Author: tianli

Leblanc, Virginie;Yokota, Mariko;Grandidier, Marie-Helene;Yoshida, Daisuke;Adriaens, Els;Cotovio, Jose;Kyoutani, Daiki;Alepee, Nathalie published 《SkinEthic HCE Eye Irritation Test: Similar performance demonstrated after long distance shipment and extended storage conditions》. The research results were published in《Toxicology In Vitro》 in 2019.Electric Literature of C8H18O2 The article conveys some information:

Assessment of ocular irritation risk is an international regulatory requirement in the safety evaluation of products. In response to this need, L’Oreal developed the SkinEthic Human Corneal Epithelium (HCE) Eye Irritation Test (EIT) that has been included in OECD Test Guideline 492. SkinEthic HCE EIT is able to correctly and reliably identify chems. not requiring classification vs. labeling for eye irritation or serious eye damage according to UN GHS. In an effort to promote its global use, the performance of the method was evaluated after long-distance shipment and compared to European shipment conditions. Results obtained by Cosmos Tech. Center (Japan) after extended tissues transit were compared to results obtained in L’Oreál (France). Thirty-nine out of 40 blinded chems., representing different functional chem. classes, were consistently classified in both laboratories The SkinEthic HCE EIT test method was also evaluated for its performance after extended storage of the tissues. The performance was in agreement with the values reported in OECD TG 492, with an overall accuracy of 87.1% (based on 119 chems.), sensitivity of 95.5% and specificity of 73.5%. The reliability and relevance of SkinEthic HCE EIT test method after long-distance shipment and extended storage remain in agreement with regulatory validation criteria. The experimental procedure involved many compounds, such as 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) .

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) on heteropoly acid catalyzed dehydration yields cyclic ethers via stereospecific intramolecular SN2 mechanism. It reacts with nitriles in concentrated sulfuric acid to yield Δ1-pyrrolines.Electric Literature of C8H18O2

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Alepee, Nathalie;Leblanc, Virginie;Grandidier, Marie-Helene;Teluob, Severine;Viricel, Anaelle;Adriaens, Els;Michaut, Valerie published 《SkinEthic HCE Time-to-Toxicity on solids: A test method for distinguishing chemicals inducing serious eye damage, eye irritation and not requiring classification and labeling》. The research results were published in《Toxicology In Vitro》 in 2021.COA of Formula: C8H18O2 The article conveys some information:

This study describes the development of a Time-to-Toxicity approach for solids (TTS) based on the SkinEthic HCE tissue construct, capable to distinguish chems. that do not require classification for serious eye damage/eye irritation (No Cat.) from chems. that require classification for eye irritation (Cat. 2), and serious eye damage (Cat. 1). Briefly, the time-to-toxicity of 69 solids was evaluated by exposing SkinEthic HCE tissue constructs to the test chem. for two different time periods (30-min, and 120-min). Based on the viability observed for the different exposure periods, a classification was assigned. The within laboratory reproducibility in terms of concordance in classifications (3 UN GHS categories), based on a set of 48 solids, was 93.7%. Furthermore, 73.6% Cat. 1 (N = 24), 55.6% Cat. 2 (N = 15) and 72.2% No Cat. (N = 30) were correctly identified with the SkinEthic HCE TTS test method. This study provides evidence that the SkinEthic HCE Time-to-Toxicity method (multiple exposure times) can distinguish Cat. 2 solids from Cat. 1 solids. This is an added value compared to the SkinEthic HCE EITS method (single exposure time) that can distinguish No Cat. chems. from chems. that do require classification and labeling for eye irritation/serious eye damage (Cat. 2/Cat. 1). And 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) was used in the research process.

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) on heteropoly acid catalyzed dehydration yields cyclic ethers via stereospecific intramolecular SN2 mechanism. It reacts with nitriles in concentrated sulfuric acid to yield Δ1-pyrrolines.COA of Formula: C8H18O2

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 3,7-Dimethyloctan-3-olIn 2018, Malysheva, A. G.;Kozlova, N. Yu.;Yudin, S. M. published 《The unaccounted hazard of processes of substances transformation in the environment in the assessment of the effectiveness of the application of technologies》. 《Gigiena i Sanitariya》published the findings. The article contains the following contents:

To solve environmental problems in the current economic conditions, the use of achievements in scientific and technol. progress acquires the special significance. This primarily concerns the creation, optimization, and improvement of environmentally friendly technologies for purification and neutralization of industrial emissions, new technologies for purification and disinfection of drinking water, development and implementation of environment improving phytotechnologies and many other environmental and health-improving measures. The present system of environmental and anal. monitoring of the state of environmental objects exposed to various technologies for its recovery, based on the use of phys. and chem. or biol. factors, requires the control of chem. safety, taking into account the possibility of formation of byproducts of transformation with respect to their harmlessness for use. The studies were performed using a chromatog.-mass spectrometric system including a gas chromatograph with full electronic control of gas flows and a digital pressure and flow control mode with automatic determination of column parameters, mass spectrometric detector with a quadrupole mass analyzer that provides measurements in the range of mass numbers from 1 to 1050, and a thermal desorber with a gas sample cryo-focusing. Examples of assessing the effectiveness and chem. safety of the application of new environmental protection technologies for cleaning air emissions from a number of enterprises and measures for improving the air environment of enclosed spaces show that their application, on the one hand, is aimed at directly addressing their specific purpose, i.e., a significant reduction in the qual. and quant. composition of pollutants in production emissions has been established, including an important component in terms of environmental aspects, such as the smell and on the other hand – a neg. side effect associated with the formation of toxic and dangerous products of transformation is simultaneously established, even for substances of natural origin, a significant part of which does not have hygienic standards, and consequently their impact on public health remains unaccounted. The side effect was often manifested by a change in the direction of deterioration in the chem. composition of the environment object that is phys. and chem. affected by the use of the new technol. For an adequate assessment of the quality of the environment and chem. safety of public health, an important condition is to take into account the multicomponent nature of the composition of chem. contaminants and to take into account the transformation products of substances affecting humans under real environmental conditions. Studies focused on identification with a quant. assessment of air emission components before and after the application of a new environmental technol. or a better environmental and health improvement measure allow to monitor environmental objects taking into account the actual content and changes in the group and component composition under the influence of the chem. impact of new technol. and to make recommendations for further improvement of the new technol. from the point of view of environmental aspects, which, in turn, is aimed at preserving the health of the population. And 3,7-Dimethyloctan-3-ol (cas: 78-69-3) was used in the research process.

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Reference of 3,7-Dimethyloctan-3-ol Metabolite observed in cancer metabolism. It has a role as a human metabolite.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gurkan-Alp, A. Selen;Mumcuoglu, Mine;Andac, Cenk A.;Dayanc, Emre;Cetin-Atalay, Rengul;Buyukbingol, Erdem published 《Synthesis, anticancer activities and molecular modeling studies of novel indole retinoid derivatives》. The research results were published in《European Journal of Medicinal Chemistry》 in 2012.HPLC of Formula: 110-03-2 The article conveys some information:

In this study, novel (E)-3-(5-substituted-1H-indol-3-yl)-1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-2-en-1-one derivatives were synthesized and their anticancer effects were determined in vitro. Novel indole retinoid compounds have anti-proliferative capacity in liver, breast, and colon cancer cell lines. This anti-proliferative effect was further analyzed in breast cancer cell line panel by using the most potent compound The latter can inhibit proliferation at very low IC₅₀ concentrations in all of the breast cancer cell lines. Here, we present some evidence on apoptotic termination of cancer cell proliferation which may be primarily driven by the inhibition of RXRα and, to a lesser extent, RXRγ. And 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) was used in the research process.

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) is used as an intermediate in the preparation of 2.5-Dimethyl-2.5-bis(tertbutyl-peroxy)hexane. It is also used in the synthesis of six- and seven-membered heterocyclic boron compounds.HPLC of Formula: 110-03-2

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

HPLC of Formula: 599-64-4In 2020, Medvedev, Alexander V.;Medvedeva, Lyubov A.;Martsen, Elena;Moeser, Mathew;Gorman, Kristen L.;Lin, Benjamin;Blackwell, Brett;Villeneuve, Daniel L.;Houck, Keith A.;Crofton, Kevin M.;Makarov, Sergei S. published 《Harmonized Cross-Species Assessment of Endocrine and Metabolic Disruptors by Ecotox FACTORIAL Assay》. 《Environmental Science & Technology》published the findings. The article contains the following contents:

Environmental pollution is a threat to humans and wildlife species. Of particular concern are endocrine disrupting chems. (EDCs). An important target of EDCs is nuclear receptors (NRs) that control endocrine and metabolic responses through transcriptional regulation. Owing in part to structural differences of NRs, adverse effects of EDCs vary significantly among species. Here, we describe a multiplexed reporter assay (the Ecotox FACTORIAL) enabling parallel assessment of compounds’ effects on estrogen, androgen, thyroid, and PPARγ receptors of representative mammals, birds, reptiles, amphibians, and fish. The Ecotox FACTORIAL is a single-well assay comprising a set of species-specific, one-hybrid GAL4-NR reporter constructs transiently transfected into test cells. To harmonize cross-species assessments, we used a combination of two approaches. First, we used the same type of test cells for all reporters; second, we implemented a parallel detection of reporter RNAs. The assay demonstrated excellent quality, reproducibility, and insignificant intra-assay variability. Importantly, the EC₅₀ values for NR ligands were consistent with those reported for conventional assays. Using the assay allowed ranking the hazard potential of environmental pollutants (e.g., bisphenols, polycyclic aromatic hydrocarbons, and synthetic progestins) across species. Furthermore, the assay permitted detecting taxa-specific effects of surface water samples. Therefore, the Ecotox FACTORIAL enables harmonized assessment of the endocrine and metabolic disrupting activity of chems. and surface water in humans as well as in wildlife species. And 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) was used in the research process.

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.HPLC of Formula: 599-64-4 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of C15H16O《Access to Chiral Bisphenol Ligands (BPOL) through Desymmetrizing Asymmetric Ortho-Selective Halogenation》 was published in 2020. The authors were Xiong, Xiaodong;Zheng, Tianyu;Wang, Xinyan;Tse, Ying-Lung Steve;Yeung, Ying-Yeung, and the article was included in《Chem》. The author mentioned the following in the article:

A facile strategy to prepare potent chiral bisphenols (BPOLs) through the desymmetrizing asym. ortho-halogenation was described. Both theor. and exptl. studies were conducted in order to shed light on the mechanistic picture. The halogen handles in the BPOL products were manipulated to yield unsym. chiral BPOL ligands, which were potential privileged catalyst scaffolds and was applied in other asym. catalytic reactions.4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) were involved in the experimental procedure.

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Electric Literature of C15H16O 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Recommanded Product: 579-43-1In 2017, Mecozzi, Francesco;Dong, Jia Jia;Saisaha, Pattama;Browne, Wesley R. published 《Oxidation of Vicinal Diols to α-Hydroxy Ketones with H₂O₂ and a Simple Manganese Catalyst》. 《European Journal of Organic Chemistry》published the findings. The article contains the following contents:

α-Hydroxy ketones are valuable synthons in organic chem. Here we show that oxidation of vic-diols to α-hydroxy ketones with H₂O₂ can be achieved with an in situ prepared catalyst based on manganese salts and pyridine-2-carboxylic acid. Furthermore the same catalyst is effective in alkene epoxidation, and it is shown that alkene oxidation with the Mn^II catalyst and H₂O₂ followed by Lewis acid ring opening of the epoxide and subsequent oxidation of the alkene to α-hydroxy ketones can be achieved under mild (ambient) conditions. To complete the study, the researchers used rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) .

Desymmetrization of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas:579-43-1 Recommanded Product: 579-43-1) using chiral phosphine catalyst has been reported. Conversion of meso-hydrobenzoin to trans-stillbene oxide by treatment with an aryl sulfonyl chloride and aqueous sodium hydroxide has been reported.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Today I want to share an article with you. The article is 《Impact of crossflow microfiltration on aroma and sensory profiles of a potential functional citrus-based food》,you can find this article in 《Journal of the Science of Food and Agriculture》. The following contents are mentioned:

Citrus juices can be cold-concentrated by crossflow microfiltration (CMF) in order to obtain functional foods enriched in carotenoids, flavonoids and pectins. The work aimed to characterize the organoleptic quality of this type of micronutrient-dense foods through their aroma profile and sensory anal. Two citrus concentrates with and without a diafiltration step were compared. Both citrus products were very different, linked to aroma compound, sugar and organic acid contents. Due to its sugar/acidity balance and its better aromatic profile responsible for the citrus-floral flavor, the concentrate without diafiltration was preferred by the sensory panel. Thanks to a simple transfer model, we showed that retention of volatiles clearly varied from one aroma compound to another. The terpene hydrocarbons were the most retained by the membrane during CMF, probably because they were strongly associated with insoluble solids by adsorption. Even though the process modified their organoleptic profiles, both citrus-based products were well rated and can be consumed directly as pleasant functional drinks.3,7-Dimethyloctan-3-ol (cas: 78-69-3) were involved in the experimental procedure.

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Recommanded Product: 3,7-Dimethyloctan-3-ol Metabolite observed in cancer metabolism. It has a role as a human metabolite.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhu, Fen;Song, Yaqin;Liu, Shaohui;Nie, Jun;He, Yong published 《Preparation of polymerizable thermal initiator and its application in photo-induced thermal frontal polymerization》 in 2019. The article was appeared in 《European Polymer Journal》. They have made some progress in their research.Related Products of 110-03-2 The article mentions the following:

Photo-induced frontal polymerization has been growing interesting in the recent decades. However, the conflict among the frontal starting temperature, the storage stability and the high leachability remain problems to be solved. A new polymerizable methacrylate functionalized aliphatic peroxide thermal initiator (named as IEM-HDHP) through modifying methacrylate group into the 2,5-dihydroperoxy-2,5-dimethylhexane (HDHP) was successfully prepared In the photo-induced frontal polymerization investigated, IEM-HDHP showed medium photo-induced frontal polymerization starting temperature, frontal velocity and best storage stability compared with two com. thermal initiators (benzoyl peroxide (BPO) and 1-(2-hydroperoxypropan-2-yl) benzene) (CHP). What’s more, the lowest amount of small mol. leachability makes it outstanding from the two competitors. At the same time, IEM-HDHP is the only one to lead to the sample stick with complete and smooth appearance in this work. The experimental procedure involved many compounds, such as 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) .

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) on heteropoly acid catalyzed dehydration yields cyclic ethers via stereospecific intramolecular SN2 mechanism. It reacts with nitriles in concentrated sulfuric acid to yield Δ1-pyrrolines.Related Products of 110-03-2

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Yali;Yang, Lu;Zhang, Ke;Chen, Xiaoxiang;Wang, Hangyu;Cheng, Ping;Wang, Jinhui published 《Untargeted metabolomics analysis of different grape varieties and different parts of wine grape using gas chromatography and mass spectrometry technique》. The research results were published in《Journal of Biobased Materials and Bioenergy》 in 2021.Recommanded Product: 2425-77-6 The article conveys some information:

Natural active compounds are an important key to the development and utilization of functional foods and medicine. In this study, the chem. diversity and varietal differences of wine grape were studied by using the untargeted metabolomics method based on gas chromatog.-mass spectrometry (GC-MS), and the secondary metabolites of different cultivars and different parts were analyzed. A GC-MS-based metabolomic approach and chemometrics tools was used to identify potential active compounds in Vitis vinifera. The results showed that the content of active compounds in red wine varieties was higher than that in white wine varieties, and the content of active ingredients in grape seeds was significantly higher than that in fruits. In conclusion, this study analyzed the metabolite composition and differentiation of different wine grape fruits in Turpan as a whole, and is expected to lay a foundation for the study of wine grape and to provide a theor. basis for development and utilization of the Dietary supplement and medicine on them. The experimental procedure involved many compounds, such as 2-Hexyl-1-decanol (cas: 2425-77-6) .

2-Hexyl-1-decanol(cas: 2425-77-6) is a fatty acid that is found in the essential oils of plants and has been shown to have fungicidal properties.Recommanded Product: 2425-77-6 It has also been shown to inhibit the growth of Candida glabrata when used as a cationic surfactant.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts