Author: tianli

Category: alcohols-buliding-blocksIn 2017, Escande, Vincent;Lam, Chun Ho;Coish, Philip;Anastas, Paul T. published 《Heterogeneous Sodium-Manganese Oxide Catalyzed Aerobic Oxidative Cleavage of 1,2-Diols》. 《Angewandte Chemie, International Edition》published the findings. The article contains the following contents:

The aerobic oxidative cleavage of 1,2-diols using a heterogeneous catalyst only based on earth-abundant metals manganese and sodium is reported for the first time. This reusable catalyst cleaves a variety of substrates into aldehydes or ketones with high selectivity. The reaction requires small catalytic loadings and is performed under mild conditions using ambient pressure O₂ or air as the oxidant while producing water as the only byproduct. Mechanistic investigations reveal a monodentate, two-electron oxidative fragmentation process involving a Mn^IV species. The eco-friendly, innocuous catalyst is compatible with a wide range of functional groups and conditions, making it highly competitive with classical reagents, such as periodic acid or lead tetraacetate, as a preferred method for activated 1,2-diols. To complete the study, the researchers used rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) .

Desymmetrization of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas:579-43-1 Category: alcohols-buliding-blocks) using chiral phosphine catalyst has been reported. Conversion of meso-hydrobenzoin to trans-stillbene oxide by treatment with an aryl sulfonyl chloride and aqueous sodium hydroxide has been reported.

Reference:
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Sangjan, Worasit;Marzougui, Afef;Mattinson, D. Scott;Schroeder, Brenda K.;Bates, Austin A.;Khot, Lav R.;Sankaran, Sindhuja published 《Identification of volatile biomarkers for high-throughput sensing of soft rot and Pythium leak diseases in stored potatoes》 in 2022. The article was appeared in 《Food Chemistry》. They have made some progress in their research.Electric Literature of C10H22O The article mentions the following:

Soft rot and Pythium leak are postharvest storage diseases of potato tubers that can cause substantial crop losses in the US. This study focused on detecting volatile organic compounds (VOCs) associated with rot inoculated tubers during storage (up to 21 days) using headspace solid-phase microextraction (SPME) coupled to gas chromatog. (GC) with mass spectrometry (MS) and flame ionization detector (FID) anal. Russet Burbank and Ranger Russet tubers were inoculated with the rot pathogens. Static sampling with 50 min trapping time followed by GC-MS and GC-FID anal. identified 23 and 30 common VOCs from the pathogen inoculated tubers. Overall, n,n-dimethylmethylamine, acetone, 1-undecene, and styrene, occurred frequently and repeatability in inoculated samples based on GC-MS anal., with the latter two found using GC-FID anal. as well. Identification of such biomarkers can be useful in developing high-throughput VOC sensing systems for early disease detection in potato storage facilities. And 3,7-Dimethyloctan-3-ol (cas: 78-69-3) was used in the research process.

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Electric Literature of C10H22O Metabolite observed in cancer metabolism. It has a role as a human metabolite.

Reference:
Alcohol – Wikipedia,
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Wang, Wanyi;Wang, Xin;Zhu, Qingqing;Zhou, Qunfang;Wang, Yawei;Liao, Chunyang;Jiang, Guibin published 《Occurrence of synthetic phenolic antioxidants in foodstuffs from ten provinces in China and its implications for human dietary exposure》. The research results were published in《Food and Chemical Toxicology》 in 2022.Application In Synthesis of 2,2-Methylenebis(6-tert-butyl-p-cresol) The article conveys some information:

Synthetic phenolic antioxidants (SPAs) are widely used as food additives to delay the oxidation rate of oils and oil products. The concentrations and compositions of SPAs in Chinese residents most popular daily foods and the resulting exposure risk of SPAs are not clear. Therefore, this study collected food samples in 13 food categories (n = 289) from 10 provinces in China. At least one of the SPAs was detected in approx. 99.7% of foodstuffs, and the concentration of ∑SPAs ranged from not detected to 7830 (geometric mean (GM): 296 ng/g wet weight). 2,6-2 tert Bu p-1,4-benzoquinone (BHT-Q) was the main transformation product, but SPAs in food tend to exist in the parent form. A significant difference between food categories was analyzed. The highest GM of ΣSPAs occurred in cereals and cereal products, which was approx. 8 times higher than that in beverages. The estimated daily intakes of ΣSPAs in Chinese preschoolers, school-age children, adults and elderly individuals were 22200, 9970, 7540 and 7700 ng/kg bw/day, resp. The exposure risks of SPAs decreased with age. This is the first simultaneous anal. of SPAs in multiple provinces and multiple categories of foodstuffs. To complete the study, the researchers used 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) .

Application In Synthesis of 2,2-Methylenebis(6-tert-butyl-p-cresol)2,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

Reference:
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Application In Synthesis of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol《ansa-Ruthenium(II) Complexes of R₂NSO₂DPEN-(CH₂)_n(η⁶-Aryl) Conjugate Ligands for Asymmetric Transfer Hydrogenation of Aryl Ketones》 was published in 2015. The authors were Kisic, Andrea;Stephan, Michel;Mohar, Barbara, and the article was included in《Advanced Synthesis & Catalysis》. The author mentioned the following in the article:

New 3rd generation designer ansa-ruthenium(II) complexes featuring N,C-alkylene-tethered N,N-dialkylsulfamoyl-DPEN/η⁶-arene ligands, exhibited good catalytic performance in the asym. transfer hydrogenation (ATH) of various classes of (het)aryl ketones in formic acid/triethylamine mixture In particular, benzo-fused cyclic ketones furnished 98 to >99.9% ee using a low catalyst loading. To complete the study, the researchers used rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) .

rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas: 579-43-1 Application In Synthesis of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol) has been used in the preparation of trans-methyl meso-hydrobenzoin phosphite.

Reference:
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Recommanded Product: 78-69-3In 2019, Fu, Yu;Bak, Kathrine H.;Liu, Jing;De Gobba, Cristian;Toestesen, Marie;Hansen, Erik T.;Petersen, Mikael A.;Ruiz-Carrascal, Jorge;Bredie, Wender L. P.;Lametsch, Rene published 《Protein hydrolysates of porcine hemoglobin and blood: Peptide characteristics in relation to taste attributes and formation of volatile compounds》. 《Food Research International》published the findings. The article contains the following contents:

The objective of this study was to investigate the impact of endo- and exo-peptidase treatment on certain structural characteristics of peptides and volatile compounds of porcine Hb and whole blood hydrolyzates. Porcine Hb and whole blood were hydrolyzed by endo- and exo-peptidases. The presence of exopeptidases reduced the bitterness and altered the volatile profiles of protein hydrolyzates. Exopeptidase treatment can release terminal amino acids from peptides, which in turn may contribute to formation of volatile compounds by Maillard reactions. In contrast, endopeptidases conferred a slightly bitter taste and different volatile profiles. For Hb hydrolyzates, principal component anal. revealed that proteases were categorized into three groups based on endo- or exo-peptidase activity. Whole blood is a more complex raw material, yet the proteases were still categorized in a similar fashion. This work contributes to understanding structural characteristics responsible for taste and volatile profiles of protein hydrolyzates. To complete the study, the researchers used 3,7-Dimethyloctan-3-ol (cas: 78-69-3) .

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Recommanded Product: 78-69-3 Metabolite observed in cancer metabolism. It has a role as a human metabolite.

Reference:
Alcohol – Wikipedia,
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Bubmann, Tobias;Seidel, Andreas;Ruckdaeschel, Holger;Altstaedt, Volker published 《Transparent PC/PMMA Blends with Enhanced Mechanical Properties via Reactive Compounding of Functionalized Polymers》. The research results were published in《Polymers (Basel, Switzerland)》 in 2022.Safety of 4-(2-Phenylpropan-2-yl)phenol The article conveys some information:

Reactive compounding of terminally phenolic OH-functionalized polycarbonate (PC) with epoxy-functionalized polymethylmethacrylate (PMMA) prepared by copolymerization with glycidyl methacrylate was investigated. It was spectroscopically demonstrated that a PC/PMMA copolymer was formed during the melt reaction of the functional groups. Zirconium acetylacetonate could catalytically accelerate this reaction. Correlations of the phenomenol. (optical and mech.) properties with the mol. level and mesoscopic (morphol.) structure were discussed. By the investigated reactive compounding process, transparent PC/PMMA blends with two-phase morphologies were obtained in a continuous twin-screw extruder, which, for the first time, combined the high transmission of visible light with excellent mech. performance (e.g., synergistically improved tensile and flexural strength and high scratch resistance). The transparency strongly depended on (a) the degree of functionalization in both PC and PMMA, (b) the presence of the catalyst, and (c) the residence time of the compounding process. The in-situ-formed PC/PMMA copolymer influenced the observed macroscopic properties by (a) a decrease in the interphase tension, leading to improved and stabilized phase dispersion, (b) the formation of a continuous gradient of the polymer composition and thus of the optical refractive indexes in a diffuse mesoscopic interphase layer separating the PC and PMMA phases, and (c) an increase in the phase adhesion between PC and PMMA due to mech. polymer chain entanglement in this interphase. To complete the study, the researchers used 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) .

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Safety of 4-(2-Phenylpropan-2-yl)phenol 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

Reference:
Alcohol – Wikipedia,
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Kosower, Nechama S.;Rock, Rica A. published 《Seizures in experimental porphyria》. The research results were published in《Nature (London, United Kingdom)》 in 1968.Application In Synthesis of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride The article conveys some information:

Rats made porphyric by allylisopropylacetamide (I) are susceptible to induced convulsions. Female Sprague-Dawley rats (150-160 g.) were injected daily with 400 mg. I/kg. in 0.15M NaCl for 8-10 days. Controls received NaCl. Twenty-four hrs. after the last injection, control and exptl. animals were injected with isonicotinoylhydrazide (II) or 4-methoxymethylpyridoxol-HCl (III) at pH 7, or deoxypyridoxol-HCl (IV) at pH 7. Other animals were given pyridoxal-HCl (V) 15 min. prior to injection of the compounds At 0.75 millimoles II/kg., clonic-tonic convulsions occurred in 60% of porphyric rats and in none of the controls; at 1.12 millimoles/kg., 90% of the porphyric rats convulsed, and 20% of controls. At 0.5-2 millimoles/kg., V did not alter the convulsions induced by II. Following III at 0.25 millimoles/kg., 70% of porphyric rats convulsed, and all convulsed at 0.75 millimoles/kg. (but no controls convulsed). No difference was noted between controls and animals injected with IV. These compounds may act by interfering with pyridoxal 5-phosphate in the nervous system.5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) were involved in the experimental procedure.

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 Application In Synthesis of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in and reduces growth of S. carlsbergensis cells. DOP inhibits sphingosine-1-phosphate (S1P) lyase and reduces cyclic stretch-induced apoptosis in alveolar epithelial MLE-12 cells.

Reference:
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Electric Literature of C11H16O《Catalytic and enantioselective bromoetherification of olefinic 1,3-diols: mechanistic insight》 was published in 2016. The authors were Ke, Zhihai;Tan, Chong Kiat;Liu, Yi;Lee, Keefe Guang Zhi;Yeung, Ying-Yeung, and the article was included in《Tetrahedron》. The author mentioned the following in the article:

How can high enantioselectivity be achieved when the racemic background reaction proceeds at a rate comparable to that of the catalytic asym. reaction. We attempted to rationalize this counterintuitive observation by studying the effect of (1) catalyst structure, (2) temperature and addition sequence of components, (3) catalyst loading, and (4) Bronsted acid additives. In the course of our investigation, it was found that increasing the amount of catalyst used led to inhibition of the stoichiometric reaction. Olefinic 1,3-diol 1, 5 mol % of catalyst 3a, 1 equiv of MsOH, and NBS were added at low temperature in a specific sequence to provide the best performance for the enantioselective bromoetherification. And 4-tert-Amylphenol (cas: 80-46-6) was used in the research process.

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Electric Literature of C11H16O

Reference:
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Diler, Fatma;Burhan, Hakan;Genc, Hayriye;Kuyuldar, Esra;Zengin, Mustafa;Cellat, Kemal;Sen, Fatih published 《Efficient preparation and application of monodisperse palladium loaded graphene oxide as a reusable and effective heterogeneous catalyst for suzuki cross-coupling reaction》 in 2020. The article was appeared in 《Journal of Molecular Liquids》. They have made some progress in their research.Reference of 3,7-Dimethyloctan-3-ol The article mentions the following:

A homogeneously dispersed graphene oxide supported palladium nanomaterial (Pd@GO) has been successfully synthesized and used as a catalyst in cross-coupling reactions at room temperature Various anal. techniques such as X-ray Diffraction (XRD), XPS, transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HR-TEM) were used to characterize the monodisperse Pd@GO. Monodisperse Pd@GO nanomaterials were used for the cross-coupling reactions which brought together organic mols. with functional significance. This catalyst showed superior catalytic activity and stability for these coupling reactions. High product yields, short reaction times and mild reaction conditions, obtained by the using of developed catalysts. Importantly, the catalyst can be used at least five experiments successfully without losing its efficiency. And 3,7-Dimethyloctan-3-ol (cas: 78-69-3) was used in the research process.

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Reference of 3,7-Dimethyloctan-3-ol Metabolite observed in cancer metabolism. It has a role as a human metabolite.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ling, Xiaoxi;Masson, Eric published 《Cucurbituril Slippage: Cations as Supramolecular Lubricants》 in 2012. The article was appeared in 《Organic Letters》. They have made some progress in their research.COA of Formula: C8H18O2 The article mentions the following:

The dethreading rate of a polyaminated axle flanked by two benzo-15-crown-5 stoppers from the cavity of Cucurbit[7]uril (CB[7]) was enhanced by up to 500 times in the presence of aqueous metallic and organic cations. Cations likely stabilize the highest energy transition state of the dethreading process by interacting with both crown ether and CB[7] units.2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) were involved in the experimental procedure.

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) is used as an intermediate in the preparation of 2.5-Dimethyl-2.5-bis(tertbutyl-peroxy)hexane. It is also used in the synthesis of six- and seven-membered heterocyclic boron compounds.COA of Formula: C8H18O2

Reference:
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