is CAplus and MEDLINE.

The synthesis, excited-state dynamics, and biol. application of luminescent lanthanide salen complexes (Ln = Lu, Gd, Eu, Yb, salen = N,N’-bis(salicylidene)ethylenediamine-based ligands) with sandwich structures are described. Among them, Lu(III) complexes show unusually strong ligand-centered fluorescence with quantum yields up to 62%, although the metal center is close to a chromophore ligand. The excited-state dynamic studies including ultrafast spectroscopy for Ln-salen complexes revealed that their excited states are solely dependent on the salen ligands and the ISC rates are slow (10⁸-10⁹ s^-1). Importantly, time-dependent d. functional theory calculations attribute the low energy transfer efficiency to the weak spin-orbital coupling (SOC) between the singlet and triplet excited states. More importantly, Lu-salen has been applied as a mol. platform to construct fluorescence probes with organelle specificity in living cell imaging, which demonstrates the advantages of the sandwich structures as being capable of preventing intramol. metal-ligand interactions and behaviors different from those of the previously reported Zn-salens. Most importantly, the preliminary study for in vivo imaging using a mouse model demonstrated the potential application of Ln coordination complexes in therapeutic and diagnostic bioimaging beyond living cells or in vitro.

Inorganic Chemistry published new progress about 14703-69-6. 14703-69-6 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Phenol, name is 3-(Methylamino)phenol, and the molecular formula is C13H11NO, Quality Control of 14703-69-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Park, Myung Jun published the artcileDirect preparation of hexaalkyldisiloxanes from trialkylsilanes and cyclosiloxanes from dialkylsilanes using potassium superoxide-crown ether, Application of Triisopropylsilanol, the publication is Main Group Metal Chemistry (1999), 22(12), 713-714, database is CAplus.

Trialkysilanes, R¹R²R³SiH (R¹/R²/R³ = ⁱPr/ⁱPr/ⁱPr, Et/Et/Et, Ph/Me/Me), were readily transformed to the corresponding hexaalkyldisiloxane in high yields with KO₂-18-crown-6. Dialkylsilanes, R¹R²SiH₂ (R¹/R² = Ph/Ph, Ph/Me, n-Oct/Me, c-hex/Me, Et/Et) gave mainly octaalkylcyclotetrasiloxanes under the same reaction conditions.

Main Group Metal Chemistry published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Application of Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Yiling published the artcileAmphiphilic polymer-encapsulated Au nanoclusters with enhanced emission and stability for highly selective detection of hypochlorous acid, Recommanded Product: 2-Phenylethanethiol, the publication is RSC Advances (2021), 11(24), 14678-14685, database is CAplus and MEDLINE.

It is of vital importance to develop probes to monitor hypochlorous acid (HClO) in biol. systems as HClO is associated with many important physiol. and pathol. processes. Metal nanoclusters (NCs) are promising luminescent nanomaterials for highly reactive oxygen species (hROS) detection on the basis of their strong reaction ability with hROS. However, metal NCs typically can respond to most common hROS and are susceptible to etching by biothiols, hindering their application in the construction of effective HClO probes. Herein, we proposed a strategy to develop a nanoprobe based on Au NCs for highly sensitive and selective detection of HClO. We synthesized luminescent benzyl mercaptan-stabilized Au NCs and encapsulated them with an amphiphilic polymer (DSPE-PEG). After encapsulation, an obvious emission enhancement and good resistance to the etching by biothiols for Au NCs were achieved. More importantly, the DSPE-PEG encapsulated Au NCs can be used as a nanoprobe for detection of HClO with good performance. The luminescence of the Au NCs was effectively and selectively quenched by HClO. A good linear relationship with the concentration of HClO in the range of 5-35 μM and a limit of detection (LOD) of 1.4 μM were obtained. Addnl., this nanoprobe was successfully used for bioimaging and monitoring of HClO changes in live cells, suggesting the application potential of the as-prepared amphiphilic polymer-encapsulated Au NCs for further HClO-related biomedical research.

RSC Advances published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Recommanded Product: 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts