Month: January 2023

Halloysite-Based Nanomotors with Embedded Palladium Nanoparticles for Selective Benzyl Alcohol Oxidation was written by Wang, Jian;Zhang, Yan;Xu, Yang;Zhang, Peiping;Gao, Qian;Liang, Qing;Zhang, Wei;Li, Wenqing;Guo, Ruifeng;Jin, Bo;Miao, Shiding. And the article was included in ACS Applied Nano Materials in 2022.Product Details of 873-76-7 This article mentions the following:

Palladium (Pd) nanoparticles were impregnated in lumens of halloysite nanotubes by using ionic liquid (1-(2′-hydroxylethyl)-2,3-dimethylimidazolium chloride) as directing agents. On the basis of the asym. scroll-like structure of halloysite and the catalytic decomposition ability of Pd toward H₂O₂, the prepared catalyst (Pd-IL-HNTs) exhibited powerful self-propelled movement at an average speed of 276 ± 35μm/s in 30.0 wt % H₂O₂ solution The specific interaction between nanomotors and benzyl alc. was observed as a consequence of self-moving behavior and hydrophobic interaction introduced by ionic liquid With the synergistic coupling of the catalytic ability and powerful movement, Pd-IL-HNTs displayed outstanding catalytic benzyl alc. oxidation performance. Compared to other nonpropelling catalysts using lamellar clay (montmorillonite and kaolinite) as supports, such HNT-based nanomotors registered superior catalytic performance, and the TOF value of 118.1 h^-1 was obtained. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Product Details of 873-76-7).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Product Details of 873-76-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A Convenient and Stable Heterogeneous Nickel Catalyst for Hydrodehalogenation of Aryl Halides Using Molecular Hydrogen was written by Leonard, David K.;Ryabchuk, Pavel;Anwar, Muhammad;Dastgir, Sarim;Junge, Kathrin;Beller, Matthias. And the article was included in ChemSusChem in 2022.Category: alcohols-buliding-blocks This article mentions the following:

In this study, a nickel-based catalyst supported on titania (Ni-phen@TiO₂-800) was prepared and used as a safe alternative to pyrophoric Raney-nickel. The catalyst was prepared in a straightforward fashion by deposition of nickel(II)/1,10-phenanthroline on titania, followed by pyrolysis. The catalytic material, which was characterized by SEM, TEM, XRD and XPS, consisted of nickel nanoparticles covered with N-doped carbon layers. By using design of experiments (DoE), this nanostructured catalyst was found to be proficient for the facile and selective hydrodehalogenation of a diverse range of substrates bearing C-I, C-Br, or C-Cl bonds afforded aromatic hydrocarbons R-H [R = 1-naphthyl, 4-H₂NC₆H₄, 4-CO₂MeC₆H₄, etc.] (>30 examples). The practicality of this catalyst system was demonstrated by the dehalogenation of environmentally hazardous and polyhalogenated substrates atrazine, tetrabromobisphenol A, tetrachlorobenzene and a polybrominated di-Ph ether (PBDE). In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Category: alcohols-buliding-blocks).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

AuPt NPs with enhanced electrochemical oxidization activity for ratiometric electrochemical aptasensor was written by Zhao, Yuan;Yao, Jie;Wu, Zhenglong;Liu, Han;Zheng, Wangwang. And the article was included in Biosensors & Bioelectronics in 2022.COA of Formula: C4H10O3 This article mentions the following:

Strong and stable electrochem. beacons are critical for the achievement of sensitive and reliable electroanal. applications. In this work, the electrochem. oxidation performance of AuPt NPs was studied and firstly found to be largely enhanced under light illumination. Plasmonic AuPt NPs collected light energy after local surface plasmon resonance (LSPR) excitation and generated much more holes to participate in the electrochem. oxidation process of Pt0 in AuPt NPs. AuPt NPs with the electrochem. oxidation peak at around -0.7 V were utilized as detection probes for the fabrication of ratiometric electrochem. aptasensor, by introducing Co-MOF/Fe3O4/Ag nanosheets (NSs) with the electrochem. oxidation peak at 0.1 V as reference beacons. The aptamers of epithelial cell adhesion mol. (EpCAM) modified AuPt NPs were assembled with Co-MOF/Fe3O4/Ag NSs, which generated strong detection and reference signals at -0.7 V and 0.1 V, resp. The high affinity between EpCAM and aptamers induced the separation of AuPt NPs from Co-MOF/Fe3O4/Ag NSs, resulting in the decrease of detection signal at -0.7 V and unchanged reference signal at 0.1 V. A ratiometric electrochem. aptasensor was achieved for the sensitive and reliable quantification of EpCAM in the range from 100 pg/mL to 100 ng/mL. The limit of detection (LOD) was calculated to be 13.8 pg/mL for EpCAM. Plasmon-driven electrochem. oxidation enhancement principle provides the possibility for the design and fabrication of more strong and anti-interference electroactive plasmonic metal-Pt composite nanostructures for the electroanal. applications. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6COA of Formula: C4H10O3).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.COA of Formula: C4H10O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Freezing chicken semen: Influence of base medium osmolality, cryoprotectants, cryoprotectant concentration, and cooling rate on post-thaw sperm survival was written by Woelders, H.;de Wit, A. A. C.;Engel, B.;Hulsegge, B.;Grasseau, I.;Blesbois, E.;Bernal, B.;Santiago-Moreno, J.. And the article was included in Cryobiology in 2022.Recommanded Product: 57-55-6 This article mentions the following:

A classical chicken semen diluent (Lake’s 7.1 diluent) was modified to have lowered osmolalities (ranging from 290 to 410 mOsm/kg). The modified medium with physiol. osmolality of 325 mOsm/kg allowed cold storage of fresh semen for several days with very little loss of membrane integrity and motility, while high osmolalities inhibited motility. This modified medium was then used as base for freezing medium to test effects of the type and concentration of cryoprotective agent (CPA), and the cooling rate (CR). A number of CPAs (methylformamide, methylacetamide, DMF (DMF), dimethylacetamide (DMA), diethylformamide, and propylene glycol) were first compared by freezing semen with 0.6 mol/l of the resp. CPA at a cooling rate of 250°C/min. Post-thaw motility and membrane integrity were highest with DMA and DMF. Finally, in more detailed factorial experiments, semen from individual cocks or pooled semen was frozen using CRs of 4, 50, 250, and 440°C/min and DMA concentrations ([DMA]) of 0.4, 0.6, 1.0, and 1.5 mol/l. Straws from each semen sample x treatment combination were divided for semen assessment at three different research groups for sperm motility, membrane integrity, kinked tails, and DNA fragmentation, using microscopy, computer assisted motility anal., and flow cytometry. There were clear effects of both CR and [DMA] and their interaction. CRs 50 and 250°C/min gave best post-thaw sperm performance. Higher DMA concentrations gave better post-thaw membrane integrity, but concentrations above 1.0 mol/l can decrease sperm velocity or even inhibit sperm motility. Therefore [DMA] may best be 0.6-1.0 mol/l at a CR of 50-250°C/min. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Recommanded Product: 57-55-6).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Recommanded Product: 57-55-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Discovery of Functionally Selective 7,8,9,10-Tetrahydro-7,10-ethano-1,2,4-triazolo[3,4-a]phthalazines as GABA_A Receptor Agonists at the α₃ Subunit was written by Russell, Michael G. N.;Carling, Robert W.;Atack, John R.;Bromidge, Frances A.;Cook, Susan M.;Hunt, Peter;Isted, Catherine;Lucas, Matt;McKernan, Ruth M.;Mitchinson, Andrew;Moore, Kevin W.;Narquizian, Robert;Macaulay, Alison J.;Thomas, David;Thompson, Sally-Anne;Wafford, Keith A.;Castro, Jose L.. And the article was included in Journal of Medicinal Chemistry in 2005.Safety of 6-Methyl-2-pyridinemethanol This article mentions the following:

7,8,9,10-Tetrahydro-7,10-ethano-1,2,4-triazolo[3,4-a]phthalazine I (R¹ = Ph; R² = 2-pyridylmethyl) was previously identified as a potent partial agonist for the α₃ receptor subtype with 5-fold selectivity in binding affinity over α₁. This paper describes a detailed investigation of the substituents on this core structure at both the 3- and 6-positions. Despite evaluating a wide range of groups, the maximum selectivity that could be achieved in terms of affinity for the α₃ subtype over the α₁ subtype was 12-fold (for I [R¹ = Ph; R² = 4-(HOCH₂)C₆H₄CH₂]). Although most analogs showed no selectivity in terms of efficacy, some of them, e.g. I (R¹ = Ph; R² = 3,5-dimethyl-2-pyridylmethyl, pyrazol-1-ylmethyl), did show partial agonism at α₁ and antagonism at α₃. However, two analogs I (R¹ = Ph; R² = 1-methyl-1,2,4-triazol-3-ylmethyl, 2-propyl-1,2,4-triazol-3-ylmethyl), containing triazole substituents in the 6-position, showed significantly higher efficacy for the α₃ subtype over the α₁ subtype. This was the first indication that selectivity in efficacy in the required direction could be achieved in this series. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Safety of 6-Methyl-2-pyridinemethanol).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Safety of 6-Methyl-2-pyridinemethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Selective Difunctionalization of Unactivated Aliphatic Alkenes Enabled by a Metal-Metallaaromatic Catalytic System was written by Cui, Fei-Hu;Hua, Yuhui;Lin, Yu-Mei;Fei, Jiawei;Gao, Le-Han;Zhao, Xiaodan;Xia, Haiping. And the article was included in Journal of the American Chemical Society in 2022.Quality Control of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol This article mentions the following:

The design of organometallic catalysts is crucial in the development of catalytic reactions. Herein, the authors describe a heterometallic [Os-Cu] complex with the characteristics of bimetallics, metallaaroms. and pincer complexes. This complex serves as a highly effective catalyst for selective amino- and oxyselenation of unactivated alkenes. More than 80 examples including challenging substrates of unsym. aliphatic alkenes and amine-based nucleophiles in such reactions are provided. These reactions produce 1,2-difunctionalized products with good yields and high levels of chemo-, regio- and stereoselectivity. The study revealed that (i) the usually inert Os center activates the N- or O-centered nucleophiles, (ii) the Cu-Os bonding and its cooperative effects play essential roles in control the selectivity by bringing the reaction components into close proximity, and (iii) the metallaarom. moiety helps to stabilize the intermediate. These findings provide a versatile platform for catalyst design based on metal-metallaarom. cooperative effects that were not attained previously with bimetallic complexes. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Quality Control of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Quality Control of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Acid and light dual- stimuli-cleavable polymeric micelles was written by Fang, Jia-You;Lin, Yin-Ku;Wang, Shiu-Wei;Yu, Yung-Ching;Lee, Ren-Shen. And the article was included in Journal of Polymer Research in 2016.SDS of cas: 60463-12-9 This article mentions the following:

In this study, acid and light dual- stimuli-responsive amphiphilic AB-type methoxy poly(ethylene glycol)-acetal-ONB-poly(4-substituted-ε-caprolactone) (MPEG-a-ONB-PXCL) diblock copolymers were synthesized using ring-opening polymerization and nucleophilic substitution reactions. The prepared copolymer features an acid-cleavable acetal group and photocleavable o-nitrobenzyl linkage between the hydrophilic MPEG and hydrophobic PXCL blocks. The design enables the diblock copolymers to respond to both acid and UV light while ensuring the min. number of stimuli-reactive moieties in the copolymer structure. The disruption of the copolymeric micelles in aqueous solution was examined under the action of pH or UV light alone or under the combined stimulation pH and UV light. Under the combined stimulation of UV irradiation and pH, the micellar nanoparticles could dissociate; therefore, the loaded mols. could be released from the assemblies more efficiently than under either stimulus alone. The nanoparticles exhibited nonsignificant toxicity against human cervical cancer (HeLa) cells at concentrations ≤300 μg mL^-1. Doxorubicin (DOX)-loaded micelles facilitated the uptake of DOX by the HeLa cells at the initial stage. The dual stimuli-cleavable polymeric micelles show promising potential as new nanocarrier for precisely controlled release of encapsulated drug. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9SDS of cas: 60463-12-9).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.SDS of cas: 60463-12-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The production of some oral suspensions of the Vth Edition of the Hungarian Formulae Normales in the form of single-dose tablets was written by Petroczki, Mihaly. And the article was included in Gyogyszereszet in 1979.Related Products of 2451-01-6 This article mentions the following:

Plasdone XL [9003-39-8] was used as an adjuvant for tabletting sulfadimidine [57-68-1], salicylamide [65-45-2], Bi subsalicylate [14882-18-9], and terpin hydrate [2451-01-6]. Fast tablet disintegration is imparted by Plasdone XL. The 4 above active ingredients, formulated as suspensions in the 5th Hungarian Formulary can, thus, be advantageously used as tablets. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Related Products of 2451-01-6).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Related Products of 2451-01-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mono-N-Alkylation of Sulfonamides with Alcohols Catalyzed by Iridium N-Heterocyclic Carbene-Phosphine Complexes was written by Li, Xingzhen;Peters, Bram B. C.;Tan, Min;He, Lei;Yang, Jianping;Andersson, Pher G.;Zhou, Taigang. And the article was included in Asian Journal of Organic Chemistry in 2022.Name: (4-Chlorophenyl)methanol This article mentions the following:

A N-heterocyclic carbene-phosphine iridium complex was presented for the efficient and selective mono-N-alkylation of sulfonamides with alcs. based on a borrowing hydrogenation strategy. Herein, water was the only byproduct and this methodol. thus offered a more environmentally benign and interesting alternative to the use of traditional alkylating reagents. This facile protocol tolerated a large number of (hetero) aromatic and aliphatic sulfonamides as well as (hetero) aromatic and aliphatic alcs. to obtain the desired product is high isolated yield (up to 98%). The alkylation completely retarded after the formation of the secondary sulfonamide and no over-alkylation was observed in all cases. The option to run the reaction under solvent-free conditions as well as the scalability of this borrowing hydrogenation were key features of this protocol. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Name: (4-Chlorophenyl)methanol).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Name: (4-Chlorophenyl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nonconjugated Dendritic Iridium(III) Complexes with Tunable Pyridine-Based Ligands: Synthesis, Photophysical, Electrochemical, and Electroluminescent Properties was written by Li, Xianghong;Chen, Zhao;Zhao, Qiang;Shen, Li;Li, Fuyou;Yi, Tao;Cao, Yong;Huang, Chunhui. And the article was included in Inorganic Chemistry in 2007.Category: alcohols-buliding-blocks This article mentions the following:

A simple synthetic route was developed for preparation of iridium cyclometalated dendritic nonconjugated second-generation polybenzyloxy-substituted 2-phenylpyridine and 2-(2-benzo[b]thienyl)pyridine complexes based on tunable 2-arylpyridine ligands. From a key intermediate, 2-bromo-4-pyridinemethanol, three series of polybenzyloxy dendritic pyridine-based ligands with 2-Ph, 2-benzothienyl, and 2,4-difluorophenyl substituents were easily prepared via two-step reaction sequence comprising Suzuki coupling and etherification. Using these pyridine proligands the dendritic-substituted iridium(III) complexes cyclometalated complexes exhibiting tunable photoluminescence from blue to red were obtained. The photoluminescence quantum yields of these dendritic complexes in neat films increased with the increasing generation number of dendritic C-N-ligands. Importantly, these iridium complexes were used as dopants for successfully fabricated polymer-based electrophosphorescent light-emitting diodes (PLEDs), featuring the highest external quantum efficiency of 12.8%. In the experiment, the researchers used many compounds, for example, 2-Bromopyridine-4-methanol (cas: 118289-16-0Category: alcohols-buliding-blocks).

2-Bromopyridine-4-methanol (cas: 118289-16-0) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts