Month: January 2023

Cobalt-catalyzed asymmetric hydrogenation of ketones: A remarkable additive effect on enantioselectivity was written by Du, Tian;Wang, Biwen;Wang, Chao;Xiao, Jianliang;Tang, Weijun. And the article was included in Chinese Chemical Letters in 2021.Recommanded Product: 120121-01-9 This article mentions the following:

A chiral cobalt pincer complex, when combined with an achiral electron-rich mono-phosphine ligand, catalyzes efficient asym. hydrogenation of a wide range of aryl ketones, affording chiral alcs. with high yields and moderate to excellent enantioselectivities (29 examples, up to 93% ee). Notably, the achiral mono-phosphine ligand showed a remarkable effect on the enantioselectivity of the reaction. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Recommanded Product: 120121-01-9).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Recommanded Product: 120121-01-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bioscreening and pre-clinical evaluation of the impact of bioactive molecules from Ptychotis verticillata on the multilineage potential of mesenchymal stromal cells towards immune- and inflammation-mediated diseases was written by Bouhtit, Fatima;Najar, Mehdi;Rahmani, Saida;Melki, Rahma;Najimi, Mustapha;Sadki, Khalid;Boukhatem, Noreddine;Twizere, Jean-Claude;Meuleman, Nathalie;Lewalle, Philippe;Lagneaux, Laurence;Merimi, Makram. And the article was included in Inflammation Research in 2022.Recommanded Product: 5-Isopropyl-2-methylphenol This article mentions the following:

Mesenchymal stromal cells (MSCs) are currently used in cell reparative medicine due to their trophic and ant-inflammatory properties. The modulation of stem cell properties by phytochems. has been suggested as a tool to empower their tissue repair capacity. In vitro, MSCs are characterized by their tri-lineage potential that holds great interest for tissue regeneration. Ptychotis Verticillata (PV), an aromatic and medicinal plant, may be thus used to modulate the in vitro multilineage potential of MSCs. We screened the impact of PV-derived essential oil and their bioactive mols. (thymol and carvacrol) on the in vitro multilineage potential of MSCs. Different concentrations and incubation times of these compounds were assessed during the osteogenesis and adipogenesis of MSCs. The anal. of 75 conditions indicates that these compounds are biol. active by promoting two major differentiation lineages from MSCs. In a time- and dose-dependent manner, thymol and carvacrol increased the osteogenesis and adipogenesis. According to these preliminary observations, the addition of PV extract may stimulate the tissue regenerative and repair functions of MSCs. Further optimization of compound extraction and characterization from PV as well as cell treatment conditions should increase their therapeutic value in combination with MSCs. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Recommanded Product: 5-Isopropyl-2-methylphenol).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Recommanded Product: 5-Isopropyl-2-methylphenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Postharvest Treatment of Wood Biomass from a Large Collection of European Grape Varieties: Impact on the Selection of Polyphenol-Rich Byproducts was written by Billet, Kevin;Unlubayir, Marianne;Munsch, Thibaut;Malinowska, Magdalena Anna;de Bernonville, Thomas Duge;Oudin, Audrey;Courdavault, Vincent;Besseau, Sebastien;Giglioli-Guivarc’h, Nathalie;Lanoue, Arnaud. And the article was included in ACS Sustainable Chemistry & Engineering in 2021.Name: (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol This article mentions the following:

Grape canes are viticulture byproducts representing a sustainable source of valuable bioactive polyphenols. However, varietal origin and postharvest treatment greatly influence the effective concentration of biomols., thus limiting industrial development. With the aim to develop grape cane extracts with high polyphenol contents, the selection of a specific grape variety combined with optimized postharvest treatment is the major determinant. A previously described postharvest treatment comprising cutting grapevine stalks of 0.5 cm length and storage at 15-20°C over 2 wk was applied on a selection of 44 grape varieties representative of the genetic diversity of the whole European collection and performing the screening of polyphenol contents. Varietal rankings according to major polyphenols (catechin, epicatechin, E-resveratrol, E-piceatannol, E-ε-viniferin, E-miyabenol C, ampelopsin A, E-vitisin B, hopeaphenol, and isophopeaphenol) were performed with and without the postharvest treatment. We observed that postharvest treatment greatly influenced the total polyphenol composition but also the ranking of polyphenol-rich varieties. This polyphenol screening of grape canes from a large collection of European varieties revealed the importance of postharvest treatment together with the selection of varieties to develop natural extracts based on grapevine wood biomass enriched with mols. with health benefits. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Name: (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Name: (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Slow glycosylation: Activation of trichloroacetimidates under mild conditions using lithium salts and the role of counterions was written by Korber, Nora Katharina;Pedersen, Christian Marcus. And the article was included in Carbohydrate Research in 2022.Recommanded Product: 2216-51-5 This article mentions the following:

Glycosylations were carried out with the two glycosyl donors 4-O-acetyl-2,3-O-isopropylidene-1-O-trichloroacetimidoyl-α-L-rhamnopyranose and 2,3,4-tri-O-benzyl-1-O-trichloro-acetimidoyl-α-L-rhamnopyranose in combination with the two alcs. 1-adamantanol and L-menthol as model glycosyl acceptors. As catalysts, the five lithium salts LiNTf₂, LiI, LiClO₄, LiPF₆ and LiOTf were investigated. We demonstrated that both lithium and the resp. counterions are playing a role in the activation of trichloroacetimidate glycosyl donors at rt. Under these very mild conditions, the glycosylations are slow and completed in two to eight days. Depending on the counterion, the rate and yield of the reaction differs; however, the selectivity of all investigated lithium salts is deficient. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Recommanded Product: 2216-51-5).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Recommanded Product: 2216-51-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bimetallic CoMoO₄@C nanorod catalyzes one-pot synthesis of benzimidazoles from benzyl alcohol and o-phenylendiamine without alkali was written by Xiong, Yucong;Wang, Kaizhi;Ma, Lei;Zhu, Jiukang;Miao, Yujia;Gong, Li;Mu, Xiao;Wan, Jiang;Li, Rong. And the article was included in Applied Organometallic Chemistry in 2022.Formula: C7H7ClO This article mentions the following:

Benzimidazoles possess a series of applications for industrial chem. and biomedicine. However, the complicated synthetic steps and harsh reaction conditions limit its further development. Herein, authors reported an efficient, environmentally friendly, and stable bimetallic CoMoO4@C catalyst, which used low-cost cobalt and molybdenum as the basic raw material. In base-free conditions, it has been proved that the yield could achieve to 99.9% for the synthesis of benzimidazoles with liberating water as the sole byproduct, and the catalyst remains stable and efficient even after five successive cycle tests. Addnl., experiments and characterizations confirm the good oxidation activity of the catalyst benefits from the numerous oxygen vacancies provided by the high concentration of low-valent cobalt (Co²⁺) and the doping of carbon improves the intermol. transport of electrons. Furthermore, this strategy could potentially be applied in the industrial production of benzimidazoles. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Formula: C7H7ClO).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Formula: C7H7ClO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Applications of Ruthenium Hydride Borohydride Complexes Containing Phosphinite and Diamine Ligands to Asymmetric Catalytic Reactions was written by Guo, Rongwei;Chen, Xuanhua;Elpelt, Christian;Song, Datong;Morris, Robert H.. And the article was included in Organic Letters in 2005.COA of Formula: C8H9ClO This article mentions the following:

A series of novel trans-ruthenium hydride borohydride complexes with chiral phosphinite and diamine ligands were synthesized. They can be used in the asym. transfer hydrogenation of aryl ketones, including base-sensitive ones, to give chiral alcs. in moderate to good enantioselectivities (up to 94% ee). They are also efficient catalysts for the Michael addition of malonates to enones with enantioselectivities of up to 90%. This kind of catalyst allows a one-pot tandem Michael addition/H₂ hydrogenation protocol to build structures with multiple chiral centers. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9COA of Formula: C8H9ClO).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.COA of Formula: C8H9ClO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Direct Ruthenium-catalyzed Hydrogenation of Carboxylic Acids to Alcohols was written by Cui, Xinjiang;Li, Yuehui;Topf, Christoph;Junge, Kathrin;Beller, Matthias. And the article was included in Angewandte Chemie, International Edition in 2015.Recommanded Product: 94022-96-5 This article mentions the following:

A general protocol for the generation of alcs. by catalytic hydrogenation of carboxylic acids was described. Key to the success was the use of a combination of Ru(acac)₃, triphos and Lewis acids. The novel method showed broad substrate tolerance and a variety of aliphatic carboxylic acids including biomass-derived compounds can be smoothly reduced. In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5Recommanded Product: 94022-96-5).

2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Recommanded Product: 94022-96-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Employing Abraham and Hansen Parameters for Solubility Prediction of Ketoconazole in Binary Solvents at Various Temperatures was written by Karimzadeh, Zahra;Rahimpour, Elaheh;Acree, William E. Jr.;Jouyban, Abolghasem. And the article was included in Journal of Solution Chemistry in 2022.Application of 57-55-6 This article mentions the following:

The Jouyban-Acree model is reported to be the most accurate math. model for predicting drug solubility in the mixed solvents at various temperatures In this study, the solubility of ketoconazole is predicted using the Jouyban-Acree based general models in some previously reported co-solvency systems. For this purpose, parameters of the Hansen solubility and the Abraham solvation parameters are combined with the Jouyban-Acree model and are trained with reported solubility data for ketoconazole to reach predictive co-solvency models. For investigation of the models’ accuracies, the values for mean relative deviations of predicted data from published exptl. values are calculated and discussed. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Application of 57-55-6).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Application of 57-55-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reducing of on Polymerization Shrinkage by Application of UV Curable Dental Restorative Composites was written by Swiderska, Jolanta;Czech, Zbigniew;Swiderski, Waldemar;Kowalczyk, Agnieszka. And the article was included in Polish Journal of Chemical Technology in 2014.Formula: C16H26O7 This article mentions the following:

This manuscript describes dental compositions contain in-organic fillers, multifunctional methacrylates and photoinitiators. The main problem by application and UV curing process is the shrinkage of photoreactive dental materials during and after UV curing process. Total shrinkage of UV curable dental composites is a phenomenon of polymerization shrinkage, typical behavior for multifunctional methacrylates during polymerization process. The important factors by curing of dental composites are: kind and concentration of used methacrylates, their functionality, double bond concentration, kind and concentration of added photoinitiator and UV dose. They are investigated UV-curable dental compositions based on 2,2-bis-[4-(2-hydroxy-3-methacryxloyloxypropyl)phenyl]propane (Bis-GMA) and containing such multifunctional monomers as 1,3-butanediol dimethacrylate (1,3-BDDMA), diethylene glycol dimethacrylate (DEGDMA), tetraethylene glycol dimethacrylate (T3EGDMA), trimethylolpropane trimethacrylate (TMPTMA), polyethylene glycol 200 dimethacrylate (PEG200DA). Reduction of polymerization shrinkage of dental compositions is at the moment a major problem by dental technol. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Formula: C16H26O7).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Formula: C16H26O7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Efficient transfer hydrogenation of carbonyl compounds catalyzed by selenophenolato hydrido iron(II) complexes was written by Wang, Yangyang;Du, Zhengyin;Zheng, Tingting;Sun, Hongjian;Li, Xiaoyan. And the article was included in Catalysis Communications in 2019.Recommanded Product: 1777-82-8 This article mentions the following:

1,3-Cis-Selenophenolato hydrido iron(II) complexes I [R = H, 2-Me, 4-MeO] catalyzed transfer hydrogenation of aldehydes and ketones. Among the three complexes, catalyst I [R = H] exhibited the highest catalytic activity. The catalytic reactions took place under very mild conditions, using isopropanol as solvent and hydrogen source, tBuONa as base under 60-80°. This catalytic system had good tolerance for many functional groups, such as halides, C=C double bonds, nitro groups and cyano groups at the Ph ring of the substrates. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Recommanded Product: 1777-82-8).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Recommanded Product: 1777-82-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts