Month: January 2023

Utilization of sulfate turpentine for the preparation of medicinal products was written by Bobranski, B.;Jakobiec, T.;Pomorski, J.. And the article was included in Acta Poloniae Pharmaceutica in 1955.Recommanded Product: 2451-01-6 This article mentions the following:

By fractional distillation of sulfate turpentine, a waste product of the cellulose industry, the sample yielded approx. 40% pinene, b. 154-60°, of sufficient purity to be used for camphor and terpene hydrate synthesis. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Recommanded Product: 2451-01-6).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Recommanded Product: 2451-01-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dielectric and magnetic exchange natures of a dinuclear double-stranded hydrogen bonds helicates was written by Li, Jing;Yang, Li;Yin, Lei;Jiang, Shang-da;Ouyang, Zhong-wen;Zhang, Yi-quan;Wang, Zhen-xing;Song, You. And the article was included in Wuji Huaxue Xuebao in 2020.Application In Synthesis of 6-Methyl-2-pyridinemethanol This article mentions the following:

The dielec. and magnetic properties of a dinuclear Co(II) double-stranded helicate containing hydrogen bridging bond have been investigated. Magnetic properties, HF-EPR spectra and dielec. properties all indicate that this intramol. hydrogen bond plays an important role in the magnetic exchange interactions and dielec. properties. Ab initio calculations provide further support for above conclusions. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Application In Synthesis of 6-Methyl-2-pyridinemethanol).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Application In Synthesis of 6-Methyl-2-pyridinemethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Metallaphotoredox-enabled deoxygenative arylation of alcohols was written by Dong, Zhe;MacMillan, David W. C.. And the article was included in Nature (London, United Kingdom) in 2021.Recommanded Product: 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane This article mentions the following:

Metal-catalyzed cross-couplings are a mainstay of organic synthesis and are widely used for the formation of C-C bonds, particularly in the production of unsaturated scaffolds1. However, alkyl cross-couplings using native sp3-hybridized functional groups such as alcs. remain relatively underdeveloped2. In particular, a robust and general method for the direct deoxygenative coupling of alcs. would have major implications for the field of organic synthesis. A general method for the direct deoxygenative cross-coupling of free alcs. must overcome several challenges, most notably the in situ cleavage of strong C-O bonds3, but would allow access to the vast collection of com. available, structurally diverse alcs. as coupling partners4. Authors report herein a metallaphotoredox-based cross-coupling platform in which free alcs. are activated in situ by N-heterocyclic carbene salts for carbon-carbon bond formation with aryl halide coupling partners. This method is mild, robust, selective and most importantly, capable of accommodating a wide range of primary, secondary and tertiary alcs. as well as pharmaceutically relevant aryl and heteroaryl bromides and chlorides. The power of the transformation has been demonstrated in a number of complex settings, including the late-stage functionalization of Taxol and a modular synthesis of Januvia, an antidiabetic medication. This technol. represents a general strategy for the merger of in situ alc. activation with transition metal catalysis. In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4Recommanded Product: 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Recommanded Product: 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Green synthesis of nitriles using non-noble metal oxides-based nanocatalysts was written by Jagadeesh, Rajenahally V.;Junge, Henrik;Beller, Matthias. And the article was included in Nature Communications in 2014.Product Details of 220227-37-2 This article mentions the following:

An environmentally benign chemoselective synthesis of structurally diverse aryl, heterocyclic, allylic and aliphatic nitriles from easily available alcs. applying aqueous ammonia and mol. oxygen was described. Key to success for this synthesis was the use of nitrogen-doped graphene-layered non-noble metal oxides as stable and durable nanocatalysts. As an example a renewable synthesis of adiponitrile, an industrially important bulk chem. was reported. In the experiment, the researchers used many compounds, for example, (3,4,5-Trifluorophenyl)methanol (cas: 220227-37-2Product Details of 220227-37-2).

(3,4,5-Trifluorophenyl)methanol (cas: 220227-37-2) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Product Details of 220227-37-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Vasorelaxant effect of monoterpene carvacrol on isolated human umbilical artery was written by Djukanovic, Djordje;Bojic, Milica Gajic;Marinkovic, Sonja;Trailovic, Sasa;Stojiljkovic, Milos P.;Skrbic, Ranko. And the article was included in Canadian Journal of Physiology and Pharmacology in 2022.Formula: C10H14O This article mentions the following:

Carvacrol (CRV) is the main compound of essential oils extracted primarily from Thymus and Origanum species. Its various biol. activities were confirmed: antioxidant, anti-inflammatory, antibacterial, antifungal, anti-tumor, antinematodal, and vasorelaxant action. Although vasodilation mediated by CRV was previously described, the exact mechanism of its action has not yet been established. Hence, the aim of this study was to investigate CRV vasoactivity on human umbilical arteries (HUA) and the different pathways involved in its mechanism of action using the tissue bath methodol. CRV caused a significant decrease in vascular tension of 5-HT-pre-contracted umbilical arteries, with EC₅₀ of 442.13 ± 33.8 μmol/L (mean ± standard error of the mean-SEM). At 300 μmol/L, CRV shifted downward the 5-HT concentration-response curve with a statistical significance of p < 0.001 obtained for the four highest concentrations At a concentration of 1 mmol/L, CRV completely abolished BaCl₂-induced contraction in Ca²⁺-free Krebs-Ringer bicarbonate solution and the BAY K 8644-induced contraction in Krebs-Ringer bicarbonate solution (p < 0.001). Isopentenyl pyrophosphate, the antagonist of TRPV₃ channel, was able to decrease the efficacy of CRV (p < 0.001). The blocking of L-type Ca²⁺ channels on smooth muscle cells is the most probable mechanism of CRV-induced vasorelaxation. However, the role of TRPV₃ channels in CRV-induced vasodilation of HUA cannot be excluded either. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Formula: C10H14O).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Formula: C10H14O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Self-crosslinkable complexes based on poly(ethylene glycol) (PEG), poly(itaconic acid) (PIA) and N-methylol acrylamide (NMA) as pharmaceutical hydrophilic matrices was written by Ayres, Eliane;Ferreira, Carla Regina;Lima, Tadeu Henrique;Martins, Giuliano S.;Villanova, Janaina C. O.;Orefice, Rodrigo L.. And the article was included in Polymer Bulletin (Heidelberg, Germany) in 2016.Formula: C16H26O7 This article mentions the following:

The formation and characterization of poly(itaconic acid)/N-methylol acrylamide/poly(ethylene glycol) (PIA/NMA/PEG) complexes through in situ polymerization of itaconic acid on poly(ethylene glycol) was investigated. FTIR indicated that PEG crystallization was hindered by complex formation. The decrease in the crystallinity of PEG was also observed by DSC and indicated that the mobility of some PEG segments was inhibited by the presence of the polyacid. According to the swelling experiments, complexes proved to be suitable for use as excipient in the preparation of drug delivery systems responsive to pH changing. DMA was used to estimate the crosslink densities and the results were found to be in good agreement with the swelling results. Further, the adhesion strength of the synthesized polymers was used as preliminary evaluation of their potential of mucoadhesion. The results indicated that the adhesion performance is related to the presence of NMA. Drugs which suffer degradation in stomach pH, such as proteins and enzymes are potential candidates to be included in the systems based on PIA/NMA/PEG to pass through the stomach (pH near to 1.2-3.5). Upon reaching the initial portion of the small intestine (pH >5.5), the polymer will swell and release the active substance via diffusion and/or erosion of the matrix. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Formula: C16H26O7).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Formula: C16H26O7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fabrication and characterization of remineralizing dental composites containing calcium type pre-reacted glass-ionomer (PRG-Ca) fillers was written by da Silva Meirelles Doria Maia, Juliana Nunes;Portela, Maristela Barbosa;Sanchez Candela, Dalber Ruben;Neves, Aline de Almeida;Noronha-Filho, Jaime Dutra;Mendes, Amanda de Oliveira;Barros, Mariana Araujo;Moreira da Silva, Eduardo. And the article was included in Dental Materials in 2021.Electric Literature of C16H26O7 This article mentions the following:

To fabricate and characterize dental composites with calcium type pre-reacted glass-ionomer (PRG-Ca) fillers.PRG-Ca fillers were prepared by the reaction of calcium fluoroaluminosilicate glass with polyacrylic acid. Seven dental composites were produced from the same organic matrix (70/30 wt% Bis-GMA/TEGDMA), with partial replacement of barium borosilicate (BaBSi) fillers (60 wt%) by PRG-Ca fillers (wt%): E0 (0) – control, E1 (10), E2 (20), E3 (30), E4 (40), E5 (50) and E6 (60). Enamel remineralization was evaluated in caries-like enamel lesions induced by S. mutans biofilm using micro-CT. The following properties were characterized: degree of conversion (DC%), roughness (Ra), Knoop hardness (KHN), flexural strength (FS), flexural modulus (FM), water sorption (W_sp), water solubility (W_sl), and translucency (TP). Data were analyzed to one-way ANOVA and Tukey′s HSD test (α = 0.05).All composites with PRG-Ca induced enamel remineralization. E0 and E1 presented similar and highest DC% than E2 = E3 = E4 = E5 = E6. Ra and KHN were not influenced by PRG-Ca fillers (p < 0.05). The higher the content of PRG-Ca, the lower FS, FM and TP (p < 0.05). Wsp increased linearly with the content of PRG-Ca fillers (p < 0.05). E6 presented the highest W_sl (p < 0.05), while the Wsl of the other composites were not different from each other (p > 0.05).Incorporation of 10-40 weight% of PRG-Ca fillers endowed remineralizing potential to dental composites without jeopardizing the overall behavior of their physicochem. properties. Dental composites with PRG-Ca fillers seems to be a good alternative for reinforcing the enamel against caries development. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Electric Literature of C16H26O7).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Electric Literature of C16H26O7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Carvacrol encapsulation into nanoparticles produced from chia and flaxseed mucilage: Characterization, stability and antimicrobial activity against Salmonella and Listeria monocytogenes was written by Cacciatore, Fabiola Ayres;Maders, Caroline;Alexandre, Bibiana;Barreto Pinilla, Cristian Mauricio;Brandelli, Adriano;da Silva Malheiros, Patricia. And the article was included in Food Microbiology in 2022.Category: alcohols-buliding-blocks This article mentions the following:

Carvacrol is a natural antimicrobial with excellent antimicrobial properties against several foodborne pathogens. Encapsulation can increase carvacrol stability and solubility, and mask its pronounced odor. Mucilages have been studied as wall material for nanoparticles due to their high retention capacity of bioactive compounds and ease of chem. modifications to improve their stability. In this study, 1.67 mg/mL of carvacrol encapsulated into chia mucilage nanoparticles (CMNP) and flaxseed mucilage nanoparticles (FMNP) were produced by high-energy emulsification technique and tested against Listeria monocytogenes and Salmonella. Encapsulation efficiency around 98% of carvacrol was obtained for both formulations. CMNP showed a diameter size of 179 nm and zeta potential of -11.4 mV. Bacterial Inactivation Concentration (BIC) of CMNP was 0.42 mg/mL against Salmonella and 0.83 mg/mL against L. monocytogenes. FMNP showed diameter size of 165.3 nm and zeta potential of -12.6 mV. BIC of FMNP was 0.83 mg/mL against both microorganisms. SEM anal. showed that the nanoparticles are spherically shaped. Concentrations of BIC and 1/2 BIC were used to evaluate the kinetics of bacterial growth in the presence of antimicrobials (CMNP, FMNP and carvacrol solution). The results of this test showed that viable counts of Salmonella and L.monocytogenes were below the detection limit (1.69 log CFU/mL) after 2 h incubation (37°C) using CMNP at the BIC. The wall material, rehydrated chia and flaxseed mucilages, reduced L. monocytogenes growth during 24 h. However, unloaded nanoparticles kept the viable counts of both microorganisms 2-5 log CFU/mL below the control curve of microbial growth during the 48 h experiment, suggesting that nanostructured mucilages potentiate antimicrobial properties. The results indicate that CMNP and FMNP have potential for use as food preservatives. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Category: alcohols-buliding-blocks).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Crosslinked degradable poly(β-thioester) networks via amine-catalyzed thiol-ene click polymerization was written by Vandenbergh, Joke;Peeters, Marloes;Kretschmer, Tobias;Wagner, Patrick;Junkers, Thomas. And the article was included in Polymer in 2014.Formula: C10H14O5 This article mentions the following:

A set of binary and ternary biodegradable cross-linked poly(β-thioester) networks have been synthesized via thiol-ene Michael additions, by reacting combinations of dithiols, diacrylates and multifunctional cross-linkers. Insoluble binary thermoset networks and soluble ternary branched polymers with broad molar mass distributions are obtained in a facile manner after polymerization at room temperature for only few minutes. The networks display excellent thermal stability up to 250 °C and exhibit low glass transition temperatures The soluble branched polymers show degradation of the polyester backbone upon chem. degradation by acidic and basic solutions Finally, the (bio)degradability of ternary PBT polymer films is examined via quartz crystal microbalance measurements. Weight loss is measured as a function of time upon exposure to phosphate buffers at different pH. PBTs carrying apolar chain segments display surface degradation, while PBTs with more polar ethylene glycol segments allow for swelling in aqueous solution, which is reflected in concomitant surface and bulk degradation of the materials. Because of their biodegradability, these easy to synthesize poly(β-thioesters) networks are considered to be suitable candidates to use in future biomedical or ecol. applications. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Formula: C10H14O5).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Formula: C10H14O5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Thermal degradation mechanism and kinetics of aluminum-copper green bodies prepared by gelcasting was written by Yuan, Hai-ying;Jia, Cheng-chang;Zhang, Xin-xin;Karima, Bekouche;Wang, Zhao-li. And the article was included in Beijing Keji Daxue Xuebao in 2016.Reference of 4074-88-8 This article mentions the following:

Aluminum-copper green bodies were successfully prepared by a non-aqueous gelcasting system. SEM observations showed that the powder particles were completely wrapped by the polymer before degreasing, and the polymer in the metal body was completely removed after degreasing. A three-dimensional network polymer structure was obtained by the reaction mechanism. The degreasing process of the metal body was investigated by means of differential scanning calorimetry, thermogravimetry-derivative thermogravimetry and thermogravimetry-Fourier transform IR spectroscopy. The kinetic equations and parameters were gotten according to Coats-Redfern method for non-isothermal weight loss curves. The results indicate that at different heating rates the reaction order is 1, the activation energy and pre-exponential factor are ranging from 79.86 to 108.63 kJ·mol^-1 and 10⁶ to 10⁷ min^-1, resp. The activation energy reaction is sensitive to temperature and dynamics. The degreasing process is divided into two stages: a slight weight loss over a wide temperature range of 240-350°C is due to the random chain scission and the main weight loss around 380 to 425°C is attributed to depolymerization of monomers from the main chains and decrosslinking of the network polymer. The emissions of CO₂, CO, NO₂ and H₂O are identified during the degreasing process. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Reference of 4074-88-8).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Reference of 4074-88-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts