Author: tianli

The first application of C₂-symmetric ferrocenyl phosphinite ligands for rhodium-catalyzed asymmetric transfer hydrogenation of various ketones was written by Ak, Bunyamin;Aydemir, Murat;Durap, Feyyaz;Meric, Nermin;Baysal, Akin. And the article was included in Inorganica Chimica Acta in 2015.Name: (R)-2-Aminobutan-1-ol This article mentions the following:

Homogeneous catalysis has been responsible for many major recent developments in synthetic organic chem. The combined use of organometallic and coordination chem. has produced a number of new and powerful synthetic methods for important classes of compounds in general and for optically active substances in particular. For this aim, a new class of chiral modular C₂-sym. ferrocenyl phosphinite ligands has been prepared in good yields by using the inexpensive 1,1′-ferrocenedicarboxyaldehyde and various ferrocene based-amino alcs. as starting materials, and applied in the rhodium(I)-catalyzed asym. transfer hydrogenation (ATH) of aromatic ketones to give corresponding secondary alcs. with excellent enantioselectivities and reactivities using isoPrOH as the hydrogen source (up to 99% conversion and 99% ee). The substituents on the backbone of the ligands are found to exhibit a remarkable effect on both the activity and % ee. The structures of these ligands and their complexes have been elucidated by a combination of multinuclear NMR spectroscopy, IR spectroscopy and elemental anal. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Name: (R)-2-Aminobutan-1-ol).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Name: (R)-2-Aminobutan-1-ol

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Pining for renewable resins was written by Doehle, Jens Adolf. And the article was included in European Adhesives & Sealants in 2003.Computed Properties of C10H22O3 This article mentions the following:

In response to the demand of environment friendly adhesives, solvent based adhesives using Elliotii rosins were assessed for open time duration on one-sided and two-sided applications. The open time with slightly modified rosin was two to three times longer than with a highly modified rosin. This could be attributed to the m.p. and longer open time led to less cohesion and heat resistance of the rosin. However, the highly modified rosin turned out to be the better choice, wherein the heat resistance of the test bodies with modified rosin was around 10° higher than with the slightly modified rosin. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Computed Properties of C10H22O3).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Computed Properties of C10H22O3

Referemce:
Alcohol – Wikipedia,
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Microfluidic Janus fibers with dual thermoresponsive behavior for thermoactuation was written by Razzaq, Wasif;Serra, Christophe A.;Chan-Seng, Delphine. And the article was included in European Polymer Journal in 2022.Recommanded Product: Diethyleneglycoldiacrylate This article mentions the following:

Thermoresponsive bilayer hydrogels have gained attention due to their fast response time and excellent recovery. A side-by-side capillary-based microfluidic device has been used to produce thermoresponsive Janus fibers by photopolymerization of monomer streams. These fibers had one of their parts consisting in a thermoresponsive polymer obtained from oligo(ethylene glycol) acrylate, 2-ethoxyethyl acrylate, and poly(ethylene glycol) diacrylate, while the other one consisted in a non-thermoresponsive polymer. The fibers showed reversible coiling and uncoiling phenomena with two temperature transitions upon heating (and cooling). The unexpected dual thermoresponsiveness was investigated by screening a wide range of parameters including the nature of the photoinitiator and comonomers. The transition temperatures were tuned from 0 to 80° by varying the comonomer composition, but also the nature and concentration of the crosslinker used. The ability of these Janus fibers to act as thermally-triggered actuators was demonstrated by performing up to four heating-cooling cycles and attaching a small weight at one of the extremities of the fiber. These results pave the way to the development of easily tunable polymer-based fibrous thermoactuators. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Recommanded Product: Diethyleneglycoldiacrylate).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Recommanded Product: Diethyleneglycoldiacrylate

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Alcohol – Wikipedia,
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Selective uni- and bidirectional homologation of diborylmethane was written by Blair, Daniel J.;Tanini, Damiano;Bateman, Joseph M.;Scott, Helen K.;Myers, Eddie L.;Aggarwal, Varinder K.. And the article was included in Chemical Science in 2017.Electric Literature of C8H9FO This article mentions the following:

Diborylmethane can be homologated uni- and bidirectionally by using enantiomerically pure lithium-stabilized carbenoids to give 1,2- and 1,3-bis(boronic esters), resp., in good yield and with excellent levels of enantio- and diastereoselectivity. The high sensitivity of the transformation to steric hindrance enables the exclusive operation of either manifold, effected through the judicious choice of the type of carbenoid, which can be a sparteine-ligated or a diamine-free lithiated benzoate/carbamate. The scope of the 1,2-bis(boronic esters) so generated is complementary to that encompassed by the asym. diboration of alkenes, in that primary-secondary and primary-tertiary 1,2-bis(boronic esters) can be prepared with equally high levels of selectivity and that functional groups, such as terminal alkynes and alkenes, are tolerated. Methods for forming C₂-sym. and non-sym. anti and syn 1,3-bis(boronic esters) are also described and represent a powerful route towards 1,3-functionalized synthetic intermediates. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Electric Literature of C8H9FO).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Electric Literature of C8H9FO

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Alcohol – Wikipedia,
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Synthesis of Sialyl Lewis X Mimetics and Related Structures Using the Glycosyl Phosphite Methodology and Evaluation of E-Selectin Inhibition was written by Lin, Chun-Cheng;Shimazaki, Makoto;Heck, Marie-Pierre;Aoki, Shin;Wang, Ruo;Kimura, Teiji;Ritzen, Helena;Takayama, Shuichi;Wu, Shih-Hsiung. And the article was included in Journal of the American Chemical Society in 1996.Name: tert-Butyl ((1R,2R)-2-hydroxycyclohexyl)carbamate This article mentions the following:

This paper describes our recent study of glycosyl phosphites for glycosylation reactions, with particular emphasis on the investigation of protecting group and stereochem. effects on the anomeric reactivity and stereoselectivity, and the application of this methodol. to the synthesis of Lewis X (Le^x), Lewis Y (Le^y), glycopeptide, and sialyl Lewis X (SLe^x) mimetics. Both α-O-fucosyl-L-threonine and α-O-fucosyl-(1R,2R)-2-aminocyclohexanol were found to be effective templates for the chem./enzymic synthesis of SLe^x mimetics, and some fucopeptides prepared were 5-10 times more active than SLe^x as inhibitors of E-selectin. In the experiment, the researchers used many compounds, for example, tert-Butyl ((1R,2R)-2-hydroxycyclohexyl)carbamate (cas: 155975-19-2Name: tert-Butyl ((1R,2R)-2-hydroxycyclohexyl)carbamate).

tert-Butyl ((1R,2R)-2-hydroxycyclohexyl)carbamate (cas: 155975-19-2) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Name: tert-Butyl ((1R,2R)-2-hydroxycyclohexyl)carbamate

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Alcohol – Wikipedia,
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Ospemifene for the treatment of postmenopausal vulvar and vaginal atrophy: recommendations for clinical use was written by Pinkerton, JoAnn V.;Kagan, Risa. And the article was included in Expert Opinion on Pharmacotherapy in 2015.Quality Control of (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol This article mentions the following:

Vulvular vaginal atrophy (VVA), a component of genitourinary syndrome of menopause, is a chronic, progressive medical condition that results from estrogen deficiency at menopause. Ospemifene is a nonhormonal, estrogen receptor agonist/antagonist (ERAA) FDA-approved fro the treatment of moderate to severe dyspareunia, a symptom of VVA, due to menopause. PubMed was searched from inception to March 2015 with keywords ospemifene and vulvar vaginal atrophy; no other similar clin. reviews were found. This is a comprehensive review describing the clin. safety and efficacy of ospemifene for the treatment of dyspereunia and VVA. Ospemifene is an approved oral option for postmenopausal women seeking treatment for VVA with bothersome dyspareunia, particularly for those who have tried and failed over-the-counter options or do not want vaginal therapies. Further clin. studies are needed to evaluate the preclin. and early clin. findings of antagonistic to neutral effect on breast tissue and pos. effect on bone, which, in the future, may support the use of ospemifene to prevent bone loss or treat VVA in women at high risk or with breast cancer. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Quality Control of (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol).

(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Quality Control of (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol

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Alcohol – Wikipedia,
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Allergic contact dermatitis caused by dipropylene glycol diacrylate in the Omnipod insulin pump was written by Ulriksdotter, J.;Svedman, C.;Bruze, M.;Mowitz, M.. And the article was included in British Journal of Dermatology in 2022.Product Details of 4074-88-8 This article mentions the following:

Cases of allergic contact dermatitis (ACD) caused by isobornyl acrylate (IBOA) in the Omnipod insulin pump have previously been reported. To present three cases of patients with ACD caused by a new allergen in the pump, and results from chem. analyses. Omnipod pumps from different batches were analyzed by gas chromatog.-mass spectrometry. Aimed testing, with the department’s medical device (MD) series and substances identified in the pump including dipropylene glycol diacrylate (DPGDA) at 0·01% and 0·1% in petrolatum (pet.), was performed. Patch testing also included extracts from the device, the adhesive patch as is, and allergens from baseline series. All patients tested pos. to 0·1% DPGDA in pet., and two patients addnl. to a 0·01% concentration DPGDA was found in extracts of the Omnipod pumps brought by the patients. An Omnipod pump from an earlier batch contained tripropylene glycol diacrylate, IBOA, N,N-dimethylacrylamide, di(ethylene glycol)ethyl ether acrylate (DEGEA) but no DPGDA. One of the patients reacted pos. to all of these allergens except DEGEA, which was not tested. When suspecting ACD to MDs, DPGDA at 0·1% in pet. should be tested. The contents of Omnipod have changed over time. Patch testing with updated test series and relevance assessment of pos. reactions is a delicate task. Children, with lifelong use of MDs, risk contracting many allergies with potential cross-allergies. A question should be raised as to whether these low mol. weight acrylates should be used at all in devices constantly worn on the skin. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Product Details of 4074-88-8).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Product Details of 4074-88-8

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Partial replacement of fishmeal with corn protein concentrate in diets for rainbow trout (Oncorhynchus mykiss): Effects on growth performance, physiometabolic responses, and fillet quality was written by Hosseini Shekarabi, Seyed Pezhman;Shamsaie Mehrgan, Mehdi;Banavreh, Akbar;Foroudi, Farhad. And the article was included in Aquaculture Research in 2021.Formula: C18H32CaN2O10 This article mentions the following:

An 8-wk feeding trial was run to investigate the replacement of fishmeal with corn protein concentrate (CPC; Empyreal) in rainbow trou (100.5 ± 2.3 g) diet. Fishmeal was increasingly replaced with 0 (Control), 30 (CPC3), 60 (CPC6), 90 (CPC9) and 120 (CPC12) g/kg CPC. The results showed that the substitution of fishmeal with CPC up to 90 g/kg did not cause significant differences in the growth indexes as compared to the control group, while further replacement resulted in the reduction of the growth performance. The fillet crude protein showed no significant difference between the control diet and diets containing up to 90 g/kg CPC (p > .05). Serum biochem. parameters such as albumin and glucose did not change notably, while the highest levels of alanine aminotransferase and lactate dehydrogenase were seen in the CPC12 group (p < .05). Also, serum lysozyme activity was increased with the elevation of dietary CPC up to 90 g/kg (p < .05). The redness and yellowness of the fillet were markedly elevated with the dietary incorporation of CPC (p < .05). Taken together, the optimum range of fishmeal substitution with CPC was 81.0-82.2 g/kg CPC in rainbow diet based on the broken-line regression anal. In the experiment, the researchers used many compounds, for example, Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6Formula: C18H32CaN2O10).

Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Formula: C18H32CaN2O10

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Alcohol – Wikipedia,
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Analysis of volatiles in limoncello liqueur and aging study with sensory was written by Da Costa, Neil C.;Anastasiou, Theodore J.. And the article was included in ACS Symposium Series in 2010.Name: rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate This article mentions the following:

Limoncello is a liqueur originating from Southern Italy, and in more recent times has also been produced in neighboring countries around the Mediterranean region. It is traditionally produced by the maceration (1) of lemon peel in grain alc., water and sugar and has a distinctive bright yellow color. It has a sweet lemony taste which is not sour, as it does not contain any lemon juice. This paper describes its homemade preparation, liquid/liquid solvent extraction and gas chromatog. (GC) anal. In addition detailed gas chromatog.-mass spectrometry (GC-MS) anal. data was obtained on a sector instrument of fresh limoncello vs. five month aged Limoncello volatiles. Previous anal. work (2, 3) has described over sixty volatile components in Limoncello; the anal. work presented here identifies over two hundred components. In addition compositional changes that occur with aging are described and related to gas-chromatog.-olfactometry (GC-O) work. These changes appear to differ from those found in lemon juices or carbonated drinks. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Name: rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Name: rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Enantioselective Approach for Expanding the Three-Dimensional Space of Tetrahydroquinoline to Develop BET Bromodomain Inhibitors was written by Lespinasse, Marie-Ange;Wei, Kaiyao;Perrin, Justine;Winkler, Matthias;Hamaidia, Sieme;Leroy, Alexis;Macek Jilkova, Zuzana;Philouze, Christian;Marche, Patrice N.;Petosa, Carlo;Govin, Jerome;Emadali, Anouk;Wong, Yung-Sing. And the article was included in Chemistry – A European Journal.Electric Literature of C10H20O This article mentions the following:

The pharmaceutical industry has a pervasive need for chiral specific mols. with optimal affinity for their biol. targets. However, the mass production of such compounds is currently limited by conventional chem. routes, that are costly and have an environmental impact. Here, the authors propose easy access to obtain new tetrahydroquinolines, a motif found in many bioactive compounds, that is rapid and cost effective. Starting from simple raw materials, the procedure uses a proline-catalyzed Mannich reaction followed by the addition of BF₃·OEt₂, which generates a highly electrophilic aza-ortho-quinone methide intermediate capable of reacting with different nucleophiles to form the diversely functionalized tetrahydroquinoline. Moreover, this enantioselective one-pot process provides access for the first time to tetrahydroquinolines with a cis-2,3 and trans-3,4 configuration. As proof of concept, the authors demonstrate that a three-step reaction sequence, from simple and inexpensive starting compounds and catalysts, can generate a BD2-selective BET bromodomain inhibitor with anti-inflammatory effect. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Electric Literature of C10H20O).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Electric Literature of C10H20O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts