Month: January 2023

Asymmetric Hydrogenation of Ketones and Enones with Chiral Lewis Base Derived Frustrated Lewis Pairs was written by Gao, Bochao;Feng, Xiangqing;Meng, Wei;Du, Haifeng. And the article was included in Angewandte Chemie, International Edition in 2020.SDS of cas: 120121-01-9 This article mentions the following:

The concept of frustrated Lewis pairs (FLPs) has been widely applied in various research areas, and metal-free hydrogenation undoubtedly belongs to the most significant and successful ones. In the past decade, great efforts have been devoted to the synthesis of chiral boron Lewis acids. In a sharp contrast, chiral Lewis base derived FLPs have rarely been disclosed for the asym. hydrogenation. In this work, a novel type of chiral FLP was developed by simple combination of chiral oxazoline Lewis bases with achiral boron Lewis acids, thus providing a promising new direction for the development of chiral FLPs in the future. These chiral FLPs proved to be highly effective for the asym. hydrogenation of ketones, enones, and chromones, giving the corresponding products in high yields with up to 95% ee. Mechanistic studies suggest that the hydrogen transfer to simple ketones likely proceeds in a concerted manner. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9SDS of cas: 120121-01-9).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.SDS of cas: 120121-01-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis and resolution of Racemic trans-2-(N-benzyl)amino-1-cyclohexanol: enantiomer separation by sequential use of (R)- and (S)-mandelic acid [cyclohexanol, 2-(N-benzyl)amino, (1S,2S)- and (1R,2R)-] was written by Schiffers, Ingo;Bolm, Carsten. And the article was included in Organic Syntheses in 2008.Recommanded Product: Trans-2-(benzylamino)cyclohexanol This article mentions the following:

A method for the synthesis of the title compounds [i.e., (1R,2R)-2-[(phenylmethyl)amino]cyclohexanol and (1S,2S)-2-[(phenylmethyl)amino]cyclohexanol] is reported here. A reaction of cyclohexene oxide [i.e., 7-oxabicyclo[4.1.0]heptane] with benzenemethanamine provided a trans-racemic intermediate [i.e., (1R,2R)-rel-2-[(phenylmethyl)amino]cyclohexanol]. Salt formation of that intermediate with (S)-mandelic acid gave the desired (αS)-α-hydroxybenzeneacetic acid compound with (1R,2R)-2-[(phenylmethyl)amino]cyclohexanol (1:1) as a precipitate The corresponding (αR)-α-hydroxybenzeneacetic acid compound with (1S,2S)-2-[(phenylmethyl)amino]cyclohexanol (1:1) was obtained similarly from the (S,S)-isomer remaining in the filtrate. The above-mentioned title compounds were obtained after hydrolysis and recovery of mandelic acid. In the experiment, the researchers used many compounds, for example, Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6Recommanded Product: Trans-2-(benzylamino)cyclohexanol).

Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Recommanded Product: Trans-2-(benzylamino)cyclohexanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Characterization and identification of pork flavor compounds and their precursors in Chinese indigenous pig breeds by volatile profiling and multivariate analysis was written by Wu, Weida;Zhan, Junliang;Tang, Xiaoyan;Li, Ting;Duan, Shengnan. And the article was included in Food Chemistry in 2022.Reference of 3391-86-4 This article mentions the following:

Chinese indigenous pigs are favored for their rich flavor, which is generated through complex reactions involving lipid-oxidation-related flavor precursors. In this research, we characterized the aroma compounds and fatty acids of representative Chinese pig breeds by gas chromatog.-olfactometry-mass spectrometry (GC-O-MS) and GC-ion mobility spectrometry (GC-IMS) with multivariate anal. A total of 79 volatile compounds were identified, among which 15 compounds were selected as odorants in pork. According to multivariate statistical anal., some odorants, including hexanal, 1-octen-3-ol, 2,3-octanedione, (E, E)-2,4-decadienal and dodecanal could be discriminative compounds explaining breed-originated differences in flavor profiles. As confirmed by partial least squares regression (PLS-R), some fatty acids, including C18:1n9c, C22:6n3 and C18:3n3, were major precursors for the formation of rich flavor in indigenous pig breeds. These results revealed that fatty acids and volatile compounds were breed-dependent, and the differences in flavor were related to the variance in the fatty acid content. In the experiment, the researchers used many compounds, for example, Oct-1-en-3-ol (cas: 3391-86-4Reference of 3391-86-4).

Oct-1-en-3-ol (cas: 3391-86-4) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Reference of 3391-86-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electro organic synthesis as green and sustainable approach for synthesis of chloro substituted benzyl alcohols was written by Saharan, Ritu. And the article was included in Journal of the Indian Chemical Society in 2022.Related Products of 1777-82-8 This article mentions the following:

A green and sustainable approach for synthesis of chloro substituted benzyl alcs. has been established. In present research paper cyclic voltammetry study followed by constant current electrolysis and characterization of synthesized 2-chlorobenzyl alc., 3-chlorobenzyl alc., 4-chlorobenzyl alc. and 2,4-dichlorobenzyl alc. has been reported. Cyclic voltammetry measurements have been employed to setup optimum conditions for electrolysis and to find out electrochem. nature of various Chloro substituted benzaldehydes. Then these results have been judiciary used to carry out electrochem. reduction of various chloro substituted benzaldehydes using constant current electrolysis. Influence of scan rate and pH on reduction peaks has also been investigated referring irreversible electron transfer phenomenon in basic medium. The kinetic parameters for reduction reactions have been estimated showing the process under the influence of diffusion control. This has a scientific achievement in terms of the obtained products and their derivatives which are industrially and pharmaceutically significant chems. owing to their huge applications in petrochem. industries and medical sectors. Throat lozenges containing dichlorobenzyl alc. (DCBA) are used for treatment of respiratory tract infections. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Related Products of 1777-82-8).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Related Products of 1777-82-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Essential oils nano-emulsion confers resistance against Penicillium digitatum in primeNewhallprime navel orange by promoting phenylpropanoid metabolism was written by Yang, Ruopeng;Miao, Jinyu;Chen, Xiu;Chen, Chuying;Simal-Gandara, Jesus;Chen, Jinyin;Wan, Chunpeng. And the article was included in Industrial Crops and Products in 2022.Recommanded Product: 5-Isopropyl-2-methylphenol This article mentions the following:

Inducing natural resistance against pathogen infection in postharvest citrus by exogenous elicitor is a promising alternative to reduce postharvest losses. Here, the potential induced resistance mechanism of blended cinnamaldehyde, carvacrol and eugenol nano-emulsion against P. digitatum in primeNewhallprime navel orange (Citrus sinensis (L.) Osbeck) was evaluated through combined transcriptomic and metabolomics anal. Application of nano-emulsion maintained fruit firmness after P. digitatum inoculation, nano-emulsion reduced H₂O₂ and MDA accumulation of citrus fruit, increased PAL, C4H, 4CL and CAD activity, and higher contents of flavonoids, lignin and total phenolic compounds Furthermore, higher activities of SOD, CAT, POD and APX in nano-emulsion treated fruit possibly benefited reducing ROS accumulation and lipid peroxidation The activities of the defense enzymes CHI, GLU were higher in the nano-emulsion treated fruits. RNA-seq identified 653 differentially expressed genes (DEGs) between the control and the nano-emulsion-treated fruit at 48 hpi, including 444 up-regulated and 209 downregulated genes. Genes encoding shikimate O-hydroxycinnamoyltransferase (HCT), caffeoyl-CoA O-methyltransferase (CCoAOMT), caffeic acid 3-O-methyltransferase / acetylserotonin O-methyltransferase (COMT), cinnamyl-alc. dehydrogenase (CAD) and peroxidase (POD) were differentially expressed by nano-emulsion treatment. In addition, 175 differential accumulated metabolites between the control and the nano-emulsion-treated fruit at 48 hpi also were identified, the different accumulated metabolites from phenylpropanoid biosynthesis pathway related with disease resistance including -phenylalanine, caffeic acid, caffeoyl quinic acid, coniferyl alc., coniferaldehyde. The integrated transcriptomic and metabolomic profiling indicated that the differentially expressed genes (DEGs) and the differentially accumulated metabolites (DAMs) were mainly involved in phenylpropanoid biosynthesis pathway. Besides, the nano-emulsion significantly induced accumulation of primary metabolites including amino acids, soluble sugars, organic acids, lipids, sugar and alcs. All these results indicated that blended essential oil nano-emulsion as an antifungal delivery system to induce resistance against P. digitatum infection of ‘Newhall ‘ navel orange by promoting phenylpropanoid metabolism In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Recommanded Product: 5-Isopropyl-2-methylphenol).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Recommanded Product: 5-Isopropyl-2-methylphenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Natural cellulose fibers from Quinoa wastes reinforced carbon nanotube/ZnO bio-nanocomposite as a novel recyclable catalyst for oxidation reaction was written by Naeimi, Atena;Khoshkam, Sibgol;Eslaminejad, Touba. And the article was included in Polymer Bulletin (Heidelberg, Germany) in 2022.Electric Literature of C7H7ClO This article mentions the following:

Cellulose fibers from Quinoa wastes were successfully incorporated with multi-walled carbon nanotubes/ZnO (MWCNTs/ZnO). Manganese complex was supported on natural cellulose and reacted with MWCNT/Zn bio-nanocomposite to have MWCNT/ZnO/Mn complex@oxidized cellulose. This novel bio-nanocomposite was characterized by SEM, TEM, FT-IR, TGA, and EDS. The catalytic activity of this composite was considered on the oxidation of alcs. High conversion and selectivities of desired aldehyde and ketone products were obtained applying H2O2 and under solvent-free conditions. This heterogeneous catalyst was easily recycled and reused eight times without any significant catalytic activities and stabilities. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Electric Literature of C7H7ClO).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Electric Literature of C7H7ClO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Antioxidant defence system based oxidative stress mitigation through dietary jamun tree leaf in experimentally infected snubnose pompano, Trachinotus blochii was written by Prabu, Dhanasekaran Linga;Ebeneezar, Sanal;Chandrasekar, Selvam;Kavitha, Mookaiah;Vijayagopal, Pananghat. And the article was included in Fish Physiology and Biochemistry in 2021.Formula: C18H32CaN2O10 This article mentions the following:

A 45-day feeding trial was conducted to evaluate the effect of dietary jamun tree leaf (JL) on the antioxidant defense system-based disease resistance in juveniles of Trachinotus blochii. The juveniles of snubnose pompano were distributed into four treatment groups in triplicates. Each treatment was fed with a diet containing either 0 (0JL), 0.5 (0.5JL), 1 (1JL) and 1.5% JL (1.5JL) in the feed. After feeding trial, the fishes were exptl. infected with Vibrio parahaemolyticus. The activities of oxidative stress enzymes such as superoxide dismutase and catalase were found to be increasing with increasing level of dietary JL incorporation, and the lower value was witnessed in control group in pre- and post-challenge. After challenge, the alanine and aspartate aminotransferase activities in all the treatments were significantly increased (P < 0.05) than the pre-challenge condition and exhibited reverse trend with the antioxidant enzymes. The alk. and acid phosphatase activities were found higher in 1.5JL group and showed significant difference (P < 0.05) among the treatments. The respiratory burst activity and liver glycogen content showed an increasing trend as the level of inclusion of JL increased in the diet. The acetylcholinesterase activity was significantly plunged (P < 0.05) after exptl. infection, and JL diet fed groups showed better activity. After exptl. infection with V. parahaemolyticus, the highest relative percentage of survival was observed in 1JL and 1.5JL groups. Hence, dietary supplementation of jamun tree leaf at the level of 1% is adequate to reduce the oxidative stress and improved the innate immune status through antioxidant defense system. In the experiment, the researchers used many compounds, for example, Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6Formula: C18H32CaN2O10).

Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Formula: C18H32CaN2O10

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cyclization Reaction of 4-Acyl-1-sulfonyl-1,2,3-triazoles Possessing Phenyl Rings through Generation of Electron-deficient Carbenoids was written by Zhao, Qiang;Miura, Tomoya;Murakami, Masahiro. And the article was included in Chemistry Letters in 2019.SDS of cas: 2968-93-6 This article mentions the following:

A rhodium-catalyzed cyclization reaction of 4-acyl-1-sulfonyl-1,2,3-triazoles was reported for the synthesis of 2-indanone derivatives such as I [R = H, 5-Me, 6-OMe, etc. ; R¹ = Ms, Ts; R² = H, Ph, (CH₂)₂Ph]. Generated acceptor/acceptor carbenoids underwent cyclization by reacting either with a Ph ring through electrophilic aromatic substitution or with a benzylic C-H bond through insertion depending on the length of the carbon chain. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6SDS of cas: 2968-93-6).

2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.SDS of cas: 2968-93-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Effects of multivitamin nanoemulsion on growth performance, immune function, antioxidant ability, intestinal tissue structure and cecal microecology of growing Rex rabbits was written by Ye, Xiangyang;Gong, Ruiguang;Ren, Zhanjun. And the article was included in Dongwu Yingyang Xuebao in 2021.Category: alcohols-buliding-blocks This article mentions the following:

The aim of this experiment was to investigate the effects of multivitamin nanoemulsion on growth performance, immune function, antioxidant ability, intestinal tissue structure and cecal microecol. of growing Rex rabbits. A total of 150 healthy weaned Rex rabbits at the age of 30 days and similar body weight were selected, and randomly divided into 5 groups with 3 repetitions in each group and 10 rabbits (half male and half female) in each repetition. Rabbits in control group I were fed a granulated feed containing vitamins (100% nutritional standard), normal drinking water; rabbits in control group II fed the same granulated feed with control group I, but the drinking water added Twain-80+glycerol (the contents of them were the same as test group II). Rabbits in test groups were fed the granulated feed without vitamins, and test groups I, II and III were added multivitamin nanoemulsion including 80%, 100% and 120% nutritional standard vitamins in drinking water. The experiment lasted for 61 days including a 5-day preliminary period and a 56-day test period. The results showed as follows: compared with control group I, 1) on day 1 to 28, the diarrhea rate and diarrhea mortality were significantly reduced in control group II and test group I (P<0.05), on day 29 to 56, the average daily feed intake was significantly reduced in test groups II and III (P<0.05), while the feed/gain was not significant difference (P>0.05). 2) The thymus index was significantly reduced in test groups I and II (P<0.05), the appendix length was significantly reduced in control group II and test group II (P<0.05), and the liver index was significantly increased in test groups I and III (P<0.05). 3) The blood total antioxidant capacity in test group II and blood superoxide dismutase activity in control group II were significantly increased (P<0.05). 4) The villus height of ileum was significantly increased in control group II (P<0.01), the crypt depth of ileum was significantly reduced in test group I (P<0.05), and the villus height/crypt depth of ileum was significantly increased in all test groups and control group II (P<0.01). The lymphocyte cell proportion in simple columnar epithelium of ileum was significantly increased in control group II (P<0.05). 5) The relative abundances of Firmicutes, Ruminococcaceae and Ruminococcaceae UCG-014 in cecum were significantly reduced in test group II (P<0.05). It is concluded that adding multivitamin nanoemulsion containing the nutritional standard of 100% into the drinking water can enhance the immune function and antioxidant ability, improve the intestinal tissue structure and cecal microecol. of growing Rex rabbits. In the experiment, the researchers used many compounds, for example, Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6Category: alcohols-buliding-blocks).

Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Metal-Macrocycle Framework (MMF): Supramolecular Nano-Channel Surfaces with Shape Sorting Capability was written by Tashiro, Shohei;Kubota, Ryou;Shionoya, Mitsuhiko. And the article was included in Journal of the American Chemical Society in 2012.COA of Formula: C8H9ClO This article mentions the following:

Hollow nanostructures for the functional assembly of chem. groups with inner surface geometry and regulable stoichiometry enable steric design of interior reaction centers. Herein the authors report a metal-macrocycle framework (MMF) that forms single-crystalline nanochannels with five distinct enantiomeric pairs of guest binding pockets. During crystal-soaking experiments, the MMF crystals can encapsulate aromatic mols. with high site selectivity. First, constitutional isomers of dibromobenzene are captured and sorted into different binding pockets. Second, each of the optical isomers of (1R/1S)-1-(3-chlorophenyl)ethanol is included diastereoselectively into one of an enantiomeric pair of binding pockets. An advantage of this strategy is that the interior walls can be “repainted” via replacement of the trapped mols. with alternatives. Such guest uptake behaviors would allow highly regioselective or stereoselective reactions within the nanochannel. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9COA of Formula: C8H9ClO).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.COA of Formula: C8H9ClO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts