Month: February 2023

Study on the conversion of acrylic C=C double bonds during dark reaction after UV curing using infrared spectroscopy was written by Ma, Guo-zhang;Wu, Jian-bing;Xu, Bing-she. And the article was included in Guangpuxue Yu Guangpu Fenxi in 2010.Safety of Diethyleneglycoldiacrylate This article mentions the following:

IR spectroscopy was used to determine 1 648-1 589 cm^-1 characteristic absorption peak area so as to study the conversation of acrylic C=C double bonds after UV curing. The effects of photoinitiators, active diluents and UV curing resins on the conversion of C=C double bonds were also studied. 40%-85% Of C=C double bonds were conversed during dark reaction after 45 s UV curing. Dark reaction will be changed gently after 1.75 h, but 95% conversion of C=C double bonds needed more than 24 h. The rates of polymerization and conversation were affected by photoinitiators, the concentration of photoinitiator, oxygen inhibition, and C=C functional groups of active diluents. The rate of polymerization was affected by the C=C functional groups and types of UV curing resins, but conversation was not. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Safety of Diethyleneglycoldiacrylate).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Safety of Diethyleneglycoldiacrylate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Catalytic Hydroboration and Reductive Amination of Carbonyl Compounds by HBpin using a Zinc Promoter was written by Kumar, Ravi;Rawal, Parveen;Banerjee, Indrani;Pada Nayek, Hari;Gupta, Puneet;Panda, Tarun K.. And the article was included in Chemistry – An Asian Journal in 2022.Safety of (4-Chlorophenyl)methanol This article mentions the following:

The chemoselective hydroboration of aldehydes and ketones, catalyzed by Zinc(II) complexes [κ²-(PyCH:NR)ZnX₂] (1, R = CPh₃, X = Cl; 2, R = 2,6-ⁱPr₂C₆H₃, X = I), by pinacolborane (HBpin) at ambient temperature and under solvent-free conditions, which produced the corresponding borate esters in high yield, is reported. Zinc metal complexes 1 and 2 were derived in 80-90% yield from the reaction of iminopyridine [PyCH:NR] with anhydrous zinc dichloride in dichloromethane at room temperature The solid-state structures of both zinc complexes were confirmed using X-ray crystallog. Zinc complex 1 was also used as a competent pre-catalyst in the reductive amination of carbonyl compounds with HBpin under mild and solvent-free conditions to afford a high yield (up to 97%) of the corresponding secondary amines. The wider substrate scope of both reactions was explored. Catalytic protocols using zinc as a pre-catalyst demonstrated an atom-economic and green method with diverse substrates bearing excellent functional group tolerance. Computational studies established a plausible mechanism for catalytic hydroboration. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Safety of (4-Chlorophenyl)methanol).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Safety of (4-Chlorophenyl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Assay of terpin hydrate and codeine elixir by gas chromatography was written by Wasselman, Harold J.. And the article was included in Journal of Pharmaceutical Sciences in 1968.Reference of 2451-01-6 This article mentions the following:

Terpin hydrate and codeine after extraction from the elixir are separated and determined with the aid of two internal standards and the use of temperature-programmed gas chromatog. Using the same method, elixir of terpin hydrate can also be determined A precision and accuracy study for both elixirs is included. 25 references. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Reference of 2451-01-6).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Reference of 2451-01-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Thionyl fluoride-mediated one-pot substitutions and reductions of carboxylic acids was written by Bolduc, Trevor G.;Lee, Cayo;Chappell, William P.;Sammis, Glenn M.. And the article was included in Journal of Organic Chemistry in 2022.HPLC of Formula: 873-76-7 This article mentions the following:

Thionyl fluoride (SOF₂) is an underutilized reagent that is yet to be extensively studied for its synthetic applications. We previously reported that it is a powerful reagent for both the rapid syntheses of acyl fluorides and for one-pot peptide couplings, but the full scope of these nucleophilic acyl substitutions had not been explored. Herein, we report one-pot thionyl fluoride-mediated syntheses of peptides and amides (35 examples, 45-99% yields) that were not explored in our previous study. The scope of thionyl fluoride-mediated nucleophilic acyl substitutions was also expanded to encompass esters (24 examples, 64-99% yields) and thioesters (11 examples, 24-96% yields). In addition, we demonstrate that the scope of thionyl fluoride-mediated one-pot reactions can be extended beyond nucleophilic acyl substitutions to mild reductions of carboxylic acids using NaBH₄ (13 examples, 33-80% yields). In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7HPLC of Formula: 873-76-7).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.HPLC of Formula: 873-76-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Volumetric and Ultrasonic Studies on Interactions of Hexylene and Propylene Glycols in Aqueous Solutions of Glutaraldehyde at Different Temperatures was written by Kaur, Parminder;Chakraborty, Nabaparna;Kumar, Harsh;Singla, Meenu;Juglan, Kailash Chandra. And the article was included in Journal of Solution Chemistry in 2022.HPLC of Formula: 57-55-6 This article mentions the following:

To determine the various interactions between glutaraldehyde and glycols (hexylene and propylene), various thermodn. and acoustic properties have been analyzed by using the d. (ρ) and ultrasonic velocity (c) of liquid mixtures of (hexylene or propylene + aqueous glutaraldehyde solutions), resp., in the concentration ranges from (0.01 to 0.04) mol·kg^-1 at the temperatures of 293.15, 298.15, 303.15, 308.15 K. Thermodn. parameters including the apparent molar volume (V_Φ) and partial molar volume (V⁰Φ) have been calculated from the d. values. These parameters show that the (solute-solvent) interaction for propylene glycol is weaker as compared to hexylene glycol. Acoustic parameters including the apparent molar isentropic compressibility (K_Φ,s) and partial molar isentropic compression (K⁰Φ,s) have been determined by using ultrasonic velocity values. Pair and triplet interaction coefficients have also been determined by using partial molar volume of transfer and partial molar isentropic compression of transfer. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6HPLC of Formula: 57-55-6).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.HPLC of Formula: 57-55-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Three green seaweed extracts and their fractions for ecofriendly management of pestiferous insect Spodoptera litura was written by Sahayaraj, K.;Ravindran, C.;Thusnavis, M. Maria. And the article was included in International Journal of Environmental Science and Technology in 2022.SDS of cas: 2216-51-5 This article mentions the following:

Polyphagous pest Spodoptera litura poses a serious threat to important agriculture crops and their products. A green ecofriendly alternative to existing chem. pesticides, bio-fertilizers are preferred to protect the crop and increase their yield against pests. Hence, three common seaweed crude extracts (Caulerpa scalpelliformis, Caulerpa veravalensis, and Ulva lactuca) and chromatog. fractions of C. scalpelliformis [CS-1 (683-759) and CS-2 (1038-1130)] were screened against S. litura under different concentrations in castor leaves. Dose-dependent mortality was observed for crude extracts and their column chromatog. fractions. Conversely, fractions [CS-1 (683-759) and CS-2 (1038-1130)] recorded highest mortality at 1.0 ppm and lowest at 0.12 ppm. GC-MS anal. of C. scalpelliformis and C. veravalensis exhibited the highest peak of n-Hexadecanoic acid and 1,4-Bis(trimethylsilyl) benzene, resp. The access proportion index suggested C. scalpelliformis was more active than other seaweeds. Henceforth, the results suggest that the above seaweed extracts may be developed as bio-alternative agrochems. for pest control. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5SDS of cas: 2216-51-5).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.SDS of cas: 2216-51-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Asymmetric transfer hydrogenation of ketones in 2-propanol catalyzed by arsinooxazoline-ruthenium(II) complex was written by Tan, Duan-Ming;Chan, Kin Shing. And the article was included in Tetrahedron Letters in 2005.Quality Control of (R)-1-(3-Chlorophenyl)ethanol This article mentions the following:

Chiral arsinooxazoline Ru(II) complex was an efficient catalyst for asym. transfer hydrogenation of aromatic ketones in 2-propanol. Secondary alcs. with up to 94% enantiomeric excess were obtained at a substrate/catalyst mole ratio of 1000:1. Asym. kinetic resolution was also obtained with 1-arylalkanols at room temperature with 99% ee. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Quality Control of (R)-1-(3-Chlorophenyl)ethanol).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Quality Control of (R)-1-(3-Chlorophenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Inhibition of chemically and mechanically activated Piezo1 channels as a mechanism for ameliorating atherosclerosis with salvianolic acid B was written by Pan, Xianmei;Wan, Rentao;Wang, Yuman;Liu, Silin;He, Yu;Deng, Bo;Luo, Shangfei;Chen, Yuan;Wen, Lizhen;Hong, Tianying;Xu, Han;Bian, Yifei;Xia, Mingfeng;Li, Jing. And the article was included in British Journal of Pharmacology in 2022.Formula: C10H20O This article mentions the following:

Salvianolic acid B (SalB) is effective for treating cardiovascular diseases. However, the mol. mechanisms underlying its therapeutic effects remain unclear. Mechanosensitive Piezo1 channels play important roles in vascular biol., although their pharmacol. properties are poorly defined. Here, we aimed to identify novel Piezo1 inhibitors and gain insights into their mechanisms of action. Intracellular Ca2+ ions were measured in HUVECs, murine liver endothelial cells (MLECs), THP-1 and RAW264.7 cell lines and bone marrow-derived macrophages (BMDMs). Isometric tensions in mouse thoracic aorta were recorded. Shear-stress assays with HUVECs were conducted. Patch-clamp recordings with mech. stimulation were performed with HUVECs in whole-cell mode. Foam cell formation was induced by treating BMDMs with oxidised LDL (oxLDL). Atherosclerotic plaque assays were performed with Ldlr-/- and Piezo1 genetically depleted mice on a high-fat diet. Salvianolic acid B inhibited Yoda1-induced Ca2+ influx in HUVECs and MLECs. Similar results were observed in macrophage cell lines and BMDMs. Furthermore, we demonstrated that salvianolic acid B inhibited Yoda1- and mech. activated currents. Salvianolic acid B suppressed Yoda1-induced aortic ring relaxation and inhibited HUVECs alignment in the direction of shear stress. Addnl., Yoda1 enhanced the formation of foam cells, which was reversed by salvianolic acid B. Salvianolic acid B also inhibited formation of atherosclerotic plaques and was insensitive to Piezo1 genetic depletion. Our study provides novel mechanistic insights into the inhibitory role of salvianolic acid B against Piezo1 channels and improves our understanding of salvianolic acid B in preventing atherosclerotic lesions. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Formula: C10H20O).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Formula: C10H20O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sweeteners from Different Lingonberry Jams Influence on Bioaccessibility of Vitamin C, Anthocyanins and Antioxidant Capacity under In Vitro Gastrointestinal Digestion was written by Scrob, Teodora;Hosu, Anamaria;Cimpoiu, Claudia. And the article was included in Antioxidants in 2022.Safety of (2R,3S)-rel-Butane-1,2,3,4-tetraol This article mentions the following:

Lingonberries are considered anot fully exploited major source of antioxidants. Their health benefits are closely linked to their bioavailability. Due to growing health concerns, consumers are looking for jams prepared with sweeteners other than white sugar, which could be a good alternative to meet their needs. The aim of this research was to evaluate the influence of sucrose, fructose, erythritol, brown sugar, coconut sugar, stevia and saccharine on the bioaccessibility of vitamin C, anthocyanins andthe antioxidant capacity of lingonberry jams under in vitro gastrointestinal digestion. The vitamin C, total anthocyanin content and antioxidant capacity measured by ABTS and FRAP assays were determined spectrophotometrically. Individual anthocyanins were determined by high performance liquid chromatog. All analyzed compounds were highly altered during gastrointestinal digestion and this effect was more visible in the case of the anthocyanins. Antioxidant capacity decreased after gastric digestion, but after the gastrointestinal step, radical scavenging capacity increased, while reducing power decreased. Vitamin C bioaccessibility was neg. affected by coconut sugar addition, while stevia addition showed a protective effect. Fructose and sucrose increased the total anthocyanin stability during the intestinal phase. Stevia, fructose and coconut sugar exhibited high protection of the antioxidant capacity of lingonberry jams during digestion. In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6Safety of (2R,3S)-rel-Butane-1,2,3,4-tetraol).

(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Safety of (2R,3S)-rel-Butane-1,2,3,4-tetraol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Development of a Late-Stage Diversification Strategy for the 4- and 5-Positions of 4,5,6-Trisubstituted Indazoles was written by Barber, Joyann S.;Burtea, Alexander;Collins, Michael R.;Tran-Dube, Michelle;Patman, Ryan L.;Scales, Stephanie;Smith, Graham;Spangler, Jillian E.;Wang, Fen;Wang, Wei;Yang, Shouliang;Zhu, JinJiang;Montgomery, T. Patrick. And the article was included in Organic Letters in 2020.SDS of cas: 142253-56-3 This article mentions the following:

Indazoles represent a privileged motif in drug discovery. However, the formation of highly substituted indazoles can require the execution of lengthy synthetic routes with minimal opportunities to introduce diversity. In this report, we disclose the development of a late-stage diversification strategy for the 4- and 5-positions of 4,5,6-trisubstituted indazoles. A regioselective C-H functionalization and subsequent nucleophilic aromatic substitution provide two sequential points of diversification. The synthetic sequence delivers rapid access to an array of 4,5,6-trisubstituted indazoles in only four steps from readily available starting materials. Materials processing safety is required when using DMSO in nucleophilic substitution reactions under basic conditions due to exothermic decomposition In the experiment, the researchers used many compounds, for example, 1-Boc-Azetidine-3-yl-methanol (cas: 142253-56-3SDS of cas: 142253-56-3).

1-Boc-Azetidine-3-yl-methanol (cas: 142253-56-3) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.SDS of cas: 142253-56-3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts