Month: February 2023

Spectroscopic analysis and molecular structures of mononuclear bis(t-butyltrithiocarbonato)-nickel, -palladium and (t-butyltrithiocarbonato)(t-butylthiolato)platinum dimer was written by El-khateeb, Mohammad;Moriyama, Hayato;Yoshida, Yukihiro;Kitagawa, Hiroshi. And the article was included in Inorganica Chimica Acta in 2021.Application of 29364-29-2 This article mentions the following:

Treatment of the bis(triphenylphosphine)dichlorometal (PPh₃)₂MCl₂ (M = Ni, Pd, Pt) with the trithiocarbonato anion (Bu^tSCS^–₂) gave products depending on the metal center. In case of nickel, the product is Ni(κ²S,S-S₂CSBu^t)₂ (1) while for the palladium case, a similar complex Pd(κ²S,S-S₂CSBu^t)₂ (2) was obtained in addition to the dithiocarbonato complex (PPh₃)₂Pd(κ²S,S-S₂C:O). However, the platinum reaction gave two products, a dimeric species Pt₂(μ-SBu^t)₂(κ²S,S-S₂CSBu^t)₂ (3) and the known trithiocarbonato complex (PPh₃)₂Pt(κ²S,S-S₂C:S). These products were characterized by IR, ¹H, ¹³C{¹H} NMR and UV-Vis spectroscopy. Crystal structures of these complexes were determined by single crystal x-ray diffraction measurements. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2Application of 29364-29-2).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Application of 29364-29-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

3-Vinyl oxindole-chromone synthon as a skeletal reconstruction reactant for the synthesis of 2-hydroxy benzoyl pyridones was written by Zhang, Lei;Liu, Ren-Ming;Wang, Wei-Na;Liu, Xiong-Li;Dai, Yi-Feng;Yu, Zhang-Biao;Peng, Li-Jun. And the article was included in New Journal of Chemistry in 2022.Reference of 5856-63-3 This article mentions the following:

The first example of ring-opening and recyclization reaction of 3-vinyl oxindole-chromones I [R¹ = H, 4-F, 5-Br, etc.; R² = H, 5-F, 4-Cl, etc.] as versatile synthons, which can react with ammonia or primary aliphatic amines as binucleophiles was developed, serving as a fruitful strategy for the eco-friendly and atom-economic synthesis of a new family of skeletally diverse 2-hydroxy benzoyl pyridones II [R³ = H, CH₂CH₂OMe, CH₂CH₂CN, etc.] with high to excellent yields (70-92%). The advantages of this methodol., including the use of easily available raw materials and the catalyst-free, wide functional group tolerance, and gram-scale synthesis, make the developed methodol. a practical way to access important biol. active 2-hydroxy benzoyl pyridone mols. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Reference of 5856-63-3).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Reference of 5856-63-3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Visible-Light-Enabled Carboxylation of Benzyl Alcohol Derivatives with CO₂ Using a Palladium/Iridium Dual Catalyst was written by Jin, Yushu;Toriumi, Naoyuki;Iwasawa, Nobuharu. And the article was included in ChemSusChem in 2022.Formula: C7H7ClO This article mentions the following:

A highly efficient carboxylation of benzyl alc. derivatives with CO₂ using a palladium/iridium dual catalyst under visible-light irradiation was developed. A wide range of benzyl alc. derivatives was employed to provide benzylic carboxylic acids in moderate to high yields. Mechanistic studies indicated that the oxidative addition of benzyl alc. derivatives was possibly the rate-determining-step. It was also found that a switchable site-selective carboxylation between benzylic C-O and aryl C-Cl moieties could be achieved simply by changing the palladium catalyst. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Formula: C7H7ClO).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Formula: C7H7ClO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Novel (R)-(+)-limonene-derived ligands: synthesis and application in asymmetric transfer hydrogenations was written by Roszkowski, Piotr;Maurin, Jan K.;Czarnocki, Zbigniew. And the article was included in Tetrahedron: Asymmetry in 2012.Formula: C8H9ClO This article mentions the following:

(R)-(+)-Limonene was transformed into mono-N-tosylated-1,2-diamine derivatives using an N-tosylaziridination procedure followed by sodium azide treatment and reduction on Pd/C. The ligands obtained proved effective in the ruthenium-catalyzed asym. transfer hydrogenation protocol on aromatic ketones. Depending on the ligand and the substrate, the benzylic alc. products were obtained in nearly racemic form or up to 92% ee. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Formula: C8H9ClO).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Formula: C8H9ClO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Iron(III) Amine Bis(phenolate) Complex Immobilized on Silica-Coated Magnetic Nanoparticles: A Highly Efficient Catalyst for the Oxidation of Alcohols and Sulfides was written by Karimpour, Touraj;Safaei, Elham;Karimi, Babak;Lee, Yong-Ill. And the article was included in ChemCatChem in 2018.Synthetic Route of C7H6Cl2O This article mentions the following:

A bis(dihydroxybenzyl)glycinamide iron complex bound to silica- and magnetite nanoparticles was prepared as a magnetically recoverable and supported catalyst for green and chemoselective oxidations of primary and secondary alcs. to carboxylic acids and ketones, resp. and of sulfides to sulfoxides. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Synthetic Route of C7H6Cl2O).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Synthetic Route of C7H6Cl2O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Metal salts as new catalysts for mild and efficient aminolysis of oxiranes was written by Chini, Marco;Crotti, Paolo;Macchia, Franco. And the article was included in Tetrahedron Letters in 1990.Reference of 40571-86-6 This article mentions the following:

A new, simple, efficient, inexpensive method for aminolysis of 1,2-epoxides, by means of metal salts, is described. The reactions proceed under mild conditions in MeCN to afford β-amino alcs. with complete antistereoselectivity and generally high regioselectivity. In the experiment, the researchers used many compounds, for example, Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6Reference of 40571-86-6).

Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Reference of 40571-86-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Longitudinal two-dimensional gas chromatography mass spectrometry as a non-destructive at-line monitoring tool during cell manufacturing identifies volatile features correlative to cell product quality was written by Jimenez, Angela C.;Heist, Christopher A.;Navaei, Milad;Yeago, Carolyn;Roy, Krishnendu. And the article was included in Cytotherapy in 2022.Recommanded Product: 3391-86-4 This article mentions the following:

Cell therapies have emerged as a potentially transformative therapeutic modality in many chronic and incurable diseases. However, inherent donor and patient variabilities, complex manufacturing processes, lack of well-defined critical quality attributes and unavailability of in-line or at-line process or product anal. technologies result in significant variance in cell product quality and clin. trial outcomes. New approaches for overcoming these challenges are needed to realize the potential of cell therapies. Here the authors developed an untargeted two-dimensional gas chromatog. mass spectrometry-based method for non-destructive longitudinal at-line monitoring of cells during manufacturing to discover correlative volatile biomarkers of cell proliferation and end product potency. Specifically, using mesenchymal stromal cell cultures as a model, the authors demonstrated that GCxGC-MS of the culture medium headspace can effectively discriminate between media types and tissue sources. Headspace GCxGC-MS identified specific volatile compounds that showed a strong correlation with cell expansion and product functionality quantified by indoleamine-2,3-dioxygenase and T-cell proliferation/suppression assays. Addnl., the authors discovered increases in specific volatile metabolites when cells were treated with inflammatory stimulation. This work establishes GCxGC-MS as an at-line process anal. technol. for cell manufacturing that could improve culture robustness and may be used to non-destructively monitor culture state and correlate with end product function. In the experiment, the researchers used many compounds, for example, Oct-1-en-3-ol (cas: 3391-86-4Recommanded Product: 3391-86-4).

Oct-1-en-3-ol (cas: 3391-86-4) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Recommanded Product: 3391-86-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Effect of polar groups of polystyrenes on the self-assembly of breath figure arrays was written by Zhou, Di;Wu, Bai-Heng;Yang, Wen-Wu;Li, Xiao;Zhu, Liang-Wei;Xu, Zhi-Kang;Wan, Ling-Shu. And the article was included in Journal of Polymer Science (Hoboken, NJ, United States) in 2022.Recommanded Product: 2,2′-Oxybis(ethan-1-ol) This article mentions the following:

The breath figure (BF) process has been widely used to prepare patterned porous films. The mechanism remains to be further elucidated, especially how polymer architectures affect the stability of water droplets and the pore structure. Polystyrenes (PS) was functionalized with a series of polar groups both in chain middle and chain end, which was synthesized by using difunctional atom transfer radical polymerization (ATRP) initiators with the combination of nucleophilic substitution of the end bromine. It is found that PS with polar groups, which help to reduce interfacial tension, tends to form regular patterns at low concentration and to generate multilayered pores. The coalescence resistance measurement was performed to characterize the stabilization of water droplets from polymers by precipitation The results show opposite trend with the results of the BF process, indicating a minor role played by polymer precipitation on microdroplets stabilization. We reveal that addition of only an oxyethyl group in the chain middle of PS contributes to the formation of ordered patterns. This study helps to shed light on the impact of polymer architectures on the self-assembly behavior in the BF process. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6Recommanded Product: 2,2′-Oxybis(ethan-1-ol)).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Recommanded Product: 2,2′-Oxybis(ethan-1-ol)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hypervalent Iodine(III) Reagents with Transferable Primary Amines: Structure and Reactivity on the Electrophilic α-Amination of Stabilized Enolates was written by Poeira, Diogo L.;Negrao, Ana Claudia R.;Faustino, Helio;Coelho, Jaime A. S.;Gomes, Clara S. B.;Gois, Pedro M. P.;Marques, M. Manuel B.. And the article was included in Organic Letters in 2022.SDS of cas: 2216-51-5 This article mentions the following:

A new family of hypervalent iodine reagents containing transferable primary amine groups is described. The benziodoxolone-based reagents were synthesized on a gram-scale through operationally simple reactions in up to quant. yields. These bench-stable solids were characterized by X-ray anal. and successfully employed in the α-amination of indanone-based β-ketoesters in up to 83% yield. Mechanistic studies indicate a substitution mechanism involving an electrophilic amine. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5SDS of cas: 2216-51-5).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.SDS of cas: 2216-51-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ni(cod)(duroquinone)-Catalyzed C-N Cross-Coupling for the Synthesis of N,N-Diarylsulfonamides was written by You, Tian;Li, Junqi. And the article was included in Organic Letters in 2022.SDS of cas: 68716-49-4 This article mentions the following:

A C-N cross-coupling reaction of weakly nucleophilic N-arylsulfonamides and aryl bromides to access N,N-diarylsulfonamides RR¹NSO₂R² [R = n-Bu, Ph, 4-MeOC₆H₄, 4-F₃CC₆H₄; R¹ = Ph, 4-ClC₆H₄, 3-furyl, etc.; R² = cyclopropyl, 4-MeC₆H₄, 4-PhC₆H₄, etc.] using Ni(cod)(DQ) as a catalyst without addnl. ligands was reported. The process was compatible with electron-deficient and electron-rich aryl and heteroaryl bromides and could be applied to the derivatization of an N-arylsulfonamide pharmaceutical compound In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4SDS of cas: 68716-49-4).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.SDS of cas: 68716-49-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts