Author: tianli

A multi-residue method by supercritical fluid chromatography coupled with tandem mass spectrometry method for the analysis of chiral and non-chiral chemicals of emerging concern in environmental samples was written by Rice, Jack;Lubben, Anneke;Kasprzyk-Hordern, Barbara. And the article was included in Analytical and Bioanalytical Chemistry in 2020.Formula: C16H16O3 This article mentions the following:

Abstract: This manuscript presents the development, validation and application of a multi-residue supercritical fluid chromatog. coupled with tandem mass spectrometry method for the anal. of 140 chiral and non-chiral chems. of emerging concern in environmental samples, with 81 compounds being fully quant., 14 semi-quant. and 45 qual., validated according to European Medicine Agency (EMA) guidelines (European Medicines Agency 2019). One unified LC-MS method was used to analyze all analytes, which were split into three injection methods to ensure sufficient peak resolution The unified method provided an average of 113% accuracy and 4.5% precision across the analyte range. Limits of detection were in the range of 35 pg L^-1-0.7 μg L^-1, in both river water and wastewater, with an average LOD of 33 ng L^-1. The method was combined with solid-phase extraction and applied in environmental samples, showing very good accuracy and precision, as well as excellent chromatog. resolution of a range of chiral enantiomers including beta-blockers, benzodiazepines and antidepressants. The method resulted in quantification of 75% of analytes in at least two matrixes, and 56% in the trio of environmental matrixes of river water, effluent wastewater and influent wastewater, enabling its use in monitoring compounds of environmental concern, from their sources of origin through to their discharge into the environment. In the experiment, the researchers used many compounds, for example, 2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6Formula: C16H16O3).

2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Formula: C16H16O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The Highly Effective Cobalt Based Metal-Organic Frameworks Catalyst for One Pot Oxidative Esterification Under Mild Conditions was written by Mekrattanachai, Pagasukon;Zhu, Lei;Setthaya, Naruemon;Chindawong, Chakkresit;Song, Wei Guo. And the article was included in Catalysis Letters in 2022.HPLC of Formula: 873-76-7 This article mentions the following:

The cobalt-based metal organic frameworks (Co-MOFs) catalystwas prepared with using terephthalic acid and 4,4′-bipyridine as organic linkers by facile solvothermal method for one-pot oxidative esterification. The prepared catalyst was pyrolyzed at different temperature and then applied for oxidation of aldehyde using mol. oxygen as benign oxidant under mild conditions. The Co-MOFs pyrolyzed at 800 C (denoted as Co-MOFs-800) catalyst exhibited excellent catalytic activity, selectivity and recyclability toward the oxidative esterification of benzaldehydes. Furthermore, it was reused up to 5 runs without significant loss of activity. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7HPLC of Formula: 873-76-7).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.HPLC of Formula: 873-76-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Characterization of key odor-active compounds in thermal reaction beef flavoring by SGCxGC-O-MS, AEDA, DHDA, OAV and quantitative measurements was written by Wang, Haili;Yang, Ping;Liu, Chen;Song, Huanlu;Pan, Wenqing;Gong, Lin. And the article was included in Journal of Food Composition and Analysis in 2022.Application In Synthesis of Oct-1-en-3-ol This article mentions the following:

Thermal reaction beef flavoring is a kind of food additive. In this study, three extraction methods of dynamic headspace sampling (DHS), solid phase micro-extraction (SPME) and liquid-liquid extraction (LLE) combined with switchable two-dimensional gas chromatog.-olfactometry-mass spectrometry (SGCxGC-O-MS) were employed to characterize volatile compounds in thermal reaction beef flavoring. The odor characteristics of thermal reaction beef flavors were identified by sensory evaluation, aroma extraction dilution anal. (AEDA), dynamic headspace dilution anal. (DHDA), odor activity value (OAV) and quant. measurements. A total of 231 volatile odor compounds were identified by the three extraction methods, which including 15 aldehydes, 41 ketones, 29 alcs., 27 esters, 13 furans, 20 pyrazines, 9 sulfur-containing compounds, 18 thiophenes and thiazoles, 19 acids and 40 other compounds Ninety-eight compounds had odor activity, and 22 odor-active compounds were quant. analyzed. 2-Methyl-3-furanthiol (meaty) and bis(2-methyl-3-furanyl) disulfide (onion) had the higher FD and OAV, 3-methylbutanal (chocolate) was first identified as the key odor-active compound in thermal reaction beef flavoring, Me furfuryl disulfide (meaty), 2-ethyl-3,5-dimethylpyrazine (roasted nuts), 2,3-butanedione (caramel), linalool (floral), furfural (baked bread), 2-furfurylthiol (sulfury) and other compounds were also identified as the key aroma components in thermal reaction beef flavoring. The results showed that SPME and DHS were more suitable than LLE for the separation and extraction of volatile odor compounds in thermal reaction beef flavoring, and there were some masking and synergistic effects between odor-active compounds In the experiment, the researchers used many compounds, for example, Oct-1-en-3-ol (cas: 3391-86-4Application In Synthesis of Oct-1-en-3-ol).

Oct-1-en-3-ol (cas: 3391-86-4) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Application In Synthesis of Oct-1-en-3-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Discovery of aryl sulfonamide-selective Nav1.7 inhibitors with a highly hydrophobic ethanoanthracene core was written by Wang, Jin-tao;Zheng, Yue-ming;Chen, Yue-ting;Gu, Min;Gao, Zhao-bing;Nan, Fa-jun. And the article was included in Acta Pharmacologica Sinica in 2020.Recommanded Product: 111043-48-2 This article mentions the following:

Nav1.7 channels are mainly distributed in the peripheral nervous system. Blockade of Nav1.7 channels with small-mol. inhibitors in humans might provide pain relief without affecting the central nervous system. Based on the facts that many reported Nav1.7-selective inhibitors contain aryl sulfonamide fragments, as well as a tricyclic antidepressant, maprotiline, has been found to inhibit Nav1.7 channels, we designed and synthesized a series of compounds with ethanoanthracene and aryl sulfonamide moieties. Their inhibitory activity on sodium channels were detected with electrophysiol. techniques. We found that compound 10o potently inhibited Nav1.7 channels stably expressed in HEK293 cells (IC₅₀ = 0.64 ± 0.30 nmol/L) and displayed a high Nav1.7/Nav1.5 selectivity. In mouse small-sized dorsal root ganglion neurons, compound 10o (10, 100 nmol/L) dose-dependently decreased the sodium currents and dramatically suppressed depolarizing current-elicited neuronal discharge. Preliminary in vivo experiments showed that compound 10o possessed good analgesic activity: in a mouse visceral pain model, administration of compound 10o (30-100 mg/kg, i.p.) effectively and dose-dependently suppressed acetic acid-induced writhing. In the experiment, the researchers used many compounds, for example, 3-Hydroxy-1-methylazetidine (cas: 111043-48-2Recommanded Product: 111043-48-2).

3-Hydroxy-1-methylazetidine (cas: 111043-48-2) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Recommanded Product: 111043-48-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis of photocleavable poly(methyl methacrylate-block-D-lactide) via atom-transfer radical polymerization and ring-opening polymerization was written by Li, Hong;Rathi, Sahas;Sterner, Elizabeth S.;Zhao, Hui;Hsu, Shaw Ling;Theato, Patrick;Zhang, Yongming;Coughlin, E. Bryan. And the article was included in Journal of Polymer Science, Part A: Polymer Chemistry in 2013.SDS of cas: 60463-12-9 This article mentions the following:

The synthesis and characterization of a photocleavable block copolymer containing an ortho-nitrobenzyl (ONB) linker between poly(Me methacrylate) and poly(D-lactide) blocks is presented here. The block copolymers were synthesized via atom transfer radical polymerization (ATRP) of MMA followed by ring-opening polymerization (ROP) of D-Lactide and ROP of D-lactide followed by ATRP of MMA from a difunctional photoresponsive ONB initiator, resp. The challenges and limitations during synthesis of the photocleavable block copolymers using the difunctional photoresponsive ONB initiator are discussed. The photocleavage of the copolymers occurs under mild conditions by simple irradiation with 302 nm wavelength UV light (Relative intensity at 7.6 cm: 1500 μW/cm²) for several hours. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9SDS of cas: 60463-12-9).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.SDS of cas: 60463-12-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

GC-MS fingerprint of volatile oil from Artemisia argyi was written by Wan, Lijuan;Lu, Jinqing;Guo, Shengnan. And the article was included in Medicinal Plant in 2016.Application of 2451-01-6 This article mentions the following:

[Objective] To establish the GC-MS fingerprints for Artemisia argyi volatile oil as a basis for the identification and quality of Artemisia argyi volatile oil evaluation. [Methods] 15 batches of Artemisia argyi samples were collected, and different batches of Artemisia argyi volatile oil was extracted by steam distillation And the temperature at feed inlet was 230 °, the carrier gas was nitrogen, and the carrier gas flow rate was 0.8 mL/min. GC-MS of volatile oil in 15 batches of Artemisia argyi was analyzed by temperature programmer. The GC-MS fingerprint was established and fingerprint similarity was analyzed. [Results] P-cymene, eucalyptol, terpene alkene, thujone, camphor, borneol, 1-caryophyllene, caryophyllene oxide and other 23 characteristic components were calibrated as common characteristic peaks to establish Artemisia argyi GC-MS fingerprint. The relative retention time and RSD of relative peak of total peak had smaller differences, and 15 batches of Artemisia argyi volatile oil similarity was greater than 0.90. [Conclusions]The study established the GC-MS fingerprint of Artemisia argyi volatile oil and determined 23 characteristic peaks of Artemisia argyi volatile components, which improved Artemisia argyi essential oil quality evaluation and control system, and provided overall objective exptl. evaluation for Artemisia argyi quality. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Application of 2451-01-6).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Application of 2451-01-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

C-H Alkenylation of Heteroarenes: Mechanism, Rate, and Selectivity Changes Enabled by Thioether Ligands was written by Gorsline, Bradley J.;Wang, Long;Ren, Peng;Carrow, Brad P.. And the article was included in Journal of the American Chemical Society in 2017.COA of Formula: C9H17NO3 This article mentions the following:

Thioether ancillary ligands have been identified that can greatly accelerate the C-H alkenylation of O-, S-, and N-heteroarenes. Kinetic data suggest thioether-Pd-catalyzed reactions can be as much as 800× faster than classic ligandless systems. Furthermore, mechanistic studies revealed C-H bond cleavage as the turnover-limiting step, and that rate acceleration upon thioether coordination is correlated to a change from a neutral to a cationic pathway for this key step. The formation of a cationic, low-coordinate catalytic intermediate in these reactions may also account for unusual catalyst-controlled site selectivity wherein C-H alkenylation of five-atom heteroarenes can occur under electronic control with thioether ligands even when this necessarily involves reaction at a more hindered C-H bond. The thioether effect also enables short reaction times under mild conditions for many O-, S-, and N-heteroarenes (55 examples), including examples of late-stage drug derivatization. In the experiment, the researchers used many compounds, for example, 1-Boc-Azetidine-3-yl-methanol (cas: 142253-56-3COA of Formula: C9H17NO3).

1-Boc-Azetidine-3-yl-methanol (cas: 142253-56-3) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.COA of Formula: C9H17NO3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis and evaluation of glycosyl donors with novel leaving groups for transglycosylations employing β-galactosidase from bovine testes was written by Kroeger, Lars;Thiem, Joachim. And the article was included in Carbohydrate Research in 2007.Product Details of 60463-12-9 This article mentions the following:

Novel aryl β-D-galactopyranosides were synthesized employing phase-transfer catalysis, and assayed as potential galactose donors in the presence of β-galactosidase from bovine testes using pNP-Gal as a reference The aglycons were represented mainly by nitrophenols containing halogens, hydroxymethyl, aldehyde, carboxyl, ester or amino functions. An unusual intermol. acetyl migration onto the benzylic alc. group was observed during galactosylation of hydroxymethylnitrophenols. Pyridyl glycosides were obtained by reaction with the corresponding silver pyridinolates. Glycosides of halo-, hydroxymethyl- or methoxycarbonyl-nitrophenols as leaving groups gave virtually the same yields of transglycosylation products. A minor increase was achieved with nitrosalicylaldehyde as leaving group, whereas carboxy or amino derivatives gave very low or no yield of the transglycosylation product. Com. available donors such as resorufinyl and 4-methylumbelliferyl β-D-galactopyranosides exhibited a lower transglycosylation potential than these novel pNP-Gal derivatives In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Product Details of 60463-12-9).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Product Details of 60463-12-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis and Characterization of Conjugated Mono- and Dithiol Oligomers and Characterization of Their Self-Assembled Monolayers was written by de Boer, Bert;Meng, Hong;Perepichka, Dmitrii F.;Zheng, Jie;Frank, Martin M.;Chabal, Yves J.;Bao, Zhenan. And the article was included in Langmuir in 2003.Recommanded Product: Sodium 2-methyl-2-propanethiolate This article mentions the following:

The characterization of self-assembled monolayer mol. arrays, which serve as active layers in electronic devices, is an important step toward understanding mol.-scale electronics. To correlate the properties of self-assembled monolayers with their mol. structures, π-conjugated mono- and dithiols and aromatic dithiols with an O or S atom between two aromatic units were designed and synthesized. Their optical properties were determined by UV-visible spectroscopy. Their self-assembled monolayer films on Au surfaces were characterized by cyclic voltammetry, grazing incidence FTIR spectroscopy (GI-FTIR), and contact angle and ellipsometry measurements. Increasing the chain length from two to four Ph rings showed a more than linear increase of the intensity of the aromatic C:C ring stretch modes in GI-FTIR, indicating that the longer p-phenylene system is oriented toward the surface normal. Similar to oligophenylenes, when the number of repeat units for oligothiophene is increased, a more than linear increase of the intensity of the C:C stretch and C-H bend modes implies that the longest oligothiophenedithiol mol. is oriented close to the surface normal. Ellipsometry showed a smaller deviation from the calculated monolayer thickness with increasing number of thiophene or phenylene rings, corroborating the GI-FTIR data. The conjugated phenylene- and thiophene-based dithiols demonstrate a less tilted mol. orientation with respect to the surface normal with increasing chain length. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2Recommanded Product: Sodium 2-methyl-2-propanethiolate).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Recommanded Product: Sodium 2-methyl-2-propanethiolate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dopamine-decorated Ti₃C₂T_x MXene/cellulose nanofiber aerogels supported form-stable phase change composites with superior solar-thermal conversion efficiency and extremely high thermal storage density was written by Du, Xiaosheng;Wang, Jiuao;Jin, Linzhao;Deng, Sha;Dong, Yi;Lin, Shaojian. And the article was included in ACS Applied Materials & Interfaces in 2022.HPLC of Formula: 149-32-6 This article mentions the following:

The exploitation of from-stable phase change materials (PCMs) with superior energy storage capacity and excellent solar-thermal conversion performance is crucial for the efficient exploitation of solar energy. Herein, 2D-layered polymerized dopamine-decorated Ti₃C₂T_x MXene nanosheets (P-MXene) with superior photothermal effects and excellent oxidation stability were synthesized from Ti₃AlC₂ particles by the selective etching and self-polymerization of dopamine. Then, novel biomass-derived PCM composites, eMPCMs, were fabricated by impregnating erythritol into P-MXene/cellulose nanofiber (CNF) hybrid aerogels. The porous and interconnected 3D aerogels adequately support erythritol and resist liquid leakage during thermal storage. Differential scanning calorimetry (DSC) results showed that the eMPCMs based on P-MXene/CNF aerogels exhibited an extremely high thermal storage d. (325.4-330.6 J/g) and excellent PCM loading capacity (up to 1929%). The introduction of P-MXene nanosheets into eMPCMs significantly increased the solar-thermal conversion and storage efficiency, solar-thermal-electricity conversion capacity, and thermal conductivity of the synthesized PCM composites. Moreover, the P-MXene/CNF hybrid aerogel-based PCM composites possessed excellent long-term thermal reliability and thermostability. Hence, the synthesized eMPCMs reveal tremendous potential for efficient solar-thermal storage fields. In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6HPLC of Formula: 149-32-6).

(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.HPLC of Formula: 149-32-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts