Month: February 2023

Stepwise Access of Emissive Ir(III) Complexes Bearing a Multi-Dentate Heteroaromatic Chelate: Fundamentals and Applications was written by Zheng, Zhong;Zhu, Ze-Lin;Ho, Cheuk-Lam;Yiu, Shek-Man;Lee, Chun-Sing;Suramitr, Songwut;Hannongbua, Supa;Chi, Yun. And the article was included in Inorganic Chemistry in 2022.Computed Properties of C9H10BrNO2 This article mentions the following:

Three multi-dentate coordinated chelates LnH₂ (n = 1, 2, and 3), comprising a linked 1-(pyridin-2-yl)ethylbenzene and one pyrazolyl pyridine unit and showing either tridentate or tetradentate coordination modes, are successfully designed and synthesized. Dinuclear Ir(III) complexes [Ir(κ⁴-Ln)(μ-Cl)]₂ bearing tetradentate coordinated κ⁴-Ln chelate (2a, n = 1; 2b, n = 2; 2c, n = 3) were next obtained en route from the resp. intermediate [Ir(κ³-LnH)Cl(μ-Cl)]₂ bearing the tridentate coordinated κ³-LnH chelate (1a, n = 1; 1b, n = 2; 1c, n = 3). Next, mononuclear Ir(III) complexes Ir(κ⁴-Ln)(thd) (3a, n = 1; 3b, n = 2; 3c, n = 3) with the tetradentate chelate were obtained upon treatment of 2 with 2,2,6,6-tetramethyl-3,5-heptanedione (thd)H in the presence of K₂CO₃. Concurrently, methylation of 2c in the presence of ⁿBu₄NCl afforded tridentate Ir(κ³-L3HMe)Cl₃ (4) and, next, can be converted to tetradentate Ir(κ⁴-L3Me)Cl₂ (5) by further cyclometalation and HCl elimination in refluxing diethylene glycol monoethyl ether solution The Ir(III) complexes 3a, 4, and 5 were unambiguously identified using spectroscopic methods, together with single-crystal x-ray structural analyses on Ir(III) derivatives 3a, 4, and 5. Their photophys. and electrochem. properties were also investigated and compared with results from theor. studies. In the experiment, the researchers used many compounds, for example, 2-Bromo-6-(2-methyl-1,3-dioxolan-2-yl)pyridine (cas: 49669-14-9Computed Properties of C9H10BrNO2).

2-Bromo-6-(2-methyl-1,3-dioxolan-2-yl)pyridine (cas: 49669-14-9) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Computed Properties of C9H10BrNO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Templated Polymer Replica Nanoparticles to Facilitate Assessment of Material-Dependent Pharmacokinetics and Biodistribution was written by Song, Danzi;Cui, Jiwei;Sun, Huanli;Nguyen, Tri-Hung;Alcantara, Sheilajen;De Rose, Robert;Kent, Stephen J.;Porter, Christopher J. H.;Caruso, Frank. And the article was included in ACS Applied Materials & Interfaces in 2017.Safety of Diethyleneglycoldiacrylate This article mentions the following:

Surface modification is frequently used to tailor the interactions of nanoparticles with biol. systems. In most cases, the chem. nature of the treatments employed to modify the biol. interface (for example attachments of hydrophilic polymers or targeting groups) is the focus of attention. However, isolation of the fundamental effects of the materials employed to modify the interface are often confounded by secondary effects imparted by the underlying substrate. Herein, we demonstrate that polymer replica particles templated from degradable mesoporous silica provide a facile means to evaluate the impact of surface modification on the biol. interactions of nanomaterials, independent of the substrate. Poly(ethylene glycol) (PEG), poly(N-(2 hydroxypropyl)methacrylamide) (PHPMA), and poly(methacrylic acid) (PMA) were templated onto mesoporous silica, crosslinked and the residual particles removed. The resulting nanoparticles, comprising interfacial polymer alone, were then investigated using a range of in vitro and in vivo tests. As expected, the PEG particles showed the best stealth properties and these trends were consistent in both in vitro and in vivo studies. PMA particles showed the highest cell association in cell lines in vitro and were rapidly taken up by monocytes in ex vivo whole blood, properties consistent with the very high in vivo clearance subsequently seen in rats. In contrast, PHPMA particles showed rapid association with both granulocytes and monocytes in ex vivo whole blood, even though in vivo clearance was less rapid than the PMA particles. Rat studies confirmed better systemic exposure for PEG and PHPMA particles when compared to PMA particles. This study provides a new avenue for investigating material-dependent biol. behaviors of polymer particles, irresp. of the properties of the underlying core, and provides insights for the selection of polymer particles for future biol. applications. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Safety of Diethyleneglycoldiacrylate).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Safety of Diethyleneglycoldiacrylate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

An improved method in fabrication of smart dual-responsive nanogels for controlled release of doxorubicin and curcumin in HT-29 colon cancer cells was written by Abedi, Fatemeh;Davaran, Soodabeh;Hekmati, Malak;Akbarzadeh, Abolfazl;Baradaran, Behzad;Moghaddam, Sevil Vaghefi. And the article was included in Journal of Nanobiotechnology in 2021.Application In Synthesis of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) This article mentions the following:

Abstract: The combination therapy which has been proposed as the strategy for the cancer treatment could achieve a synergistic effect for cancer therapies and reduce the dosage of the applied drugs. On account of the the unique properties as the high absorbed water content, biocompatibility, and flexibility, the targeting nanogels have been considred as a suitable platform. Herein, a non-toxic pH/thermo-responsive hydrogel P(NIPAAm-co-DMAEMA) was synthesized and characterized through the free-radical polymerization and expanded upon an easy process for the preparation of the smart responsive nanogels; i.e., the nanogels were used for the efficient and controlled delivery of the anti-cancer drug doxorubicin (DOX) and chemosensitizer curcumin (CUR) simultaneously like a promising strategy for the cancer treatment. The size of the nanogels, which were made, was about 70 nm which is relatively optimal for the enhanced permeability and retention (EPR) effects. The DOX and CUR co-loaded nanocarriers were prepared by the high encapsulation efficiency (EE). It is important to mention that the controlled drug release behavior of the nanocarriers was also investigated. An enhanced ability of DOX and CUR-loaded nanoformulation to induce the cell apoptosis in the HT-29 colon cancer cells which represented the greater antitumor efficacy than the single-drug formulations or free drugs was resulted through the In vitro cytotoxicity. Overall, according to the data, the simultaneous delivery of the dual drugs through the fabricated nanogels could synergistically potentiate the antitumor effects on the colon cancer (CC). [graphic not available: see fulltext]. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Application In Synthesis of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate)).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Application In Synthesis of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Exploiting the enzymatic machinery of Arthrobacter atrocyaneus for oxidative kinetic resolution of secondary alcohols was written by Silva, Camila R.;Souza, Juliana C.;Araujo, Lidiane S.;Kagohara, Edna;Garcia, Thais P.;Pelizzari, Vivian H.;Andrade, Leandro H.. And the article was included in Journal of Molecular Catalysis B: Enzymatic in 2012.Recommanded Product: 171032-87-4 This article mentions the following:

We evaluated Arthrobacter atrocyaneus (R1AF57) as producer of oxidoreductases for oxidative kinetic resolution of racemic secondary alcs. via oxidation reaction. This bacterium was isolated from Amazon soil samples using medium enriched with (RS)-1-(4-methylphenyl)ethanol as a carbon source. The kinetic resolution of several secondary alcs. through enantioselective oxidation mediated by resting cells and growing cells of A. atrocyaneus was efficiently achieved for the most alcs. In general, it was possible to obtain only the (S)-enantiomer from (RS)-1-arylethanols. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Recommanded Product: 171032-87-4).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Recommanded Product: 171032-87-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ultraviolet Light Detectable Circularly Polarized Room Temperature Phosphorescence in Chiral Naphthalimide Self-Assemblies was written by An, Shuguo;Gao, Liang;Hao, Aiyou;Xing, Pengyao. And the article was included in ACS Nano in 2021.Category: alcohols-buliding-blocks This article mentions the following:

The combination of circularly polarized luminescence (CPL) and pure-organic room temperature phosphorescence (RTP) potentially facilitates the construction of organic chiroptical optoelectronics and display materials, which however are challenging to use in realizing smart control of luminescent colors and switchable chiroptical properties. Here, we show a host-guest strategy to fabricate color-tunable RTP-based circularly polarized phosphorescence. Naphthalimides were conjugated directly to chiral segments, of which supramol. chirality and CPL activities in solid-states could be triggered by substituting bromine atoms on amines. Introducing tetracyanobenzene as an achiral host matrix via simple grinding would allow for the intersystem crossing to trigger red RTP and corresponding CPL by excitation lower than 320 nm, with a large Stokes shift more than 300 nm. The critical excitation wavelength of the RTP switch is determined by the absorbance of tetracyanobenzene. When the excitation wavelength was larger than 320 nm, blue fluorescence dominated with turned off RTP and CPL. The excitation wavelength-dependent RTP and CPL switch allows for detecting UV light, showing distinguishable red-blue luminescent color transition, accompanied by on/off RTP. Changing the host matrix from tetracyanobenzene to tricyanobenzene or dicyanobenzene could adjust the critical detecting wavelength limit from 320 to 300 nm. This work establishes a strategy to realize color-tunable, UV light detectable RTP and CPL under smart control. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Category: alcohols-buliding-blocks).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The marked influence of steric and electronic properties of ancillary pyridylthioether ligands on the rate of allene insertion into the palladium-carbon bond was written by Canovese, Luciano;Visentin, Fabiano;Chessa, Gavino;Santo, Claudio;Uguagliati, Paolo;Bandoli, Giuliano. And the article was included in Journal of Organometallic Chemistry in 2002.Application In Synthesis of Sodium 2-methyl-2-propanethiolate This article mentions the following:

Neutral Me chloro complexes (L)Pd(Me)Cl 1 containing 6-R’-2-R-thiomethylpyridine ancillary ligands L (R’N-SR, R’ = H, Me, Cl; R = Me, Et, CHMe₂, CMe₃, Ph) were obtained by reaction of L with (COD)Pd(Me)Cl. Complexes 1 were carbonylated with CO to give corresponding acetyl derivatives 2. Kinetics of insertion of 1,1-dimethylpropadiene and 1,1,3,3-tetramethylpropadiene into the palladium-carbon bond in 1 and 2 was studied by ¹H-NMR and UV-vis techniques. The rate of reaction is strongly dependent on the steric and electronic properties of the ancillary ligand and of the allene. The distortion induced by R’ on the main coordination plane of the complex (allowed by sulfur sp³ hybridization) activates the complex to nucleophilic attack by the allene. Increase of electrophilicity of the palladium core, caused by lowering of the basicity of L results in further enhancement of the rate of allene insertion. The rate constants for complexes with L = 6-chloro-2-phenylthiomethylpyridine (ClN-SPh) are the greatest observed so far for similar reactions. The associative asynchronous mechanism of the insertion reaction is discussed. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2Application In Synthesis of Sodium 2-methyl-2-propanethiolate).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Application In Synthesis of Sodium 2-methyl-2-propanethiolate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The influence of dietary beta-1,3-glucan on growth performance, feed utilization, antioxidative and immune status of Pacific white shrimp, Litopenaeus vannamei was written by Xu, Bingying;Zhang, Gangwei;Wang, Lei;Sagada, Gladstone;Zhang, Jinzhi;Shao, Qingjun. And the article was included in Aquaculture Nutrition in 2021.Application In Synthesis of Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate This article mentions the following:

Prebiotics, i.e., β-1,3-glucans are widely used immunostimulants in aquaculture. A 70-day feeding trial was conducted to investigate the effects of dietary β-1,3-glucan on growth performance, feed utilization, antioxidative and immune status of Pacific white shrimp (Litopenaeus vannamei). Six iso-energetic and iso-nitrogenous diets with dietary β-1,3-glucan levels at 0, 0.04, 0.08. 0.16, 0.32 and 0.64 g kg-1 were fed to six replicates of shrimp (initial mean weight 0.98 ± 0.02 g). The diet with 0.16 g kg-1 β-1,3-glucan significantly improved weight gain and decreased feed conversion ratio of the shrimp. Compared with shrimp fed the basal diet, protein efficiency ratio was significantly higher in the β-1,3-glucan supplemented groups. Hepatopancreatic amylase activity was significantly increased by the β-1,3-glucan supplementation. The 0.16 g kg-1 β-1,3-glucan supplemented diet significantly improved serum total superoxide dismutase activity. The lowest hepatopancreatic malondialdehyde content was observed in the 0.64 g kg-1 β-1,3-glucan group. This study suggested that appropriate inclusion level of β-1,3-glucan can improve the growth performance, feed utilization and improve the antioxidative capacity of Pacific white shrimp, with optimum supplemental level being about 0.156 g kg-1 based on the weight gain in our results. In the experiment, the researchers used many compounds, for example, Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6Application In Synthesis of Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate).

Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Application In Synthesis of Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A New Combination Inhibitor Based on Tomato Pomace Extract and Organosilane for Enhanced Anticorrosion Performance of Steel was written by Vorobyova, Viktoria;Skiba, Margarita;Julia, Zaporozhets. And the article was included in Chemistry Africa in 2022.Formula: C10H14O This article mentions the following:

The study aims to assess the effect of extract based inhibiting mixture, i.e., tomato pomace and organosilanes (Vinyltrimethoxysilane (VS)) against corrosion of steel in atm. environment. Such compositions can be used as polymer-type corrosion inhibitors for steel. The developed blend VCI based on tomato pomace extract (TPE) and organosilane provide a long-term protection from corrosion processes under the model conditions of carbon steel. The results show that the protection efficiency of the film reaches 96.97%. The tomato pomace extract chem. composition was analyzed by Head Space-Solid Phase Micro Extraction-Gas Chromatog.-Mass Spectrometry (HS-SPME-GC-MS). The major volatile compounds ot the TPE include alcs., esters, aldehydes, ketones and terpene compounds as described by panelists of HS-SPME-GC-MS. Electrochem. studies reveal decreased corrosion current densities from 4.29 x 10-4 to 0.65 x 10-4 A cm^-2 and increased polarization resistance under the conditions of periodic moisture condensation. FT-IR absorption peak obtained at 954, 1142, 1230 cm^-1 revealed the formation of Fe-O-Si, Si-O-Si and Si-O-C bonds. The protective film consesed of silane and extract offered the highest corrosion resistance since the corrosion protective barrier minimized the oxygen access and prevented corrosion of mild steel to a greater extent where the EDX anal. showed a high intense signal of Si and C. The mixture of phytochem. extract and organosilane were incorporated in a paint coating. The addition of additive increases the inhibitory properties of the final coating while keeping the barrier properties of the coating. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Formula: C10H14O).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Formula: C10H14O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis and structure activity relationships of cyanopyridone based anti-tuberculosis agents was written by Jian, Yanlin;Hulpia, Fabian;Risseeuw, Martijn D. P.;Forbes, He Eun;Munier-Lehmann, Helene;Caljon, Guy;Boshoff, Helena I. M.;Van Calenbergh, Serge. And the article was included in European Journal of Medicinal Chemistry in 2020.Related Products of 2968-93-6 This article mentions the following:

The synthesis of a series of aryl-shifted cyanopyridone analogs I [R = H, 2-Cl, OPh, etc.; R¹ = H, 4-ClC₆H₄O, OBn, etc.; R² = H, 4-Cl, 4-MeC₆H₄O, etc.] was reported. These compounds generally lacked significant MtbTMPK inhibitory potency, but some analogs did exhibit promising antitubercular activity. Analog I [R = H; R¹ = H; R² = 4-Ph] demonstrated a 10-fold increased antitubercular activity. Many analogs with whole-cell antimycobacterial activity were devoid of significant cytotoxicity. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6Related Products of 2968-93-6).

2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Related Products of 2968-93-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

C-H and C-S Bond Cleavage in Uranium(III) Thiolato Complexes was written by Arliguie, Therese;Lescop, Christophe;Ventelon, Lionel;Leverd, Pascal C.;Thuery, Pierre;Nierlich, Martine;Ephritikhine, Michel. And the article was included in Organometallics in 2001.Electric Literature of C4H9NaS This article mentions the following:

Reduction of the uranium(IV) thiolates Cp^*₂U(SR)₂ (Cp^* = η-C₅Me₅, R = Ph, Me, ⁱPr or ^tBu) with sodium amalgam afforded the corresponding U(III) complexes Na[Cp^*₂U(SR)₂] (R = Ph, 2a; Me, 2b; ⁱPr, 2c) or the U(IV) sulfide Na[Cp^*₂U(S^tBu)(S)]. C-S bond cleavage of a thiolate ligand was also observed during the thermal decomposition of 2c into the sulfide Na[Cp^*₂U(SⁱPr)(S)], whereas 2b was transformed in refluxing THF into the thiametallacyclopropane complex Na[Cp^*₂U(SMe)(SCH₂)], resulting from C-H bond activation of a SMe group. The x-ray crystal structures of [Na(18-crown-6)(THF)₂][Cp^*₂U(SⁱPr)₂], [Na(18-crown-6)][Cp^*₂U(S^tBu)(S)], and [Na(18-crown-6)(THF)₂][Cp^*₂U(SMe)(SCH₂)] have been determined In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2Electric Literature of C4H9NaS).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Electric Literature of C4H9NaS

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts