Author: tianli

Li, Yunfei; Liu, Jia; Chen, Xuepeng; Yuan, Xiaole; Li, Nan; He, Weihua; Feng, Yujie published the artcile< Tailoring spatial structure of electroactive biofilm for enhanced activity and direct electron transfer on iron phthalocyanine modified anode in microbial fuel cells>, Quality Control of 492-62-6, the main research area is phthalocyanine modified anode electroactive biofilm electricity electrochem property; C-type cytochromes; Electroactive biofilm; Extracellular electron transfer; Iron phthalocyanine; Microbial fuel cell; Spatial structure.

Electroactive biofilm (EAB) has been considered as the core determining electricity generation in microbial fuel cells (MFCs), and its spatial structure regulation for enhanced activity and selectivity is of great concern. In this study, iron phthalocyanine (FePc) was introduced into a carbon cloth (CC) electrode, aiming at improving the affinity between the anode and outer membrane c-type cytochromes (OM c-Cyts) and achieving a highly active EAB. The FePc modified CC anode (FePc-CC) effectively improved the viability of EAB and enriched the Geobacter species up to 44.83% (FePc-CC) from 6.97% (CC). The FePc-CC anode achieved a much higher power d. of 2419 mW m-2 than the CC (560 mW m-2) and a remarkable higher biomass loading of 2477.2 ± 84.5μg cm-2 than the CC (749.3 ± 31.3μg cm-2). As the charge transfer resistance was decreased by 58.6 times from 395.2 Ω (CC) to 6.74 Ω (FePc-CC), the interfacial reaction rate was accelerated and the direct electron transfer via OM c-Cyts was promoted. This work provides an effective method to improve the EAB activity by regulating its spatial structure, and opens the door toward the development of highly active EAB using metal phthalocyanines in MFCs.

Biosensors & Bioelectronics published new progress about Binding energy. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Quality Control of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Huang, Fei; Hong, Ruiyue; Yi, Yang; Bai, Yajuan; Dong, Lihong; Jia, Xuchao; Zhang, Ruifen; Wang, Guangjin; Zhang, Mingwei; Wu, Jian published the artcile< In vitro digestion and human gut microbiota fermentation of longan pulp polysaccharides as affected by Lactobacillus fermentum fermentation>, Related Products of 3458-28-4, the main research area is Lactobacillus Dimocarpus fermentation polysaccharide gut; Digestion; Fermentation; Longan polysaccharide.

This study investigated the effect of Lactobacillus fermentum fermentation treatment on the gastrointestinal digestion and fermentation in vitro of polysaccharides from longan pulp. Polysaccharide isolated from unfermented and fermented longan pulp named LP and LP-F, resp. The mol. weight of LP-F declined from 109.62 ± 10.66 kDa to 51.46 ± 6.26 kDa while that of LP declined from 221.63 ± 2.41 kDa to 69.68 ± 2.36 kDa with gastrointestinal digestion. At same time, the reducing sugars content of LP and LP-F were both increased significantly. In addition, after 48 h gut microbiota fermentation, there were more total short chain fatty acids and acetic acid, as well as more Enterococcus, Bifidobacterium, and Clostridium in LP-F fermentation culture than those in LP fermentation culture. Moreover, LP-F fermentation culture showed lower pH value and less residual carbohydrate percentage than that of LP. These results indicated that LP-F is easier than LP to be fermented by human gut microbiota.

International Journal of Biological Macromolecules published new progress about Bifidobacterium. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Related Products of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Alfonzo, Edwin; Hande, Sudhir M. published the artcile< Photoredox and Weak Bronsted Base Dual Catalysis: Alkylation of α-Thio Alkyl Radicals>, Related Products of 699-12-7, the main research area is radical alkylation thioether photoredox Bronsted base dual catalysis.

We report the C-H activation of thioethers to α-thio alkyl radicals and their addition to electron-deficient olefins to afford alkylated products through dual photoredox and weak Bronsted base catalysis. Mechanistic studies are consistent with a two-step activation mechanism, where oxidation of thioethers to their corresponding sulfide radical cations by an acridinium photoredox catalyst is followed with deprotonation by trifluoroacetate to generate α-thio alkyl radicals and trifluoroacetic acid (TFA). Exptl. studies support the involvement of TFA in all subsequent steps leading to product formation.

ACS Catalysis published new progress about Alkenes, electron-deficient Role: RCT (Reactant), RACT (Reactant or Reagent). 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Related Products of 699-12-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Matthew, Susan; Chen, Qi-Yin; Ratnayake, Ranjala; Fermaintt, Charles S.; Lucena-Agell, Daniel; Bonato, Francesca; Prota, Andrea E.; Lim, Seok Ting; Wang, Xiaomeng; Diaz, J. Fernando; Risinger, April L.; Paul, Valerie J.; Oliva, Maria Angela; Luesch, Hendrik published the artcile< Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site>, Product Details of C19H16O, the main research area is natural product marine cyanobacterium cyclodepsipeptide Gatorbulin1 total synthesis; antitumor agent tubulin targeted chemotherapy microtubule drug mechanism action; GB1 total synthesis esterification protection peptide coupling macrolactamization reduction; crystal structure tubulin CB1 complex NMR conformer chelation fluorescence; cyanobacteria; marine natural product; microtubules; total synthesis; tubulin.

Tubulin-targeted chemotherapy has proven to be a successful and wide spectrum strategy against solid and liquid malignancies. Therefore, new ways to modulate this essential protein could lead to new antitumoral pharmacol. approaches. Currently known tubulin agents bind to six distinct sites at α/β-tubulin either promoting microtubule stabilization or depolymerization We have discovered a seventh binding site at the tubulin intradimer interface where a novel microtubule-destabilizing cyclodepsipeptide, termed gatorbulin-1 (GB1), binds. GB1 has a unique chemotype produced by a marine cyanobacterium. We have elucidated this dual chem. and mechanistic novelty through multidimensional characterization, starting with bioactivity-guided natural product isolation and multinuclei NMR-based structure determination, revealing the modified pentapeptide with a functionally critical hydroxamate group. and validation by total synthesis. The modified pentapeptide was validated by total synthesis. We have investigated the pharmacol. using isogenic cancer cell screening, cellular profiling, and complementary phenotypic assays, and unveiled the underlying mol. mechanism by in vitro biochem. studies and high-resolution structural determination of the α/β-tubulin-GB1 complex.

Proceedings of the National Academy of Sciences of the United States of America published new progress about (Fluorenylmethoxy)carbonyl group. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Product Details of C19H16O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jakubczyk, Karolina; Skonieczna-Zydecka, Karolina; Kaldunska, Justyna; Stachowska, Ewa; Gutowska, Izabela; Janda, Katarzyna published the artcile< Effects of resveratrol supplementation in patients with non-alcoholic fatty liver disease-a meta-analysis>, Name: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is meta analysis resveratrol hepatoprotectant nonalcoholic fatty liver disease; Non-alcoholic fatty liver disease (NAFLD); meta-analysis; resveratrol.

Non-alc. fatty liver disease (NAFLD) is regarded as one of the most common liver pathologies in many societies. Resveratrol, as a phenolic compound with powerful antioxidant and anti-inflammatory properties exerting pos. effects on the lipid profile and lipid accumulation and also on insulin resistance, appears to be an effective, natural, and safe complementary treatment option in NAFLD therapy. This meta-anal. was undertaken to evaluate the effects of resveratrol supplementation in NAFLD patients. To this end, scientific databases PubMed/Medline/Embase were searched up to 19 March 2020. We included seven randomized clin. trials (RCTs) with a total of 302 patients with NAFLD. In all the trials included in the anal., resveratrol was administered daily over periods between 56 and 180 days in doses ranging from 500 mg to 3000 mg a day. The results of this meta-anal. reveal that resveratrol supplementation, irresp. of the dose or duration, did not affect the analyzed parameters (p < 0.05). The sole exception was an increase in alanine aminotransferase following the administration of resveratrol (p = 0.041). Currently available evidence is insufficient to confirm the efficacy of resveratrol in the management of NAFLD. Due to the inconsistencies between the existing scientific reports, a number of which found a pos. effect on NAFLD-related parameters; further research in this area is needed. Nutrients published new progress about Anti-inflammatory agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Name: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Al-Dhubaibi, Mohammed Saleh; Shahzad, Muhammad; Al-Senaid, Adel Ibrahim; El-Hakim, Ashraf Hamouda Abd; Elneam, Ahmed Ibrahim Abd published the artcile< Phototherapy enhanced vitamin D level in psoriasis>, Related Products of 434-16-2, the main research area is meta analysis UV B radiation vitamin D psoriasis.

Phototherapy: broadband UVB (BUVB), narrowband UVB (NB-UVB) and heliotherapy is commonly used treatment modalities for widespread psoriasis. Vitamin D3, cholecalciferol, is produced in the epidermis by UV radiation (290-315 nm) of 7-dehydrocholesterol. 25-hydroxyvitamin D [25(OH) D], and 1, 25-dihydroxyvitamin D [1, 25(OH) 2D] are the major circulating metabolites. Sun exposure is the strongest factor influencing 25(OH) D. Therefore, the aim of this review was to investigate whether phototherapy was able to influence vitamin D level in psoriasis and its beneficial effect on psoriasis by increasing vitamin D level. We conducted a systematic review to assess the association between phototherapy and vitamin D status in psoriasis that was reviewed in Jan. and Apr. 2018. An electronic published work search was performed using PubMed, Ovid MEDLINE, Google Scholar, and Saudi Digital Library database and Medline. A total of 592 eligible articles by searching PubMed, Ovid MEDLINE, Google Scholar, and Saudi Digital Library. The titles and abstracts of 164 manuscripts were found to potentially fulfill search criteria. After the application of inclusion standards and full-text review, 23 manuscripts remained for inclusion. The sample size was 659 psoriasis patients. A total of 23 studies summarize the effect of phototherapy on vitamin D in psoriasis. Daily artificial UV therapy is an effective treatment for psoriasis patients, and vitamin D scores taking into consideration the type of UV, skin pigmentations, age of the patient and initial level of serum vitamin D.

Research Journal of Pharmaceutical, Biological and Chemical Sciences published new progress about Homo sapiens. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Related Products of 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Su; Van der Eycken, Erik V.; Sharma, Upendra K. published the artcile< Remote Alkenylation via Carbopalladation/1,4-Palladium Migration/Heck Reaction Sequence with Unactivated Alkenyl Alcohols>, Computed Properties of 627-27-0, the main research area is isochroman preparation regioselective chemoselective; alkenyl alc alkenylation carbopalladation migration Heck reaction.

Intramol. C-H bond activation via 1,4-palladium migration has become a synthetic tool to enable remote functionalization of C-H bonds. In this work, authors report a Pd-catalyzed remote alkenylation with unactivated alkenyl alcs. involving a 1,4-palladium migration step. This method provides a regioselective access to synthesize substituted unsaturated alcs. in a single operational step.

Advanced Synthesis & Catalysis published new progress about Alkenyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Computed Properties of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yongpisanphop, J. published the artcile< Searching for a plant species having a potent bioherbicide using in silico approach>, SDS of cas: 87-73-0, the main research area is Medicago bioherbicide L2 Aminoadipate aldisine weed control.

Toxic herbicide residue in the environment is one of the most important problems in the world, especially in the agricultural country. To solve this problem, an effectively new bioherbicide needs to be discovered urgently. This motivated to search the novel bioherbicide. In silico technique has been accepted as a promising tool to discover new active compounds Based on 2D structural similarity, 18 new natural compounds were obtained from the KNApSAcK database. Among the structural leads, 12 natural phyto-compounds were selected to calculate the lowest free energy of binding value using mol. docking. Comp_7 and Comp_10 showed the lowest free energy of binding -7.84 and -7.43 kcal/mol resp. which were similar to glyphosate (-8.49 kcal/mol). Based on the binding interaction using ProteinsPlus program, a natural phyto-compound (Comp_7: L-2-Aminoadipate) was identified as a potential bioherbicide. It could be found in Medicago sativa L. Significantly, this procedure becomes a high powerful tool to increase the probability to discover the new potent bioherbicide and identify the plant host species for weed control. Moreover, M. sativa should be extracted to test the property of weed control for further study.

Research Journal of Chemistry and Environment published new progress about Alfalfa. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, SDS of cas: 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kiourtzidis, Mikis; Kuehn, Julia; Schutkowski, Alexandra; Baur, Anja C.; Hirche, Frank; Stangl, Gabriele I. published the artcile< Inhibition of Niemann-Pick C1-like protein 1 by ezetimibe reduces uptake of deuterium-labeled vitamin D in mice>, Category: alcohols-buliding-blocks, the main research area is ezetimibe NPC1L1 Cyp3a11 cholesterol vitamin D deuterium; Ezetimibe; Intestinal absorption; Mice; Npc1l1; Vitamin D.

The current study aimed to elucidate the effect of long-term inhibition of Npc1l1 by ezetimibe on uptake and storage of orally administered triple deuterated vitamin D3. Therefore, 30 male wild-type mice were randomly assigned into three groups and received diets with 25μg/kg of vitamin D3-d3 that contained 0, 50 or 100 mg/kg ezetimibe for six weeks. Mice fed diets with 50 or 100 mg/kg ezetimibe had lower circulating levels of cholesterol than control mice. In contrast, the concentrations of 7-dehydrocholesterol in serum and liver were higher in mice treated with ezetimibe than in control mice, indicating an increased sterol synthesis to compensate for cholesterol reduction In comparison to the control group, mice treated with ezetimibe had lower concentrations of deuterated vitamin D3 compared with the control group in serum, liver, kidney, adipose tissues and muscle. The protein expression of the vitamin D hydroxylases Cyp2r1, Cyp27a1, Cyp3a11, Cyp24a1 and Cyp2j3 in liver and Cyp27b1 and Cyp24a1 in kidney remained largely unaffected by ezetimibe. To conclude, Npc1l1 appears to be crucial for the uptake of orally ingested vitamin D because long-term inhibition of Npc1l1 by ezetimibe strongly reduced the levels of deuterium-labeled vitamin D in the body; the observed rise in deuterated 25-hydroxyvitamin D3 in serum of these mice can not be explained by the expression levels of the key enzymes involved in vitamin D hydroxylation.

Journal of Steroid Biochemistry and Molecular Biology published new progress about Adipose tissue (retroperitoneal). 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ivanovic, Stefan; Mandrone, Manuela; Simic, Katarina; Ristic, Mirjana; Todosijevic, Marina; Mandic, Boris; Godevac, Dejan published the artcile< GC-MS-based metabolomics for the detection of adulteration in oregano samples>, Computed Properties of 87-73-0, the main research area is GCMS metabolomic detection adulteration oregano sample.

Oregano is one of the most used culinary herb and it is often adulterated with cheaper plants. In this study, GC-MS was used for identification and quantification of metabolites from 104 samples of oregano (Origanum vul-gare and O. onites) adulterated with olive (Olea europaea), venetian sumac (Cotinus coggygria) and myrtle (Myrtus communis) leaves, at five different concentration levels. The metabolomics profiles obtained after the two-step derivatization, involving methoxyamination and silanization, were subjected to multivariate data anal. to reveal markers of adulteration and to build the regression models on the basis of the oregano-to-adulterants mixing ratio. Orthogonal partial least squares enabled detection of oregano adulterations with olive, Venetian sumac and myrtle leaves. Sorbitol levels distinguished oregano samples adulterated with olive leaves, while shikimic and quinic acids were recognized as discrimination factor for adulteration of oregano with venetian sumac. Fructose and quinic acid levels correlated with oregano adulteration with myrtle. Orthogonal partial least squares discriminant anal. enabled dis-crimination of O. vulgare and O. onites samples, where catechollactate was found to be discriminating metabolite.

Journal of the Serbian Chemical Society published new progress about Adulterants. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Computed Properties of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts