Author: tianli

Guo, Pengfei;Liao, Shengyun;Wang, Shun;Shi, Jing;Tong, Xinli published 《Highly efficient and selectivity-controllable aerobic oxidative cleavage of C-C bond over heterogeneous Fe-based catalysts》. The research results were published in《Journal of Catalysis》 in 2021.Synthetic Route of C14H14O2 The article conveys some information:

A base-free selectivity-controllable aerobic oxidative cleavage of C-C bond with heterogeneous Fe-based catalysts (Fe_xO_y-N@C₃N₄) was developed. In the presence of oxygen, 1,2-diols were selectively transformed to the corresponding aldehyde, while the Me esters were orientedly produced from 1,2-diones in methanol medium.rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) were involved in the experimental procedure.

rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas: 579-43-1 Synthetic Route of C14H14O2) has been used in the preparation of trans-methyl meso-hydrobenzoin phosphite.

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SDS of cas: 148-51-6In 1940, Harris, Stanton A. published 《Vitamin B₆. II. Reactions and derivatives》. 《Journal of the American Chemical Society》published the findings. The article contains the following contents:

Vitamin B₆-HCl (I) in an equal mixture of C₅H₅N and Ac₂O, allowed to stand overnight and then heated on a steam bath for 20 min., gives vitamin B₆ triacetate-HCl [2-methyl-3-acetoxy-4,5-bis(acetoxymethyl)-pyridine-HCl], m. 157°; it is stable in 0.01 N HCl but is slowly hydrolyzed in 0.01 N alkali at 37°. Vitamin B₆ dibromide-HBr (II) and 3 equivalents AcOAg in a 22% solution of AcOK in AcOH, heated on the steam bath for 0.5 hrs., give 25% of vitamin B₆ diacetate-HCl [2-methyl-3-hydroxy-4,5-bis(acetoxymethyl) pyridine-HCl], m. 160-1°; the aqueous solution gives a good FeCl₃ test; it has the same relative stability as the tri-Ac derivative Reduction of II with a PdBaSO₄ catalyst in EtOH gives 40% of 2,4,5-trimethyl-3-hydroxypyridine, m. 178°; HCl salt, m. 216°. Catalytic reduction of I with the Adams catalyst gives 2,4-dimethyl-3-hydroxy-5-hydroxymethylpyridine-HCl, m. 267-8°; this is weakly active for the growth and promotion of acid formation by Streptobacterium plantarum, whereas III is inactive. I, exactly neutralized with 1 equivalent of MeONa in MeOH and heated at 125° for 4 hrs., gives a small yield of 2-methyl-3-hydroxy-4-methoxymethyl-5-hydroxymethylpyridine-HCl (III), m. 181°. To complete the study, the researchers used 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) .

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 SDS of cas: 148-51-6) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in and reduces growth of S. carlsbergensis cells. DOP inhibits sphingosine-1-phosphate (S1P) lyase and reduces cyclic stretch-induced apoptosis in alveolar epithelial MLE-12 cells.

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Han, Yu;Hu, Li-Xin;Liu, Ting;Liu, Jing;Wang, Yu-Qing;Zhao, Jia-Hui;Liu, You-Sheng;Zhao, Jian-Liang;Ying, Guang-Guo published 《Non-target, suspect and target screening of chemicals of emerging concern in landfill leachates and groundwater in Guangzhou, South China》. The research results were published in《Science of the Total Environment》 in 2022.Related Products of 140-66-9 The article conveys some information:

Landfill sites have been regarded as a significant source of chems. of emerging concern (CECs) in groundwater. However, our understanding about the compositions of CECs in landfill leachate and adjacent groundwater is still very limited. Here we investigated the CECs in landfill leachates and groundwater of Guangzhou in South China by target, suspect and non-target anal. using high-resolution mass spectrometry (HRMS). A variety of CECs (n = 242), including pharmaceuticals (n = 64), pharmaceutical intermediates (n = 18), personal care products (n = 9), food additives (n = 18), industrial chems. (n = 82, e.g., flame retardants, plasticizers, antioxidants and catalysts), pesticides (n = 26), transformation products (n = 8) and other organic compounds (n = 17) were (tentatively) identified by non-target and suspect screening. 142 CECs were quantitated with target anal., and among them 37, 24 and 27 CECs were detected resp. in the raw leachate (272-1780μg/L), treated leachate (0.25-0.81μg/L) and groundwater (0.10-53.7μg/L). The CECs in the raw leachates were efficiently removed with the removal efficiencies greater than 88.7%. Acesulfame, bisphenol F and ketoprofen were the most abundant compounds in both treated leachate and groundwater. The CECs in groundwater was found most likely to be originated from the landfill sites. Our results highlight the importance of non-target screening in identifying CECs, and reveal the contamination risk of groundwater by landfill leachate. To complete the study, the researchers used 4-tert-Octylphenol (cas: 140-66-9) .

4-tert-Octylphenol(cas: 140-66-9) is a common environmental pollutant showing weak estrogenic effects.Related Products of 140-66-9 It has been shown to cause harm to vertebrate male reproductive systems.

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Seshasayee, Mahadevan Subramanya;Savage, Phillip E. published 《Oil from plastic via hydrothermal liquefaction: Production and characterization》 in 2020. The article was appeared in 《Applied Energy》. They have made some progress in their research.Application In Synthesis of 2-Hexyl-1-decanol The article mentions the following:

We determined the effect of batch holding time (0.5 h, 1 h) and temperature (350-450°C) on the yield, composition, and quality of oil formed from the hydrothermal treatment of polypropylene (PP), polystyrene (PS), polycarbonate (PC), and polyethylene terephthalate (PET). The highest oil yields for each material ranged from just 16 wt% for PET to 86 wt% for polystyrene. The depolymerization of plastics to produce oil occurs fastest in the supercritical water regime (T > 400°C). The higher heating value (HHV) of the oil from PP and PS (44-45 MJ/kg) is comparable to that of gasoline (HHV ∼ 43.4 MJ/kg). The oil from PC and PET had lower heating values but further treatment to remove oxygen atoms would increase the energy d. Increasing the hydrothermal reaction severity (longer times, higher supercritical temperatures) reduces oil yields but increases heating values. Increasing temperature causes more aromatization in the oil from PP and PS and promotes dehydration reactions during hydrothermal treatment of PET and PC. The oil from PC contained bisphenol-A as a major product. Obtaining such monomers from hydrothermal treatment would provide a revenue stream in addition to oil and thereby improve the process economics. And 2-Hexyl-1-decanol (cas: 2425-77-6) was used in the research process.

2-Hexyl-1-decanol(cas: 2425-77-6) is a fatty acid that is found in the essential oils of plants and has been shown to have fungicidal properties.Application In Synthesis of 2-Hexyl-1-decanol It has also been shown to inhibit the growth of Candida glabrata when used as a cationic surfactant.

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Singh, R. P.;Korytnyk, W. published 《Pyridoxine chemistry. VII. Some modifications in the 4-position of pyridoxol》. The research results were published in《Journal of Medicinal Chemistry》 in 1965.Synthetic Route of C8H12ClNO2 The article conveys some information:

cf. preceding abstract Derivatives of I were prepared by treatment of 2,2,8-trimethyl-4H-m-dioxino[4,5-c]pyridine-5-methanol benzoate with HCl. I (R = OH) refluxed with SOCl₂ and the residue treated with EtOH produced I (R = Cl). The catalytic (C) hydrogenation of I (R = Cl) afforded I (R = H). I (R = H) refluxed in KOH gave 4-deoxypyridoxine (II). I (R = Cl) stirred with Na₂S₂O₅ produced I (R = SO₃H). KCNS refluxed with I (R = Cl) gave I (R = SCN). Similarly, I (R = Cl) stirred with NaHS gave I (R = SH). I (R = H) was as active and I (R = SO₃H) one-half as active as II in depressing lymphocyte count in rats fed a pyridoxine deficient diet, while the other reported derivatives were inactive. None of the other compounds inhibited the growth of Saccharomyces carlsbergensis. Cf. Schmidt, and Giesselmann, CA 58, 1429d. The experimental procedure involved many compounds, such as 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) .

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 Synthetic Route of C8H12ClNO2) is a strong antagonist of vitamin B6. Deoxypyridoxine hydrochloride has been used as an analytical reference standard for the quantification of the analyte in food samples using high performance liquid chromatography.

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Morisawa, Yasuhiro;Kataoka, Mitsuru;Watanabe, Taiichiro;Kitano, Noritoshi;Matsuzawa, Toshiaki published 《Anticoccidal agents. IV. Modification at the 5-position of 4-deoxypyridoxol and α4-norpyridoxol》. The research results were published in《Agricultural and Biological Chemistry》 in 1975.Formula: C8H12ClNO2 The article conveys some information:

In an attempt to relate structure to anticoccidial activity, a number of 5-modified analogs of 4-deoxypyridoxol (I) and α4-norpyridoxol (II) have been synthesized and their biol. activities examined The compounds prepared include the 5-(3-hydroxypropyl), 5-(2-hydroxyethyl), 5-(1-hydroxyethyl), formyl and acetyl analogs of I, and 5-(3-hydroxypropyl), formyl, ethoxycarbonyl, carbamoyl and hydroxyl analogs of II. Among these compounds, 4-deoxyisopyridoxal (III) and α4-norisopyridoxal (IV) exhibited anticoccidil activity. To complete the study, the researchers used 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) .

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 Formula: C8H12ClNO2) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in and reduces growth of S. carlsbergensis cells. DOP inhibits sphingosine-1-phosphate (S1P) lyase and reduces cyclic stretch-induced apoptosis in alveolar epithelial MLE-12 cells.

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Lazewska, Dorota;Olejarz-Maciej, Agnieszka;Kaleta, Maria;Bajda, Marek;Siwek, Agata;Karcz, Tadeusz;Doroz-Plonka, Agata;Cichon, Urszula;Kuder, Kamil;Kiec-Kononowicz, Katarzyna published 《4-tert-Pentylphenoxyalkyl derivatives – Histamine H₃ receptor ligands and monoamine oxidase B inhibitors》 in 2018. The article was appeared in 《Bioorganic & Medicinal Chemistry Letters》. They have made some progress in their research.Quality Control of 4-tert-Amylphenol The article mentions the following:

The synthesis and biol. activity of 4-tert-pentylphenoxypropyl derivatives I (m = 1, 2, 3, etc.; n = 1; R = H, 2-CH₃, 2,6-(CH₃)₂, 3,5-(CH₃)₂, etc.) are described in this manuscript. All compounds (except one) showed human histamine H₃ receptor affinity with K_i values below 760 nM. The inhibitory activity towards human monoamine oxidase B (hMAO B) was evaluated using a fluorometric Amplex-Red assay, and most of the compounds were found to be effective in the submicromolar range. Among them, 1-(3-(4-tert-pentylphenoxy)propyl)pyrrolidine I (m = 1; n = 1; R = H) exhibited hMAO B inhibitory activity with an IC₅₀ value of 4.5 nM. In addition, hMAO B inhibition by I (m = 1; n = 1; R = H) was shown to be non-competitive and reversible. Further, recently described potent histamine H₃ receptor ligands – 4-tert-pentylphenoxyalkyl derivatives (with a 4-8 carbon spacer) – were evaluated for hMAO B inhibitory activity, and some of them displayed activity in the submicromolar range. Selected compounds were also tested for human MAO A (hMAO A) inhibitory potencies and exhibited no activity. Moreover, mol. modeling studies were carried out for tested compounds to explain their mol. mechanism of hMAO B inhibition and the selectivity of compounds for hMAO B over hMAO A. The experimental procedure involved many compounds, such as 4-tert-Amylphenol (cas: 80-46-6) .

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group. Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble.Quality Control of 4-tert-Amylphenol

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Koelmel, Jeremy P.;Lin, Elizabeth Z.;DeLay, Kayley;Williams, Antony J.;Zhou, Yakun;Bornman, Riana;Obida, Muvhulawa;Chevrier, Jonathan;Godri Pollitt, Krystal J. published 《Assessing the External Exposome Using Wearable Passive Samplers and High-Resolution Mass Spectrometry among South African Children Participating in the VHEMBE Study》 in 2022. The article was appeared in 《Environmental Science & Technology》. They have made some progress in their research.Computed Properties of C15H16O The article mentions the following:

Children in low- and middle-income countries are often exposed to higher levels of chems. and are more vulnerable to the health effects of air pollution. Little is known about the diversity, toxicity, and dynamics of airborne chem. exposures at the mol. level. We developed a workflow employing state-of-the-art wearable passive sampling technol. coupled with high-resolution mass spectrometry to comprehensively measure 147 children’s personal exposures to airborne chems. in Limpopo, South Africa, as part of the Venda Health Examination of Mothers, Babies, and Their Environment (VHEMBE). 637 environmental exposures were detected, many of which have never been measured in this population; of these 50 airborne chem. exposures of concern were detected, including pesticides, plasticizers, organophosphates, dyes, combustion products, and perfumes. Biocides detected in wristbands included p,p’-dichlorodiphenyltrichloroethane (p,p’-DDT), p,p’-dichlorodiphenyldichloroethane (p,p’-DDD), p,p’-dichlorodiphenyldichloroethylene (p,p’-DDE), propoxur, piperonyl butoxide, and triclosan. Exposures differed across the assessment period with 27% of detected chems. observed to be either higher or lower in the wet or dry seasons. And 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) was used in the research process.

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Computed Properties of C15H16O 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

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Mao, Mengmei;Zhang, Le;Yao, Hanlin;Wan, Li;Xin, Zhong published 《Development and Scale-up of the Rapid Synthesis of Triphenyl Phosphites in Continuous Flow》. The research results were published in《ACS Omega》 in 2020.SDS of cas: 80-46-6 The article conveys some information:

A novel method for the synthesis of tri-Ph phosphite and its derivatives was developed in continuous flow. With a total residence time of 20 s, the target product was prepared in a microreactor, and the reaction time was significantly shortened compared with standard single batch reaction conditions. The reaction of various substrates gave the corresponding products in good to excellent yields under optimized conditions. The reactants could be employed in a stoichiometric ratio, making the reaction more efficient, economical, and environmentally friendly. Scale-up apparatus was designed and assembled, and the kilogram-scale production (up to 18.4 kg/h) of tris(2,4-di-tert-butylphenyl) phosphite was achieved in 88% yield. PCl₃. And 4-tert-Amylphenol (cas: 80-46-6) was used in the research process.

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group.Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. SDS of cas: 80-46-6

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Abednatanzi, Sara;Gohari Derakhshandeh, Parviz;Tack, Pieter;Muniz-Miranda, Francesco;Liu, Ying-Ya;Everaert, Jonas;Meledina, Maria;Vanden Bussche, Flore;Vincze, Laszlo;Stevens, Christian V.;Van Speybroeck, Veronique;Vrielinck, Henk;Callens, Freddy;Leus, Karen;Van Der Voort, Pascal published 《Elucidating the promotional effect of a covalent triazine framework in aerobic oxidation》 in 2020. The article was appeared in 《Applied Catalysis, B: Environmental》. They have made some progress in their research.Recommanded Product: 2425-77-6 The article mentions the following:

Synergistic catalysis holds great promise to enhance the catalytic performance of heterogeneous catalysts suffering from sluggish reaction kinetics. Much effort has been dedicated to the development of bimetallic systems in which the two promoter elements display synergistic benefits compared to monometallic counterparts. However, the use of bimetallic catalysts inescapably raises the cost of preparation and environmental issues. This study discovers a synergistic effect when using a bipyridine covalent triazine framework (bipy-CTF) as support for an Ir^III complex in the aerobic oxidation reaction. The detailed mechanistic study provides insights into the function of the bipy-CTF in this synergistic catalysis. The EPR and in-situ XANES analyses confirm the applicability of bipy-CTF to activate oxygen and alc., resulting in an enhancement of the performance of the Ir^III complex to exceed the activity of the homogeneous counterpart. This is an unprecedented report on promoting the activity of a heterogeneous catalyst through its solid support.2-Hexyl-1-decanol (cas: 2425-77-6) were involved in the experimental procedure.

2-Hexyl-1-decanol(cas: 2425-77-6) has been shown to inhibit the growth of b16 mouse melanoma cells, suggesting it may be useful for treating skin cancer.Recommanded Product: 2425-77-6 This fatty acid also has transport properties and can form hydrogen bonds with other molecules.

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