Author: tianli

Recommanded Product: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochlorideIn 1960, Wendt, Gerhard;Bernhart, F. W. published 《The structure of a sulfur-containing compound with vitamin B₆ activity》. 《Archives of Biochemistry and Biophysics》published the findings. The article contains the following contents:

Pyridoxal-HCl (0.001 mole) was added to a warm solution of 0.001 mole 2,4-dinitrophenylhydrazine in 40 ml. of 95% EtOH, the mixture gently heated 5 min., after cooling the orange-yellow crystals collected and suspended 3 times in water with stirring (30 min.) (the crystal color changed to red), filtered off, dried, and recrystallized from iso-BuOH to give yellow crystals of 2,4-dinitrophenylhydrazone, m. 256-7°. To 500 mg. diacetate of bis-4-pyridoxyl disulfide (IV) (500 mg.) in 5 ml. 0.1N HCl was added acetone to a slight turbidity. After standing in the cold, 360 mg. crystals of di-HCl salt separated, m. 222°. IV.2HCl (441 mg.) dissolved in 220 ml. H₂O, neutralized with 168 mg. NaHCO₃, shaken with 2.0 g. Raney Ni catalyst and 3 atm. H 4 hrs. at 25°, the catalyst removed, the combined filtrates concentrated in vacuo in 10 ml., solid NaHCO₃ added to pH 8.6, the solution extracted with CHCl₃ 30 hrs., the extract concentrated to a sirup which was dissolved in EtOH, and alc. HCl added yielded 250 mg. crystals, m. 264-5°. IV.2HCl (500 mg.), 600 mg. Sn foil, and 6 ml. 4N HCl was shaken 20 hrs. at room temperature; after diluting with H₂O the Sn removed as sulfide by filtration, the filtrate dried in vacuo, and recrystallized from EtOH gave 250-300 mg. 4-pyridoxyl mercaptan (VI). VI (100 mg. in 25 ml. H₂O) was adjusted to pH 8.5 with 2N NH₄OH and air passed through the solution until the nitroprusside test was neg. Oxidation was accompanied by the precipitation of the free base of IV in 66% yield, m. 222°. A mixed sample of SB₈.2HCl (Berhart, et al., CA 54, 19993c) and IV.2HCl did not depress the m.p. The identity of both compounds was proved by paper chromatography. To complete the study, the researchers used 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) .

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 Recommanded Product: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride) is a strong antagonist of vitamin B6. Deoxypyridoxine hydrochloride has been used as an analytical reference standard for the quantification of the analyte in food samples using high performance liquid chromatography.

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Paradiz Dominguez, Maximilian;Demirkurt, Beguem;Grzelka, Marion;Bonn, Daniel;Galmiche, Laurent;Audebert, Pierre;Brouwer, Albert M. published 《Fluorescent Liquid Tetrazines》 in 2021. The article was appeared in 《Molecules》. They have made some progress in their research.Synthetic Route of C16H34O The article mentions the following:

Tetrazines with branched alkoxy substituents are liquids at ambient temperature that despite the high chromophore d. retain the bright orange fluorescence that is characteristic of this exceptional fluorophore. Here, we study the photophys. properties of a series of alkoxy-tetrazines in solution and as neat liquids We also correlate the size of the alkoxy substituents with the viscosity of the liquids We show using time-resolved spectroscopy that intersystem crossing is an important decay pathway competing with fluorescence, and that its rate is higher for 3,6-dialkoxy derivatives than for 3-chloro-6-alkoxytetrazines, explaining the higher fluorescence quantum yields for the latter. Quantum chem. calculations suggest that the difference in rate is due to the activation energy required to distort the tetrazine core such that the nπ*S₁ and the higher-lying ππ*T₂ states cross, at which point the spin-orbit coupling exceeding 10 cm^-1 allows for efficient intersystem crossing to occur. Femtosecond time-resolved anisotropy studies in solution allow us to measure a pos. relationship between the alkoxy chain lengths and their rotational correlation times, and studies in the neat liquids show a fast decay of the anisotropy consistent with fast exciton migration in the neat liquid films. And 2-Hexyl-1-decanol (cas: 2425-77-6) was used in the research process.

2-Hexyl-1-decanol(cas: 2425-77-6) has been shown to inhibit the growth of b16 mouse melanoma cells, suggesting it may be useful for treating skin cancer.Synthetic Route of C16H34O This fatty acid also has transport properties and can form hydrogen bonds with other molecules.

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Shabani, Mahtab;Keshavarz, Seyed Tahmoures;Farahmandghavi, Farhid;Imani, Mohammad published 《Long-lasting adsorption of golden flower oil on polyvinyl alcohol/clinoptilolite (PVA/CP) xerogel particles》 in 2020. The article was appeared in 《Applied Clay Science》. They have made some progress in their research.Synthetic Route of C10H22O The article mentions the following:

The present work aimed to study the adsorption and desorption characteristics of Golden Flower Oil (GFO) on xerogel particles made of Clinoptilolite (CP), a natural zeolite and polyvinyl alc. (PVA). Firstly, chem. composition and phys. characteristics of GFO (by GC/MS) and CP (by SEM and BET) were thoroughly characterized. PVA/CP xerogel was synthesized then and characterized by SEM, BET, TGA, and DSC techniques. Adsorption of the 12 GFO components on the CP and PVA/CP xerogel surface was investigated in different concentrations of GFO components. Both adsorbents showed concentration-independent and selective adsorption for GFO components. The selective adsorption index showed a direct relationship with polarity (δ_P) of the components and inversely correlated with their molar volume (V_m). Adsorption isotherms of the components were fitted by Langmuir, Freundlich, and Temkin equations. Maximum monolayer GFO adsorption on PVA/CP surface was equal to 231.93 mg g^-1 compared to 198.73 mg g^-1 for CP as an adsorbent. The maximum desorbed amount for each of the components was directly related to the V_m parameter and the weight percentage of each GFO component in the oil and inversely related to δ_P. Multilayer desorbed amount from PVA/CP xerogel particles (366.03 mg g^-1) was less than that for CP particles (573.36 mg g^-1) supporting PVA/CP for retaining GFO for longer periods. To complete the study, the researchers used 3,7-Dimethyloctan-3-ol (cas: 78-69-3) .

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Synthetic Route of C10H22O Metabolite observed in cancer metabolism. It has a role as a human metabolite.

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Quality Control of 3,7-Dimethyloctan-3-ol《Ruthenium nanoparticle-intercalated montmorillonite clay for solvent-free alkene hydrogenation reaction》 was published in 2015. The authors were Upadhyay, Praveenkumar;Srivastava, Vivek, and the article was included in《RSC Advances》. The author mentioned the following in the article:

Well-characterized, ruthenium nanoparticle-intercalated montmorillonite clay was used as a catalyst in solvent-free alkene hydrogenation reactions and the corresponding products were obtained in good yields. The catalytic activity of ruthenium nanoparticle-intercalated montmorillonite clay was successfully tested with 16 different functionalized and non-functionalized alkenes. Apart from alkene reduction, the ruthenium nanoparticle-intercalated montmorillonite clay was also tested in Wittig-type reactions for obtaining dehydrobrittonin A, an important intermediate for the synthesis of brittonin A. Ruthenium nanoparticle-intercalated montmorillonite clay was found to be active in the synthesis of dehydrobrittonin A and brittonin A. The ability to recycle the catalyst nine times, together with low catalyst loading, high catalytic activity and catalytic selectivity were noteworthy advantages of the proposed protocol.3,7-Dimethyloctan-3-ol (cas: 78-69-3) were involved in the experimental procedure.

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Quality Control of 3,7-Dimethyloctan-3-ol Metabolite observed in cancer metabolism. It has a role as a human metabolite.

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Hamada, Yoshio;Ohta, Hiroko;Miyamoto, Naoko;Sarma, Diganta;Hamada, Takashi;Nakanishi, Tomoya;Yamasaki, Moe;Yamani, Abdellah;Ishiura, Shoichi;Kiso, Yoshiaki published 《Significance of interactions of BACE1-Arg235 with its ligands and design of BACE1 inhibitors with P₂ pyridine scaffold. [Erratum to document cited in CA151:049158]》 in 2009. The article was appeared in 《Bioorganic & Medicinal Chemistry Letters》. They have made some progress in their research.Category: alcohols-buliding-blocks The article mentions the following:

On page 2438, Table 2 is incorrect; the correct version of the table is given. And (S)-2-Amino-2-(4-fluorophenyl)ethanol (cas: 224434-01-9) was used in the research process.

(S) – 2-amino-2 – (4-fluorophenyl) ethanol (cas: 224434-01-9) has the characteristics of alcohol. In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. Category: alcohols-buliding-blocks

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Ma, Xue-feng;Ru, Chao;Liu, Yu-qing;Song, Xue;Lu, Zhou-min published 《Ultrasonic-assisted solvent extraction of essential oil and main components of Citrus reticulata Blanco cv. Manau Gan》. The research results were published in《Shipin Yanjiu Yu Kaifa》 in 2021.Quality Control of 2,2-Methylenebis(6-tert-butyl-p-cresol) The article conveys some information:

The extraction solvent and material-liquid ratio were selected to optimize the essential oil extraction process of Citrus reticulata Blanco cv. Manau Gan. Results showed that the most suitable solvent for the essential oil extraction of Citrus reticulata Blanco cv. Manau Gan was petroleum ether, with a material-to-liquid ratio of 1:15 (g/mL). Three factors-ultrasonic time, temperature, and power were selected for a single-factor experiment An orthogonal condition optimization experiment was carried out for the ultrasonic extraction parameters of the essential oil of Citrus reticulata Blanco cv. Manau Gan. The optimization results were as follows: ultrasound time, 120 min; ultrasound temperature, 50 °C; and ultrasonic power, 60 W. The essential oil extraction rate of Citrus reticulata Blanco cv. Manau Gan reached 2.47% under these conditions. A total of 19 compounds were identified from the essential oil of Citrus reticulata Blanco cv. Manau Gan by gas chromatog.-mass spectrometry analyses, accounting for 97.60% of total volatiles. Thus, the optimized process could be used to extract the essential oil of Citrus reticulata Blanco cv. Manau Gan. And 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) was used in the research process.

Quality Control of 2,2-Methylenebis(6-tert-butyl-p-cresol)2,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

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Grover, Aman;Kaur, Ramandeep;Mohiuddin, Irshad;Malik, Ashok K.;Aulakh, Jatinder Singh;Tsang, Yiu Fai;Kim, Ki-Hyun published 《Surfactant-modified Zn/Al-layered double hydroxides for efficient extraction of alkyl phenols from aqueous samples》 in 2019. The article was appeared in 《Environmental Research》. They have made some progress in their research.Related Products of 599-64-4 The article mentions the following:

Zn/Al-layered double hydroxides (LDHs) modified by sodium dodecylsulfate (SDS) were synthesized as a hydrophobic organic sorbent via urea hydrolysis. LDHs were applied as adsorbent for solid phase extraction (SPE) anal. to determine three alkylphenols (namely, p-tert-amylphenol (PTAP), p-cumylphenol (PCP), and p-n-octylphenol (POP)) in water samples using gas chromatog.-mass spectrometry. The extraction efficiency was optimized by adjusting key variables of eluent volume, eluent type, sample flow rate, adsorbent amount, pH, and the effect of salt addition Under the optimal conditions, APs showed excellent linearity (1-250 ng/mL: R2 > 0.99) and reproducibility (relative standard deviation: <5%). The detection limits for PTAP, PCP, and POP were 19, 16, and 33 pg/mL, resp. LDHs based SPE method offered high recovery for aqueous samples (e.g., 83.2-99.46%) with enhanced reusability (e.g., up to 10 cycles). The feasibility of the developed method has thus been validated for quantitation of three alkyl phenols (i.e., PTAP, PCP, and POP) in aqueous environmental samples with high sensitivity and good stability. To complete the study, the researchers used 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) .

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Related Products of 599-64-4 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

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Zhou, Binghua;Zhou, Ying;Lai, Lujie;Chen, Ziling;Li, Jiajia;Jiang, Yunliang;Liu, Jian;Wang, Zhipeng;Xue, Zhigang published 《Fabrication of Borate-Based Porous Polymer Electrolytes Containing Cyclic Carbonate for High-Performance Lithium Metal Batteries》 in 2021. The article was appeared in 《ACS Applied Energy Materials》. They have made some progress in their research.Name: 2,5-Dimethyl-2,5-hexanediol The article mentions the following:

A series of borate-based porous polymer electrolytes (B-PPEs) is prepared by incorporating the copolymers containing cyclic boroxine and cyclic carbonate groups into poly(vinylidene fluoride) (PVDF) through the phase inversion method. The dense and well-interconnected pores are obtained in the polymer matrix when the content of the copolymer reached 40 wt %. The ethylene-oxygen chain segments in the copolymer can facilitate the mobility of polymer chains and form the uniform distribution of pores in the B-PPEs. The B-PPEs show an enhanced ionic conductivity of 1.32 x 10^-3 S cm^-1 at 30 °C, which is due to the uniform well-interconnected pores in the polymer host. The cyclic carbonate units interact with the liquid electrolyte, which could improve the electrolyte uptake capacity of the polymer matrix. Benefited from the Lewis acid-base interactions between boron moieties and the anions of the lithium salt, the lithium-ion transference number of B-PPEs is also significantly improved. Compared to the pure PVDF-based electrolyte, the Li/B-PPEs/Li cell displays a very stable polarization voltage and the long-time cycling for 1000 h at a c.d. of 0.2 mA cm^-2. Moreover, the Li/B-PPEs/LiFePO₄ cells deliver a higher capacity of 143.0 mAh g^-1 at 0.2 C and 86% capacity retention after 150 cycles. The B-PPEs could be a promising candidate for enhancing the safety and electrochem. properties of lithium metal batteries.2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) were involved in the experimental procedure.

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) was used in the synthesis of six- and seven-membered heterocyclic boron compounds containing intramolecular N-B bond.Name: 2,5-Dimethyl-2,5-hexanediol

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Reference of 2-Hexyl-1-decanolIn 2020, Temerdashev, Z. A.;Milevskaya, V. V.;Ryabokon’, L. P.;Latin, N. N.;Kiseleva, N. V.;Nagalevskii, M. V. published 《Identification and Determination of the Components of Garden Sage (Salvia officinalis L.) Essential Oil, Isolated by Different Extraction Methods》. 《Journal of Analytical Chemistry》published the findings. The article contains the following contents:

We studied the component composition of the essential oil of garden sage (Salvia officinalis L.), obtained by various extraction methods. Essential oils were obtained by hydrodistillation and subcritical CO2 extraction, supercritical fluid extraction, and subcritical extraction with solid-phase and liquid-liquid preconcentration The components were identified by comparing the recorded mass spectra with the spectra of individual compounds and the data of the NIST07 and WILEY8 data bases. For all extraction methods, the major essential oil components were 1,8-cineole, camphor, α-thujone, β-thujone, borneol, 4-terpineol, β-caryophyllene, β-caryophyllene oxide, and viridiflorol. The concentration of analytes in the extracts varied depending on the extraction method. In total, 104 components were identified in the extracts, of which 30 were extracted by hydrodistillation, 32 by subcritical CO2 extraction, 14 by supercritical fluid extraction, 46 and 62 by subcritical extraction with solid-phase and liquid-liquid extraction into the organic phase. An increase in the number of components in more stringent extraction methods as compared to hydrodistillation showed that, in the extracts, a deeper decomposition of macrocomponents might take place, except for camphor. And 2-Hexyl-1-decanol (cas: 2425-77-6) was used in the research process.

2-Hexyl-1-decanol(cas: 2425-77-6) is a branched alcohol. It is one of the constituent of the essential oil, extracted from the roots of Adiantum flabellulatum. Reference of 2-Hexyl-1-decanol

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Recommanded Product: 140-66-9《Gonadal Soma-Derived Factor Expression is a Potential Biomarker for Predicting the Effects of Endocrine-Disrupting Chemicals on Gonadal Differentiation in Japanese Medaka (Oryzias Latipes)》 was published in 2022. The authors were Horie, Yoshifumi;Kanazawa, Nobuhiro;Takahashi, Chiho;Tatarazako, Norihisa;Iguchi, Taisen, and the article was included in《Environmental Toxicology and Chemistry》. The author mentioned the following in the article:

Chems. with androgenic or estrogenic activity induce the sex reversal and/or intersex condition in various teleost fish species. Previously, we reported that exposure to 17α-methyltestosterone, bisphenol A, or 4-nonylphenol induces changes in expression of the gonadal soma-derived factor (gsdf) gene accompanied by disruption of gonadal differentiation in Japanese medaka (Oryzias latipes). These findings suggest that gsdf expression might be a useful biomarker for predicting the potential effect of chems. on gonadal differentiation. We examined the gsdf expression in Japanese medaka exposed to chems. with estrogenic or androgenic activity. Exposure to the androgenic steroid 17β-trenbolone at 0.5-22.1μg/L induced the development of ovotestis (presence of ovarian tissue with testicular tissue) and female-to-male sex reversal in XX embryos, and exposure at 6.32 and 22.1μg/L significantly increased gsdf expression in XX embryos compared with controls at developmental stage 38 (1 day before hatching). In the present study, no statistically significant difference in gsdf mRNA expression was observed after exposure to 17β-estradiol, 17α-ethinylestradiol, and 4-t-octylphenol, which have estrogenic activity. In addition, antiandrogenic chems. or chems. without endocrine-disrupting activity did not induce changes in gsdf expression in XX or XY embryos. Thus, an increase in gsdf expression after androgen exposure was observed in XX embryos. Together, these findings indicate that gsdf expression might be useful for predicting the adverse effect of chems. on gonadal differentiation.4-tert-Octylphenol (cas: 140-66-9) were involved in the experimental procedure.

4-tert-Octylphenol(cas: 140-66-9) is a common environmental pollutant showing weak estrogenic effects.Recommanded Product: 140-66-9 It has been shown to cause harm to vertebrate male reproductive systems.

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