Month: January 2023

Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents was written by Waszkielewicz, A. M.;Gunia-Krzyzak, A.;Powroznik, B.;Sloczynska, K.;Pekala, E.;Walczak, M.;Bednarski, M.;Zeslawska, E.;Nitek, W.;Marona, H.. And the article was included in Bioorganic & Medicinal Chemistry in 2016.Recommanded Product: 5856-63-3 This article mentions the following:

A series of thirty N-(phenoxy)alkyl or N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols has been designed, synthesized and evaluated for anticonvulsant activity in MES, 6 Hz test, and pilocarpine-induced status epilepticus. Among the title compounds, the most promising seems to be I with proved absolute configuration with x-ray anal. and enantiomeric purity. The compound is effective in MES test with ED₅₀ = 12.92 mg/kg b.w. and its rotarod TD₅₀ = 33.26 mg/kg b.w. The activity dose is also effective in a neurogenic pain model-the formalin test. Within high throughput profile assay, among eighty one targets, the strongest affinity of the compound is observed towards σ receptors and 5-HT transporter and the compound does not bind to hERG. It also does not exhibit mutagenic properties in the Vibrio harveyi test. Moreover, murine liver microsomal assay and pharmacokinetics profile (mice, iv, p.o., i.p.) indicate that the liver is the primary site of biotransformation of the compound, suggesting that both I and its metabolite(s) are active, compensating probably low bioavailability of the parent mol. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Recommanded Product: 5856-63-3).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Recommanded Product: 5856-63-3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reinforced catalytic oxidation of polyoxometalate@charge transfer complex by on-site heating from photothermal conversion was written by Chen, Xiaofei;Yang, Aibing;Wang, Gengxin;Wei, Mingfeng;Liu, Ning;Li, Bao;Wu, Lixin. And the article was included in Chemical Engineering Journal (Amsterdam, Netherlands) in 2022.Recommanded Product: (4-Chlorophenyl)methanol This article mentions the following:

Near IR (NIR) absorption at low energy region has been demonstrated to devoted to photothermal conversion efficiently. This process provides a possibility for valuable extension in emerging photothermal catalysis following a specific approach of mol. composition To exploit novel photothermal materials in increasing the catalytic activity of comment catalysts, a typical yet unnoticed charge transfer (CT) complex of 3,3′,5,5′-tetramethylbenzidine (TMB_CT) is used here as an on-site heater. Through the electrostatic complexation of cationic CT complex bearing strong NIR absorption with series polyanionic clusters, composite catalysts are prepared These nano-assembled catalysts in size of 5-10 nm display integrated NIR photothermal effect and highly enhanced catalysis for the mild oxidation of toluene and its derivatives into corresponding alcs. with high conversion and selection. While NIR photothermal stability of TMB_CT is maintained, the catalytic activity of inorganic clusters is largely improved. The increments in conversion unattainable under external heating condition are realized and the extension to the mild oxidation of thioethers and olefins into sulfoxides and epoxides with acceptable catalytic recyclability and structural stability are demonstrated. All results from the detailed characterizations figure out the applicability of the NIR photothermal conversion to the catalytic reactions with similar catalytic centers. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Recommanded Product: (4-Chlorophenyl)methanol).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Recommanded Product: (4-Chlorophenyl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In-situ synthesis of Ru-WO_X/biochar catalyst for conversion of cellulose toward ethylene glycol was written by Huang, Haiyun;Chen, Lungang;Gu, Canshuo;Zhang, Xinghua;Liu, Jianguo;Zhang, Qi;Wang, Chenguang;Ma, Longlong;Liao, Yuhe. And the article was included in Cellulose (Dordrecht, Netherlands) in 2022.Related Products of 57-55-6 This article mentions the following:

Efficient utilization of renewable biomass plays a vital role in CO₂ mitigation. Direct conversion of cellulose, the most abundant fraction in lignocellulosic biomass, into ethylene glycol is a promising route. In this work, by using the biowaste pomelo peel as the carbon precursor, the Ru-WO_X/biochar (BC) bifunctional catalyst was prepared via pyrolysis in a nitrogen atm. without further reduction Cellulose could be efficiently converted into ethylene glycol with a yield of 68.8% after 10 h using Ru-WO_X/BC at the temperature of 220 °C and 3 MPa H₂. The effects of reaction temperature, reaction time, H₂ pressure and catalysts obtained from different pyrolysis temperatures on the yield of ethylene glycol were investigated. The characterization and reaction results showed that the gas generated from pyrolysis of pomelo peel could partially reduce ruthenium precursor to metallic form. Metallic Ru can not only promote the reduction of W⁶⁺ to W⁵⁺, but also work on hydrogenation reaction. The catalyst and preparation method have a promising application in cellulose conversion. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Related Products of 57-55-6).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Related Products of 57-55-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Potential of polymethacrylate pseudo crown ethers as solid state polymer electrolytes was written by Moins, S.;Martins, J. C.;Krumpmann, A.;Lemaur, V.;Cornil, J.;Delbosc, N.;Decroly, A.;Dubois, Ph.;Lazzaroni, R.;Gohy, J.-F.;Coulembier, O.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2017.Related Products of 109-17-1 This article mentions the following:

The association of kinetic studies, DFT calculations and ¹H-⁷Li NMR analyses allowed the control of the cyclo-ATRP of PEG₉DMA and the production of polymethacrylate pseudo crown-ethers of various molar masses. Their potential to act as a solid-state polymer electrolyte in Li-ion batteries has been highlighted and may come from the supramol. organization of the cyclo-PEG forming a Li⁺ diffusion channel. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Related Products of 109-17-1).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Related Products of 109-17-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rongalite-Mediated Transition Metal- and Hydride-Free Chemoselective Reduction of α-Keto Esters and α-Keto Amides was written by Golla, Sivaparwathi;Kokatla, Hari Prasad. And the article was included in Journal of Organic Chemistry in 2022.Formula: C7H7ClO This article mentions the following:

A transition metal- and hydride-free protocol was developed for the chemoselective reduction of α-keto esters and αketo amides using rongalite as a reducing agent. Here, rongalite acts as a hydride-free reducing agent via a radical mechanism. This protocol offered the synthesis of a wide range of α-hydroxy esters ArCHOHC(O)OR [Ar = Ph, 4-MeC₆H₄, 1-naphthyl, etc.; R = Et, i-Pr, Bn, etc.] and α-hydroxy amides ArCHOHC(O)NR¹R² [Ar = Ph, 4-MeC₆H₄, 4-MeOC₆H₄, etc.; R¹ = H, Me; R² = Ph, 4-MeC₆H₄, Bn, etc.] with 85-98% yields. This chemoselective method was compatible with other reducible functionalities such as halides, alkenes, amides and nitriles. The use of inexpensive rongalite (ca. $0.03/1 g), mild reaction conditions, and gram-scale synthesis were some of the key features of this methodol. Also, cyclandelate, a vasodilator drug, was synthesized in gram scale with 79% yield. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Formula: C7H7ClO).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Formula: C7H7ClO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Photolabile Well-Defined Polystyrene Grafted on Silica Nanoparticle via Nitroxide-Mediated Polymerization (NMP) was written by Ho, Hien The;Phan, Trang N. T.;Bonnevide, Marine;Malicki, Nicolas;Couty, Marc;Jestin, Jacques;Gigmes, Didier. And the article was included in Macromolecular Rapid Communications in 2021.Application of 60463-12-9 This article mentions the following:

Herein, the synthesis of a novel nitroxide-mediated polymerization (NMP) initiator bearing a photolabile ortho-nitrobenzyl (oNB) group allowing surface-initiated NMP preparation of well-defined photoresponsive polystyrene grafted on silica nanoparticles is described. The photocleavable and photoresponsive properties of the prepared materials are demonstrated using small angle X-ray scattering (SAXS) characterization. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Application of 60463-12-9).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Application of 60463-12-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fate and transport modelling framework for assessing risks to soil and groundwater from chemicals accidentally released during surface operations: An Australian example application from shale gas developments was written by Mallants, Dirk;Doble, Rebecca;Beiraghdar, Yousef. And the article was included in Journal of Hydrology (Amsterdam, Netherlands) in 2022.Name: 2,2′-Oxybis(ethan-1-ol) This article mentions the following:

Shale and tight gas developments in the Beetaloo (28,000 km²) and Cooper (139,000 km²) basins of Australia are subject to stringent State and Federal Government controls and assessments. Several scientific investigations are ongoing to improve the scientific basis of the risks from unconventional gas developments to water and the environment. In this study a framework was developed to derive estimates of chem. dilution associated with leakage to groundwater from accidental release of chems. used for shale and tight gas extraction in Australia. The quant. assessment accounted for key landscape parameters that determine natural attenuation: soil type, depth to groundwater and groundwater velocity. Both basins were discretised into 1000 x 1000 m² grids for which the unsaturated zone and groundwater dilution factors were derived. Migration of chems. through deep unsaturated zones was calculated with the HYDRUS-1D simulator, taking account of best-available hydraulic properties from a digital soil database. A three-dimensional anal. solution of the advection-dispersion equation provided estimates of dilution in groundwater after solutes travelled 500 m from the center (source location) to the edge of every grid cell. The combined vadose zone-groundwater dilution factors were used to determine under which conditions concentrations of hydraulic fracturing chems. or flowback water accidentally released into the environment would decrease to levels that are no longer considered harmful to the environment. When the method was applied to 39 hydraulic fracturing chems. scheduled for stimulation of a shale gas well, ecotoxicol. risk quotients (RQ) were calculated to indicate which chems. were of no environmental concern. This work contributes to increasing the efficiency of quant. impact assessments and provides a framework to develop dedicated monitoring and management practices to support regulation and management of the gas industry in Australia. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6Name: 2,2′-Oxybis(ethan-1-ol)).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Name: 2,2′-Oxybis(ethan-1-ol)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Novel series of pyrrolotriazine analogs as highly potent pan-Aurora kinase inhibitors was written by Abraham, Sunny;Hadd, Michael J.;Tran, Lan;Vickers, Troy;Sindac, Janice;Milanov, Zdravko V.;Holladay, Mark W.;Bhagwat, Shripad S.;Hua, Helen;Ford Pulido, Julia M.;Cramer, Merryl D.;Gitnick, Dana;James, Joyce;Dao, Alan;Belli, Barbara;Armstrong, Robert C.;Treiber, Daniel K.;Liu, Gang. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.Recommanded Product: Sodium 2-methyl-2-propanethiolate This article mentions the following:

The synthesis and SAR for a novel series of pyrrolotriazines as pan-Aurora kinase inhibitors are described. Optimization of the cyclopropane carboxamide terminus of lead compound I resulted in analogs with high cellular activity and improved rat PK profiles. Notably, pyrrolotriazine II demonstrated tumor growth inhibition in a mouse xenograft model. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2Recommanded Product: Sodium 2-methyl-2-propanethiolate).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Recommanded Product: Sodium 2-methyl-2-propanethiolate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ruthenium-catalyzed hydrogenation of aromatic ketones using chiral diamine and monodentate achiral phosphine ligands was written by Wang, Mengna;Zhang, Ling;Sun, Hao;Chen, Qian;Jiang, Jian;Li, Linlin;Zhang, Lin;Li, Li;Li, Chun. And the article was included in Catalysis Communications in 2021.SDS of cas: 171032-87-4 This article mentions the following:

The Ru-catalyzed asym. hydrogenation of ketones with chiral diamine and monodentate achiral phosphine has been developed. A wide range of ketones were hydrogenated to afford the corresponding chiral secondary alcs. in good to excellent enantioselectivities (up to 98.1% ee). In addition, an appropriate mechanism for the asym. hydrogenation was proposed and verified by NMR spectroscopy. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4SDS of cas: 171032-87-4).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.SDS of cas: 171032-87-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor was written by Arasappan, Ashok;Bennett, Frank;Bogen, Stephane L.;Venkatraman, Srikanth;Blackman, Melissa;Chen, Kevin X.;Hendrata, Siska;Huang, Yuhua;Huelgas, Regina M.;Nair, Latha;Padilla, Angela I.;Pan, Weidong;Pike, Russell;Pinto, Patrick;Ruan, Sumei;Sannigrahi, Mousumi;Velazquez, Francisco;Vibulbhan, Bancha;Wu, Wanli;Yang, Weiying;Saksena, Anil K.;Girijavallabhan, Viyyoor;Shih, Neng-Yang;Kong, Jianshe;Meng, Tao;Jin, Yan;Wong, Jesse;McNamara, Paul;Prongay, Andrew;Madison, Vincent;Piwinski, John J.;Cheng, Kuo-Chi;Morrison, Richard;Malcolm, Bruce;Tong, Xiao;Ralston, Robert;Njoroge, F. George. And the article was included in ACS Medicinal Chemistry Letters in 2010.HPLC of Formula: 29364-29-2 This article mentions the following:

Boceprevir (SCH 503034), 1, a novel HCV NS3 serine protease inhibitor discovered in our laboratories, is currently undergoing phase III clin. trials. Detailed investigations toward a second generation protease inhibitor culminated in the discovery of narlaprevir (SCH 900518), 37, with improved potency (∼10-fold over 1), pharmacokinetic profile and physicochem. characteristics, currently in phase II human trials. Exploration of synthetic sequence for preparation of 37 resulted in a route that required no silica gel purification for the entire synthesis. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2HPLC of Formula: 29364-29-2).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.HPLC of Formula: 29364-29-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts