tianli, Author at Alcohols-buliding-blocks

Pamukcu, Rifat’s team published research in Gastroenterology in 1988-10-31 | 6054-98-4

Gastroenterology published new progress about Colon. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Synthetic Route of 6054-98-4.

Pamukcu, Rifat; Hanauer, Stephen B.; Chang, Eugene B. published the artcile< Effect of disodium azodisalicylate on electrolyte transport in rabbit ileum and colon in vitro. Comparison with sulfasalazine and 5-aminosalicyclic acid>, Synthetic Route of 6054-98-4, the main research area is azodisalicylate electrolyte transport intestine; diarrhea azodisalicylate.

Azodisalicylate, used to treat ulcerative colitis, causes diarrhea in ≤12.5% of patients. The in vitro effects of azodisalicylate, sulfasalazine, and 5-aminosalicylic acid on rabbit intestinal electrolyte transport were studied. Distal ileal mucosae mounted in Ussing chambers were exposed to varying concentrations of the drugs. Mucosal addition of azodisalicylate (>5 mM) caused the greatest anion-dependent increase in short-circuit current of 83 μA/cm2. Isotope flux measurements suggest that azodisalicylate may stimulate predominantly electrogenic HCO3- secretion and induce net NaCl secretion. In contrast, serosal addition of azodisalicylate and sulfasalazine decreased short-circuit current, and 5-aminosalicylic acid had no effect. Azodisalicylate had no effect on ion transport in distal colon. The effects of azodisalicylate in ileum were not inhibited with piroxicam (an inhibitor of cyclooxygenase). Mucosal cAMP and cGMP levels were unchanged after ileal exposure to azodisalicylate. Azodisalicylate appears to be a mechanistically unusual secretagogue, possibly explaining the increased incidence of diarrhea seen in patients taking the drug.

Gastroenterology published new progress about Colon. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Synthetic Route of 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zu, Han’s team published research in Microbial Cell Factories in 2020-12-31 | 6290-03-5

Microbial Cell Factories published new progress about Candida parapsilosis. 6290-03-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H10O2, Computed Properties of 6290-03-5.

Zu, Han; Gu, Jie; Zhang, Hui; Fan, Anwen; Nie, Yao; Xu, Yan published the artcile< Highly enantioselective synthesis of (R)-1,3-butanediol via deracemization of the corresponding racemate by a whole-cell stereoinverting cascade system>, Computed Properties of 6290-03-5, the main research area is R13 butanediol deracemization racemate stereoinverting cascade system; (R)-1,3-butanediol; Oxidation–reduction cascade; Racemate; Stereoselectivity; Whole-cell catalysis.

Abstract: Background: Deracemization, the transformation of the racemate into a single stereoisomeric product in 100% theor. yield, is an appealing but challenging option for the asym. synthesis of optically pure chiral compounds as important pharmaceutical intermediates. To enhance the synthesis of (R)-1,3-butanediol from the corresponding low-cost racemate with minimal substrate waste, we designed a stereoinverting cascade deracemization route and constructed the cascade reaction for the total conversion of racemic 1,3-butanediol into its (R)-enantiomer. This cascade reaction consisted of the absolutely enantioselective oxidation of (S)-1,3-butanediol by Candida parapsilosis QC-76 and the subsequent asym. reduction of the intermediate 4-hydroxy-2-butanone to (R)-1,3-butanediol by Pichia kudriavzevii QC-1. Results: The key reaction conditions including choice of cosubstrate, pH, temperature, and rotation speed were optimized systematically and determined as follows: adding acetone as the cosubstrate at pH 8.0, a temperature of 30°C, and rotation speed of 250 rpm for the first oxidation process; in the next reduction process, the optimal conditions were: adding glucose as the cosubstrate at pH 8.0, a temperature of 35°C, and rotation speed of 200 rpm. Conclusions: The step-by-step cascade reaction efficiently produced (R)-1,3-butanediol from the racemate by biosynthesis and shows promising application prospects.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fukudome, Chiaki’s team published research in Scientia Horticulturae (Amsterdam, Netherlands) in 2022-07-27 | 87-73-0

Scientia Horticulturae (Amsterdam, Netherlands) published new progress about Anthesis. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Application of C6H10O8.

Fukudome, Chiaki; Takisawa, Rihito; Nakano, Ryohei; Kusano, Miyako; Kobayashi, Makoto; Motoki, Ko; Nishimura, Kazusa; Nakazaki, Tetsuya published the artcile< Analysis of mechanism regulating high total soluble solid content in the parthenocarpic tomato fruit induced by pat-k gene>, Application of C6H10O8, the main research area is parthenocarpic tomato fruit soluble solid patk gene expression.

Total soluble solid (TSS) in tomatoes is an important trait that affects consumer’s preference. Previous studies have observed high TSS content in parthenocarpic tomato fruits induced by a parthenocarpic gene, pat-k. However, the mechanisms regulating high TSS content remain unknown. Hence, we have investigated the water content, metabolites involved with high TSS content, and gene expression related to starch synthesis in tomato fruits to elucidate the mechanism regulating high TSS content. We have found that independent of fruit water content, parthenocarpic fruits induced by pat-k had higher TSS content than pollinated fruits on Pat-k homozygous plants. Addnl., metabolome anal. of mature fruits has revealed that fructose influenced the difference in TSS content between pollinated fruits on Pat-k homozygous plants and the parthenocarpic fruits on pat-k homozygous plants. Furthermore, high performance liquid chromatog. (HPLC) anal. showed that not only fructose contents but also glucose contents were higher in the parthenocarpic fruits on pat-k homozygous plants than pollinated fruits on Pat-k homozygous plants, suggesting that increases in these sugar contents influenced the high TSS content in the pat-k-induced parthenocarpic fruits. We also have found that parthenocarpic fruits had high starch content and upregulated Sus4, which is involved in starch synthesis, during the early stages of fruit development. Since previous reports have suggested that high starch content during the early stages of fruit development attributed to high sugar content in mature tomato fruits, our results suggest that high accumulation of starch in young fruits could be involved with high TSS content in parthenocarpic fruits induced by pat-k.

Scientia Horticulturae (Amsterdam, Netherlands) published new progress about Anthesis. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Application of C6H10O8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Asgary, Sedigheh’s team published research in Reviews in Endocrine & Metabolic Disorders in 2019-06-30 | 501-36-0

Reviews in Endocrine & Metabolic Disorders published new progress about Body weight. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Safety of (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.

Asgary, Sedigheh; Karimi, Raheleh; Momtaz, Saeideh; Naseri, Rozita; Farzaei, Mohammad Hosein published the artcile< Effect of resveratrol on metabolic syndrome components: A systematic review and meta-analysis>, Safety of (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is metabolic syndrome component resveratrol effect; Meta-analysis; Metabolic syndrome; Metabolism; Resveratrol.

This paper summarized 16 controlled studies and evaluated the correlation of resveratrol supplementation with metabolic parameters such as the body weight, waist circumference (WC), systolic blood pressure (sbp), HDL, total cholesterol, triglyceride and glucose levels. This meta-anal. was carried out to determine the association between the resveratrol intake with metabolic parameters in metabolic syndrome patients. PubMed, Scopus, Cochrane and Google Scholar were searched from inception to Dec. 2018 using relevant keywords. All articles were independently reviewed by two authors using predetermined selection criteria. We have selected the studies that investigated the effects of resveratrol on metabolic parameters. Of 16 studies, 10 were performed on human subjects, and in 6 studies animal models were used. Standard mean difference (SMD) with 95% confidence interval were determined using Der Simonian and Laird random-effects modeling, when there was a significant heterogeneity between studies. Funnel plot and Egger′s test were conducted to examine the risk of publication bias. Pooled effect sizes in human studies indicated a significant impact of resveratrol supplementation on glucose level [-1.73 (-2.99, -0.47); p = 0.007] and WC [-1.73 (-2.79, -0.67); p = 0.001] compared with the control group. Also combining the results of studies on rat samples (n = 6), indicated significant effect of resveratrol on decreasing weight [-22.95 (-44.74, -1.17); p = 0.04], TGs [-6.76 (-11.10, -2.42); p = 0.001], sbp [-7.30 (-12.48, -2.13); p = 0.006], and it can influence significantly on increasing HDL level (4.75 (1.87, 7.63); p = 0.001). However, resveratrol was not significantly effective on total cholesterol in both samples. The results of subgroup anal. of human studies showed that resveratrol has significant effect on metabolic parameters (glucose level and WC) at the dosage of > 500 mg and with long-term interventions ≥ 10 wk. Administration of resveratrol can meaningfully reduce the BW, WC, TGs, and glucose level, also it can increase HDL, but not total cholesterol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Herron, Josi M’s team published research in Chemical Research in Toxicology in 2021-05-17 | 434-16-2

Chemical Research in Toxicology published new progress about Apoptosis. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, SDS of cas: 434-16-2.

Herron, Josi M.; Tomita, Hideaki; White, Collin C.; Kavanagh, Terrance J.; Xu, Libin published the artcile< Benzalkonium Chloride Disinfectants Induce Apoptosis, Inhibit Proliferation, and Activate the Integrated Stress Response in a 3-D in Vitro Model of Neurodevelopment>, SDS of cas: 434-16-2, the main research area is benzalkonium chloride neural stem cell neurosphere apoptosis proliferation stress.

We previously found that the widely used disinfectants, benzalkonium chlorides (BACs), alter cholesterol and lipid homeostasis in neuronal cell lines and in neonatal mouse brains. Here, we investigate the effects of BACs on neurospheres, an in vitro three-dimensional model of neurodevelopment. Neurospheres cultured from mouse embryonic neural progenitor cells (NPCs) were exposed to increasing concentrations (from 1 to 100 nM) of a short-chain BAC (BAC C12), a long-chain BAC (BAC C16), and AY9944 (a known DHCR7 inhibitor). We found that the sizes of neurospheres were decreased by both BACs but not by AY9944. Furthermore, we observed potent inhibition of cholesterol biosynthesis at the step of DHCR7 by BAC C12 but not by BAC C16, suggesting that cholesterol biosynthesis inhibition is not responsible for the observed reduction in neurosphere growth. By using immunostaining and cell cycle anal., we found that both BACs induced apoptosis and decreased proliferation of NPCs. To explore the mechanisms underlying their effect on neurosphere growth, we carried out RNA sequencing on neurospheres exposed to each BAC at 50 nM for 24 h, which revealed the activation of the integrated stress response by both BACs. Overall, these results suggest that BACs affect neurodevelopment by inducing the integrated stress response in a manner independent of their effects on cholesterol biosynthesis.

Chemical Research in Toxicology published new progress about Apoptosis. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, SDS of cas: 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Arab, Leila’s team published research in Planta in 2019-02-28 | 87-73-0

Planta published new progress about Aromatic amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Recommanded Product: D-Glucosaccharic acid.

Arab, Leila; Seegmueller, Stefan; Kreuzwieser, Juergen; Eiblmeier, Monika; Rennenberg, Heinz published the artcile< Atmospheric pCO2 impacts leaf structural and physiological traits in Quercus petraea seedlings>, Recommanded Product: D-Glucosaccharic acid, the main research area is Quercus seedling leaf structural physiol trait oxidative stress ROS; Amino acid; Carbohydrate; Carbon dioxide; Cellulose; Glutathione reductase; Lignin.

Sessile oak (Quercus petraea Liebl.) was grown for ca. half a year from seeds at ambient control (525 ppm), 750, 900, and 1000 ppm atm. pCO2 under controlled conditions. Increasing pCO2 enhanced biomass production, modified the cell wall composition of the leaves in favor of cellulose at the expense of lignin, and enhanced the foliar non-structural carbohydrate level, in particular the sucrose content; as well as total N content of leaves by increased levels of all major N fractions, i.e., soluble proteins, total amino acids, and structural N. The enhanced total amino acid level was largely due to 2-ketoglutarate and oxalo acetate-derived compounds Increasing pCO2 alleviated oxidative stress in the leaves as indicated by reduced H2O2 contents. High in vitro glutathione reductase activity at reduced H2O2 contents suggests enhanced ROS scavenging, but increased lipid peroxidation may also have contributed, as indicated by a neg. correlation between malone dialdehyde and H2O2 contents. Almost all these effects were at least partially reversed, when pCO2 exceeded 750 or 900 ppm. Apparently, the interaction of atm. pCO2 with leaf structural and physiol. traits of Q. petraea seedlings is characterized by a dynamic response depending on the pCO2 level.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yagishita, Mayuko et al. published new experimental results with the assistance of cas: 80-46-6

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Recommanded Product: 80-46-6

Yagishita, Mayuko;Kubo, Takuya;Otsuka, Koji;Nakayama, Shoji F.;Nakajima, Daisuke published 《Development of a database strategy based on liquid chromatography-quadrupole time-of-flight mass spectrometry for the screening of 75 estrogenic chemicals from treated sewage effluent》 in 2021. The article was appeared in 《Separation Science plus》. They have made some progress in their research.Recommanded Product: 80-46-6 The article mentions the following:

The detection of endocrine disrupting chems. such as estrogenic compounds in environmental samples is a hot topic of research. In this context, this study describes a new screening method for 75 estrogenic chems. from environmental water samples based on two databases built from the data obtained from liquid chromatog. with quadrupole time-of-flight mass spectrometry. A first database, named ”DATABASE I,” is constructed from the retention time and m/z of mol. weight-related ions with measured accurate mass of the 75 estrogenic chems. A second database, ”DATABASE II,” includes the collision-induced fragmentation spectra with measured accurate mass of the compounds These databases are resp. applied for a rough screening and precise identification of the estrogenic chems. of sewage effluents as follows: Step (1): A treated sewage effluent sample is subjected to anal. using the time-of-flight scan mode, and a rough screening using DATABASE I is performed. Step (2): The obtained candidate estrogenic chems. by step 1 are measured using the targeted tandem mass spectrometry mode in which collision energy dependence fragmentations of them are induced. The resulting fragmentation mass spectra are screened using DATABASE II. The application of these two databases improved the accuracy in the identification of estrogenic chems., reducing the risk of misidentification.4-tert-Amylphenol (cas: 80-46-6) were involved in the experimental procedure.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cas: 2425-77-6 was involved in experiment | Nature Energy 2021

2-Hexyl-1-decanol(cas: 2425-77-6) has been shown to inhibit the growth of b16 mouse melanoma cells, suggesting it may be useful for treating skin cancer.Category: alcohols-buliding-blocks This fatty acid also has transport properties and can form hydrogen bonds with other molecules.

Li, Chao;Zhou, Jiadong;Song, Jiali;Xu, Jinqiu;Zhang, Huotian;Zhang, Xuning;Guo, Jing;Zhu, Lei;Wei, Donghui;Han, Guangchao;Min, Jie;Zhang, Yuan;Xie, Zengqi;Yi, Yuanping;Yan, He;Gao, Feng;Liu, Feng;Sun, Yanming published 《Non-fullerene acceptors with branched side chains and improved molecular packing to exceed 18% efficiency in organic solar cells》. The research results were published in《Nature Energy》 in 2021.Category: alcohols-buliding-blocks The article conveys some information:

Mol. design of non-fullerene acceptors is of vital importance for high-efficiency organic solar cells. The branched alkyl chain modification is often regarded as a counter-intuitive approach, as it may introduce an undesirable steric hindrance that reduces charge transport in non-fullerene acceptors. Here we show the design and synthesis of a highly efficient non-fullerene acceptor family by substituting the beta position of the thiophene unit on a Y6-based dithienothiophen[3,2-b]-pyrrolobenzothiadiazole core with branched alkyl chains. It was found that such a modification to a different alkyl chain length could completely change the mol. packing behavior of non-fullerene acceptors, leading to improved structural order and charge transport in thin films. An unprecedented efficiency of 18.32% (certified value of 17.9%) with a fill factor of 81.5% is achieved for single-junction organic solar cells. This work reveals the importance of the branched alkyl chain topol. in tuning the mol. packing and blend morphol., which leads to improved organic photovoltaic performance.2-Hexyl-1-decanol (cas: 2425-77-6) were involved in the experimental procedure.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Learn more about cas: 148-51-6 | Cancer Research 1956

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 Name: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride) is a strong antagonist of vitamin B6. Deoxypyridoxine hydrochloride has been used as an analytical reference standard for the quantification of the analyte in food samples using high performance liquid chromatography.

Scott, Kenneth G.;Daniels, Marie B. published 《The relation between iodine-131 metabolism, tumor growth, and regression》 in 1956. The article was appeared in 《Cancer Research》. They have made some progress in their research.Name: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride The article mentions the following:

Ability of tumors to alter the normal metabolic pathway of I¹³¹ and compounds labeled with it (iodide-trapping syndrome) (I) is characterized by higher than normal retention of I¹³¹ by skin, muscle, gastrointestinal tract, and plasma, and a lower than normal thyroid uptake and urinary excretion of I¹³¹. I was elicited in rats by isografts and homografts of a transmissible fibrosarcoma, but not by homoiografts (which regressed after 5-7 days of growth). The data suggest that local and systemic I parallels progressive tumor growth and is absent in tumor implants destined to regress. To complete the study, the researchers used 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) .

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cas: 140-66-9 was involved in experiment | Journal of Environmental Chemical Engineering 2021

4-tert-Octylphenol(cas: 140-66-9) has been used as a reference standard for the determination of the analyte in water samples using ultra-high-performance liquid chromatography/tandem mass spectrometry (UHPLC/MS/MS).Recommanded Product: 140-66-9

Lopez-Velazquez, Khirbet;Guzman-Mar, Jorge L.;Montalvo-Herrera, Teresa J.;Mendiola-Alvarez, Sandra Y.;Villanueva-Rodriguez, Minerva published 《Efficient photocatalytic removal of four endocrine-disrupting compounds using N-doped BiOBr catalyst under UV-Vis radiation》. The research results were published in《Journal of Environmental Chemical Engineering》 in 2021.Recommanded Product: 140-66-9 The article conveys some information:

A mixture of four endocrine-disrupting compounds (EDCs [17β-estradiol, 17α-ethinylestradiol, bisphenol A, and 4-tert-octylphenol]) was removed from aqueous solution using the N-doped BiOBr semiconductor (N = 10 and 20 wt%) easily prepared via microwave-assisted solvothermal synthesis. The N₂₀BiOBr semiconductor showed the highest photocatalytic activity achieving the complete degradation of the EDCs, and 53.5% of mineralization in 240 min. Moreover, the toxicity of the mixture was reduced to moderate levels (from 90 to 47.5% of inhibition of the bioluminescence of V. fischeri). The high efficiency of N₂₀BiOBr for EDCs removal was attributed to the increase of the sp. surface area and the effective separation of photogenerated charges by effect of N incorporation. The main photogenerated species involved in the degradation of the pollutants were the superoxide radicals (O^·-2) and photo-holes (h+), and a possible photocatalytic activation mechanism was proposed where suggests the active participation of oxygen vacancies. Addnl., N₂₀BiOBr demonstrated excellent chem. and photocatalytic stability after four reuse cycles. Therefore, doping BiOBr with N constitutes a suitable and efficient strategy for the photocatalytic removal of a mixture of hazardous pollutants such as EDCs in water, with potential application in tertiary decontamination processes. The experimental procedure involved many compounds, such as 4-tert-Octylphenol (cas: 140-66-9) .

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts