Month: January 2023

Synthesis of Mannosylerythritol Lipid Analogs and their Self-Assembling Properties, Recovery Effects on Damaged Skin Cells, and Antibacterial Activity was written by Kondo, Takanori;Yasui, Chihiro;Miyajima, Ikkei;Banno, Taisuke;Asakura, Kouichi;Fukuoka, Tokuma;Ushimaru, Kazunori;Koga, Maito;Saika, Azusa;Morita, Tomotake;Takahashi, Yoshiaki;Hayashi, Chigusa;Igarashi, Masayuki;Takahashi, Daisuke;Toshima, Kazunobu. And the article was included in Chemistry – A European Journal in 2022.Synthetic Route of C4H10O4 This article mentions the following:

Synthesis of three types of purpose-designed mannosylerythritol lipid (MEL)-D analogs with decanoyl groups, β-GlcEL-D, α-GlcEL-D, and α-MEL-D, was accomplished utilizing our boron-mediated aglycon delivery (BMAD) methods. Their self-assembling properties, recovery effects on damaged skin cells, and antibacterial activity were evaluated. It was revealed, for the first time, that α-GlcEL-D and α-MEL-D only generated giant vesicles, indicating that slight differences in the steric configuration of an erythritol moiety and fatty acyl chains affect the ability to form vesicles. Analog α-MEL-D exhibited significant recovery effects on damaged skin cells. Furthermore, α-MEL-D exhibited antibacterial activity as high as that for MEL-D, indicating that α-MEL-D is a promising artificial sugar-based material candidate for enhancing the barrier function of the stratum corneum, superior to a known cosmetic ingredient, and possesses antibacterial activity. In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6Synthetic Route of C4H10O4).

(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Synthetic Route of C4H10O4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nickel-catalyzed electrochemical reductive relay cross-coupling of alkyl halides with alkyl carboxylic acids was written by Jiao, Ke-Jin;Ma, Cong;Liu, Dong;Qiu, Hui;Cheng, Bin;Mei, Tian-Sheng. And the article was included in Organic Chemistry Frontiers in 2021.Recommanded Product: 2968-93-6 This article mentions the following:

A highly regioselective Ni-catalyzed electrochem. (undivided cell) reductive relay cross-coupling between alkyl carboxylic acids and alkyl bromides was developed. This strategy allowed the direct acylation of benzylic C(sp³)-H bonds in good yields from com. available alkyl carboxylic acids, thus provided an alternative strategy for the synthesis of dialkyl ketones. Various functional groups were tolerated under mild reaction conditions. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6Recommanded Product: 2968-93-6).

2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Recommanded Product: 2968-93-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis and basic properties of fluorinated core-shell acrylic latexes containing perfluoroalkyl acrylate in the shell was written by Liu, Quan;Tang, Weiming;Chen, Yichi;Huang, Min. And the article was included in Applied Mechanics and Materials in 2013.Recommanded Product: 4074-88-8 This article mentions the following:

Fluoroacrylic copolymer latexes with core-shell structure were synthesized by free-radical emulsion copolymerization, using fluorine-containing acrylic monomer of dodecafluoroheptyl methacrylate (DFMA) and fluorine-free acrylic monomers. The chem. composition was characterized by Fourier transform IR (FTIR) spectroscopy. The basic properties of the latexes including mainly hydrophobicity, chem. stability, chem.- and corrosion-resistance were investigated. Significant improvement in the chem.- and corrosion-resistance were observed for the fluorinated copolymer although only 5 weight% (based on the total monomers amount) of DFMA was copolymerized In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Recommanded Product: 4074-88-8).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Recommanded Product: 4074-88-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

CuCo₂O₄ photocatalyst for bifunctional applications: Toxic dye degradation and antimicrobial activity was written by Chen, Mengying;Yang, Xiuying;Wang, Yousheng;Zhang, Xuyuan;Liang, Ning;Zhao, Longshan. And the article was included in Materials Science in Semiconductor Processing in 2022.SDS of cas: 57-55-6 This article mentions the following:

In this paper, an environmentally friendly and facile method for the synthesis of CuCo₂O₄ nanosheets using deep eutectic solvent was reported. The synthesized CuCo₂O₄ nanosheets were characterized by SEM (SEM), XPS, X-ray diffraction (XRD), zeta potential research, Brunauer-Emmett-Teller (BET) surface area anal., Fourier transform IR spectroscopy (FT-IR), diffuse reflectance spectroscopy (DRS) and photoluminescence (PL) techniques. The CuCo₂O₄ nanosheets were successfully applied in degradation of organic dyes based on excellent photocatalytic activity. In the photocatalytic system, with 15 mg catalyst, 99.96% Methyl orange, 99.89% Congo red and 99.90% Amaranth (MO: 300 mg L^-1, CR:300 mg L^-1, AM: 80 mg L^-1) in 200 mL solution were degraded in 120 min, resp. Then, it was proved that removal of dyes was made up of original Langmuir adsorption and first order kinetics. Moreover, the nanomaterial could be reused for six cycles with slight decline of degradation efficiency, proving its high stability. In addition to good photocatalytic activity, the nanomaterial exhibited excellent antimicrobial activity against Escherichia coli and Staphylococcus aureus, achieving a complete bactericidal effect at a concentration of 100μg mL^-1. In conclusion, the as-synthesized nanomaterial had high photocatalytic activity and good antibacterial activity, which was expected to be applied in practical wastewater treatment. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6SDS of cas: 57-55-6).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.SDS of cas: 57-55-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Oxidative amidation of aromatic aldehydes with amine hydrochloride salts catalyzed by silica-coated magnetic carbon nanotubes (MagCNTs@SiO₂)-immobilized imine-Cu(I) was written by Saberi, Dariush;Heydari, Akbar. And the article was included in Applied Organometallic Chemistry in 2014.COA of Formula: C4H11NO This article mentions the following:

Mesoporous silica-coated magnetic carbon nanotubes were prepared; their surface functionalization, followed by reaction with CuI, were carried out to develop a Cu-grafted functionalized mesoporous material. This system is able to catalyze oxidative amidation of aromatic aldehydes with amine hydrochloride salts, generating amide derivatives in moderate to good yields. Magnetic properties of this catalyst led to easy separation as well as providing significant recyclability. Copyright © 2013 John Wiley & Sons, Ltd. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3COA of Formula: C4H11NO).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.COA of Formula: C4H11NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cobalt-catalyzed carboxylation of aryl and vinyl chlorides with CO₂ was written by Wang, Yanwei;Jiang, Xiaomei;Wang, Baiquan. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020.Product Details of 68716-49-4 This article mentions the following:

The transition-metal-catalyzed carboxylation of aryl and vinyl chlorides with CO₂ is rarely studied, and has been achieved only with a Ni catalyst or combination of palladium and photoredox. In this work, the cobalt-catalyzed carboxylation of aryl and vinyl chlorides and bromides with CO₂ has been developed. These transformations proceed under mild conditions and exhibit a broad substrate scope, affording the corresponding carboxylic acids in good to high yields. In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4Product Details of 68716-49-4).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Product Details of 68716-49-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nucleophilic addition of arylmethylzinc reagents (ArCH₂ZnCl) to formaldehyde: An easy access to 2-(hetero)arylethyl alcohols was written by Bhatt, V. P.;Samant, S. D.;Pednekar, Suhas. And the article was included in Synthetic Communications in 2017.Computed Properties of C9H9F3O This article mentions the following:

The nucleophilic addition of benzyl zinc reagents derived from inexpensive and abundant benzyl chlorides to paraformaldehyde was reported. The reaction investigated herein is hitherto unknown and was found to be selective, operationally simple, atom- and step-economical and high yielding to deliver phenethyl alcs. utilized as key perfumery ingredients in 60-83% yields. After successful establishment of the reaction condition, the reaction was also scaled up successfully to deliver a large-scale preparation of the phenethyl alc. In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5Computed Properties of C9H9F3O).

2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Computed Properties of C9H9F3O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mesoporous Mn-Se/Al₂O₃: A recyclable and reusable catalyst for selective oxidation of alcohols was written by Zeng, Yan;Chen, Tian;Zhang, Xu;Chen, Ying;Zhou, Hongwei;Yu, Lei. And the article was included in Applied Organometallic Chemistry in 2022.Application of 873-76-7 This article mentions the following:

Mesoporous Mn-Se/Al₂O₃ were easily fabricated by calcining the selenium sources with the manganese and aluminum hydroxides. It was an efficient catalyst for alc. oxidation using H₂O₂ as the clean oxidant, afforded carbonyls 58%-83% yields. The reaction of primary alcs. were produced aldehydes specifically, while no carboxylic acids were generated. The easily accessible features and low cost of Mn-Se/Al₂O₃ was endowed the material great potential in the industrial-scale applications. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Application of 873-76-7).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Application of 873-76-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Production of α-terpineol from α-pinene was written by Benkli, Kadriye;Isikdag, Ilhan;Baser, K. Husnu Can. And the article was included in Acta Pharmaceutica Turcica in 1995.Product Details of 2451-01-6 This article mentions the following:

α-Terpineol (I) is a monoterpenic alc. used as a fragrance material in the perfumery industry and for the production of some volatile compounds Several techniques have been described in the literature for its synthesis. These techniques recommend the conversion of olefinic terpenes to their hydrochlorides or esters with acids, followed by hydrolysis into the desired alc. This paper describes a method which involves hydration of α-pinene (II) to terpinhydrate which is then dehydrated to give I. Cation exchange resin was also used in an oxygen-free medium to obtain I in higher (73%) yield from II. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Product Details of 2451-01-6).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Product Details of 2451-01-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ketals of L-rhamnoheptonolactones: potential mimics of L-rhamnose was written by Wheatley, Joseph R.;Beacham, Annable R.;Lilley, Paul M. de Q.;Watkin, David J.;Fleet, George W. J.. And the article was included in Tetrahedron: Asymmetry in 1994.Safety of (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate This article mentions the following:

Isopropylidene and cyclohexylidene ketals of γ- and δ-heptonolactones derived from Kiliani ascensions of protected L-rhamnose. The x-ray crystal structure of 7-deoxy-3,4-O-isopropylidene-L-glycero-L-galacto-heptono-1,5-lactone provides an example of a δ-lactone in a boat conformation with a substituent in a flagpole position. The size of ring in the lactones is completely consistent with Hudson’s classical lactone rotation rule of 1910. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0Safety of (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate).

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Safety of (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts