Author: tianli

Luo, Zhe; Lu, Changtong; Histand, Gary; Lin, Dongen published the artcile< One-Step Visible Light Photoredox-Catalyzed Purine C8 Alkoxylation with Alcohol>, Application of C4H8O, the main research area is alkoxypurine preparation green chem; purine alc alkoxylation one step visible light photoredox catalyst.

A cross-dehydrogenation coupling reaction between purines and alcs., induced by visible light, using an acridinium photocatalyst and air as the sole oxidant, to synthesize a series of C8-alkoxy purine derivatives was developed. This protocol is a green and novel method to construct the C8-O bond on a purine ring with high step and atom economy.

Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Application of C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ji, Hyegeun; Kim, Hoikyung; Beuchat, Larry R.; Ryu, Jee-Hoon published the artcile< Synergistic antimicrobial activities of essential oil vapours against Penicillium corylophilum on a laboratory medium and beef jerky>, Electric Literature of 78-70-6, the main research area is Penicillium essential oil vapor antimicrobial synergism beef jerky; Beef jerky; Essential oil vapours; Intermediate-moisture food; Penicillium corylophilum; Synergistic antifungal effect; Xerophilic mold.

This study was done to determine the antifungal activities of essential oil (EO) vapors of 97 plants against Penicillium corylophilum and to test combinations of EO vapors for synergistic antifungal effects. Among 97 com. available EOs extracted from plant parts, garlic, cinnamon bark, may chang (mountain pepper), citronella, thyme thymol, oregano, spearmint, and thyme linalool EO vapors exhibited relatively strong antifungal activities. The minimal inhibitory concentrations of these EO vapors were 0.0390-0.6250 μL/mL. A combination of cinnamon bark, citronella, and may chang EO vapors, as well as a combination of cinnamon bark and citronella EO vapors, showed synergistic inhibitory activities to P. corylophilum on a laboratory medium. A combination of cinnamon bark, citronella, and may chang EO vapors had synergistic activity in inhibiting growth of P. corylophilium on beef jerky. Observations reported here provide basic information valuable when developing strategies to inhibit the growth of P. corylophilum and possibly other moderately xerophilic molds on intermediate-moisture foods.

International Journal of Food Microbiology published new progress about Allium sativum. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Electric Literature of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Jia; Cao, Lei; Qu, Jun-Ze; Chen, Ting-Ting; Su, Zi-Jie; Hu, Yun-Long; Wang, Ying; Yao, Ming-Dong; Xiao, Wen-Hai; Li, Chun; Li, Bo; Yuan, Ying-Jin published the artcile< NVD-BM-mediated genetic biosensor triggers accumulation of 7- dehydrocholesterol and inhibits melanoma via Akt1/NF-kB signaling>, Electric Literature of 434-16-2, the main research area is NVD-BM; cancer cell regression; cholesterol 7-desaturase; genetic biosensor; melanoma.

Aberrant activation of the cholesterol biosynthesis supports tumor cell growth. In recent years, significant progress has been made by targeting rate-limiting enzymes in cholesterol biosynthesis pathways to prevent carcinogenesis. However, precise mechanisms behind cholesterol degradation in cancer cells have not been comprehensively investigated. Here, we report that codon optimization of the orthologous cholesterol 7- desaturase, NVD-BM from Bombyx mori, significantly slowed melanoma cell proliferation and migration, and inhibited cancer cell engraftment in nude mice, by converting cholesterol to toxic 7-dehydrocholesterol. Based on these observations, we established a synthetic genetic circuit to induce melanoma cell regression by sensing tumor specific signals in melanoma cells. The dual-input signals, RELA proto-oncogene (RELA) and signal transducer and activator of transcription 1 (STAT1), activated NVD-BM expression and repressed melanoma cell proliferation and migration. Mech., we observed that NVD-BM decreased Akt1-ser473 phosphorylation and inhibited cytoplasmic RELA translocation. Taken together, NVD-BM was identified as a tumor suppressor in malignant melanoma, and we established a dual-input biosensor to promote cancer cell regression, via Akt1/NF-κB signaling. Our results demonstrate the potential therapeutic effects of cholesterol 7-desaturase in melanoma metabolism, and provides insights for genetic circuits targeting 7-dehydrocholesterol accumulation in tumors.

Aging published new progress about 434-16-2. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Electric Literature of 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Yi-yong; Xue, Yi-ting published the artcile< Optimization of microwave assisted extraction, chemical characterization and antitumor activities of polysaccharides from porphyra haitanensis>, Synthetic Route of 3458-28-4, the main research area is microwave extraction antitumor polysaccharide porphyra; Antitumor; Chemical characterization; Microwave assisted extraction; Polysaccharides; Porphyra haitanensis.

Microwave assisted extraction (MAE) technol. was used to extract polysaccharides from Porphyra Haitanensis (PHP) with water. Polysaccharide yield was used as index to evaluate the extraction process. Effects of ratio of water to raw material (X1), microwave power (X2) and extraction time (X3) on polysaccharide yield were investigated. Based on single factor experiment, MAE process of PHP was optimized using response surface methodol. Chem. characterization of PHP was investigated based on anal. of chem. compositions, monosaccharide and thermal gravimetric. The antitumor activities of PHP in vivo and in vitro were evaluated. The results indicated that the optimal conditions for MAE of PHP were ratio of water to raw material 28.98(mL/g), microwave power 77.84 W and extraction time 14.14 min. MAE was a suitable and efficient technique for PHP extraction compared with traditional hot water extraction Anal. of chem. characterization showed that PHP contained 75.36 ± 1.48% of total carbohydrates, 24.63 ± 1.69% of uronic acid residue and no proteins with monosaccharides such as rhamnose, arabinose, xylose, mannose, glucose, and galactose in a molar ratio of 10.25:9.38:1:12.45:9.9:11.55. Thermal gravimetric anal. suggested that PHP was relatively stable below 170°C. PHP had obvious effect on inhibiting proliferation, inducing apoptosis of SGC-7901 tumor cells in vitro and antitumor effect on SGC-7901 tumor-bearing mice in vivo. The results suggested that PHP had the potential for clin. use in cancer prevention and treatment.

Carbohydrate Polymers published new progress about Antitumor agents. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Synthetic Route of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

K. Bains, Amreen; Ankit, Yadav; Adhikari, Debashis published the artcile< Bioinspired Radical-Mediated Transition-Metal-Free Synthesis of N-Heterocycles under Visible Light>, Safety of 1-(4-Fluorophenyl)ethyl Alcohol, the main research area is nitrogen heterocycle preparation; alc oxidation pyrene iminoquinone photocatalyst; amidine alc oxidation pyrene iminoquinone photocatalyst; carbonyl compound preparation; biomimetic catalysis; hydrogen atom transfer; pyrimidine; quinoline; topaquinone.

A redox-active iminoquinone motif connected with π-delocalized pyrene core has been reported that can perform efficient two-electron oxidation of a class of substrates. The design of the mol. was inspired by the organic redox cofactor topaquinone (TPQ), which executes amine oxidation in the enzyme, copper amine oxidase. Easy oxidation of both primary and secondary alcs. such as benzylalc., hexanol, 1-phenylethan-1-ol, cyclohexanol, etc. happened in the presence of catalytic KOtBu, which could reduce the ligand backbone to its iminosemiquinonate form under photoinduced conditions. Moreover, this easy oxidation of alcs. under aerobic condition could be elegantly extended to multi-component, one-pot coupling for the synthesis of quinolines e.g., I and pyrimidines II (R1 = Ph, 2-methylphenyl, 1-naphthyl, etc.; R2 = Ph, 4-chlorophenyl, 2-thienyl, etc.; R3 = H, Cl, Me, Br, etc.). This organocatalytic approach is very mild (70°C, 8 h) compared to a multitude of transition-metal catalysts that have been used to prepare these heterocycles e.g., I and II. A detailed mechanistic study proves the intermediacy of the iminosemiquinonate-type radical and a critical hydrogen atom transfer step to be involved in the dehydrogenation reaction.

ChemSusChem published new progress about Alcohols Role: PRP (Properties), RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Safety of 1-(4-Fluorophenyl)ethyl Alcohol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Carlson, Lars A.; Hedbom, Christina; Helgstrand, Erik; Misiorny, Alfons; Sjoberg, Berndt; Stjernstrom, Nils E.; Westin, Gertrud published the artcile< Potential hypolipidemic agents. VI. Syntheses of some new halo-substituted pyridine compounds. Effects on noradrenaline-stimulated free fatty acid mobilization>, Formula: C6H6ClNO, the main research area is pyridine halo hydroxy hypolipidemic; hypolipidemic halopyridine.

The pyridines I (R = CHO, CH2OH, CH2CN, CH2CO2H, CH2OCH2Ph, CH2O2CNHPh CH2O2CCMe2OC6H4Cl-p, etc.; R1 = 5-F, 6-F, 5-Cl, 6-Cl, 5-Br) were prepared Thus I (R = CH2OH, R1 = 5-F) was treated with SOCl2 and the product treated with KCN to give I (R = CH2CN, R1 = 5-F), which was hydrolyzed to give I (R = CH2CO2H, R1 = 5-F). 5-Fluoronicotinic acid and 5-fluoro-3-pyridylmethanol were oxidized with H2O2 to give the pyridine oxides (II, R = CO2H, R = CH2OH, resp.). The N-methylnicotinic acid (III) was also prepared The pharmacol. effects of the compounds on noradrenaline-induced free fatty acid mobilization in dogs was determined and related to nicotinic acid.

Acta Pharmaceutica Suecica published new progress about Lipids Role: RCT (Reactant), RACT (Reactant or Reagent). 22620-34-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H6ClNO, Formula: C6H6ClNO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Iona, Roberto; Bassetti, Mauro published the artcile< Dimerization of Aromatic Terminal Alkynes Featuring Hydrophilic Functional Groups under Ruthenium and Acid Promoted Catalysis. Competitive Alkyne Hydration upon Substituent Effect>, Formula: C9H8O, the main research area is dimeric diarylenyne stereoselective preparation; aryl terminal alkyne hydrophilic functional group dimerization ruthenium catalyst.

The self-coupling (hydroalkynylation) process of aromatic terminal alkynes RC6H4CCH to give dimeric 1,4-diaryl-1-en-3-yne products (trans-RC6H4CCCH=CHC6H4R) is catalyzed by the complex [{RuCl(μ-Cl)(η6-p-cymene)}2] with sodium acetate co-catalyst dissolved in neat acetic acid, the reaction proceeding with high trans-stereoselectivity under mild conditions (r.t.) even for substrates with protic or polar substituent groups (e. g. R = 3-OH, 4-CH2OH, 4-NHAc, -CHO, 4-tetra-O-acetyl-β-D-glucopyranoside). In presence of strongly electron donating arene substituents, NMe2 and NH2, the triple bond is activated toward exclusive triple bond hydration by reaction with acetic acid at room temperature also in absence of the ruthenium catalyst.

ChemistrySelect published new progress about Alkenynes Role: SPN (Synthetic Preparation), PREP (Preparation). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Formula: C9H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tsui, Brian T. H.; Sung, Molly M. H.; Kinas, Jenny; Hahn, F. Ekkehardt; Morris, Robert H. published the artcile< A Ruthenium Protic N-Heterocyclic Carbene Complex as a Precatalyst for the Efficient Transfer Hydrogenation of Aryl Ketones>, Reference of 403-41-8, the main research area is bipyridinylimidazolylidene ruthenium pincer complex preparation catalyst reduction aryl ketone; crystal structure bipyridinylimidazolylidene ruthenium pincer complex; mol structure bipyridinylimidazolylidene ruthenium pincer complex.

A neutral azole precursor to a protic N-heterocyclic carbene (pNHC) ligand, 6-((4,5-diphenyl-1H-imidazol-1-yl)methyl)-2,2′-bipyridine (3), was prepared from 6-(bromomethyl)-2,2′-bipyridine (2) and 4,5-diphenylimidazole. [RuCl(pNHC-bpy)(PPh3)2](PF6) (4) bearing a protic, bipyridine-tethered NHC ligand was prepared by refluxing 3 with RuCl2(PPh3)3 and KPF6 in MeOH and was characterized by NMR spectroscopy, mass spectrometry, elemental anal., and a single-crystal x-ray diffraction study. The hydrido complex [RuH(pNHC-bpy)(PPh3)2](PF6) (5) was prepared by reaction of 4 with NaBH4 in EtOH and characterized by NMR and FTIR spectroscopy. Complex 5 was used as the catalyst (0.1 mol % loading) in the transfer hydrogenation of a range of alkyl/aryl ketones in basic iso-PrOH at 60°. Bulky alkyl groups or ortho-substituted aryl groups at the ketones slowed down or inhibited the catalytic transformation. The addition of an excess of PPh3 also slowed the catalysis, providing an indication for a mechanism involving phosphine dissociation, while the addition of an excess of elemental Hg had only a small effect on the conversion. The importance of K cations in the mechanism is consistent with the observation of reduced catalytic conversion when [2,2,2]-cryptand was present or when 1,8-diazabicyclo[5.4.0]undec-7-ene was used as the base. A plausible homogeneous catalysis mechanism involving the innersphere addition of hydride to the substrate in the transition state TS1 is supported by d. functional theory calculations where the K ion has replaced the H atom of the N-H group in a protic NHC.

Organometallics published new progress about Alkylidenes Role: CAT (Catalyst Use), PEP (Physical, Engineering or Chemical Process), PRP (Properties), SPN (Synthetic Preparation), USES (Uses), PROC (Process), PREP (Preparation) (Ru pincer complexes). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Reference of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Molaei, Somayeh; Tamoradi, Taiebeh; Ghadermazi, Mohammad; Ghorbani-Choghamarani, Arash published the artcile< Synthesis and characterization of MCM-41@AMPD@Zn as a novel and recoverable mesostructured catalyst for oxidation of sulfur containing compounds and synthesis of 5-substituted tetrazoles>, Recommanded Product: 2-(Phenylthio)ethanol, the main research area is mesoporous silica zinc bound preparation recyclable oxidation cycloaddition catalyst; sulfoxide disulfide preparation; tetrazole preparation; oxidation sulfide thiol peroxide zinc bound mesoporous silica catalyst; cycloaddition azide nitrile zinc bound mesoporous silica catalyst.

Zinc bound to mesoporous silica MCM-41 functionalized with (3-chloropropyl)trimethoxysilane and 2-amino-2-methyl-1,3-propanediol was prepared as a recyclable catalyst for solvent-free oxidation of sulfides and thiols with H2O2 to form sulfides and disulfides, resp., and for the cycloaddition of NaN3 to nitriles in PEG-400 to yield tetrazoles. The catalyst was used eight times for oxidation and cycloaddition reactions with < 10% decrease in yield over the eight reaction cycles. Microporous and Mesoporous Materials published new progress about Chemoselectivity. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Recommanded Product: 2-(Phenylthio)ethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts