Author: tianli

Chen, Yueting; Weng, Yuanyuan; Zhou, Min; Meng, Yiyu; Liu, Jialu; Yang, Lin; Zuo, Zhaojiang published the artcile< Linalool- and α-terpineol-induced programmed cell death in Chlamydomonas reinhardtii>, SDS of cas: 78-70-6, the main research area is Chlamydomonas programmed cell death linalool alpha terpineol algaecide; Algaecide; Chlamydomonas reinhardtii; Linalool; Programmed cell death; α-Terpineol.

Plant allelochems. effectively inhibit and/ or control algal growth, and have potential to use as algaecide. To uncover the lethal mechanism of 2 anti-algal compounds linalool and α-terpineol identified from Cinnamomum camphora extracts, and promote their development as algaecide, the H2O2 production, photosynthetic abilities, H2O2 content burst in linalool treatment at 0.5 h and in α-terpineol treatment at 1 h, with increases of 2.7 folds and 1.3 folds, resp., compared to that at 0 h. The photosynthetic pigments gradually degraded, and Fv/Fm gradually declined to zero, indicating that the cell death was not a necrosis due to the gradual disappearance of physiol. process. In C. reinhardtii cells, the caspase-9-like and caspase-3-like were activated in the treatments with the 2 compounds for 1 h. With prolonging the treatment time, the fluorescent intensity of the cell nucleuses stained by DAPI gradually enhanced and then faded, and the genomic DNA isolated from the cells gradually degraded. These hallmarks indicated that the death of C. reinhardtii cells in linalool and α-terpineol treatments was a (PCD) triggered by the increased reactive oxygen species (ROS). Compared to α-terpineol treatment, linalool treatment showed stronger promoting effects on PCD at the same time point, which may be caused by the higher ROS content inducing higher caspase-9-like and caspase-3-like activities in a short time.

Ecotoxicology and Environmental Safety published new progress about Algicides. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, SDS of cas: 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hu, Zhengyu; Zhou, Hongli; Li, Yaping; Wu, Meifu; Yu, Ming; Sun, Xinshun published the artcile< Optimized purification process of polysaccharides from Carex meyeriana Kunth by macroporous resin, its characterization and immunomodulatory activity>, Electric Literature of 3458-28-4, the main research area is Carex polysaccharide macroporous resin purification immunomodulation; Carex meyeriana Kunth; Polysaccharides; Purification.

The anal. hierarchy process (AHP) combined with response surface methodol. (RSM) was used to optimize the purification conditions of crude polysaccharides from Carex meyeriana Kunth (CMKP) by macroporous resin. The optimal purification conditions as follows: elution volume of 2.74 BV, flow rate of 1.88 BV/h, and sample concentration of 2.10 mg/mL. Under the optimal conditions, the purification comprehensive score was 63.59 ± 1.56% (n = 3), which was agreed closely to the predicted value (64.02%). Two fractions of polysaccharides (CMKP-1 and CMKP-2) were obtained using a DEAE-52 column. Fourier Transform IR (FTIR) spectroscopy spectra revealed the general characteristic absorption peaks of CMKP-1 and CMKP-2. Congo-red test indicated that CMKP-1 and CMKP-2 have triple helix conformation. CMKP-1 and CMKP-2 were both composed of Man, Rib, Rha, GluA, GalA, Glu, Gal, Xyl, Ara and Fuc in a molar ratio of 8.93:1:4.62:1.41:1.78:10.7:24.69:4.51:15.92:1.27 and 7.85:1:5.05:1.99:3.15:12.47:15.41:1.54:6.91:3.15, resp. The major mol. weight of CMKP-1 and CMKP-2 was 22.30 kDa and 48.10 kDa, resp. Moreover, CMKP-1 and CMKP-2 had immunostimulatory effects on RAW264.7 cells in a certain concentration range. It could be used as potential immunomodulatory agents in medicine or functional food fields.

International Journal of Biological Macromolecules published new progress about Carex meyeriana. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Electric Literature of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

McKay, G.; Kelly, J. C.; McConvey, I. F. published the artcile< The adsorption of pollutants from aqueous effluents using a two-resistance mass-transfer model>, HPLC of Formula: 6054-98-4, the main research area is phenol adsorption wastewater treatment model; dye adsorption wastewater treatment model.

The adsorption of various pollutants, such as PhOH, p-chlorophenol and different dyes, on to activated C and chitin (a high mol. weight polymer obtained from crustacea) was studied in an agitated batch system at a temperature of 18 ± 2°. Two methods were used to predict concentration decay curves and correlate theor. and exptl. data. Both methods are based on external mass transfer and internal diffusion as the controlling mass-transfer resistances. The 1st method is a rapid anal. solution enabling external mass-transfer coefficients and effective diffusivities to be determined, but is restricted to the assumption that a pseudo-anal. isotherm is applicable. The 2nd method, based on a pseudo-anal. solution, is applicable to operating lines and tie lines terminating at any point on the isotherm, but requires longer computational time. Values of mass-transfer coefficients and effective diffusivities are presented for all systems.

Adsorption Science & Technology published new progress about Adsorptive wastewater treatment. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, HPLC of Formula: 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Qi, Xinghao; Zheng, Tingting; Zhou, Junhao; Dong, Yanhong; Zuo, Xia; Li, Xiaoyan; Sun, Hongjian; Fuhr, Olaf; Fenske, Dieter published the artcile< Synthesis and Catalytic Activity of Iron Hydride Ligated with Bidentate N-Heterocyclic Silylenes for Hydroboration of Carbonyl Compounds>, HPLC of Formula: 403-41-8, the main research area is iron silylene amidine supported hydride complex preparation hydroboration catalyst; aldehyde ketone hydroboration pinacolboronate preparation alc iron silylene catalyst; crystal structure iron silylene amidine supported hydride complex; mol structure iron silylene amidine supported hydride complex.

We report the synthesis of a novel bidentate N-heterocyclic silylene (NHSi) ligand, N-(LSi:)-N-methyl-2-pyridinamine (1) (L = PhC(NtBu)2), and the first bischelate disilylene iron hydride I, [(Si,N)(Si,C)Fe(H)(PMe3)] (2, R = tBu), and monosilylene iron hydride, [(Si,C)Fe(H)(PMe3)3] (2′), through Csp2-H activation of the NHSi ligand. Compounds 1 and 2 were fully characterized by spectroscopic methods and single-crystal X-ray diffraction anal. D. functional theory calculations indicated the multiple-bond character of the Fe-Si bonds and the π back-donation from Fe(II) to the Si(II) center. Moreover, the strong donor character of ligand 1 enables 2 to act as an efficient catalyst for the hydroboration reaction of carbonyl compounds at room temperature Chemoselective hydroboration is attained under these conditions. This might be the first example of hydroboration of ketones and aldehydes catalyzed by a silylene hydrido iron complex. A catalytic mechanism was suggested and partially exptl. verified.

Organometallics published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, HPLC of Formula: 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hu, Weichao; Zhao, Yuqing; Yang, Yong; Zhang, Huifang; Ding, Chunbang; Hu, Chao; Zhou, Lijun; Zhang, Zhongwei; Yuan, Shu; Chen, Yanger; Yuan, Ming published the artcile< Microwave-assisted extraction, physicochemical characterization and bioactivity of polysaccharides from Camptotheca acuminata fruits>, Product Details of C6H12O6, the main research area is Camptotheca fruit polysaacharide CAP3 antioxidant immunomodulatory activity; Antioxidant activity; Camptotheca acuminate polysaccharides; Immunomodulatory activity; Microwave-assisted extraction.

Microwave-assisted extraction of polysaccharides from Camptotheca acuminate (CAPs) was optimized by response surface methodol. The optimal parameters were as follows: microwave power, 600 W; liquid-solid ratio, 40:1 g/mL; extraction time, 14 min; and extraction temperature, 70 °C. Under these conditions, the yield of CAPs reached up to 8.61%. CAP-3, an acidic polysaccharide with a mol. weight of 121.34 kDa, was separated and purified from CAPs, which was only composed of glucose and mannose. CAP-3 exhibited strong antioxidant activity against DPPH (IC50: 0.78 mg/mL), hydroxyl radicals (IC50: 0.84 mg/mL) and also showed synergistic antioxidative effect with ascorbic acid in vitro. Meanwhile, CAP-3 could protect plasmid DNA from oxidative damage. Moreover, CAP-3 could improve immunomodulatory activity of RAW264.7 cells through promoting the phagocytosis and nitric oxide release. Therefore, CAP-3 had a strong potential in functional food, pharmaceuticals and cosmetics industries.

International Journal of Biological Macromolecules published new progress about Antioxidants. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Product Details of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hu, Jingcheng; Zeng, Li; Hu, Jiayu; Ma, Rui; Liu, Xue; Jiao, Ying; He, Haoyu; Chen, Siyu; Xu, Zhexi; Wang, Hongfei; Lei, Aiwen published the artcile< Electrochemical Difunctionalization of Terminal Alkynes: Access to 1,4-Dicarbonyl Compounds>, Name: (4-Ethynylphenyl)methanol, the main research area is dicarbonyl compound preparation; terminal alkyne ketoester electrochem difunctionalization.

Herein, a feasible electrosynthesis method to access 1,4-dicarbonyl compounds such as I [R = Ph, 4-MeC6H4, 2-thienyl, etc.; R1 = Me, OMe, OEt, Oi-Pr; R2 = Me; R3 = Me; R2R3 = (CH2)3, (CH2)4, (CH2)5] had been developed from simple alkynes and 1,3-dicarbonyl compounds When the undivided cell was combined with the constant current mode, aryl alkynes containing numerous medicinal motifs with 1,3-dicarbonyl esters or ketones reacted smoothly. External oxidant and catalyst-free conditions conformed to the requirements of green synthesis.

Organic Letters published new progress about Alkynes, α- Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Name: (4-Ethynylphenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Jian Jeffrey; Liu, Qingyian; Yuan, Chester; Gore, Vijay; Lopez, Patricia; Ma, Vu; Amegadzie, Albert; Qian, Wenyuan; Judd, Ted C.; Minatti, Ana E.; Brown, James; Cheng, Yuan; Xue, May; Zhong, Wenge; Dineen, Thomas A.; Epstein, Oleg; Human, Jason; Kreiman, Charles; Marx, Isaac; Weiss, Matthew M.; Hitchcock, Stephen A.; Powers, Timothy S.; Chen, Kui; Wen, Paul H.; Whittington, Douglas A.; Cheng, Alan C.; Bartberger, Michael D.; Hickman, Dean; Werner, Jonathan A.; Vargas, Hugo M.; Everds, Nancy E.; Vonderfecht, Steven L.; Dunn, Robert T. II; Wood, Stephen; Fremeau, Robert T. Jr.; White, Ryan D.; Patel, Vinod F. published the artcile< Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious β-secretase inhibitors for the potential treatment of Alzheimer's disease>, Computed Properties of 660867-80-1, the main research area is aminooxazoline azaxanthene derivative preparation oral beta secretase inhibitor Alzheimer’s; 3-Azaxanthene; Alzheimer’s disease (AD); Aminooxazoline; Amyloid; Aβ peptides; Xanthene; β-Secretase (BACE1).

The β-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) is one of the most hotly pursued targets for the treatment of Alzheimer’s disease. We used a structure- and property-based drug design approach to identify 2-aminooxazoline 3-azaxanthenes as potent BACE1 inhibitors which significantly reduced CSF and brain Aβ levels in a rat pharmacodynamic model. Compared to the initial lead 2, compound 28 exhibited reduced potential for QTc prolongation in a non-human primate cardiovascular safety model.

Bioorganic & Medicinal Chemistry Letters published new progress about Alzheimer disease. 660867-80-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H18BNO2, Computed Properties of 660867-80-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chardon, Aurelien; Rouden, Jacques; Blanchet, Jerome published the artcile< Borinic Acid Mediated Hydrosilylations: Reductions of Carbonyl Derivatives>, Synthetic Route of 403-41-8, the main research area is borinic acid mediated hydrosilylation reduction ketone aldehyde imine.

4-Fluoro-2-chlorophenylborinic acid acts as a precatalyst in the presence of phenylsilane for the facile reduction of ketones, aldehydes and imines. Notably, synergistic mediation of a tertiary amine was found essential to trigger silicon to boron hydride transfer to generate a key amine-diarylhydroborane Lewis complex.

European Journal of Organic Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Synthetic Route of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gao, Heng Ya; Peng, Wen Li; Meng, Pan Pan; Feng, Xue Feng; Li, Jian Qiang; Wu, Hui Qiong; Yan, Chang Sheng; Xiong, Yang Yang; Luo, Feng published the artcile< Correction: Lanthanide separation using size-selective crystallization of Ln-MOFs [Erratum to document cited in CA167:016029]>, Application In Synthesis of 6054-98-4, the main research area is size selective crystallization separation lanthanide olsalazine MOF erratum; crystal structure lanthanide olsalazine MOF preparation erratum.

The authors regret that although the CCDC numbers are correct in the ESI document, the numbers indicated in the manuscript are incorrect. The correct CCDC numbers are included below: 1537206?1537208, 1537213?1537215, 1537218?1537221, 1537250, 1537558, 1545014.

Chemical Communications (Cambridge, United Kingdom) published new progress about Crystal structure. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Application In Synthesis of 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chenavas, Sophie; Fiorini-Puybaret, Christel; Joulia, Philippe; Larrouquet, Camille; Waton, Hugues; Martinez, Agathe; Casabianca, Herve; Fabre, Bernard published the artcile< New formylated phloroglucinol compounds from Eucalyptus globulus foliage>, Related Products of 4396-13-8, the main research area is Eucalyptus formylated phloroglucinol compound acylphloroglucinol.

Two new acylphloroglucinols were isolated from the leaves of Eucalyptus globulus Labill and identified as macrocarpals P (1) and Q (2). Structural elucidations were carried out using conventional 1D and 2D NMR and mass spectrometry together with complementary techniques (UV and IR). Macrocarpal Q was a diastereoisomer of macrocarpal E (3), configuration of which was not precised. Simultaneous isolation of macrocarpals E and Q allowed to determine the configurations of both compounds The diformylphloroglucinol (4) was also isolated as well as already known compounds grandinol, macrocarpals D, I, L, N, O and am-1.

Phytochemistry Letters published new progress about Eucalyptus globulus. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Related Products of 4396-13-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts