Author: tianli

Preparation and antioxidant activity of α-pyridoin and its derivatives was written by Hatanaka, Masashi;Takahashi, Kyoko;Nakamura, Shigeo;Mashino, Tadahiko. And the article was included in Bioorganic & Medicinal Chemistry in 2005.SDS of cas: 49669-14-9 This article mentions the following:

Focusing on α-pyridoin (1, 1,2-di(2-pyridyl)-1,2-ethenediol) as the lead compound of the novel antioxidative enediol, we synthesized 5,5′- or 6,6′-bis-substituted derivatives of 1 from disubstituted pyridines. The antioxidant activity of 1 and its synthetic derivatives 2-7 was evaluated by DPPH (1,1-diphenyl-2-picrylhydrazyl radical) scavenging assay and inhibition of lipid peroxidation In the DPPH assay, 1 exhibited an activity stronger than that of ascorbic acid, and 5,5′-dimethyl-(5) or 5,5′-dimethoxy-substituted derivatives (6) exhibited more potent activity than 1. The DPPH scavenging activities of α-pyridoins were correlated with their oxidation potential and thus the electron d. of enediol. 5 and 6 effectively inhibited lipid peroxidation in the rat liver microsome/tert-Bu hydroperoxide system. Therefore, 5 and 6 serve as good candidates for a pharmacol. useful enediol antioxidant. In the experiment, the researchers used many compounds, for example, 2-Bromo-6-(2-methyl-1,3-dioxolan-2-yl)pyridine (cas: 49669-14-9SDS of cas: 49669-14-9).

2-Bromo-6-(2-methyl-1,3-dioxolan-2-yl)pyridine (cas: 49669-14-9) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.SDS of cas: 49669-14-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Assessment of the antioxidant, antimicrobial and antibiofilm activities of essential oils for potential application of active chitosan films in food preservation was written by Mouhoub, Anouar;Guendouz, Amine;Belkamel, Abdeljalil;El Alaoui Talibi, Zainab;Ibnsouda Koraichi, Saad;El Modafar, Cherkaoui;Delattre, Cedric. And the article was included in World Journal of Microbiology & Biotechnology in 2022.Recommanded Product: 5-Isopropyl-2-methylphenol This article mentions the following:

In the food industry, the development of microbial biofilms is a serious problem that leads to the contamination and deterioration of food products. To overcome that, our aim consists of searching for natural antimicrobial and non-toxic compounds (essential oils EOs), which might be used alone or adsorbed on natural biopolymer films (chitosan). In this work, the antioxidant activity of eight EOs was evaluated by DPPH radical-scavenging method while their antibacterial activity was determined by diffusion on agar and microdilution methods. Among all tested EOs, Eugenia caryophyllus, Cinnamomum zeylanicum Blume and Thymus satureioides Cosson showed high antioxidant activities at the concentration of 25.6 mg/mL, with resp. values of (86.26%, 81.75%, and 76%), and strong antibacterial activity against Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, and Enterococcus hirae, with (MIC) values ≤ 4μL/mL. At the concentration of 1μL/mL, these EOs tested alone, showed values of antibiofilm-forming activity ranging from 79.43 to 99.33% and from 44.18 to 94.17%, when they are adsorbed onto chitosan film. These promising results confirm that these three EOs have a good potential for an eventual application in the food industry, as antimicrobial and antioxidant agents, or as active biodegradable food packaging, if combined with chitosan. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Recommanded Product: 5-Isopropyl-2-methylphenol).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Recommanded Product: 5-Isopropyl-2-methylphenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Arene-Immobilized Ru(II)/TsDPEN Complexes: Synthesis and Applications to the Asymmetric Transfer Hydrogenation of Ketones was written by Doherty, Simon;Knight, Julian G.;Alshaikh, Hind;Wilson, James;Waddell, Paul G.;Wills, Corinne;Dixon, Casey M.. And the article was included in European Journal of Inorganic Chemistry in 2021.SDS of cas: 171032-87-4 This article mentions the following:

The Noyori-Ikariya (arene)Ru(II)/TsDPEN precatalyst was anchored to amorphous SiO₂ and DAVISIL through the η⁶-coordinated arene ligand via a straightforward synthesis and the derived systems, (arene)Ru(II)/TsDPEN@silica and (arene)Ru(II)/TsDPEN@DAVISIL, form highly efficient catalysts for the asym. transfer hydrogenation of a range of electron-rich and electron-poor aromatic ketones, giving good conversion and excellent ee’s under mild reaction conditions. Also, catalyst generated in situ immediately prior to addition of substrate and H donor, by reaction of SiO₂-supported [(arene)RuCl₂]₂ with (S,S)-TsDPEN, was as efficient as that generated from its preformed counterpart [(arene)Ru{(S,S)-TsDPEN}Cl]@silica. Gratifyingly, the initial TOFs (up to 1085 h^-1) and ee’s (96-97%) obtained with these catalysts either rivaled or outperformed those previously reported for catalysts supported by either SiO₂ or polymer immobilized through one of the N atoms of TsDPEN. While the high ee’s were also maintained during recycle studies, the conversion dropped steadily over the 1st three runs due to gradual leaching of the Ru. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4SDS of cas: 171032-87-4).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.SDS of cas: 171032-87-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Identification of chemical components from essential oils and aqueous extracts of some medicinal plants and their nematicidal effects on Meloidogyne incognita was written by Ardakani, A. S.;Hosseininejad, S. A.. And the article was included in Journal of Basic & Applied Zoology in 2022.Formula: C10H14O This article mentions the following:

Essential oils from aerial parts of Achillea wilhelmsii, Tanacetum polycephalum and Teucrium polium were isolated by using Clevenger-type apparatus and tested at different concentrations for their nematicidal activity against the second stage juvenile (J2) of Meloidogyne incognita in vitro condition. The chem. components of the essential oils and seed extracts of each plant (0.2 g) were extracted with maceration with methanol/acetic acid mixture (85:15, volume/volume). Anal. was done by Gas Chromatog., GC-Mass Spectrometry) and HPLC. Identified chem. components were tested after this on J2 of M. incognitain. NMR spectroscopy was done to investigate the properties of organic mols. by drawing their spectrum using Broker AVANCE AQS-300 MHz. Significant difference was achieved on nematicidal activity of essential oils based on the plant species and oil concentrations GC and GC-MS led to identification of 41, 39 and 45 major compounds from T. polium, T. polycephalum and A. wilhelmsii oils, resp. A number of 10 components with different ranges of percentage were recorded in all of the tested plants oils. Use of HPLC resulted in identification of 4, 3 and 2 chem. compounds in the extracts of A. wilhelmsii, T. polycephalum and T. polium, resp. The nematicidal activity of com. polyphenols at the concentration of 1100 ppm showed 58.3, 48.9, 28.2 and 26.8 percentages J2 mortalities by catechin, coumarin, gallic acid and chlorogenic, resp. Nematotoxicity test of com. terpenoids showed the highest J2 mortalities (more than 80%), in concentrations of 100 and 200 ppm limonene, β-pinene and α-pinene. However, it was less than 30% of J2 mortality caused by terpinen-4-ol, α-terpineol and linalool. Compounds such as Limonene, β-pinene and α-pinene were detected in all of the tested plants, A. wilhelmsii, T. polycephalum and T. polium, having an effective nematicidal action vs. terpinen-4-ol, α-terpineol and linalool. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Formula: C10H14O).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Formula: C10H14O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis and preliminary evaluation of anticonvulsant activity of some [4-(benzyloxy)benzoyl]- and [4-(benzyloxy)benzyl]aminoalkanol derivatives was written by Waszkielewicz, Anna M.;Cegla, Marek;Marona, Henryk. And the article was included in Acta Poloniae Pharmaceutica in 2007.Safety of 3-Amino-3-methylbutan-1-ol This article mentions the following:

A variety of appropriate [4-(benzyloxy)benzoyl]- and [4-(benzyloxy)benzyl]aminoalkanol derivatives was synthesized and evaluated for anticonvulsant activity using the maximal electroshock (MES) and s.c. pentylenetetrazole (ScMet) tests in mice and rats. Neurotoxicity was determined by the rotorod test. The most active compounds in the MES test in mice were the appropriate 4-(benzyloxy)benzyl derivatives of (R,S)- and S-(+)-2-amino-1-butanol, 3-[4-(benzyloxy)benzyl]amino-3-methyl-1-butanol, and S-(+)-2-[4-(benzyloxy)benzyl]amino-3-methyl-1-butanol, all exhibiting 100% anti-MES protection (at 30 mg/kg, mice, i.p.) and non-toxic in the active doses. 4-[4-(Benzyloxy)benzyl]amino-1-butanol exhibited activity in both MES and ScMet (100 mg/kg, mice, i.p., 100% anticonvulsant protection, 0.5 h and 4 h after administration, resp.). In the experiment, the researchers used many compounds, for example, 3-Amino-3-methylbutan-1-ol (cas: 42514-50-1Safety of 3-Amino-3-methylbutan-1-ol).

3-Amino-3-methylbutan-1-ol (cas: 42514-50-1) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Safety of 3-Amino-3-methylbutan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Prediction of infinite-dilution activity coefficients with neural collaborative filtering was written by Tan, Tian;Cheng, Hongye;Chen, Guzhong;Song, Zhen;Qi, Zhiwen. And the article was included in AIChE Journal in 2022.Recommanded Product: 1,2-Propanediol This article mentions the following:

Accurate prediction of infinite dilution activity coefficient (γ^∞) for phase equilibrium and process design is crucial. In this work, an exptl. γ^∞ dataset containing 295 solutes and 407 solvents (21,048 points) is obtained through data integrating, cleaning, and filtering. The dataset is arranged as a sparse matrix with solutes and solvents as columns and rows, resp. Neural collaborative filtering (NCF), a modern matrix completion technique based on deep learning, is proposed to fully fill in the γ^∞ matrix. Ten-fold cross-validation is performed on the collected dataset to test the effectiveness of the proposed NCF, proving that NCF outperforms the state-of-the-art phys. model and previous machine learning model. The completed γ^∞ matrix makes solvent screening and extension of UNIFAC parameters possible. Taking two typical hard-to-sep. systems (benzene/cyclohexane and Me cyclopentane/n-hexane mixtures) as examples, the NCF-developed database provides high-throughput screening for separation systems in terms of solvent selectivity and capacity. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Recommanded Product: 1,2-Propanediol).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Recommanded Product: 1,2-Propanediol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Molecular imprinted hydrogels in drug delivery applications was written by Bates, Jeffrey S.;Whitson, Luke R.;Albertson, Kelan M.;Hickerson, Nathan S.;Nichols, Patrick E.;Larson, Bethany E.;Sparks, Taylor D.. And the article was included in MRS Online Proceedings Library in 2015.Formula: C16H26O7 This article mentions the following:

Mol. imprinting is the process by which mols. are imprinted into the matrix of a material through non-covalent bonding, including hydrogen bonding and van der Waals interactions. In this study hydrogels were imprinted with glaucoma medication with the purpose of creating a reusable ocular drug delivery device with reversible binding sites. The material was synthesized and tested with UV-Vis spectroscopy to determine the concentration of the released drug after twelve hours in distilled water. Modifications were made to the polymer to explore methods required for the proper delivery of the drug over an adequate period of time. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Formula: C16H26O7).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Formula: C16H26O7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Versatile one-pot synthesis of 3-alkenylcoumarins was written by Konigs, Pia;Neumann, Olivia;Hackeloeer, Kristina;Kataeva, Olga;Waldvogel, Siegfried R.. And the article was included in European Journal of Organic Chemistry in 2008.Electric Literature of C9H10O3 This article mentions the following:

A variety of 2-acyl-, 2-aroyl- and 2-formyl-substituted phenols are converted in a one-pot reaction with α,β-unsaturated carboxylic acid chlorides into the corresponding 3-alkenylcoumarins. Especially the labile 3-vinylcoumarins are readily available by the simple to perform protocol. If longer alkenyl chains are involved in position 3, small mols. with excellent organo gelating properties are established. The mode of action for such aggregates is confirmed by X-ray anal. of an analog. In the experiment, the researchers used many compounds, for example, 2′,6′-Dihydroxy-4′-methylacetophenone (cas: 1634-34-0Electric Literature of C9H10O3).

2′,6′-Dihydroxy-4′-methylacetophenone (cas: 1634-34-0) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Electric Literature of C9H10O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Oxidative Kinetic Resolution of Aromatic Alcohols Using Iron Nanoparticles was written by Sonnenberg, Jessica F.;Pichugin, Dmitry;Coombs, Neil;Morris, Robert H.. And the article was included in Topics in Catalysis in 2013.HPLC of Formula: 120121-01-9 This article mentions the following:

Using the transfer hydrogenation (TH) pre-catalyst trans-(R,R)[Fe(NCMe)CO(PPh₂C₆H₄CH = NCHPh-)₂][BF₄]₂ (1) the authors studied the reverse reaction, oxidative kinetic resolution, and were able to achieve turn-over frequencies up to 335 h^-1 and s-values in favor of the (R)-alc. up to 10.2. Using racemic 1-phenylethanol the authors optimized reaction conditions to maximize enantioselectivity and turn-over frequency (TOF) and studied the effect of different proton/hydride acceptors, temperatures, and bases. Using KOCMe₃ as the base and benzophenone in THF as the solvent and acceptor at 45°, the authors tested substrates with varying electronic and steric factors. By increasing the steric bulk at the alc., the enantioselectivity increased, however the TOF decreased dramatically. Varying the electronics of the substrates using electron withdrawing and donating substituents showed a less significant effect. Probably the active species in catalysis is zero-valent iron nanoparticles (Fe NPs), a postulate that the authors support with microscopy imaging, sub-stoichiometric poisoning experiments, and anal. of the reaction profile. Further support is given in terms of a polymer-supported substrate experiment whereby the active species in catalysis is too large to permeate the pores of a functionalized polymer. Probably this is the 1st reported example of using a nanoparticle surface for oxidative kinetic resolution In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9HPLC of Formula: 120121-01-9).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.HPLC of Formula: 120121-01-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

3D Printed CO₂-Based Triblock Copolymers and Post-Printing Modification was written by Wei, Peiran;Bhat, Gulzar A.;Cipriani, Ciera E.;Mohammad, Hamza;Schoonover, Krista;Pentzer, Emily B.;Darensbourg, Donald J.. And the article was included in Angewandte Chemie, International Edition in 2022.Synthetic Route of C3H8O2 This article mentions the following:

We report the facile synthesis and 3D printing of a series of triblock copolymers consisting of soft and hard blocks and demonstrate that alkene pendant groups of the hard block can be covalently modified. The polymers are prepared using a salenCo(III)TFA/PPNTFA binary catalyst system and 1,2-propanediol as a chain transfer agent, providing an efficient one-pot, two-step strategy to tailor polymer thermal and mech. properties. Thixotropic inks suitable for direct ink write printing were formulated by dissolving the block copolymers in organic solvent and dispersing NaCl particles. After printing, porous structures were produced by removing solvent and NaCl with water to give printed structures with surfaces that could be modified via UV-initiated thiol-ene click reactions. Alternatively, a tetra-thiol could be incorporated into the ink and used for crosslinking to give objects with high solvent resistance and selective degradability. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Synthetic Route of C3H8O2).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Synthetic Route of C3H8O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts