February 2023 - Page 25 of 129 - Alcohols-buliding-blocks

Duppeti, Haritha et al. published their research in Flavour and Fragrance Journal in 2022 | CAS: 3391-86-4

Oct-1-en-3-ol (cas: 3391-86-4) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Quality Control of Oct-1-en-3-ol

Influence of processing conditions on the aroma profile of Litopenaeus vannamei by SPME-GC-MS was written by Duppeti, Haritha;Kempaiah, Bettadaiah Bheemanakere;Manjabhatta, Sachindra Nakkarike. And the article was included in Flavour and Fragrance Journal in 2022.Quality Control of Oct-1-en-3-ol This article mentions the following:

This study reports the aroma profile of Litopenaeus vannamei under different processing conditions such as raw, boiled, hot air dried, microwave dried and roasted using SPME-GC-MS. A total of 86 volatile compounds were identified, among which 38 compounds reported as aroma-active compounds (AAC) having the odor activity value (OAV) greater than one. The microwave-dried shrimp meat (MSM) exhibited the highest summation of odor activity value, and roasted shrimp meat (RSM) showed the highest concentration of aroma-active compounds (3448.78 μg/g). The partial least square regression (PLSR) anal. and cluster anal. (CA) showed that MSM and RSM are related to each other in their aroma characteristics while boiled shrimp meat (BSM) is different than these samples. The results of this study illustrate the typical volatile markers and the impact of processing methods on flavor generation in L. vannamei, which should be examined for the assessment of its freshness and product development based on shrimp flavor. In the experiment, the researchers used many compounds, for example, Oct-1-en-3-ol (cas: 3391-86-4Quality Control of Oct-1-en-3-ol).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Check, Casey et al. published their research in European Polymer Journal in 2015 | CAS: 4074-88-8

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Reference of 4074-88-8

Effects of nanoparticles on photopolymerization of acrylate monomers in forming nano-composites was written by Check, Casey;Chartoff, Richard;Chang, Sean. And the article was included in European Polymer Journal in 2015.Reference of 4074-88-8 This article mentions the following:

The UV photopolymerization of diethylene glycol-diacrylate and isobornyl-acrylate based nano-composites was studied with respect to reaction conversion with variations in UV light exposure. The composites contained various amounts of well dispersed ZrO₂ nanoparticles. The degree of conversion achieved vs light intensity was measured by DSC for various compositions ranging from 0 to 30% by weight of nanoparticles. It was found that including nanoparticles in the monomer increased the conversion achieved considerably. This is attributed to the acceleration of the reaction through interactions with the silane surface ligand on the nanoparticles. The upper limit for conversion was limited because of vitrification and was different for each monomer. Also noted was that the detailed effects of particle concentration on conversion are quite different for the two monomers. Conversion vs. UV exposure data such as those presented provide information necessary for determining the appropriate UV exposure required for creating nano-composites by inkjet printing with optimized phys., mech., and optical properties. The results indicate that it is important to determine this information for forming nano-composites from any specific monomer/nanoparticle combination. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Reference of 4074-88-8).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cai, Aijie et al. published their research in Angewandte Chemie, International Edition in 2021 | CAS: 128607-22-7

(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.COA of Formula: C24H23ClO2

Copper-Catalyzed Difluoromethylation of Alkyl Iodides Enabled by Aryl Radical Activation of Carbon-Iodine Bonds was written by Cai, Aijie;Yan, Wenhao;Wang, Chao;Liu, Wei. And the article was included in Angewandte Chemie, International Edition in 2021.COA of Formula: C24H23ClO2 This article mentions the following:

A novel strategy that leveraged the halogen abstraction ability of aryl radicals, thereby engaging a diverse range of alkyl iodides in copper-catalyzed Negishi-type cross-coupling reactions at room temperature Specifically, aryl radicals generated via copper catalysis efficiently initiate the cleavage of the carbon-iodide bonds of alkyl iodides. The alkyl radicals thus generated enter the copper catalytic cycles to couple with a difluoromethyl zinc reagent, thus furnished the alkyl difluoromethane products. This unprecedented Negishi-type difluoromethylation approach was applied to the late-stage modification of densely functionalized pharmaceutical agents and natural products. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7COA of Formula: C24H23ClO2).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Yong et al. published their research in ACS Medicinal Chemistry Letters in 2016 | CAS: 5856-63-3

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Application of 5856-63-3

Discovery of Pyrazolo[1,5-a]pyrimidine TTK Inhibitors: CFI-402257 is a Potent, Selective, Bioavailable Anticancer Agent was written by Liu, Yong;Laufer, Radoslaw;Patel, Narendra Kumar;Ng, Grace;Sampson, Peter B.;Li, Sze-Wan;Lang, Yunhui;Feher, Miklos;Brokx, Richard;Beletskaya, Irina;Hodgson, Richard;Plotnikova, Olga;Awrey, Donald E.;Qiu, Wei;Chirgadze, Nickolay Y.;Mason, Jacqueline M.;Wei, Xin;Lin, Dan Chi-Chia;Che, Yi;Kiarash, Reza;Fletcher, Graham C.;Mak, Tak W.;Bray, Mark R.;Pauls, Henry W.. And the article was included in ACS Medicinal Chemistry Letters in 2016.Application of 5856-63-3 This article mentions the following:

This work describes a scaffold hopping exercise that begins with known imidazo[1,2-a]pyrazines, briefly explores pyrazolo[1,5-a][1,3,5]triazines, and ultimately yields pyrazolo[1,5-a]pyrimidines as a novel class of potent TTK inhibitors. An X-ray structure of a representative compound is consistent with 1¹/₂ type inhibition and provides structural insight to aid subsequent optimization of in vitro activity and physicochem. and pharmacokinetic properties. Incorporation of polar moieties in the hydrophobic and solvent accessible regions modulates physicochem. properties while maintaining potency. Compounds with enhanced oral exposure were identified for xenograft studies. The work culminates in the identification of a potent (TTK K_i = 0.1 nM), highly selective, orally bioavailable anticancer agent (CFI-402257) for IND enabling studies. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Application of 5856-63-3).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Yanzhao et al. published their research in Organic Letters in 2018 | CAS: 120121-01-9

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Synthetic Route of C8H9ClO

A Ferrocene-Based NH-Free Phosphine-Oxazoline Ligand for Iridium-Catalyzed Asymmetric Hydrogenation of Ketones was written by Wang, Yanzhao;Yang, Guoqiang;Xie, Fang;Zhang, Wanbin. And the article was included in Organic Letters in 2018.Synthetic Route of C8H9ClO This article mentions the following:

A new type of ferrocene-based phosphine-oxazoline ligand has been prepared over a few simple steps. An iridium complex of this ligand is air stable and exhibits excellent performance for the asym. hydrogenation of simple ketones (up to 98% yield, up to 99% ee, and 20000 S/C). Exo-α,β-unsaturated cyclic ketones could be regiospecifically hydrogenated to give chiral allylic alcs. with good results. This study indicates that P,N-ligands can also efficiently promote Ir-catalyzed asym. hydrogenation without NH-hydrogen-bonding assistance. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Synthetic Route of C8H9ClO).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rafanelli, Claudio E. et al. published their research in Water, Air, and Soil Pollution in 1978 | CAS: 2451-01-6

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. The oxygen atom of the strongly polarized O鈥旽 bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Name: rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate

Photochlorination of organic substances by aqueous chloride ions codissolved with anionic NO_x^–. Part II. Effect of nitrite was written by Rafanelli, Claudio E.;Petriconi, Gianna L.;Papee, Henry M.. And the article was included in Water, Air, and Soil Pollution in 1978.Name: rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate This article mentions the following:

Aqueous NO₂^– codissolved with Cl^– promotes photochlorination of some reactive organic compounds in contact with those solutions Both overall patterns of the process and the quantum yields of this Cl transfer into the organic phase are very similar to the patterns and yields of reactions which involved NO₃^– and were carried out under artificial illumination. With analogy to those photoreactions of NO₃^–-Cl^– systems, the overall kinetics outlined in the laboratory for systems comprising NO₂^– are also followed, with higher quantum yields, under sunlight illumination. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Name: rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pham, Hoai Linh Linh et al. published their research in Journal of Sol-Gel Science and Technology in 2022 | CAS: 111-46-6

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Quality Control of 2,2′-Oxybis(ethan-1-ol)

Morphological evolution of 3D ZnO hierarchical nanostructures by diethylene glycol-assisted sol-gel synthesis for highly effective photocatalytic performance was written by Pham, Hoai Linh Linh;Nguyen, Van Hao;Nguyen, Van Khien;Tran, Nhu Hoa Thi;Le, Hong Phong Thi;Tran, Thi Huong;Nguyen, Hong Nhung;Lam, Kieu Giang Thi;Dang, Van Thanh. And the article was included in Journal of Sol-Gel Science and Technology in 2022.Quality Control of 2,2′-Oxybis(ethan-1-ol) This article mentions the following:

In this study, we focus on synthesizing various 3D ZnO hierarchical nanostructures (ZnH) for highly effective photocatalytic performance via an innovative sol-gel method using diethylene glycol as an assembly-guiding agent. The morphol. of 3D ZnH can be turned from nanospheres into nanoplate blocks and nanosheet-based flowers by increasing the concentration of diethylene glycol. Possible growth mechanisms are proposed for different assembly architectures. Anal. of characterization techniques reveal that the synthesized hierarchical structures exhibited a large sp. surface area, high degree of crystallinity, and a band gap in the range 2.95-3.11 eV, depending on their morphol. X-ray photoelectron and photoluminescence spectroscopy revealed the presence of rich oxygen vacancies introduced by the 3D ZnO hierarchical morphol. The photodegradation experiment results presented in ZnO nanosheet-based flower shown superior photoactivity of rhodamine B degradation compared with nanospheres and nanoplate blocks structures. This is attributed to the larger surface area, enhanced light absorption, and more effective photogenerated charge separation on account of their rich Vo. The establishment of relevant structural-optical property relationships is expected to provide deeper insights into the potential use of ZnH for innovative devices. Graphical abstract [graphic not available: see fulltext]. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6Quality Control of 2,2′-Oxybis(ethan-1-ol)).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fu, Yonghao et al. published their research in Aquaculture in 2022 | CAS: 137-08-6

Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Electric Literature of C18H32CaN2O10

Effects of dietary chromium yeast levels on growth performance, anti-oxidative capacity, immune response and flesh quality of abalone Haliotis discus hannai was written by Fu, Yonghao;Guo, Jinshu;Wu, Zhenhua;Yu, Xiaojun;Guo, Yanlin;Huang, Dong;Li, Xinxin;Zhang, Wenbing;Mai, Kangsen. And the article was included in Aquaculture in 2022.Electric Literature of C18H32CaN2O10 This article mentions the following:

A 110-day feeding trial was conducted to investigate the effects of dietary chromium (Cr) on the growth performance, immune response, anti-oxidative capacity, stress resistance, flesh quality of abalone Haliotis discus hannai. Seven isonitrogenous and isolipidic exptl. diets were formulated with graded levels of Cr (0.04, 0.67, 1.21, 1.58, 2.21, 2.72 and 3.33 mg/kg) from Cr yeast. The results showed that weight gain rate (WGR) was highest in the group with 1.21 mg/kg of dietary Cr. Based on the broken-line regression anal. for WGR, the dietary Cr requirement of abalone was estimated to be 1.32 mg/kg. With the increase of dietary Cr level from 0.04 to 1.21 mg/kg, the total anti-oxidative capacity and lysozyme activity in the cell-free hemolymph were increased and then decreased when the dietary Cr level exceeded 1.21 mg/kg. After the challenge of Vibrio parahaemolyticus, the cumulative mortality of abalone was significantly decreased in the group with 1.21 mg/kg of dietary Cr compared with that in the control group. Meanwhile, after the heat stress test, the cumulative mortality of abalone was significantly reduced in the groups with 1.58, 2.21 and 2.72 mg/kg of dietary Cr compared with that in the control group. The liquid and water loss of foot muscle were significantly increased in the groups with 2.72 and 3.33 mg/kg of dietary Cr. With the increase of dietary Cr levels, the hardness of foot muscle was significantly elevated. The chewiness of foot muscle was significantly increased with the increase of dietary Cr level from 0.04 to 1.21 mg/kg, and thereafter showed no significant difference when dietary Cr exceeded 1.21 mg/kg. In conclusion, based on the WGR, dietary Cr requirement of abalone (initial weight: 22.31 卤 0.31 g) was estimated to be 1.32 mg/kg. Appropriate dietary Cr levels (1.21-1.58 mg/kg) had pos. effects on growth performance, immune response, anti-oxidation, anti-stress and flesh quality of abalone. Overhigh dietary Cr level (2.72-3.33 mg/kg) decreased the flesh quality. Excessive dietary Cr level (3.33 mg/kg) had a neg. effect on the health of abalone. In the experiment, the researchers used many compounds, for example, Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6Electric Literature of C18H32CaN2O10).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Murthia, Ponugubati R. K. et al. published their research in Current Catalysis in 2014 | CAS: 121282-70-0

tert-Butyl (trans-2-hydroxycyclohexyl)carbamate (cas: 121282-70-0) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Reference of 121282-70-0

Revisiting Iodine-Mediated N-tert-Butoxycarbonylation of Amines was written by Murthia, Ponugubati R. K.;Kumar, Gondrala P.;Rambabua, Dandela;Rao, Mandava V. B.;Pal, Manojit. And the article was included in Current Catalysis in 2014.Reference of 121282-70-0 This article mentions the following:

The revisiting of iodine-mediated N-Boc (N-tert-butoxycarbonyl) protection of RNH₂ (R = C₆H₅, 4-FC₆H₄, 2-HOC₆H₄, etc.) revealed that the reaction can be performed using a lower quantity of iodine as a catalyst within a shorter reaction time. In addition to various aliphatic and aromatic amines, the reaction was found to be equally effective and selective for the N-Boc protection of amino acid, guanidine, thiourea and N-(diaminomethylene)-1,1,1-trifluoromethanesulfonamide. The operational simplicity, high yield, mild and solvent-free nature are the other features of this process. In the experiment, the researchers used many compounds, for example, tert-Butyl (trans-2-hydroxycyclohexyl)carbamate (cas: 121282-70-0Reference of 121282-70-0).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gedik, Osman et al. published their research in South African Journal of Botany in 2022 | CAS: 499-75-2

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Reference of 499-75-2

Determining the essential oil components and plant nutrient element values of some Satureja genotypes was written by Gedik, Osman;Kocabas, Yusuf Ziya;Cinar, Orcun. And the article was included in South African Journal of Botany in 2022.Reference of 499-75-2 This article mentions the following:

The essential oil components and plant nutrient element values of a total of 4 different genotypes of two different species in the genus Satureja were determined in the present study. Nurhak, Baskonus, and Kapidere genotypes were classified as belonging to Satureja hortensis L., and Goksun genotype to Satureja cuneifolia Ten. The plant samples of the genotypes were taken during the flowering period, dried in the shade, and the resulting herbals were used for essential oil extraction and plant nutrient identification. The essential oil ratio among the genotypes was between 1.83-3.00% and the highest essential oil ratio was obtained from the Baskonus genotype with 3.00%. A total of 27 different components were determined in the essential oil of the genotypes, and the main components were found to be carvacrol (5.28-64.00%) and thymol (0.28-40.96%), -terpinene (17.23-32.36%), and cymene (7.78-16.80%). Regarding the plant nutrients, the highest Ca, Mn, Fe, and Mg values were found in Kapidere genotype; Zn, Na, and P in Baskonus genotype, K in Nurhak and Baskonus genotypes, and the highest Cu was detected in Nurhak genotype. Baskonus genotype stood out in terms of essential oil and carvacrol ratios. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Reference of 499-75-2).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts