Author: tianli

Formula: C15H16OIn 2022, Ling, Meiqi;Yu, Kaifeng;Wang, Jian;Wang, Honghua;Nie, Heran;Wang, Zhipeng;Zhou, Guangyuan published 《Synthesis and pyrolysis mechanism of phenolphthalein poly(aryl ether sulfone) containing isopropyl groups》. 《Thermochimica Acta》published the findings. The article contains the following contents:

A novel phenolphthalein poly(aryl ether sulfone) polymer containing iso-Pr groups (iPrPESC) has been successfully synthesized by S_N2 aromatic nucleophilic polycondensation reaction. The pyrolysis mechanism and behavior of iPrPESC were investigated by thermogravimetry coupled with Fourier transform IR spectroscopy and pyrolysis combined with gas chromatog./mass spectrometry. TG-FTIR and Py-GC/MS were used to identify the thermal decomposition products and to determine the possible thermal degradation mechanism. The main mechanism for iPrPESC was one-stage pyrolysis involving main-chain random scission, and the major products of SO₂ and phenol were released from the sulfone and ether groups in iPrPESC. The thermal degradation activation energy of iPrPESC was calculated to be 151 ± 4 and 139 ± 4 kJ mol^-1 by the Flynn-Wall-Ozawa and Kissinger methods, resp., which were much lower than that of phenolphthalein poly(aryl ether sulfone). Furthermore, introduction of iso-Pr groups on the main chain can significantly reduce the char yield. The experimental procedure involved many compounds, such as 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) .

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Formula: C15H16O 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

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Heyl, Dorothea;Harris, Stanton A.;Folkers, Karl published 《Chemistry of vitamin B₆. IX. Derivatives of 5-deoxypyridoxine》. The research results were published in《Journal of the American Chemical Society》 in 1953.Quality Control of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride The article conveys some information:

cf. C.A. 47, 8745g. The 5-deoxy derivatives (I) of pyridoxine (II), pyridoxal (III), and pyridoxamine (IV) were prepared and characterized. The I can participate normally in biochemical reactions involving the substituent at the 4-position but cannot be phosphorylated like II, III, and IV. As expected the I had no vitamin B₆ activity but were effective antimetabolites. Codecarboxylase has been catalytically hydrogenated to 5-deoxypyridoxine (V); both II and III yielded under the same conditions a mixture of 4-deoxypyridoxine (VI) and V. The absorption spectra of 5-deoxypyridoxal (VII) (recorded) and pure pyridoxal-5-phosphate (codecarboxylase) (VIII) at pH 11.0 and 1.9, resp., are almost identical. The deep yellow color of both VII and VIII in alk. solution together with other absorption characteristics is ascribed to a quinoid structure. 2-Methyl-3-hydroxy-4-methoxymethyl-5-chloromethylpyridine (IX).HCl (2.38 g.) in 125 cc. MeOH was shaken with H in the presence of 2 g. 5% Pd-Darco, the mixture filtered, and the filtrate concentrated to 20 cc. to yield 1.5 g. (75%) 2,5-dimethyl-3-hydroxy-4-methoxymethylpyridine (X).HCl, m. 152-3° (from EtOH-Et₂O). IX.HCl (23.7 g.) reduced similarly in 2 equal portions, each one in 600 cc. MeOH with 5 g. Pd catalyst yielded 19.0 g. (94%) X.HCl. X.HCl (1.47 g.) in 50 cc. 4N HCl heated 3 hrs. at 180-90° in a sealed tube, the colorless solution filtered, the filtrate concentrated to dryness, and the H₂O removed azeotropically with EtOH and C₆H₆ yielded 0.96 g. (70%) V.HCl, m. 143-3.5° (from EtOH-Et₂O); treated with excess NaHCO₃ gave V, m. 181-2° (from EtOH). X.HCl was treated in H₂O with NaHCO₃, the mixture concentrated in vacuo and extracted with Et₂O, the extract evaporated, 3.1 g. of the residual free base heated 18 hrs. with 50 cc. MeOH and 50 cc. liquid NH₃ in a sealed tube, the mixture evaporated in vacuo to dryness, MeOH added and removed twice by distillation, and the residue extracted with Et₂O to leave 1.86 g. (60%) 5-deoxypyridoxamine (XI); m. 160-1° (from MeOH); 2,5-dimethyl-3-p-toluenesulfonoxy-4-p-toluenesulfonylaminopyridine-HCl, m. 194-5° (from EtOH). A small sample of XI was heated 20 min. with Ac₂O on a steam bath, the solution concentrated to dryness, the residue treated with EtOH, distilled to dryness, dissolved in HCl, treated with Darco, neutralized with NaHCO₃, chilled, and the crystalline deposit recrystallized from C₆H₆ containing a few drops EtOH to give 2,5-dimethyl-3-acetoxy-4-acetylaminomethylpyridine, m. 174-5°. V.HCl (5.7 g.) was stirred 2 hrs. at 60-70° with 2.8 g. MnO₂, 1.5 cc. H₂SO₄, and 75 cc. H₂O, the mixture filtered, the filtrate concentrated in vacuo, the sirup taken up in 15 cc. H₂O, excess solid AcONa added, and the thick, crystalline precipitate cooled, filtered off, and washed with ice water to give 1.30 g. (29%) VII, m. 108-9° (from petr. ether); the aqueous filtrate from VII gave with 2 g. NH₂OH.HCl 0.9 g. (18%) oxime of VII, m. 239-40° (decomposition) (from EtOH). To the aqueous filtrate of a similar run were added 12 g. NaOAc and 4.5 g. NH₂OH.HCl and the mixture was heated 10 min. on a steam bath to yield 2.43 g. (49%) oxime of VII. VII in CHCl₃ treated with excess alc. HCl, the solution evaporated in vacuo to dryness, a little H₂O added and removed in vacuo, and the residue treated with CHCl₃ yielded VII.HCl, m. 191-3° (decomposition). VII (90 mg.) in 1 cc. H₂O was cooled in ice, the pH adjusted to 11 with 6N NaOH, 4 drops 30% H₂O₂ added, the mixture adjusted to pH 3 with HCl and cooled, and the precipitate washed with H₂O, EtOH, and Et₂O to yield 70 mg. (85%) 2,5-dimethyl-3,4-dihydroxypyridine, decomposed 262-70°. Crude Ca codecarboxylase (0.5 g.) was suspended in H₂O and treated with 0.7 cc. 6N HCl, the mixture filtered, the filtrate diluted to 50 cc. shaken 2.25 hrs. at atm. pressure with H and 0.5 g. 10% Pd-C, filtered and concentrated to dryness in vacuo, the residue dissolved in about 3 cc. H₂O, the solution treated with excess solid NaHCO₃, filtered, the filter residue washed with H₂O, the combined filtrate and washings were concentrated in vacuo to 5 cc., the concentrate extracted 21 hrs. continuously with CHCl₃, the extract evaporated, and the residue treated with alc. HCl and precipitated with Et₂O to give 0.07 g. V.HCl, m. 140-1°. III.HCl (0.35 g.) was treated with 0.10 g. CaO and 0.17 g. H₃PO₄ and hydrogenated similarly to give 0.08 g. (24%) VI.HCl, m. 264-5°, and 0.11 g. (33%) V.HCl; the aqueous filtrate left from the CHCl₃-extraction was concentrated to dryness, the residue extracted with EtOH, and the extract acidified with alc. HCl to give 0.11 g. (30%) I.HCl. Similar hydrogenation of 0.40 g. I.HCl in 0.3 cc. 6N HCl and 50 cc. H₂O for 4-5 hrs. gave 0.16 g. (42%) VI.HCl and 0.09 g. (24%) V.HCl. Attempted similar hydrogenation of V gave only recovered starting material. To complete the study, the researchers used 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) .

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 Quality Control of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in and reduces growth of S. carlsbergensis cells. DOP inhibits sphingosine-1-phosphate (S1P) lyase and reduces cyclic stretch-induced apoptosis in alveolar epithelial MLE-12 cells.

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Rech, Jeromy James;Neu, Justin;Qin, Yunpeng;Samson, Stephanie;Shanahan, Jordan;Josey, Richard F. III;Ade, Harald;You, Wei published 《Designing Simple Conjugated Polymers for Scalable and Efficient Organic Solar Cells》 in 2021. The article was appeared in 《ChemSusChem》. They have made some progress in their research.Quality Control of 2-Hexyl-1-decanol The article mentions the following:

Conjugated polymers have a long history of exploration and use in organic solar cells, and over the last twenty-five years, marked increases in the solar cell efficiency were achieved. However, the synthetic complexity of these materials has also drastically increased, which makes the scalability of the highest-efficiency materials difficult. If conjugated polymers could be designed to exhibit both high efficiency and straightforward synthesis, the road to com. reality would be more achievable. For that reason, a new synthetic approach was designed towards PTQ10 (=poly[(thiophene)-alt-(6,7-difluoro-2-(2-hexyldecyloxy)quinoxaline)]). The new synthetic approach to make PTQ10 brought a significant reduction in cost (1/7th the original) and could also easily accommodate different side chains to move towards green processing solvents. Furthermore, high-efficiency organic solar cells were demonstrated with a PTQ10:Y6 blend exhibiting approx. 15% efficiency. To complete the study, the researchers used 2-Hexyl-1-decanol (cas: 2425-77-6) .

2-Hexyl-1-decanol(cas: 2425-77-6) has been shown to inhibit the growth of b16 mouse melanoma cells, suggesting it may be useful for treating skin cancer.Quality Control of 2-Hexyl-1-decanol This fatty acid also has transport properties and can form hydrogen bonds with other molecules.

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Pan, Hui-Jie;Lin, Yamei;Gao, Taotao;Lau, Kai Kiat;Feng, Wei;Yang, Binmiao;Zhao, Yu published 《Catalytic Diastereo- and Enantioconvergent Synthesis of Vicinal Diamines from Diols through Borrowing Hydrogen》. The research results were published in《Angewandte Chemie, International Edition》 in 2021.Category: alcohols-buliding-blocks The article conveys some information:

Authors present herein an unprecedented diastereoconvergent synthesis of vicinal diamines from diols through an economical, redox-neutral process. Under cooperative ruthenium and Lewis acid catalysis, readily available anilines and 1,2-diols (as a mixture of diastereomers)couple to forge two C-N bonds in an efficient and diastereoselective fashion. By identifying an effective chiral iridium/phosphoric acid co-catalyzed procedure, the first enantioconvergent double amination of racemic 1,2-diols has also been achieved, resulting in a practical access to highly valuable enantioenriched vicinal diamines. And rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) was used in the research process.

rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas: 579-43-1 Category: alcohols-buliding-blocks) has been used in the preparation of trans-methyl meso-hydrobenzoin phosphite.

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Electric Literature of C16H34OIn 2020, Choinska, Renata;Piasecka-Jozwiak, Katarzyna;Chablowska, Beata;Dumka, Justyna;Lukaszewicz, Aneta published 《Biocontrol ability and volatile organic compounds production as a putative mode of action of yeast strains isolated from organic grapes and rye grains》. 《Antonie van Leeuwenhoek》published the findings. The article contains the following contents:

Abstract: The inhibiting activity of three yeast strains belonging to Pichia kudriavzevii, Pichia occidentalis, and Meyerozyma quilliermondii/Meyerozyma caribbica genera against common plant pathogens representing Mucor spp., Penicillium chrysogenum, Penicillium expansum, Aspergillus flavus, Fusarium cereals, Fusarium poae, as well as Botrytis cinerea genera was investigated. The yeast strains tested had a pos. impact on growth inhibition of all target plant pathogens. The degree of inhibition was more than 50% and varied depending on both the yeast antagonist and the mold. Et esters of medium-chain fatty acids, phenylethyl alc., and its acetate ester prevailed among the analyzed volatile organic compounds (VOCs) emitted by yeasts in the presence of the target plant pathogens. Due to the method used, assuming no contact between the antagonist and the pathogen, the antagonistic activity of the yeast strains studied resulted mainly from the production of biol. active VOCs. Moreover, the antagonistic activity was not only restricted to a single plant pathogen but effective towards molds of different genera, making the yeast strains studied very useful for potential application in biol. control. And 2-Hexyl-1-decanol (cas: 2425-77-6) was used in the research process.

2-Hexyl-1-decanol(cas: 2425-77-6) has been shown to inhibit the growth of b16 mouse melanoma cells, suggesting it may be useful for treating skin cancer.Electric Literature of C16H34O This fatty acid also has transport properties and can form hydrogen bonds with other molecules.

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Safety of 2,2-Methylenebis(6-tert-butyl-p-cresol)《Determination of antioxidants in food and water-based food simulants by supercritical fluid chromatography》 was published in 2021. The authors were Huang, Lin;Xiao, Lei;Zhu, Yan;Shou, Dan;Jin, Micong;Han, Xinghao, and the article was included in《Fenxi Shiyanshi》. The author mentioned the following in the article:

A novel pretreatment method based on syringe for filter solid-phase extraction was developed and combined with supercritical fluid chromatog. (SFC) to determine the migration of antioxidants in packaging materials to two water-based food simulants, and applied to test real sample. The amount of sorbent and SFC conditions were optimized. Under the optimized conditions, all the studied six target antioxidants have good linearity (R²>0.999) in their resp. concentration ranges with limits of detection (LODs) ranging from 25 to 35 ng/mL. Mean recoveries of targets were between 82.0% and 96.0% in ultrapure water, and between 76.2% and 103.0% in 3% acetic acid solution, with the relative standard deviations (RSD) no more than 8.8%. The method is adaptable for analyzing the antioxidants in com. non-alc. beverage and their packaging materials (soaking in different food simulants). The experimental procedure involved many compounds, such as 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) .

Safety of 2,2-Methylenebis(6-tert-butyl-p-cresol)2,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

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Qiao, Lizhen;Sun, Ruiting;Tao, Yuan;Yan, Yang published 《New low viscous hydrophobic deep eutectic solvents for the ultrasound-assisted dispersive liquid-liquid microextraction of endocrine-disrupting phenols in water, milk and beverage》. The research results were published in《Journal of Chromatography A》 in 2022.Safety of 4-(2-Phenylpropan-2-yl)phenol The article conveys some information:

In the present work, several new hydrophobic deep eutectic solvents (HDESs) were prepared with quaternary ammonium salts as hydrogen bond acceptors (HBAs) and salicylate esters as hydrogen bond donors (HBDs). Then, the obtained HDESs were used as extraction solvents to establish an ultrasound-assisted dispersive liquid-liquid microextraction method combined with high-performance liquid chromatog.-UV detection technique for the determination of four endocrine-disrupting phenols (EDPs) compounds One of the obtained HDESs composed of tetrabutylammonium chloride (N4444Cl) and Me salicylate possessed a viscosity of 89.28 mPa·s lower than most reported ionic HDESs (>200 mPa·s), and the low viscous HDES was selected as the optimal extraction solvent. Several key parameters affecting the extraction efficiency were investigated, including the type and volume of HDES, ultrasound time, sample solution pH and salt addition Under the optimized exptl. conditions, the proposed method had good coefficients of determination (R2 > 0.9976) in the linear range of 0.5-400μg·L-1, the limits of quantification and limits of detection resp. were 0.5-2.5μg·L-1 and 0.25-1μg·L-1, and the recoveries were in the range of 81.79-109.82%. Finally, the method was used for the preconcentration and determination of EDPs in different samples, including bottled water, tea beverage and milk.4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) were involved in the experimental procedure.

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Safety of 4-(2-Phenylpropan-2-yl)phenol 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

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Liu, Guang-Xue;Xu, Feng;Shang, Ming-Ying;Wang, Xuan;Cai, Shao-Qing published 《The relative content and distribution of absorbed volatile organic compounds in rats administered asari radix et rhizoma are different between powder- and decoction-treated groups》. The research results were published in《Molecules》 in 2020.Recommanded Product: 80-46-6 The article conveys some information:

Asari Radix et Rhizoma (ARR) is an important traditional Chinese medicine. Volatile organic compounds (VOCs) are the main active constituents of ARR. Research on the metabolite profile of VOCs and the difference of absorbed constituents in vivo after an administration of ARR decoction and powder will be helpful to understand the pharmacol. activity and safety of ARR. In this study, headspace solid-phase microextraction gas chromatog. mass spectrometry (HS-SPME-GC-MS) was applied to profile the VOCs from ARR in rats in vivo. A total of 153 VOCs were tentatively identified; 101 were original constituents of ARR (98 in the powder-treated group and 43 in the decoction-treated group) and 15 were metabolites, and their metabolic reactions were mainly oxidation and reduction, with only two cases of methylation and esterification, and 37 unclassified compounds were identified only in the ARR-treated group. Of the 153 VOCs identified, 131 were reported in rats after oral administration of ARR for the first time, containing 79 original constituents, 15 metabolites, and 37 unclassified compounds In the powder-treated group, methyleugenol, safrole, 3,5-dimethoxytoluene (3,5-DMT), 2,3,5-trimethoxytoluene (2,3,5-TMT), and 3,4,5-trimethoxytoluene (3,4,5-TMT) were the main absorbed constituents, the relative contents of which were significantly higher compared to the decoction-treated group, especially methyleugenol, safrole, and 3,5-DMT. In the decoction-treated group, 3,4,5-TMT, 2,3,5-TMT, kakuol, and eugenol were the main constituents with a higher content and wider distribution. The results of this study provide a reference for evaluating the efficacy and safety of ARR. To complete the study, the researchers used 4-tert-Amylphenol (cas: 80-46-6) .

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group.Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Recommanded Product: 80-46-6

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Lomas, John S. published 《¹H NMR spectra of alcohols and diols in chloroform: DFT/GIAO calculation of chemical shifts》 in 2014. The article was appeared in 《Magnetic Resonance in Chemistry》. They have made some progress in their research.Safety of 2,5-Dimethyl-2,5-hexanediol The article mentions the following:

Proton NMR shifts of aliphatic alcs. in chloroform have been computed on the basis of d. functional theory, the solvent being included by the integral-equation-formalism polarizable continuum model of Gaussian 09. Relative energies of all conformers are calculated at the Perdew, Burke and Ernzerhof (PBE)0/6-311+G(d,p) level, and NMR shifts by the gauge-including AO method with the PBE0/6-311+G(d,p) geometry and the cc-pVTZ basis set. The 208 computed CH proton NMR shifts for 34 alcs. correlate very well with the exptl. values, with a gradient of 1.00 ± 0.01 and intercept close to zero; the overall root mean square difference (RMSD) is 0.08 ppm. Shifts for CH protons of diols in chloroform are well correlated with the theor. values for (isotropic) benzene, with similar gradient and intercept (1.02 ± 0.01, -0.13 ppm), but the overall RMSD is slightly higher, 0.12 ppm. This approach generally gives slightly better results than the CHARGE model of Abraham et al. The shifts of unsaturated alcs. in benzene have been re-examined with Gaussian 09, but the overall fit for CH protons is not improved, and OH proton shifts are worse. Shifts of vinyl protons in alkenols are systematically overestimated, and the correlation of computed shifts against the exptl. data for unsaturated alcs. follows a quadratic equation. Splitting the 20 compounds studied into two sets, and applying empirical scaling based on the quadratic for the first set to the second set, gives an RMSD of 0.10 ppm. A multi-standard approach gives a similar result. Copyright © 2014 John Wiley & Sons, Ltd. The experimental procedure involved many compounds, such as 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) .

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) on heteropoly acid catalyzed dehydration yields cyclic ethers via stereospecific intramolecular SN2 mechanism. It reacts with nitriles in concentrated sulfuric acid to yield Δ1-pyrrolines.Safety of 2,5-Dimethyl-2,5-hexanediol

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Related Products of 599-64-4In 2020, Yan, Xin;Yi, Chengwu;Wang, Yonghui;Cao, Wudi;Mao, Danni;Ou, Qingqing;Shen, Peiyao;Wang, Huijuan published 《Multi-catalysis of nano-zinc oxide for bisphenol A degradation in a dielectric barrier discharge plasma system: Effect and mechanism》. 《Separation and Purification Technology》published the findings. The article contains the following contents:

As a widely used chem. material, bisphenol A (BPA) is often used to produce kinds of chems., which lead risk to the ecol. environment and human health. Based on the multi-catalysis of the nano-ZnO and multi-effect (chem. and phys.) formed in the dielec. barrier discharge plasma (DBDP) system, the synergistic elimination of the BPA in the DBDP system combined with nano-ZnO was evaluated. The obtained exptl. results showed that the superior adding amount of the nano-ZnO was 50 mg/L and the synergistic system on the condition had the best effect for the BPA degradation (85.4%), which was 17% higher than that in the sole DBDP system. When O₂ was bubbled into the reaction system, the degradation efficiency of the BPA in the synergistic system reached 100% after 20 min treatment. Compared with the alk. solution, the acidic and weakly acidic solution could obtain higher treatment efficiency. ^.OH and O^–₂ had a vital role for the BPA elimination in the synergistic system. The intermediate products detected by LC-MS included 4-cumylphenol, 4-isopropenylphenol, 4-tert-butylphenol, propiophenone, 1-(4-hydroxyphenyl) ethanone, tert-butylbenzene, benzoquinone and 1,4-dihydroxybenzene. The experimental procedure involved many compounds, such as 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) .

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Related Products of 599-64-4 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

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