Author: tianli

New Stable Catalytic Electrodes Functionalized with TEMPO for the Waste-Free Oxidation of Alcohol was written by Karimi, Babak;Ghahremani, Mina;Ciriminna, Rosaria;Pagliaro, Mario. And the article was included in Organic Process Research & Development in 2018.Safety of (2,4-Dichlorophenyl)methanol This article mentions the following:

The authors report the 1st catalytically active and stable sol-gel electrode functionalized with the TEMPO moiety for the highly selective oxidation of alcs. with an elec. current only. The method shows broad applicability to different substrates, opening the route to the widespread adoption of this eminently clean technol. by the fine chem. and pharmaceutical industries. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Safety of (2,4-Dichlorophenyl)methanol).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Safety of (2,4-Dichlorophenyl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Asymmetric reduction of halo-substituted arylalkanones with Rhizopus arrhizus was written by Salvi, Neeta A.;Chattopadhyay, Subrata. And the article was included in Tetrahedron: Asymmetry in 2008.HPLC of Formula: 171032-87-4 This article mentions the following:

The Rhizopus arrhizus-mediated asym. reduction of various haloaryl alkanones furnished the resp. (S)-carbinols, e.g., I, with good to excellent enantioselectivities. It was found that the reaction course was primarily governed by the relative position of the halogen with respect to the carbonyl group, and its size. The relative order of efficacies of the nature of the halogen and their substitution pattern were Br > Cl > F and o- > p- > m-. The ortho-effect was the most predominant factor in the stereochem. outcome of the reaction, which was also confirmed with some non-halo-substituted acetophenones. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4HPLC of Formula: 171032-87-4).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.HPLC of Formula: 171032-87-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pore volume accessibility of particulate and monolithic stationary phases was written by Urban, Jiri. And the article was included in Journal of Chromatography A in 2015.COA of Formula: C16H26O7 This article mentions the following:

A chromatog. characterization of pore volume accessibility for both particulate and monolithic stationary phases is presented. Size-exclusion calibration curves were used to determine the pore volume fraction that is accessible for six alkylbenzenes and twelve polystyrene standards in THF as the mobile phase. Accessible porosity was then correlated with the size of the pores from which individual compounds are just excluded. The author has determined pore volume accessibility of com. available columns packed with fully and superficially porous particles, as well as with silica-based monolithic stationary phase. The author also has studied pore accessibility of polymer-based monolithic stationary phases. Suggested protocol was used to characterize pore formation at the early stage of the polymerization, to evaluate an extent of hypercrosslinking during modification of pore surface, and to characterize the pore accessibility of monolithic stationary phases hypercrosslinked after an early termination of polymerization reaction. Pore volume accessibility was also correlated to column efficiency of both particulate and monolithic stationary phases. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1COA of Formula: C16H26O7).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.COA of Formula: C16H26O7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis of 6-alkyl-2-pyridinecarboxaldehyde derivatives and their Schiff bases was written by Qiu, Chuan-jiang;Gao, Yu;Zhang, Yue-cheng;Zhang, Yi-ning;Zhao, Ji-quan. And the article was included in Hecheng Huaxue in 2009.Computed Properties of C7H9NO This article mentions the following:

2-Methyl-6-alkylpyridine derivatives were obtained from pyridinecarbonyl chlorides and 2-propanamine by amidation and heterocyclization. 6-Alkyl-2-pyridinecarboxaldehyde derivatives were prepared by a four-step synthesis and further condensation of said aldehydes with benzenamine derivatives provided the above-mentioned target compounds [i.e., N-[[6-alkyl-2-pyridinyl]methylene]benzenamine derivatives] and their structures were confirmed by UV-Vis, NMR, FT-IR, MS. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Computed Properties of C7H9NO).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Computed Properties of C7H9NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Analysis of solid binary systems containing simvastatin was written by Ledeti, Ionut;Vlase, Gabriela;Ciucanu, Ionel;Olariu, Tudor;Fulias, Adriana;Suta, Lenuta-Maria;Belu, Ionela. And the article was included in Revista de Chimie (Bucharest, Romania) in 2015.Recommanded Product: Calcium 2-hydroxypropanoate pentahydrate This article mentions the following:

This study belongs to a dedicated series of investigations regarding the compatibility in binary solid systems of active pharmaceutical ingredients and different pharmaceutical excipients, aiming as a preliminary formulation study. The compatibility/incompatibility of a currently used statin drug – simvastatin – with three pharmaceutical excipients – calcium lactate pentahydrate, mannitol and magnesium stearate was investigated by employing three instrumental techniques – namely thermal anal., Fourier-transform IR spectroscopy and powder X-Ray diffraction. In the experiment, the researchers used many compounds, for example, Calcium 2-hydroxypropanoate pentahydrate (cas: 5743-47-5Recommanded Product: Calcium 2-hydroxypropanoate pentahydrate).

Calcium 2-hydroxypropanoate pentahydrate (cas: 5743-47-5) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Recommanded Product: Calcium 2-hydroxypropanoate pentahydrate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Single microcrystals of organoplatinum(II) complexes with high charge-carrier mobility was written by Che, Chi-Ming;Chow, Cheuk-Fai;Yuen, Mai-Yan;Roy, V. A. L.;Lu, Wei;Chen, Yong;Chui, Stephen Sin-Yin;Zhu, Nianyong. And the article was included in Chemical Science in 2011.Quality Control of 2-Bromo-6-(2-methyl-1,3-dioxolan-2-yl)pyridine This article mentions the following:

Hydrogen-bonding pyrazolyl and imidazolyl motifs are incorporated into organoplatinum(II) complexes and are harmonized with extended π-π and Pt^II···Pt^II interactions to align the planar cations into a quasi-1-D columnar structure or a quasi-2D framework. A field-effect electron mobility up to 20 cm²V^-1s^-1 was recorded with a single-microcrystal transistor. Crystalline samples of one of the organoplatinum(II) complexes show intriguing thermoluminescent and vapor luminescent properties. In the experiment, the researchers used many compounds, for example, 2-Bromo-6-(2-methyl-1,3-dioxolan-2-yl)pyridine (cas: 49669-14-9Quality Control of 2-Bromo-6-(2-methyl-1,3-dioxolan-2-yl)pyridine).

2-Bromo-6-(2-methyl-1,3-dioxolan-2-yl)pyridine (cas: 49669-14-9) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Quality Control of 2-Bromo-6-(2-methyl-1,3-dioxolan-2-yl)pyridine

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

QSAR models to predict mutagenicity of acrylates, methacrylates and α, β-unsaturated carbonyl compounds was written by Perez-Garrido, Alfonso;Helguera, Aliuska Morales;Rodriguez, Francisco Giron;Cordeiro, M. Natalia D. S.. And the article was included in Dental Materials in 2010.SDS of cas: 4074-88-8 This article mentions the following:

The purpose of this study is to develop a quant. structure-activity relationship (QSAR) model that can distinguish mutagenic from nonmutagenic species with α,β-unsaturated carbonyl moiety using two endpoints for this activity, i.e. Ames test and mammalian cell gene mutation test, and also to gather information about the mol. features that most contribute to eliminate the mutagenic effects of these chems. Two data sets were used for modeling the two mutagenicity endpoints: (1) Ames test and (2) mammalian cells mutagenesis. The former comprised 220 mols., while the latter comprised 48 substances, ranging from acrylates and methacrylates to α,β-unsaturated carbonyl compounds The QSAR models were developed by applying linear discriminant anal. (LDA) along with different sets of descriptors computed using the DRAGON software. For both endpoints, there was a concordance of 89% in the prediction and 97% confidentiality by combining the three models for the Ames test mutagenicity. We have also identified several structural alerts to assist the design of new monomers. These individual models and especially their combination are attractive from the point of view of mol. modeling and could be used for the prediction and design of new monomers that do not pose a human health risk. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8SDS of cas: 4074-88-8).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.SDS of cas: 4074-88-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A new chiral sulfinyl-NH-pyridine ligand for Ir-catalyzed asymmetric transfer hydrogenation reaction was written by Tang, Lei;Wang, Qiwei;Wang, Juanjuan;Lin, Zechao;Wang, Xiaobei;Cun, Linfeng;Yuan, Weicheng;Zhu, Jin;Liao, Jian;Deng, Jingen. And the article was included in Tetrahedron Letters in 2012.Application In Synthesis of (S)-1-(2-Fluorophenyl)ethanol This article mentions the following:

A new flexible C₁-sym. tridentate ligand (S)-N-(2-(tert-butylsulfinyl)benzyl)-1-(pyridin-2-yl)methanamine (I) was successfully prepared and utilized as a chiral ligand for Ir(I)-catalyzed ATH (asym. transfer hydrogenation) reactions. Without any cooperation of other chiral centers, encouraging ee and conversion values have been achieved, which provides a better understanding of these types of ligands and a new strategy to develop new high-efficiency chiral catalysts for asym. reactions. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Application In Synthesis of (S)-1-(2-Fluorophenyl)ethanol).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Application In Synthesis of (S)-1-(2-Fluorophenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Discovery of potential competitive inhibitors against With-No-Lysine kinase 1 for treating hypertension by virtualscreening, inverse pharmacophore-based lead optimization,and molecular dynamics simulations was written by Jonniya, N. A.;Sk, M. F.;Roy, R.;Kar, P.. And the article was included in SAR and QSAR in Environmental Research in 2022.Reference of 10083-24-6 This article mentions the following:

The With-No-Lysine (WNK) has received attention because of its involvement in hypertension. Genetic mutation in the genes of WNK, leading to its overexpression, has been reported in Familial Hyperkalemic Hypertension, and thus WNK is considered a potential drug target. Herein, we have performed a highthroughput virtual screening of ∼11,000 compounds, mainly the natural phytochem. compounds and kinase inhibitory libraries, to find potential competitive inhibitors against WNK1. Initially, candidates with a docking score of ∼ -10.0 kcal/mol or less were selected to further screen their good pharmacol. properties by applying absorption, distribution, metabolism, excretion, and toxicity (ADMET). Finally, six docked compounds bearing appreciable binding affinities and WNK1 selectivity were complimented with 500 ns long all-atom mol. dynamic simulations. Subsequently, the MMPBSA scheme (Mol. Mechanics Poisson Boltzmann Surface Area) suggested three phytochem. compounds C00000947, C00020451, and C00005031, with favorable binding affinity against WNK1. Among them, C00000947 acts as the most potent competitive inhibitor of WNK1. Further, inverse pharmacophore-based lead optimization of the C00000947 leads to one potential compound, meciadanol, which shows better binding affinity and specificity than C00000947 towards WNK1, which may be further exploited to develop effective therapeutics against WNK1-associated hypertension after in vitro and in vivo validation. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Reference of 10083-24-6).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Reference of 10083-24-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Heterogeneous Catalytic Method for the Copper(II)-Catalysed Addition of H-Phosphinates and Secondary Phosphine Oxides to Phenylacetylene was written by Juhasz, Kinga;Varga, Bence;Bagi, Peter;Hell, Zoltan. And the article was included in Catalysis Letters in 2022.SDS of cas: 2216-51-5 This article mentions the following:

Copper(II) on 4 Å mol. sieve was found to be an efficient heterogeneous catalyst in the addition of different H-phosphinates and secondary phosphine oxides to phenylacetylene. All hydrophosphinylation reactions were completely regioselective, as only β-isomers were formed, and the E-alkenylphosphinates and E-alkenylphosphine oxides were synthesized in moderate to excellent yields. The catalyst could be reused multiple times in the reaction. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5SDS of cas: 2216-51-5).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.SDS of cas: 2216-51-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts