Author: tianli

Chang, Sue-Joan published 《Vitamin B₆ antagonists alter the function and ultrastructure of mice endothelial cells》 in 2000. The article was appeared in 《Journal of Nutritional Science and Vitaminology》. They have made some progress in their research.Product Details of 148-51-6 The article mentions the following:

Vitamin B₆ is necessary for normal cell membrane function and stability. We studied both the function and ultrastructure of aortic and arterial endothelial cells (EC) in vitamin B₆ deficiency induced by vitamin B₆ antagonists 4-deoxypyridoxine HCl (dPN·HCl) and isonicotinylhydrazide (INH) given in drinking water to 1-mo-old ICR mice. The mice were fed normal laboratory chow and divided into 3 groups. Mice in group I were given distilled water (control), group II was given 0.1 mg dPN·HCl/mL water, and group III 0.4 mg INH/mL water. After 5 mo the blood plasma concentrations of B₆ vitamers pyridoxal-5′-phosphate (PLP) and pyridoxal (PL) were analyzed by HPLC. With arachidonic acid (AA) as a precursor, the PGI₂ production by EC was assayed by thin-layer chromatog. (TLC) as an indicator of endothelial function. Aorta and arterioles from the foot pad were removed, stained with osmium tetraoxide, and examined by transmission electron microscopy to evaluate the EC ultrastructure. The blood plasma concentrations of PLP, PL, and total B₆ were lowest for mice fed INH, followed by dPN·HCl and control. The PGI₂ production was paralleled by the plasma vitamin B₆ status, with the lowest levels in the INH group, followed by the dPN·HCl group. Abnormalities in the EC ultrastructure were found in both dPN·HCl and INH groups, including cells detached from underlying elastic tissue, with prominent pinocytotic vesicles and swelling and/or indistinct cristae of mitochondria. Thus, vitamin B₆ antagonists can induce a deficient status that alters the function and ultrastructure of EC similar to vascular disease.5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) were involved in the experimental procedure.

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 Product Details of 148-51-6) is a strong antagonist of vitamin B6. Deoxypyridoxine hydrochloride has been used as an analytical reference standard for the quantification of the analyte in food samples using high performance liquid chromatography.

Reference:
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Related Products of 579-43-1In 2020, Fujita, Masashi;Kobayashi, Fumihisa;Ide, Takafumi;Egami, Hiromichi;Hamashima, Yoshitaka published 《Oxidative and Redox-Neutral Approaches to Symmetrical Diamines and Diols by Single Electron Transfer/Hydrogen Atom Transfer Synergistic Catalysis》. 《European Journal of Organic Chemistry》published the findings. The article contains the following contents:

Homocoupling reactions of benzylamines and benzyl alcs. were examined under synergistic catalysis conditions with a photoredox catalyst and thiobenzoic acid as a hydrogen atom abstractor. When pivalaldehyde was used as an electron acceptor, oxidative dimerization proceeded selectively, whereas the use of benzaldehydes or iminium ions as electron acceptors resulted in redox-neutral coupling. These reactions afforded sym. 1,2-diamines and 1,2-diols in good yields. To complete the study, the researchers used rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) .

Desymmetrization of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas:579-43-1 Related Products of 579-43-1) using chiral phosphine catalyst has been reported. Conversion of meso-hydrobenzoin to trans-stillbene oxide by treatment with an aryl sulfonyl chloride and aqueous sodium hydroxide has been reported.

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SDS of cas: 599-64-4《In Vitro Screening of 21 Bisphenol A Replacement Alternatives: Compared with Bisphenol A, the Majority of Alternatives Are More Cytotoxic and Dysregulate More Genes in Avian Hepatocytes》 was published in 2021. The authors were Crump, Doug;Sharin, Tasnia;Chiu, Suzanne;O’Brien, Jason M., and the article was included in《Environmental Toxicology and Chemistry》. The author mentioned the following in the article:

An avian in vitro screening approach was used to determine the effects of 21 bisphenol A (BPA) alternatives. Cytotoxicity and dysregulation of genes associated with estrogen response and other toxicol. relevant pathways evoked by these alternatives were compared with BPA. Most of the BPA alternatives (15/21) were equally or more cytotoxic than BPA in chicken embryonic hepatocytes; variability in cell viability was associated with chem. structure and the log octanol-water partition coefficient (logP) values. A neg. linear relationship (r2 = 0.745; p = 0.49-07; n = 18) was observed between logP and the log median lethal concentration (logLC50) values. The least cytotoxic BPA alternatives elicited the greatest gene dysregulation and, overall, most of the alternatives altered more genes than BPA (measured with a custom polymerase chain reaction array). This overall approach shows promise for use as a screen for hazard-based prioritization of BPA replacement alternatives and to ideally identify those that may be less harmful and/or require addnl. toxicity testing.4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) were involved in the experimental procedure.

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.SDS of cas: 599-64-4 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

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Baral, Ek Raj;Lee, Jun Hee;Kim, Jeung Gon published 《Diphenyl Carbonate: A Highly Reactive and Green Carbonyl Source for the Synthesis of Cyclic Carbonates》. The research results were published in《Journal of Organic Chemistry》 in 2018.Application In Synthesis of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol The article conveys some information:

A practical, safe, and highly efficient carbonylation system involving a di-Ph carbonate, an organocatalyst, and various diols is presented herein and produces highly valuable cyclic carbonates. In reactions with a wide range of diols, di-Ph carbonate was activated by bicyclic guanidine 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) as a catalyst, which successfully replaced highly toxic and unstable phosgene or its derivatives while maintaining the desired high reactivity. Moreover, this new system can be used to synthesize sterically demanding cyclic carbonates such as tetrasubstituted pinacol carbonates, which are not accessible via other conventional methods. The experimental procedure involved many compounds, such as rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) .

Desymmetrization of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas:579-43-1 Application In Synthesis of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol) using chiral phosphine catalyst has been reported. Conversion of meso-hydrobenzoin to trans-stillbene oxide by treatment with an aryl sulfonyl chloride and aqueous sodium hydroxide has been reported.

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Related Products of 579-43-1《Highly efficient cationic palladium catalyzed acetylation of alcohols and carbohydrate-derived polyols》 was published in 2016. The authors were Mensah, Enoch A.;Reyes, Francisco R.;Standiford, Eric S., and the article was included in《Catalysts》. The author mentioned the following in the article:

The development of a new facile method for the acetylation of alcs. and carbohydrate-derived polyols is described. This method relies on the nature of the cationic palladium catalyst, Pd(PhCN)₂(OTf)₂, which is generated in situ from Pd(PhCN)₂Cl₂ and AgOTf to catalyze the acetylation reaction. This new acetylation protocol is very rapid and proceeds under mild conditions with only 1 mol% of catalyst loading at room temperature This new method has been applied to a variety of different alcs. with different levels of steric hindrance, as well as carbohydrate-derived polyols to provide the corresponding fully acetylated products in excellent yields. And rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) was used in the research process.

rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas: 579-43-1 Related Products of 579-43-1) has been used in the preparation of trans-methyl meso-hydrobenzoin phosphite.

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Reference of 2-Hexyl-1-decanol《Pressurized entrained-flow pyrolysis of lignite for enhanced production of hydrogen-rich gas and chemical raw materials》 was published in 2020. The authors were Tahmasebi, Arash;Maliutina, Kristina;Matamba, Tawanda;Kim, Jong-Ho;Jeon, Chung-Hwan;Yu, Jianglong, and the article was included in《Journal of Analytical and Applied Pyrolysis》. The author mentioned the following in the article:

This paper reports the enhanced production of H₂ and polyaromatics during lignite pyrolysis under pressurized entrained-flow conditions. The pyrolysis temperature and pressure ranged between 600-900°C and 0.1-4.0 MPa, resp., and were found to greatly influence the yield and composition of pyrolysis products. The results showed that the concentration of H₂ in the light gas fraction increased drastically with pyrolysis temperature and pressure, reaching 91.69 vol% at 900°C and 4.0 MPa, which corresponded to H₂ generation of 0.27 m³/kg coal. The yield of polycyclic aromatic hydrocarbons (PAHs) such as naphthalene, biphenylene, fluorene, phenanthrene, pyrene, and fluoranthene was also promoted at elevated pyrolysis temperatures and pressures. The highest PAHs concentration of 90.4 area% in the pyrolysis oil was obtained at 900°C and 4.0 MPa. It was also found that the changes in the hydrogen distribution under pressurized entrained-flow conditions mainly took place during the secondary pyrolysis reactions. It was postulated that hydrogen was formed via aromatization, condensation, aromatic ring growth mechanism, and direct cleavage reactions. The findings of this study showed that lignite could be efficiently converted to H₂-rich gas, PAHs as chem. raw materials, and energy-dense lignite char via a novel poly-generation system based on pressurized entrained-flow pyrolysis. To complete the study, the researchers used 2-Hexyl-1-decanol (cas: 2425-77-6) .

2-Hexyl-1-decanol(cas: 2425-77-6) is a fatty acid that is found in the essential oils of plants and has been shown to have fungicidal properties.Reference of 2-Hexyl-1-decanol It has also been shown to inhibit the growth of Candida glabrata when used as a cationic surfactant.

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Kamata, Ryo;Nakajima, Daisuke;Shiraishi, Fujio published 《Agonistic effects of diverse xenobiotics on the constitutive androstane receptor as detected in a recombinant yeast-cell assay》. The research results were published in《Toxicology In Vitro》 in 2018.Product Details of 80-46-6 The article conveys some information:

The constitutive androstane receptor (CAR) is a nuclear receptor and transcription factor regulating proteins involved in xenobiotic metabolism Agonist activation of the CAR can trigger metabolic activation and toxification as well as detoxification and clearance; accordingly, xenobiotic substances acting as CAR ligands may pose a threat to human and animal health. The authors used yeast cells transduced with the human CAR and the response pathway to measure the CAR-agonistic activities of 549 synthetic or natural compounds: 216 of the tested compounds exhibited CAR-agonistic effects. Eighty-four percent of CAR-activating compounds were aromatic compounds, and >65% of these active compounds were aromatic hydrocarbons, bisphenols, monoalkyl phenols, phthalates, styrene dimers, di-Ph ethers, organochlorines, and organophosphates. The ten most potent compounds were 4-tert-octylphenol (4tOP; reference substance), 4-nonylphenol, diethylstilbestrol, benzyl Bu phthalate, 2-(4-hydroxyphenyl)-2,4,4-trimethylchroman, o,p’-DDT, methoxychlor, di-Pr phthalate, hexestrol, and octachlorostyrene. The activities of these nine non-reference compounds exceeded 10% of the 4tOP activity. Anal. of para-monoalkyl phenols suggests that branching of the alkyl group and chlorination at the ortho position raises potency. This study provides critical information for identifying the potential of CAR-mediated toxic hazards and for understanding the relevant mechanism. The experimental procedure involved many compounds, such as 4-tert-Amylphenol (cas: 80-46-6) .

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group. Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble.Product Details of 80-46-6

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Smoum, Reem;Haj, Christeene;Hirsch, Shira;Nemirovski, Alina;Yekhtin, Zhannah;Bogoslavsky, Benny;Bakshi, Gaganjyot Kaur;Chourasia, Mukesh;Gallily, Ruth;Tam, Joseph;Mechoulam, Raphael published 《Fenchone Derivatives as a Novel Class of CB2 Selective Ligands: Design, Synthesis, X-ray Structure and Therapeutic Potential》 in 2022. The article was appeared in 《Molecules》. They have made some progress in their research.Product Details of 80-46-6 The article mentions the following:

A series of novel cannabinoid-type derivatives was synthesized by the coupling of (1S,4R)-(+) and (1R,4S)-(-)-fenchones I (R = H, Me, n-pentyl, 2-methylbutan-2-yl, etc.; R¹ = H, hexyl; R² = H, OMe) with various resorcinols RC₆H₃(OH)₂/phenols RC₆H₄OH. The fenchone-resorcinol derivatives I were fluorinated using Selectfluor and demethylated using sodium ethanethiolate in DMF (DMF). The absolute configurations of four compounds were determined by X-ray single crystal diffraction. The fenchone-resorcinol analogs I possessed high affinity and selectivity for the CB2 cannabinoid receptor. One of the analogs synthesized, I (R = 2-methyloctan-2-yl, R¹ = H, R² = OMe (II)), had a high affinity (K_i = 3.51 nM) and selectivity for the human CB2 receptor (hCB2). In the [³⁵S]GTPγS binding assay, the lead compound was found to be a highly potent and efficacious hCB2 receptor agonist (EC₅₀ = 2.59 nM, E_(max) = 89.6%). Two of the fenchone derivatives I were found to possess anti-inflammatory and analgesic properties. Mol.-modeling studies elucidated the binding interactions of (II) within the CB2 binding site.4-tert-Amylphenol (cas: 80-46-6) were involved in the experimental procedure.

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group.Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Product Details of 80-46-6

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Product Details of 110-03-2In 2019, Ye, Yang;Chen, Haifeng;Sessler, Jonathan L.;Gong, Hegui published 《Zn-Mediated Fragmentation of Tertiary Alkyl Oxalates Enabling Formation of Alkylated and Arylated Quaternary Carbon Centers》. 《Journal of the American Chemical Society》published the findings. The article contains the following contents:

Zn-mediated reduction of readily accessible dialkyl oxalates derived from tertiary alcs. provides an efficient approach to C-O bond fragmentation and alkyl radical formation. With MgCl₂ as the indispensable additive and Ni as the promoter, trapping the radical with activated alkenes and aryl-Ni intermediates allows for the generation of alkylated and arylated all-carbon quaternary centers. To complete the study, the researchers used 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) .

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) on heteropoly acid catalyzed dehydration yields cyclic ethers via stereospecific intramolecular SN2 mechanism. It reacts with nitriles in concentrated sulfuric acid to yield Δ1-pyrrolines.Product Details of 110-03-2

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Formula: C11H16O《Predicting the toxicity of substituted aromatic compounds to fathead minnows using artificial neural network》 was published in 2017. The authors were Li, Qinling;Yang, Yuliang, and the article was included in《Jisuanji Yu Yingyong Huaxue》. The author mentioned the following in the article:

Ninety-two substituted aromatic compounds (containing alkyl-benzenes, nitrobenzene, phenols and anilines) were calculated and 13 quantum chem. parameters were obtained using ab initio. The prediction model was established quant. relationship between the acute toxicity to fathead minnows of a set of substituted aromatic compounds on using BP-ANN and RBF-ANN method. The correlation coefficients of the prediction model were 0.958 and 0.967. Exptl. results showed: BP-ANN and RFB-ANN were better than the multiple regression methods. The results showed that there was nonlinear relationship between toxicity and the quantum chem. parameters. And 4-tert-Amylphenol (cas: 80-46-6) was used in the research process.

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Formula: C11H16O

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