Author: tianli

The Influence of Modified Experimental Dental Resin Composites on the Initial In Situ Biofilm-A Triple-Blinded, Randomized, Controlled Split-Mouth Trial was written by Burgard, Niklas;Kienitz, Melanie;Jourdan, Claudia;Ruettermann, Stefan. And the article was included in Polymers (Basel, Switzerland) in 2021.Quality Control of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) This article mentions the following:

The purpose of the study was to investigate the bacterial viability of the initial biofilm on the surface of exptl. modified dental resin composites. Twenty-five healthy individuals with good oral hygiene were included in this study. In a split-mouth design, they received acrylic splints with five exptl. composite resin specimens. Four of them were modified with either a novel polymeric hollow-bead delivery system or methacrylated polymerizable Irgasan (Antibacterial B), while one specimen served as an unmodified control (ST). A delivery system based on Poly-Pore was loaded with one of the active agents: Tego Protect 5000 (Antiadhesive A), Dimethicone (Antiadhesive B), or Irgasan (Antibacterial A). All study subjects refrained from toothbrushing during the study period. Specimens were detached from the splints after 8 h and given a live/dead staining before fluorescence microscopy. A Friedman test and a post hoc Nemenyi test were applied with a significance level at p < 0.05. In summary, all materials but Antibacterial B showed a significant antibacterial effect compared to ST. The results suggested the role of the materials′ chem. in the dominance of cell adhesion. In conclusion, dental resin composites with Poly-Pore-loaded active agents showed antibacterial effectiveness in situ. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Quality Control of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate)).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Quality Control of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nonadherent Zwitterionic Composite Nanofibrous Membrane with a Halloysite Nanocarrier for Sustained Wound Anti-Infection and Cutaneous Regeneration was written by Feng, Yunbo;Wang, Qian;He, Min;Zhao, Weifeng;Liu, Xiaoling;Zhao, Changsheng. And the article was included in ACS Biomaterials Science & Engineering in 2020.Application of 109-17-1 This article mentions the following:

Wound dressing synechia and sustained postoperative bacterial infection would cause serious secondary damage to nascent cutaneous tissue and impede normal regeneration of injured wound. Endowing wound dressings with nonadherent capability and long-lasting antibacterial property could optimize the postoperative wound healing conditions and promote wound tissue neogenesis, which have important clin. application value and demand. In this study, novel nanocarrier-embedded zwitterionic composite nanofibrous membranes are fabricated using the co-electrospinning/photo-crosslinking method for the purpose of painless removal and eliminating long-lasting antibacterial infection during postoperative wound therapy. The prepared membranes possess good biocompatibility, excellent antibiofouling ability against both bacteria and plasma proteins, and platelet and L929 cell adhesion. Furthermore, in vitro and in vivo antibacterial evaluations exhibit that the composite nanofibrous membranes with a sustained drug release profile could effectively inhibit bacterial proliferation for at least 16 days. Addnl., in vivo wound regeneration assessment indicates that the obtained membranes could better enhance skin regeneration than the com. 3M Tegaderm film, which highlights the application prospect of such novel zwitterionic composite nanofibrous membranes for sustained postoperative wound anti-infection and cutaneous regeneration. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Application of 109-17-1).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Application of 109-17-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Transcriptomics and Metabolomics Analyses Reveal Defensive Responses and Flavonoid Biosynthesis of Dracaena cochinchinensis (Lour.) S. C. Chen under Wound Stress in Natural Conditions was written by Liu, Yang;Gao, Shixi;Zhang, Yuxiu;Zhang, Zhonglian;Wang, Qiuling;Xu, Yanhong;Wei, Jianhe. And the article was included in Molecules in 2022.Quality Control of (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol This article mentions the following:

Dracaena cochinchinensis has special defensive reactions against wound stress. Under wound stress, D. cochinchinensis generates a resin that is an important medicine known as dragon’s blood. However, the mol. mechanism underlying the defensive reactions is unclear. Metabolomics and transcriptomics analyses were performed on stems of D. cochinchinensis at different timepoints from the short term to the long term after wounding. According to the 378 identified compounds, wound-induced secondary metabolic processes exhibited three-phase characteristics: short term (0-5 days), middle term (10 days-3 mo), and long term (6-17 mo). The wound-induced transcriptome profile exhibited characteristics of four stages: within 24 h, 1-5 days, 10-30 days, and long term. The metabolic regulation in response to wound stress mainly involved the TCA cycle, glycolysis, starch and sucrose metabolism, phenylalanine biosynthesis, and flavonoid biosynthesis, along with some signal transduction pathways, which were all well connected. Flavonoid biosynthesis and modification were the main reactions against wound stress, mainly comprising 109 flavonoid metabolites and 93 wound-induced genes. A group of 21 genes encoding CHS, CHI, DFR, PPO, OMT, LAR, GST, and MYBs were closely related to loureirin B and loureirin C. Wound-induced responses at the metabolome and transcriptome level exhibited phase characteristics. Complex responses containing primary metabolism and flavonoid biosynthesis are involved in the defense mechanism against wound stress in natural conditions, and flavonoid biosynthesis and modification are the main strategies of D. cochinchinensis in the long-term responses to wound stress. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Quality Control of (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Quality Control of (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cluster [Re₃S₅(Dppe)₃]⁺ and its oxidation to [Re₃S₄(SO₂)(Dppe)₃]⁺ was written by Petrov, P. A.;Ryzhikov, M. R.;Kuratieva, N. V.;Konchenko, S. N.. And the article was included in Russian Journal of Coordination Chemistry in 2016.Product Details of 29364-29-2 This article mentions the following:

The reaction of cluster [Re₃S₄(Dppe)₃Br₃]Br with sodium tert-Bu thiolate affords trinuclear cationic cluster [Re₃S₅(Dppe)₃]Br (1). The oxidation of cluster 1 with air gives [Re₃S₄(SO₂)(Dppe)₃]Cl (2), which is characterized by x-ray diffraction anal. in the form of solvate 2·3.5CH₂Cl₂ (CIF file CCDC 1401732). The DFT calculations indicate the triplet ground state of the [Re₃S₅(Dppe)₃]⁺ cation and a significant spin d. on the equatorial sulfide ligands, favoring the oxidation of the cluster. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2Product Details of 29364-29-2).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Product Details of 29364-29-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chemoselective, Scalable Nickel-Electrocatalytic O-Arylation of Alcohols was written by Zhang, Hai-Jun;Chen, Longrui;Oderinde, Martins S.;Edwards, Jacob T.;Kawamata, Yu;Baran, Phil S.. And the article was included in Angewandte Chemie, International Edition in 2021.Related Products of 68716-49-4 This article mentions the following:

Herein a Ni-catalyzed electrochem. driven protocol to afford aryl-alkyl ether bonds through O-arylation of alcs. was depicted. This electrochem. method did not require strong base, exogenous expensive transition metal catalysts (e.g., Ir, Ru), and could easily be scaled up in either a batch or flow setting. Interestingly, e-etherification exhibited an enhanced substrate scope over the mechanistically related photochem. variant as it tolerated tertiary amine functional groups in the alc. nucleophile. with a broad substrate scope in an operationally simple way. In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4Related Products of 68716-49-4).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Related Products of 68716-49-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Apiaceae essential oil nanoemulsions as effective wheat protectants against five arthropod pests was written by Kavallieratos, Nickolas G.;Nika, Erifili P.;Skourti, Anna;Perinelli, Diego Romano;Spinozzi, Eleonora;Bonacucina, Giulia;Cappellacci, Loredana;Morshedloo, Mohammad Reza;Canale, Angelo;Benelli, Giovanni;Maggi, Filippo. And the article was included in Industrial Crops and Products in 2022.Application of 499-75-2 This article mentions the following:

The essential oils (EOs) produced by a number of Apiaceae species are well known for their insecticidal efficacy against a wide spectrum of insects, including vectors, stored product and agricultural pests. In the real world, rawly formulated EOs are scarcely effective due to their low chem. stability, limited persistence into the environment, and poor hydrophilicity. Therefore, for practical applications they need to be encapsulated using nanocarriers. In the present study, we evaluated two novel EO-based nanoemulsions (NEs) derived from Pimpinella anisum and Trachyspermun ammi, two plants with documented insecticidal effectiveness, for the management of stored product insects causing economic damages, including Tribolium castaneum, Tribolium confusum, Tenebrio molitor, Trogoderma granarium adults or larvae, and Acarus siro adults or nymphs. The NEs were prepared by a high-pressure homogenization procedure and determined according to the distribution of particle size through dynamic light scattering. Pimpinella anisum EO resulted mainly dominated by the phenylpropanoid (E)-anethole, while T. ammi EO was mainly composed of thymol, p-cymene, and γ-terpinene. Each EO-based NE was tested at two concentrations (500 and 1000 ppm) on stored wheat. We evaluated mortality values of the arthropod pests after 4 h, 8 h, and 16 h, and daily from 1 to 7 days. Complete mortality was achieved for T. castaneum larvae on wheat sprayed with 1000 ppm of 4% (weight/weight) P. anisum EO-based NE after 6 days of exposure. Similarly, the 8% (weight/weight) T. ammi EO-based NE killed 100.0% of the tested T. confusum larvae after 7 days to 1000 ppm. When A. siro adults were exposed to 1000 ppm of the 8% (weight/weight) T. ammi EO-based NE, 89.4% of the tested individuals were killed after 7 days. Binary EO-based NE combination toxicity tests were also carried out. Almost all T. molitor adults (97.8%) died after 7 days to 1000 ppm of 3% (weight/weight) T. ammi + 3% (weight/weight) P. anisum EO-based NE. The 3% (weight/weight) T. ammi + 3% (weight/weight) P. anisum EO-based NE killed 98.6% of T. granarium adults after 7 days at 1000 ppm. Overall, the tested Apiaceae EO-based NEs exhibited relevant pesticidal efficacy under short exposure intervals, therefore they could be taken into account as auxiliary management tools towards the sustainable protection of durable commodities in storages. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Application of 499-75-2).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Application of 499-75-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Access to Optically Active Aryl Halohydrins Using a Substrate-Tolerant Carbonyl Reductase Discovered from Kluyveromyces thermotolerans was written by Xu, Guo-Chao;Yu, Hui-Lei;Zhang, Xiao-Yan;Xu, Jian-He. And the article was included in ACS Catalysis in 2012.Recommanded Product: 120121-01-9 This article mentions the following:

By genome data mining, a carbonyl reductase tool box was designed and developed for chiral alc. synthesis. On the basis of systematic comparison of the specific activity and substrate tolerance toward α-chloroacetophenone among reductases in this tool box, KtCR, a highly substrate-/product-tolerant carbonyl reductase from Kluyveromyces thermotolerans, was identified. The reduction of a series of substituted aryl ketones was investigated using this newly mined biocatalyst. Almost all of the ketones tested were asym. reduced into corresponding chiral alcs. in 99% ee. Substrates with substituents adjacent to the carbonyl group or those with substituents on the para position of the Ph ring were easier to reduce. For α-choloacetophenone as a representative substrate, as much as 154 g/L (1.0 M) of the substrate was asym. reduced within merely 12 h by lyophilized cells of Escherichia coli/pET28-KtCR, resulting in an isolated yield of 92%, an enantiopurity of >99% ee, and a total turnover number of 5000, which was five times higher than the highest record reported so far. These results indicate the great potential of KtCR in practical synthesis of valuable aryl halohydrins as versatile chiral synthons. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Recommanded Product: 120121-01-9).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Recommanded Product: 120121-01-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chiral manganese(IV) complexes derived from Schiff base ligands: Synthesis, characterization, in vitro cytotoxicity and DNA/BSA interaction was written by Li, Zhen;Niu, Meiju;Chang, Guoliang;Zhao, Changqiu. And the article was included in Journal of Photochemistry and Photobiology, B: Biology in 2015.Quality Control of (R)-2-Aminobutan-1-ol This article mentions the following:

Two new pairs of chiral manganese(IV) complexes with Schiff-base ligands, Λ-[Mn(R-L¹)₂]·2(CH₃OH) (Λ–1) and Δ-[Mn(S-L¹)₂]·2(CH₃OH) (Δ–1), Λ-[Mn(R-L²)₂]·(H₂O)₂ (Λ–2) and Δ-[Mn(S-L²)₂]·(H₂O)₂ (Δ–2), {H₂L¹ = (R/S)-(±)-1-[(1-hydroxymethyl-propylimino)methyl]naphthalen-2-ol, H₂L² = (R/S)-(±)-1-[(1-Hydroxymethyl-2-phenylethylimino)methyl]-naphthalen-2-ol} have been synthesized, and fully characterized by elemental analyses, UV-Vis spectrum, CD spectrum, FT-IR spectrum, mass spectrum, and single crystal X-ray diffraction (SXRD). The interaction of the four chiral Mn(IV) complexes with CT-DNA and BSA were also investigated by various spectroscopic techniques (UV-visible, fluorescence spectroscopic). The results show that the Δ-complexes exhibit more efficient CT-DNA interaction with respect to the Λ-complexes. All the complexes could quench the intrinsic fluorescence of BSA by a static quenching process. In addition, the vitro cytotoxicity of these complexes toward four kinds of cancerous cell lines (A549, HeLa, HL-60, and Caco-2) was assayed by the MTT method, which exhibited to be selectively active against certain cell lines. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Quality Control of (R)-2-Aminobutan-1-ol).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Quality Control of (R)-2-Aminobutan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Deep eutectic solvents based biorefining of Value-added chemicals from the diatom Thalassiosira andamanica at room temperature was written by Singh, Kuldeep;Krishna Paidi, Murali;Kulshrestha, Akshay;Bharmoria, Pankaj;Kumar Mandal, Subir;Kumar, Arvind. And the article was included in Separation and Purification Technology in 2022.Reference of 57-55-6 This article mentions the following:

The extraction and biorefining of value-added chems. from bioresources using green solvents are among the key agenda of the circular bioeconomy. Herein we have developed a deep eutectic solvent (DESs) based biorefining approach for clean separation and purification of value-added Fucoxanthin, Chlorophyll, and Biosilica from a diatom microalgae, Thalassiosira andamanica. Several hydrophilic/hydrophobic (DESs) based on quaternary ammonium salt as hydrogen bond acceptor and organic acids and alcs. as hydrogen bond donors were synthesized and tested for microalgae biomass dissolution and biorefining via the phase partitioning method. In an optimized process, ∼30 wt% of fresh weight diatom could be dissolved in hydrophilic DESs at room temperature, followed by a record extraction of 19.93 mg/g of Fucoxanthin via phase partitioning, with a 53% increase in yield and an 81% increase in selectivity over conventional solvents. ¹H NMR, FTIR, LCMS, UV, and HPLC techniques were used to characterize the extracted Fucoxanthin. Subsequently, a hydrophobic DES was added to the remaining hydrophilic DESs and residual biomass and Chlorophyll were extracted into the upper hydrophobic DES layer and Biosilica (80 mg/g) was recovered by simple centrifugation. Extracted Biosilica showed an excellent adsorption capacity of 224.71 mg/g for the removal of methylene blue (MB) dye from water (94.3% up to 88.8% after 4th consecutive steps). Whereas Chlorophyll extracted in the hydrophobic DES phase exhibited excellent photostability (6 folds greater than conventional solvent) indicating the efficacy of DESs as photoprotector for light-sensitive pigments. This is the first report wherein besides an extractant DES also acted as a good photostabilizer. Addnl., we have replaced the acid-based extraction method for Biosilica with non-toxic DESs. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Reference of 57-55-6).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Reference of 57-55-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mixed Diboration of Alkynes Catalyzed by LiOH: Regio- and Stereoselective Synthesis of cis-1,2-Diborylalkenes was written by Peng, Sihan;Liu, Guixia;Huang, Zheng. And the article was included in Organic Letters in 2018.Electric Literature of C16H20B2N2O2 This article mentions the following:

A diboration of terminal alkynes with an unsym. diboron reagent pinBBdan has been achieved using LiOH as the catalyst in the presence of stoichiometric amounts of MeOH, affording 1,2-diborylalkenes with different boryl groups. The reaction proceeds in a highly regio- and stereoselective manner through cis-addition of pinBBdan to the C-C triple bond, with the Bdan moiety being incorporated at the internal position. By taking advantage of the different reactivities of the two boryl groups, the mixed diboration product can undergo the sequential, chemoselective cross-couplings with aryl bromides to form trisubstituted alkenes. In the experiment, the researchers used many compounds, for example, 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-naphtho[1,8-de][1,3,2]diazaborinine (cas: 1214264-88-6Electric Literature of C16H20B2N2O2).

2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-naphtho[1,8-de][1,3,2]diazaborinine (cas: 1214264-88-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Electric Literature of C16H20B2N2O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts