Author: tianli

Synthesis of new pyrrolidine-1,2-dicarboxamides and investigation of their activity for the synthesis of aminonitriles was written by Aydin, Ozge;Yolacan, Cigdem;Aydogan, Feray. And the article was included in American Chemical Science Journal in 2016.Recommanded Product: 5856-63-3 This article mentions the following:

New pyrrolidine-1,2-dicarboxamide derivatives were synthesized by the amidation reactions of some amines, an amino alc. and an amino acid ester with (S)-1-(phenylcarbamoyl)pyrrolidine-2-carboxylic acid, which was obtained by the reaction of L-proline with Ph isocyanate. Activities of these compounds for the synthesis of aminonitriles via Strecker reaction were investigated. The aminonitriles were obtained in good yields; however, no significant asym. induction was observed In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Recommanded Product: 5856-63-3).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Recommanded Product: 5856-63-3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Guanidinoacetic acid supplementation totally based on vegetable meal diet improved the growth performance, muscle flavor components and sensory characteristics of on-growing grass carp (Ctenopharygodon idella) was written by Yang, Ling-Lan;Wu, Pei;Feng, Lin;Jiang, Wei-Dan;Liu, Yang;Kuang, Sheng-Yao;Tang, Ling;Zhou, Xiao-Qiu. And the article was included in Aquaculture in 2021.Electric Literature of C18H32CaN2O10 This article mentions the following:

This study was conducted to examine the effects of guanidinoacetic acid (GAA) supplementation totally based on vegetable meal diet on growth performance, muscle flavor components and sensory characteristics of on-growing grass carp (Ctenopharygodon idella). Fish were fed with one fishmeal diet and five vegetable meal diets supplemented with graded levels of GAA (0, 150, 300, 450 and 600 mg/kg GAA diet) for 60 days. After the feeding period, we discovered that appropriate GAA supplementation totally based on vegetable meal diet could (1) improve the percentage weight gain (PWG), feed intake (FI) and feed efficiency (FE) of grass carp; (2) increase muscle flavor nucleotide (IMP), flavor-related fatty acid and amino acid contents; (3) improve muscle postmortem pH, water-holding capacity and firmness to enhance sensory characteristics, which were partly related to postmortem glycolysis, d. of myofiber and collagen. Furthermore, based on the growth indicator PWG, muscle DHA, pH and firmness, the appropriate levels of GAA supplementation in vegetable meal diet for on-growing grass carp (169.46-600.89 g) were estimated as to be 335.35, 313.75, 321.72 and 314.61 mg/kg, resp. Summarily, this study is the first to demonstrate that GAA supplementation totally based on vegetable meal diet elevated the growth performance, muscle flavor components and sensory characteristics of grass carp. In the experiment, the researchers used many compounds, for example, Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6Electric Literature of C18H32CaN2O10).

Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Electric Literature of C18H32CaN2O10

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Knowledge of genito-urinary syndrome of menopause among Italian gynecologists: the DIADEM survey was written by Alvisi, Stefania;Baldassarre, Maurizio;Gava, Giulia;Mancini, Ilaria;Cagnacci, Angelo;Seracchioli, Renato;Meriggiola, Maria Cristina. And the article was included in Maturitas in 2021.Application of 128607-22-7 This article mentions the following:

The objective of this study was to present an updated picture of the knowledge and attitudes of Italian gynecologists with regard to the genitourinary syndrome of menopause (GSM). An anonymous survey was sent via electronic mail to 3892 gynecologists. Three hundred and seventy-four out of 3892 invited Italian gynecologists replied to the survey (response rate 9.7%). Most (84%) had a good knowledge of GSM and 74% reported that they investigated it during clinic visits, but most of them underestimated its prevalence. The most frequently prescribed treatment was topical hormonal therapy (60%), followed by vaginal moisturizers and lubricants (16%), ospemifene (12%) and systemic hormone therapy (12%). According to the clin. experience of respondents, the most effective therapy is local hormonal therapy (36%), followed by ospemifene (30%). According to respondents, less than 50% of patients continue therapy after 12 mo, due to the discomfort in vaginal application, the cost of oral therapies and the fear of possible side-effects. With the limitation of the low response rate, this study suggests that although Italian gynecologists who answered the survey had some knowledge of GSM, they underestimated its prevalence, did not know its most bothersome symptoms and had inadequate knowledge of the efficacy of treatments, patient compliance and satisfaction. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Application of 128607-22-7).

(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Application of 128607-22-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

An asymmetric Salamo-based Zn complex supported on Fe₃O₄ MNPs: a novel heterogeneous nanocatalyst for the silyl protection and deprotection of alcohols under mild conditions was written by Yao, Hongyan;Wang, Yongsheng;Razi, Maryam Kargar. And the article was included in RSC Advances in 2021.Formula: C7H6Cl2O This article mentions the following:

A magnetic asym. Salamo-based Zn complex (H2L = salen type di-Schiff bases)-supported on the surface of modified Fe₃O₄ (Fe₃O₄@H₂L-Zn) as a new catalyst was designed and characterized via numerous anal. techniques such as FT-IR spectroscopy, XRD, EDS, ICP-AES, SEM, TEM, TGA and VSM. An efficient and sustainable synthetic protocol were presented for the synthesis of silyl ether substructures via the silyl protection of alcs. under mild conditions. The synthetic protocol involved a two-component solvent-free reaction between various hydroxyl-bearing substrates and hexamethyldisilazane (HMDS) as an inexpensive silylating agent using Fe₃O₄@H₂L-Zn MNPs as a magnetically separable, recyclable and reusable heterogeneous catalyst. Fe₃O₄@H2L-Zn MNPs were also applied for the removal of silyl protecting groups from hydroxyl functions using water in DCM under green conditions. The catalyst demonstrated good to excellent catalytic yield efficiency for both the reactions compared to the com. metal-based catalysts under green conditions for a wide range of substrates. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Formula: C7H6Cl2O).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Formula: C7H6Cl2O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Oxalohydrazide Ligands for Copper-Catalyzed C-O Coupling Reactions with High Turnover Numbers was written by Ray, Ritwika;Hartwig, John F.. And the article was included in Angewandte Chemie, International Edition in 2021.Recommanded Product: 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane This article mentions the following:

Here, we report a class of ligands based on oxalohydrazide cores and N-amino pyrrole and N-amino indole units that generates long-lived copper catalysts for couplings that form the C-O bonds in biaryl ethers. These Cu-catalyzed coupling of phenols with aryl bromides occurred with turnovers up to 8000, a value which is nearly two orders of magnitude higher than those of prior couplings to form biaryl ethers and nearly an order of magnitude higher than those of any prior copper-catalyzed coupling of aryl bromides and chlorides. This ligand also led to copper systems that catalyze the coupling of aryl chlorides with phenols and the coupling of aryl bromides and iodides with primary benzylic and aliphatic alcs. A wide variety of functional groups including nitriles, halides, ethers, ketones, amines, esters, amides, vinylarenes, alcs. and boronic acid esters were tolerated, and reactions occurred with aryl bromides in pharmaceutically related structures. In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4Recommanded Product: 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Recommanded Product: 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Effect of various seasonings on the quality retention of dried mackerel (Scomber scombrus Linnaeus) was written by Kobayashi, Fumiyuki;Kimura, Ryusuke;Aoki, Ryoma;Tamura, Koji;Ozawa, Ryo;Odake, Sachiko. And the article was included in Journal of Food Processing and Preservation in 2022.Application In Synthesis of Oct-1-en-3-ol This article mentions the following:

The effect of seasonings on the quality retention of dried mackerel (Scomber scombrus Linnaeus) was investigated by analyzing the components of the seasonings and prepared dried mackerel. The pH, water content, salt concentration, and inosinic acid content of dried mackerel were influenced by the water content of seasoning liquid The free amino acid content of dried mackerel depended on the seasoning liquid The DPPH radical-scavenging activity of mirin seasoning liquid was significantly higher than that of salt and chorizo, and that of black seven spices (shichimi) and chorizo seasoning powders was extremely high. The content of some aldehydes, alkenes, and alkane of dried mackerel flavored with mirin, shichimi, and chorizo was significantly lower than that flavored with salt. Hexanal concentration further decreased in dried mackerel flavored with shichimi and chorizo. Therefore, the use of shichimi and chorizo as seasoning powders was effective for maintaining the quality of dried mackerel. The production and consumption of dried fish have decreased yearly in Japan. Recently, two types of seasonings flavored with shichimi and chorizo have been, therefore, developed for preparing dried mackerel. These seasonings consisted of liquid and powder. This is the first attempt to use seasoning powders in the production of dried mackerel. This study demonstrated that the generation of fishy volatile components from dried mackerel was inhibited by the shichimi and chorizo seasoning powders. In the experiment, the researchers used many compounds, for example, Oct-1-en-3-ol (cas: 3391-86-4Application In Synthesis of Oct-1-en-3-ol).

Oct-1-en-3-ol (cas: 3391-86-4) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Application In Synthesis of Oct-1-en-3-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mechanism of the Aryl-F Bond-Forming Step from Bi(V) Fluorides was written by Planas, Oriol;Peciukenas, Vytautas;Leutzsch, Markus;Noethling, Nils;Pantazis, Dimitrios A.;Cornella, Josep. And the article was included in Journal of the American Chemical Society in 2022.Application of 68716-49-4 This article mentions the following:

The authors describe a combined exptl. and theor. mechanistic study of the C(sp²)-F bond formation from neutral and cationic high-valent organobismuth(V) fluorides, featuring a dianionic bis-aryl sulfoximine ligand. An exhaustive assessment of the substitution pattern in the ligand, the sulfoximine, and the reactive aryl on neutral triarylbismuth(V) difluorides revealed that formation of dimeric structures in solution promotes facile Ar-F bond formation. Noteworthy, theor. modeling of reductive elimination from neutral Bi(V) difluorides agrees with the exptl. determined kinetic and thermodn. parameters. Also, the addition of external fluoride sources leads to inactive octahedral anionic Bi(V) trifluoride salts, which decelerate reductive elimination. However, a parallel anal. for cationic bismuthonium fluorides revealed the crucial role of tetrafluoroborate anion as fluoride source. Both exptl. and theor. analyses conclude that C-F bond formation occurs through a low-energy five-membered transition-state pathway, where the F anion is delivered to a C(sp²) center, from a BF₄ anion, reminiscent of the Balz-Schiemann reaction. The knowledge gathered throughout the study permitted a rational assessment of the key parameters of several ligands, identifying the simple sulfone-based ligand family as an improved system for the stoichiometric and catalytic fluorination of arylboronic acid derivatives In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4Application of 68716-49-4).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Application of 68716-49-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Catalyst-free Synthesis of 6-Hydroxy Indoles via the Condensation of Carboxymethyl Cyclohexadienones and Amines was written by Reddy, Reddy Rajasekhar;Adlak, Komalkant;Ghorai, Prasanta. And the article was included in Journal of Organic Chemistry in 2017.Related Products of 5856-63-3 This article mentions the following:

An efficient catalyst-free synthesis of 6-hydroxy indoles, e.g., I, from carboxymethyl cyclohexadienones and primary amines has been developed. The aza-Michael addition of the in situ formed enamine, generated through the condensation of carboxymethyl unit of the substrates with an external amine, to cyclohexadienone moiety followed by rearomatization reaction to provide such indoles. Anilines, aliphatic amines, α-chiral aliphatic amines, or even ammonia were used as amine counterpart. Some of the cyclohexadienones gave 6-amino indoles instead of 6-hydroxy indoles using the Re₂O₇ catalyst. Various post methodol. transformations were performed to explore the synthetic utility of the synthesized hydroxy indoles. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Related Products of 5856-63-3).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Related Products of 5856-63-3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Method for detecting ¹⁴C and ³H labelled substances on thin-layer chromatograms was written by Jolchine, Genevieve. And the article was included in Physiologie Vegetale in 1964.Safety of 6-Methyl-2-pyridinemethanol This article mentions the following:

This method extends the sensitivity for detecting ³H on chromatograms. After the developing solvent was removed, the chromatogram was treated with a solution of 0.4% 2,5-diphenyloxazole and 0.01% 1,4-bis(4-methyl-5-phenyl-2-oxazolyl)benzene in toluene dithiophene (I). Following the evaporation of I, the chromatogram was left in contact with Kodak Regulix-HS type 2 film for 24 hrs. The method was tested with succinic-2,3-³H acid and succinic-¹⁴C acid; the lower limit of detection for ¹⁴C was 0.001 μc./cm.² A photomultiplier can be used in place of the film for quant. measurements. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Safety of 6-Methyl-2-pyridinemethanol).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Safety of 6-Methyl-2-pyridinemethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Analysis of 44 pharmaceuticals consumed by elderly using liquid chromatography coupled to tandem mass spectrometry was written by Gomez-Canela, Cristian;Sala-Comorera, Teresa;Pueyo, Victor;Barata, Carlos;Lacorte, Silvia. And the article was included in Journal of Pharmaceutical and Biomedical Analysis in 2019.Application of 1777-82-8 This article mentions the following:

Elderly people represent about the 15% of the total world population and often include a polymedicated age group with an average consumption of 5-10 pills per day. The main pharmaceuticals consumed are antianalgesics, antidiabetics, anti-parkinson compounds, anti-convulsants, drugs to treat constipation and drugs to treat cancer. We have developed a multiresidue method for the anal. of 44 selected pharmaceuticals prioritized according to the foremost consumption by the elderly in effluents from senior residences. Given the complexity of these waters, method optimization included the selection of the extraction cartridge, pH and volume, and the optimization of the liquid chromatog.-tandem mass spectrometry conditions to minimize matrix effects and obtain high yields. Good method performance was obtained, with recoveries at 27-116% and high sensitivity. The method was tested in a preliminar study to determine pharmaceuticals released in situ from the untreated effluents of the senior residences. High concentrations were detected, with levels at 0.20-2891 μg L^-1 attributed to the high consumption of drugs in the studied residences, which gather at ∼100 residents. The most detected pharmaceuticals were aspirin, macrogol, levofloxacin, cyclophosphamide, diclofenac, ibuprofen, paracetamol, carbamazepine, levetiracetam, pregabalin, quetiapine, chlormetiazole, trazodone, caffeine, 2,4-dichlorobenzyl alc. and amylmetacresol. This study describes the anal. conditions to determine the outmost consumed pharmaceuticals in wastewaters released from senior residences. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Application of 1777-82-8).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Application of 1777-82-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts