Author: tianli

Safety of 2,2-Methylenebis(6-tert-butyl-p-cresol)In 2021, Hayeemasae, Nabil;Ismail, Hanafi published 《Application of silane-treated tea waste powder as a potential filler for natural rubber composites》. 《BioResources》published the findings. The article contains the following contents:

The aim of this work was to develop sustainable composites based on natural rubber (NR) and tea waste (TW) composites. The main concern was the compatibility mismatch between NR and TW. The presence of polar groups in the TW contributes to the weak interaction between relatively hydrophobic NR and TW. Therefore, silane coupling agent was introduced to enhance the properties of the composites. Treating the TW by silane coupling agent greatly influenced the overall properties of the composites. It speeded up the curing process due to its ability to reduce possible adsorption of accelerator by TW. Better interaction between TW and rubber matrix was clearly observed as evidenced by the maximum torque (M_H) and tensile properties of the composites. Such findings can be verified by the Q_f/Q_g values, indicating better rubber-filler interaction when silane was used. Moreover, scanning electron microscope (SEM) images also provided some evidence related to the tensile properties observed It can be concluded that the new composite based on NR and TW was successfully prepared with the contribution of a silane coupling agent. And 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) was used in the research process.

Safety of 2,2-Methylenebis(6-tert-butyl-p-cresol)2,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

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Related Products of 80-46-6《Study on capillary GC fingerprint of Guominxing Biyan Granules》 was published in 2016. The authors were Hu, Jun-hua;Ren, Ji-hua;Wang, Xue;Li, Jia-chun;Huang, Wen-zhe;Wang, Zhen-zhong;Xiao, Wei, and the article was included in《Zhongcaoyao》. The author mentioned the following in the article:

Objective To establish the capillary GC fingerprint of Guominxing Biyan Granules and give a new method for quality control. Methods The capillary GC was used. The ingredients of common peaks were analyzed by FID and MS. The HP-5 Ph Me Siloxane (30 m×0.32 mm, 0.25 μm) was used for capillary column. The chromatog. conditions were as follows: the temperature of inlet was 200 degree C in splitless sampling, the detector temperature was 250 degree C, the column initial temperature was 50 degree C, 3 degree C/min rose to 140 degree C, keeping 2 min and 10 degree C/min rose to 200 degree C, keeping 2 min. Results Capillary GC fingerprint of volatile oil in Allergic Rhinitis Particles was established. Twelve peaks were selected as the fingerprint peaks of Allergic Rhinitis Particles. The ingredients of common peaks were designated by GC-MS. The similarity between the fingerprint of 10 batches of Allergic Rhinitis Particles Samples were 0.90. Conclusion The established capillary GC fingerprint has desirable precision, reproducibility, and stability, and can be applied to the quality control of Guominxing Biyan Granules.4-tert-Amylphenol (cas: 80-46-6) were involved in the experimental procedure.

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group. Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble.Related Products of 80-46-6

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Formula: C15H16O《Accelerated SuFEx Click Chemistry For Modular Synthesis》 was published in 2022. The authors were Smedley, Christopher J.;Homer, Joshua A.;Gialelis, Timothy L.;Barrow, Andrew S.;Koelln, Rebecca A.;Moses, John E., and the article was included in《Angewandte Chemie, International Edition》. The author mentioned the following in the article:

The development of accelerated SuFEx click chem. (ASCC), an improved SuFEx method for the efficient and catalytic coupling of aryl and alkyl alcs. with a range of SuFExable hubs was reported. Barton’s hindered guanidine base (2-tert-butyl-1,1,3,3-tetramethylguanidine; BTMG) was demonstrated as a superb SuFEx catalyst, when used in synergy with silicon additive hexamethyldisilazane (HMDS), yielded stable S-O bond linkages in a single step; often within minutes. The powerful combination of BTMG and HMDS reagents allowed for catalyst loadings as low as 1.0 mol % and in congruence with click-principles, provided a scalable method that is safe, efficient and practical for modular synthesis. ASSC expands the number of accessible SuFEx products and will find significant application in organic synthesis, medicinal chem., chem. biol., and materials science. And 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) was used in the research process.

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Formula: C15H16O 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

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Pan, Liangkun;Ke, Zhihai;Yeung, Ying-Yeung published 《Lewis Base Catalyzed Dioxygenation of Olefins with Hypervalent Iodine Reagents》. The research results were published in《Organic Letters》 in 2021.Category: alcohols-buliding-blocks The article conveys some information:

1,2-Diols were extremely useful building blocks in organic synthesis. Hypervalent iodine reagents were useful for the vicinal dihydroxylation of olefins to gave 1,2-diols under metal-free conditions, but strongly acidic promoters were often required. Herein, synthesis of 1,2-diols R¹CHOHCHOHR² [R¹ = n-hexyl, Ph, Bn, etc.; R² = H, Ph] and acetals R³CH₂CH(OMe)₂ [R³ = Ph, 4-MeOC₆H₄, (4-acetoxyphenyl), etc.] via catalytic vicinal dioxygenation of olefins with hypervalent iodine reagents using Lewis bases as catalysts was reported. The conditions were mild and compatible with various functional groups. To complete the study, the researchers used rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) .

Desymmetrization of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas:579-43-1 Category: alcohols-buliding-blocks) using chiral phosphine catalyst has been reported. Conversion of meso-hydrobenzoin to trans-stillbene oxide by treatment with an aryl sulfonyl chloride and aqueous sodium hydroxide has been reported.

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Hu, Junjie;Liu, Jinhuan;Lv, Xiaomei;Yu, Lili;Lan, Shanhong;Li, Yanliang;Yang, Yan published 《Assessment of epigenotoxic profiles of Dongjiang River: A comprehensive of chemical analysis, in vitro bioassay and in silico approach》 in 2021. The article was appeared in 《Environmental Pollution (Oxford, United Kingdom)》. They have made some progress in their research.Product Details of 140-66-9 The article mentions the following:

This research explored the occurrence, epigenetic toxic profiling and main toxic pollutants of POPs in surface water of Dongjiang River, southern China. The concentrations of selected POPs including polycyclic aromatic hydrocarbons (PAHs), endocrine disrupting chems. (EDCs), phthalate esters (PAEs) and polybrominated di-Ph ethers (PBDEs) of surface water from 18 sites were investigated. ∑16PAHs and ∑4EDCs were at a moderate level, while ∑6PAEs and ∑6PBDEs had low pollution levels. PAHs, EDCs and PAEs showed higher concentrations in dry season than those in wet season, and the loading of selected POPs in tributaries was higher than those in mainstream due to intensive manufactures and lower runoff volume Moreover, activities of DNA methyltransferase (DNMT)1, histone deacetylase (HDAC2, HDAC8) were confirmed to be sensitive indicators for epigenetic toxicity. The DNMT1-mediated epigenetic equivalency toxicity of organic extracts in Dongjiang River were more serious than those of HDAC2 and HDAC8. Correlation anal. shown binding affinity between POPs and DNMT1, HDAC2 and HDAC8 could be regarded as toxic equivalency factors. Risk assessment suggested that 4-nonylphenol and bisphenol A were the largest contributors to epigenetic risk. This study is the first attempt to quantify epigenetic toxicity and epigenetic risk evaluation of river water.4-tert-Octylphenol (cas: 140-66-9) were involved in the experimental procedure.

4-tert-Octylphenol(cas: 140-66-9) has been used as a reference standard for the determination of the analyte in water samples using ultra-high-performance liquid chromatography/tandem mass spectrometry (UHPLC/MS/MS).Product Details of 140-66-9

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Safety of rel-(1R,2S)-1,2-Diphenylethane-1,2-diolIn 2020, Chatterjee, Gourav;Shadangi, Krushna Prasad;Mohanty, Kaustubha published 《Effect of Catalyst Bed Height on the Yield and Composition of Non-edible Seed Pyrolytic Oil》. 《Waste and Biomass Valorization》published the findings. The article contains the following contents:

The thermal and catalytic vapor cracking of non-edible seed such as Kassod seed was studied in a fixed bed reactor. The effect of temperature on the yield of pyrolytic liquid was observed from thermal pyrolysis and the optimum temperature was determined At the optimum temperature catalytic vapor cracking using CaO was studied by varying the catalyst loading as well as the bed height. The effect of catalyst loading and bed height on the yield, fuel properties, distillation temperature and composition of pyrolytic oil were determined The results confirmed that thermal pyrolysis of Kassod seed at 550°C yielded 50.21 wt% of pyrolytic liquid containing 39.86 wt% and 10.35 wt% organic and aqueous phase resp. The highest yield of pyrolytic oil (organic liquid) was 31.2 wt% and 22.95 wt% obtained at 2 wt% loading of catalyst at a bed height of 8.5 cm and 11.1 cm resp. The effect of catalytic vapor cracking with the variation in the bed height on the fuel properties confirmed that increasing the catalyst bed height raised the basicity of the pyrolytic oil. The gross calorific value of the oil increased at higher wt% of catalyst loading and were better at the catalyst bed height of 11.1 cm. The catalytic vapor cracking enhanced the fuel properties of the pyrolytic oil by the formation of more volatile components in the pyrolytic oil. The variation in the composition of the pyrolytic oil with and without catalyst was confirmed from the GC-MS anal.rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) were involved in the experimental procedure.

Desymmetrization of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas:579-43-1 Safety of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol) using chiral phosphine catalyst has been reported. Conversion of meso-hydrobenzoin to trans-stillbene oxide by treatment with an aryl sulfonyl chloride and aqueous sodium hydroxide has been reported.

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Reference of 2-Hexyl-1-decanol《Chemosensory approach supported-analysis of wintering radishes produced in Jeju island by different processing methods》 was published in 2021. The authors were Hong, Seong Jun;Boo, Chang Guk;Lee, Jookyeong;Hur, Seong Wook;Jo, Seong Min;Jeong, Hyangyeon;Yoon, Sojeong;Lee, Youngseung;Park, Sung-Soo;Shin, Eui-Cheol, and the article was included in《Food Science and Biotechnology》. The author mentioned the following in the article:

The purpose of this study was to investigate sensory characteristics in radishes, processed through different methods, using chemosensory-assisted instruments. For electronic tongue (E-tongue) anal., freeze-dried radish was high in the sensor values of sourness, umami, and sweetness, however, the saltiness was the lowest. In particular, the sensor values of taste freeze-dried radish have changed more than that of thermally processed radishes. Unlike the results of E-tongue, volatiles of freeze-dried radish have changed less than that of thermally processed radishes. In detail, amounts of sulfur-containing compound (thiophene) in freeze-dried radish were relatively higher than thermally processed radishes by an electronic nose. For gas chromatog.-mass spectrometry and GC-olfactometry, the amount of sulfur-containing compounds in freeze-dried radish were also relatively higher than thermally processed radishes, and odor active compounds were also high in freeze-dried radish.2-Hexyl-1-decanol (cas: 2425-77-6) were involved in the experimental procedure.

2-Hexyl-1-decanol(cas: 2425-77-6) is a fatty acid that is found in the essential oils of plants and has been shown to have fungicidal properties.Reference of 2-Hexyl-1-decanol It has also been shown to inhibit the growth of Candida glabrata when used as a cationic surfactant.

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Guan, Honghao;Sun, Shutao;Mao, Ying;Chen, Lei;Lu, Ran;Huang, Jiancheng;Liu, Lei published 《Iron(II)-Catalyzed Site-Selective Functionalization of Unactivated C(sp³)-H Bonds Guided by Alkoxyl Radicals》 in 2018. The article was appeared in 《Angewandte Chemie, International Edition》. They have made some progress in their research.Recommanded Product: 78-69-3 The article mentions the following:

An alkoxyl radical guided strategy for site-selective functionalization of unactivated methylene and methine C-H bonds enabled by an Fe^II-catalyzed redox process is described. The mild, expeditious, and modular protocol allows efficient remote aliphatic fluorination, chlorination, amination, and alkynylation of structurally and electronically varied primary, secondary, and tertiary hydroperoxides with excellent functional-group tolerance. The application for one-pot 1,4-hydroxyl functionalization of non-oxygenated alkane substrates initiated by aerobic C-H oxygenation is also demonstrated. The experimental procedure involved many compounds, such as 3,7-Dimethyloctan-3-ol (cas: 78-69-3) .

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Recommanded Product: 78-69-3 Metabolite observed in cancer metabolism. It has a role as a human metabolite.

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Huang, Shiyang;McDonald, James A.;Kuchel, Rhiannon P.;Khan, Stuart J.;Leslie, Greg;Tang, Chuyang Y.;Mansouri, Jaleh;Fane, Anthony G. published 《Surface modification of nanofiltration membranes to improve the removal of organic micropollutants: Linking membrane characteristics to solute transmission》 in 2021. The article was appeared in 《Water Research》. They have made some progress in their research.HPLC of Formula: 140-66-9 The article mentions the following:

Surface modification of nanofiltration (NF) membranes has great potential to improve the removal of organic micropollutants (OMs) by NF membranes. This study used polydopamine (PDA) as a model coating to comprehensively link the changes in membrane properties with the changes in transmission of 34 OMs. The membrane characterization demonstrated that a thicker, denser, and more hydrophilic PDA coating can be achieved by increasing the PDA deposition time from 0.5 to 4 h. Overall, the transmissions of target OMs were reduced by PDA-coated NF membranes compared to unmodified NF membranes. The neutral hydrophobic compounds showed lower transmissions for longer PDA coating (PDA4), while the neutral hydrophilic compounds tended to show lower transmissions for shorter PDA coating (PDA0.5). To explain this, competing effects provided by the PDA coatings are proposed including sealing defects, inducing cake-enhanced concentration polarization in the coating layer for neutral hydrophilic compounds, and weakened hydrophobic adsorption for neutral hydrophobic compounds For charged compounds, PDA4 with the greatest neg. charge among the PDA-coated membranes showed the lowest transmission. Depending on the mol. size and hydrophilicity of the compounds, the transmission of OMs by the PDA4 coating could be reduced by 70% with only a 26.4% decline in water permeance. The correlations and mechanistic insights provided by this work are highly useful for designing membranes with sp. surface properties via surface modification to improve the removal of OMs without compromising water production To complete the study, the researchers used 4-tert-Octylphenol (cas: 140-66-9) .

4-tert-Octylphenol(cas: 140-66-9) is a common environmental pollutant showing weak estrogenic effects.HPLC of Formula: 140-66-9 It has been shown to cause harm to vertebrate male reproductive systems.

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Aszyk, Justyna;Wozniak, Mateusz Kacper;Kubica, Pawel;Kot-Wasik, Agata;Namiesnik, Jacek;Wasik, Andrzej published 《Comprehensive determination of flavouring additives and nicotine in e-cigarette refill solutions. Part II: Gas-chromatography-mass spectrometry analysis》. The research results were published in《Journal of Chromatography A》 in 2017.HPLC of Formula: 78-69-3 The article conveys some information:

Flavouring compounds are an essential part of e-liquid products for cigarettes. In general, they are regarded as safe for ingestion, but they may have unrecognized risks when they are inhaled. In some cases, manufactures do not currently abide by the Tobacco Products Directive (2014/40/EU) and do not declare the detailed contents of e-liquids on their labels. To help evaluate the health impact of flavouring substances, there is a need for comprehensive approaches to determine their concentrations in e-liquids For this purpose, a GC-EI-MS method was developed and validated for the simultaneous determination of 46 commonly used flavor additives in e-liquids The proposed method performed well in terms of the key validation parameters: accuracy (84-113%), inter-/intra-day precision: 0.1-10% and 1-11%, resp., and sensitivity (limit of detection: 3-87 ng/mL). The sample preparation step was based on a simple “dilute & shoot” approach. This study is a complementary method to the LC-MS/MS procedure described in Part I. Both approaches are suitable for the comprehensive determination of 88 flavouring compounds and nicotine and can be used as tools for the rapid evaluation of the quality and safety of e-cigarette products.3,7-Dimethyloctan-3-ol (cas: 78-69-3) were involved in the experimental procedure.

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.HPLC of Formula: 78-69-3 Metabolite observed in cancer metabolism. It has a role as a human metabolite.

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