Author: tianli

Effect of elicitors on secondary metabolites biosynthesis in Zataria multiflora Boiss. was written by Asadollahei, Majid Vakil;Yousefifard, Maryam;Tabatabaeian, Javad;Nekonam, Marzieh Sabagh;Mahdavi, Sayyed Mohammad Ehsan. And the article was included in Industrial Crops and Products in 2022.Application of 499-75-2 This article mentions the following:

Zataria multiflora Boiss.(ZM) is an aromatic herb that is used in various industries, especially in pharmaceuticals and food. However, the inducer effect of elicitors on ZM, with the aim of increasing the bioactive compounds production, is understudied. This study analyzes the influence of a biotic (chitin) and abiotic (copper nanoparticle) elicitor on ZM under in vitro and greenhouse conditions. In the first step, having established in Murashige and Skoog medium (MS) based on the node culture method, the explants transferred to media with different blended to survey the improvements in growth. The modified MS having faster growth and propagation in ZMs was chosen. In the second step, when explants were grown and rooted enough, they were transmitted to the media of elicitors, including four copper oxide nanoparticle concentrations (0, 25, 50, & 100 mg L-1) and four chitin concentrations (0, 50, 100 & 200 mg L-1) at two exposure times (5 and 10 days) to measure biochem. attributes. The anal. showed that the highest contents of the total phenolic (6.44 mg g-1 FW), anthocyanins (39.59 mg g-1 FW), flavonols (0.76 mg g-1 FW), and flavonoids (0.97 mg g-1 FW) compounds were observed in the elicited ZMs. In addition, the components of secondary metabolites were identified by gas chromatog.-mass spectrometry (GC-MS) anal. It was revealed that the highest amount of thymol and carvacrol, as the main compositions of ZM, was in the copper oxide nanoparticle (2.51% and 38.03% resp.), control (2.34% and 28.51% resp.), and chitin (1.92% and 9.84% resp.) ZMs in turn. The present research indicates that choosing an appropriate elicitor, concentration, and exposure time for augmenting the production of bioactive compounds in each plant species is consequential so as to provide the possibility of utilizing in industry. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Application of 499-75-2).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Application of 499-75-2

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Alcohol – Wikipedia,
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Selective Oxidation of Alkylarenes to the Aromatic Ketones or Benzaldehydes with Water was written by Zhang, Jin;Du, Jihong;Zhang, Chenyang;Liu, Kun;Yu, Feifei;Yuan, Yongkun;Duan, Baogen;Liu, Renhua. And the article was included in Organic Letters in 2022.COA of Formula: C7H7ClO This article mentions the following:

Here a palladium-catalyzed oxidation method for converting alkylarenes into the aromatic ketones or benzaldehydes ArC(O)R¹ [Ar = Ph, 4-MeC₆H₄, 4-HOC₆H₄, etc.; R¹ = H, Ph, 4-ClC₆H₄, etc.] with water as the only oxygen donor was reported. This C-H bond oxidation functionalization did not require other oxidants and hydrogen acceptors, and H₂ was the only byproduct. The oxygen atom introduced into the products was confirmed to be from water by the MS anal. on the product of the ¹⁸O-labeled water reaction. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7COA of Formula: C7H7ClO).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.COA of Formula: C7H7ClO

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Alcohol – Wikipedia,
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Complete chiral induction from enantiopure 1,2-diamines to benzophenone-based achiral bisphosphane ligands in Noyori-type Ru^II catalysts was written by Jing, Qing;Sandoval, Christian A.;Wang, Zheng;Ding, Kuiling. And the article was included in European Journal of Organic Chemistry in 2006.Related Products of 171032-87-4 This article mentions the following:

The design and synthesis are reported of a novel class of Ru^II catalysts (R,R)-I⁺Cl^– (Ar = Ph, R = H, 5-t-Bu, 4-t-Bu; Ar = 3,5-Me₂C₆H₃, R = H) composed of achiral benzophenone-based bisphosphine ligands and enantiopure 1,2-diamines for the asym. hydrogenation of aryl ketones. The developed catalysts show excellent enantioselectivities (up to 97% ee) and activities (up to S/C = 10,000) in the hydrogenation of a variety of aromatic ketones. Complete chiral induction from the enantiopure 1,2-diamine to the achiral bisphosphine ligand was observed The coordination of the C:O moiety in I to the cationic Ru^II center is considered to be of key importance in providing a higher thermodn. and kinetic rotation barrier for the flexible bisphosphine ligand, resulting in the preferential formation of only one diastereomer, and thus explaining the high enantioselectivity of the catalyst. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Related Products of 171032-87-4).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Related Products of 171032-87-4

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

WSDTNBI: a novel network-based inference method for virtual screening was written by Wu, Zengrui;Ma, Hui;Liu, Zehui;Zheng, Lulu;Yu, Zhuohang;Cao, Shuying;Fang, Wenqing;Wu, Lili;Li, Weihua;Liu, Guixia;Huang, Jin;Tang, Yun. And the article was included in Chemical Science in 2022.Computed Properties of C14H12O4 This article mentions the following:

In recent years, the rapid development of network-based methods for the prediction of drug-target interactions (DTIs) provides an opportunity for the emergence of a new type of virtual screening (VS), namely, network-based VS. Herein, we reported a novel network-based inference method named wSDTNBI. Compared with previous network-based methods that use unweighted DTI networks, wSDTNBI uses weighted DTI networks whose edge weights are correlated with binding affinities. A two-pronged approach based on weighted DTI and drug-substructure association networks was employed to calculate prediction scores. To show the practical value of wSDTNBI, we performed network-based VS on retinoid-related orphan receptor γt (RORγt), and purchased 72 compounds for exptl. validation. Seven of the purchased compounds were confirmed to be novel RORγt inverse agonists by in vitro experiments, including ursonic acid and oleanonic acid with IC50 values of 10 nM and 0.28μM, resp. Moreover, the direct contact between ursonic acid and RORγt was confirmed using the X-ray crystal structure, and in vivo experiments demonstrated that ursonic acid and oleanonic acid have therapeutic effects on multiple sclerosis. These results indicate that wSDTNBI might be a powerful tool for network-based VS in drug discovery. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Computed Properties of C14H12O4).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Computed Properties of C14H12O4

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Overall Safety of Ospemifene in Postmenopausal Women from Placebo-Controlled Phase 2 and 3 Trials. was written by Simon, James A;Altomare, Corrado;Cort, Susannah;Jiang, Wei;Pinkerton, JoAnn V. And the article was included in Journal of women’s health (2002) in 2018.Electric Literature of C24H23ClO2 This article mentions the following:

OBJECTIVE: To evaluate the safety of daily oral ospemifene 60 mg, estrogen agonist/antagonist, used to treat moderate-to-severe dyspareunia due to postmenopausal vulvovaginal atrophy, which is part of genitourinary syndrome of menopause. METHODS: Post hoc analysis of safety data (treatment-emergent adverse events [TEAEs]) pooled from six phase 2 and 3 randomized, double-blind, multicenter placebo-controlled studies, evaluating the effects of ospemifene 60 mg on the breast, cardiovascular system, and bone in postmenopausal women. RESULTS: At least one TEAE was reported by 67.6% (840/1242) and 54.1% (518/958) of women taking ospemifene 60 mg and placebo, respectively. Most TEAEs were mild or moderate and occurred within 4 to 12 weeks. The most commonly reported TEAEs with ospemifene were hot flush (8.5% vs. 3.3% for placebo) and urinary tract infection (6.5% vs. 4.8%). Discontinuation due to TEAEs was 7.6% with ospemifene and 3.8% with placebo. Most women discontinued treatment due to adverse events (AEs): hot flushes, muscle spasms, headache, and vaginal discharge. Serious AEs occurred infrequently (ospemifene, 2.6%; placebo, 1.8%); most were not considered related to treatment. Breast cancer and other breast-related TEAE incidences were comparable between ospemifene (2.5%) and placebo (2.2%), and cardiovascular TEAE incidence, including deep vein thrombosis, was low with ospemifene (0.3%) and placebo (0.1%). CONCLUSION: No unexpected safety signals were reported, and discontinuation due to TEAEs was low, with use of ospemifene 60 mg versus placebo in six phase 2 and 3 trials, suggesting a lack of detrimental effects on the breast, bone, and cardiovascular health of postmenopausal women when ospemifene is used to effectively treat moderate-to-severe postmenopausal dyspareunia. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Electric Literature of C24H23ClO2).

(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Electric Literature of C24H23ClO2

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Alcohol – Wikipedia,
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High activity iridium catalyst for the asymmetric hydrogenation of aromatic ketones was written by Li, Chun;Zhang, Lin;Du, You;Zheng, Xue-Li;Fu, Hai-Yan;Chen, Hua;Li, Rui-Xiang. And the article was included in Catalysis Communications in 2012.Application of 171032-87-4 This article mentions the following:

The asym. hydrogenation of aromatic ketones catalyzed by iridium complexes was investigated in the presence of chiral diamines and achiral phosphines. The catalytic system with triphenylphosphine and 9-amino(9-deoxy)epicinchonine exhibited high activity and enantioselectivity in the asym. hydrogenation of simple aromatic ketones. A series of simple aromatic ketones were hydrogenated completely in just 2 h at room temperature with good ee value (up to 87%). In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Application of 171032-87-4).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Application of 171032-87-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Highly selective photocatalytic oxidation of alcohols under the application of novel metal organic frameworks (MOFs) based catalytic system was written by Wei, Xiu-Zhi;Wondu Dagnaw, Fentahun;Liu, Jianguo;Ma, Longlong. And the article was included in Journal of Colloid and Interface Science in 2023.Category: alcohols-buliding-blocks This article mentions the following:

Carboxylic acid is one of the most crucial and widely used organic chems. in daily human life activities. Hence preparation of this important chem. was performed under the application of the highly selective photo-catalysts through oxidation of alcs. to carboxylic acids. Herein, we have designed and disclosed a binary NH₂-MIL-125(Ti)/ NaBr) catalyst system to realize the effective transformation of alcs. into carboxylic acids under visible light irradiation Hence, derivatives of benzyl alc. containing either electron withdrawing and donating groups as well as aliphatic primary alcs. were effectively converted into the corresponding carboxylic acids. Based on our findings, NH₂-MIL-125(Ti) based photocatalytic system has shown efficient and highly selective activities for oxidation of alc. especially the in-situ conversion of co-catalyst NaBr into the corresponding free radical can enhance the alc. oxidation performance of the catalytic system. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Category: alcohols-buliding-blocks).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A versatile ternary ion pair complex of 2′-amino-1,1′-binaphthalen-2-ol for sensing enantiomers and assignment of absolute configuration was written by Lakshmipriya, Anamalagundam;Sumana, Gaonkar;Suryaprakash, Nagaraja Rao. And the article was included in Tetrahedron: Asymmetry in 2017.Recommanded Product: (R)-2-Aminobutan-1-ol This article mentions the following:

2′-Amino-1,1′-binaphthalen-2-ol (NOBIN) serves as a versatile chiral solvating agent (CSA) in the presence of trifluoromethanesulfonic acid (TFMS). The formation of a ternary complex was established by NMR, UV-visible, fluorescence and IR studies. The mechanism of interactions among the three components in the ternary complex is proposed and the ternary complex structures of different diastereomers were established by DFT based theor. calculations The present protocol has its ubiquity not only in the anal. of the enantiomeric composition of mols. possessing diverse functionalities, but also in determining the stereospecific assignment of hydroxy acids. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Recommanded Product: (R)-2-Aminobutan-1-ol).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Recommanded Product: (R)-2-Aminobutan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Small-dipole-molecule-containing electrolytes for high-voltage aqueous rechargeable batteries was written by Huang, Zhaodong;Wang, Tairan;Li, Xinliang;Cui, Huilin;Liang, Guojin;Yang, Qi;Chen, Ze;Chen, Ao;Guo, Ying;Fan, Jun;Zhi, Chunyi. And the article was included in Advanced Materials (Weinheim, Germany) in 2022.Electric Literature of C4H10O4 This article mentions the following:

High-voltage aqueous rechargeable batteries are promising competitors for next-generation energy storage systems with safety and high specific energy, but they are limited by the absence of low-cost aqueous electrolytes with a wide electrochem. stability window (ESW). The decomposition of aqueous electrolytes is mainly facilitated by the hydrogen bond network between water mols. and the water mols. in the solvation sheath. Here, three types of small dipole mols. (small mols. containing a dipole; glycerol (Gly), erythritol (Et), and acrylamide (AM)) are reported to develop aqueous electrolytes with high safety and wide ESW (over 2.5 V) for aqueous lithium-, sodium-, and zinc-ion batteries, resp. The solvation-sheath structures are explored by ab initio mol. dynamics (MD) simulations, demonstrating that three types of dipole mols. deplete the water mols. in the solvation sheath of the charge carrier and break the hydrogen bond network between the water mols., thus effectively expanding the ESW. A battery constructed from lithium titanate and lithium manganate in Gly-containing electrolyte exhibits an output voltage of 2.45 V and retains a specific capacity of 119.6 mAh g-1 after 400 cycles. This work provides another strategy for exploiting low-cost high-voltage electrolytes for aqueous energy-storage systems. In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6Electric Literature of C4H10O4).

(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Electric Literature of C4H10O4

Referemce:
Alcohol – Wikipedia,
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A QSAR study of Overton’s tadpole data was written by Lipnick, Robert L.. And the article was included in Progress in Clinical and Biological Research in 1989.Computed Properties of C10H22O3 This article mentions the following:

Previously published data (Overton, E., 1901) on the narcotic and toxic effects of a number of organic compounds in Rana temporaria tadpoles were evaluated for structure-activity relationships. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Computed Properties of C10H22O3).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Computed Properties of C10H22O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts