Month: January 2023

Fe₃O₄ nanoparticles-mediated solar-driven enzymatic PET degradation with PET hydrolase was written by Li, Zixuan;Chen, Kun;Yu, Linling;Shi, Qinghong;Sun, Yan. And the article was included in Biochemical Engineering Journal in 2022.Electric Literature of C4H10O3 This article mentions the following:

Cost-effective and eco-friendly treatment or recycled use of poly (ethylene terephthalate) (PET) is highly desired. Enzymic PET degradation is considered a promising approach, but currently available PET hydrolases (PETases) have low activity at ambient temperature Thus, elevating the reaction system temperature in a cost-effective way becomes a key to the economical enzymic PET degradation Herein, we proposed solar-driven enzymic PET degradation with DuraPETase, a stable mutant of PETase, by using Fe₃O₄ nanoparticles (NPs) as the solar-to-thermal agent. Simulated solar irradiation could elevate the suspension of Fe₃O₄ NPs from 25°C to 46°C for the effective PET degradation The enzyme immobilized onto Fe₃O₄ NPs, DuraPETase@Fe₃O₄, had higher stability than free DuraPETase, but a 10-d PET degradation experiments under simulated solar irradiation revealed that free DuraPETase in the presence of Fe₃O₄ NPs was approx. three times more effective than the DuraPETase@Fe₃O₄ system because of the superiority of free DuraPETase in degrading PET. This implies that enzyme immobilization is unnecessary in such a single-use system. By contrast, the DuraPETase-only system showed only 15.5% efficiency of the Fe₃O₄-mediated solar-driven system with free DuraPETase. The research demonstrated the potential of the Fe₃O₄-mediated solar-driven enzymic PET degradation strategy for further development in different practical scenarios. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6Electric Literature of C4H10O3).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Electric Literature of C4H10O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tsuneonella suprasediminis sp. nov., isolated from the Pacific Ocean was written by Gao, Yan;Li, Guangyu;Fang, Chen;Shao, Zongze;Wu, Yue-Hong;Xu, Xue-Wei. And the article was included in International Journal of Systematic and Evolutionary Microbiology in 2021.Application of 10030-85-0 This article mentions the following:

A Gram-stain-neg., rod-shaped and aerobic bacterial strain, named Ery12^T, was isolated from the overlying water of the Lau Basin in the Southwest Pacific Ocean. Strain Ery12^T showed high 16S rRNA gene sequences similarity to Tsuneonella flava MS1-4^T (99.9%), T. mangrovi MCCC 1K03311^T (98.1%), Altererythrobacter ishigakiensis NBRC 107699^T (97.3%) and exhibited ≤97.0% sequence similarity with other type strains of species with validly published names. Growth was observed in media with 0-10.0% NaCl (optimum 0-1.0%, w/v), pH 5.0-9.5 (optimum 6.0-7.0) and 10-42°C (optimum 30-37°C). The predominant respiratory quinone was ubiquinone 10 (Q-10). The major cellular fatty acid was summed feature 8 (C18:1 ω7c and/or C18:1 ω6c). The major polar lipids were sphingoglycolipid, phosphatidyglycerol, diphosphatidylglycerol, phosphatidylethanolamine, phosphatidylcholine, three unidentified glycolipids, one unidentified aminoglycolipid and one unidentified lipid. The DNA G + C content was 60.8%. The ANI and in silico DDH values between strain Ery12^T and the type strains of its closely related species were 71.0-91.8% and 19.5-44.6%, resp. According to the phenotypic, chemotaxonomic, phylogenetic and genomic data, strain Ery12^T represents a novel species of the genus Tsuneonella, for which the name Tsuneonella suprasediminis is proposed. The type strain is Ery12^T (= CGMCC 1.16500^T = MCCC 1A04421^T = KCTC 62388^T). We further propose to reclassify Altererythrobacter rhizovicinus and Altererythrobacter spongiae as Pelagerythrobacter rhizovicinus comb. nov. and Altericroceibacterium spongiae comb. nov., resp. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0Application of 10030-85-0).

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Application of 10030-85-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chiral Imidazolium-Functionalized Au Nanoparticles: Reversible Aggregation and Molecular Recognition was written by Lomeli-Rosales, Diego Alberto;Rangel-Salas, Irma Idalia;Zamudio-Ojeda, Adalberto;Carbajal-Arizaga, Gregorio Guadalupe;Godoy-Alcantar, Carolina;Manriquez-Gonzalez, Ricardo;Alvarado-Rodriguez, Jose Guadalupe;Martinez-Otero, Diego;Cortes-Llamas, Sara Angelica. And the article was included in ACS Omega in 2016.Name: (R)-2-Aminobutan-1-ol This article mentions the following:

Gold nanoparticles (AuNPs) stabilized by imidazolium salts derived from amino acids [glycine (1), rac-alanine (2), L-phenylalanine (3), and rac-methionine (4)] were prepared The AuNPs were stabilized the most by 4, which kept the particles dispersed in water for months at pH > 5.5. These AuNPs exhibited a well-defined absorption band at 517 nm and had an average particle size of 11.21 ± 0.07 nm. The 4-AuNPs were reversibly aggregated by controlling the pH of the solution Chiral R,R-4-AuNPs and S,S-4-AuNPs were synthesized, and the chiral environment on the nanoparticle surface was confirmed using CD; these nanoparticles exhibited a mol. recognition of chiral substrates. Furthermore, they showed potential for separating racemic mixtures when supported on a layered double hydroxide. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Name: (R)-2-Aminobutan-1-ol).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Name: (R)-2-Aminobutan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Enantioselective Synthesis, Configurational Stability, and Reactivity of Lithium α-tert-Butylsulfonyl Carbanion Salts was written by Scholz, Roland;Hellmann, Gunther;Rohs, Susanne;Oezdemir, Diana;Raabe, Gerhard;Vermeeren, Cornelia;Gais, Hans-Joachim. And the article was included in European Journal of Organic Chemistry in 2010.Recommanded Product: Sodium 2-methyl-2-propanethiolate This article mentions the following:

The reactions of enantiopure S-tert-Bu sulfones of the type R¹CH(R²)SO₂tBu (≥99 % ee) with lithiumorganyl compounds gave the corresponding chiral α-sulfonyl carbanion salts [R¹C(R²)SO₂tBu]Li with ≥94 % ee. The enantioselectivity of the deprotonation of the phenyl- but not dialkyl-substituted sulfones is strongly dependent on the nature of the lithiumorganyl. Because of this observation and the strong decrease in enantioselectivity in the presence of TMEDA and HMPA, we propose an intramol. proton transfer following complexation of the sulfone by RLi. Racemization of [R¹C(R²)SO₂tBu]Li follows first-order kinetics and seems to be mainly an enthalpic process with a small neg. activation entropy, as revealed by polarimetric measurements at low temperatures This is in accordance with C_α-S bond rotation as the rate-determining step. The salts [R¹C(R²)SO₂tBu]Li have half-lives of racemization in the order of several hours at -105 °C. The deuteration of the salts at -105 °C with CF₃CO₂D proceeded with enantioselectivities of ≥94 % ee, the magnitude of which was not significantly affected by the presence of TMEDA and HMPA. The salts also reacted with carbon-based electrophiles at low temperatures with high enantioselectivity. The conversion of R¹CH(R²)SO₂tBu via [R¹C(R²)SO₂tBu]Li to R¹C(R²,E)SO₂tBu, which involves the loss of stereogenicity at the α-stereogenic center and its re-establishment upon reaction of the chiral carbanion with electrophiles, occurred with high overall enantioselectivity. Electrophiles attack the anionic C atom of [R¹C(R²)SO₂tBu]Li with high selectivity on the side syn to the O atoms and anti to the tert-Bu group. The reactivity of the dialkyl-substituted salts [R¹C(R²)SO₂tBu]Li (R¹, R² = alkyl) is significantly higher than that of the benzylic salts [RC(Ph)SO₂tBu]Li (R = alkyl) and the HMPA-coordinated SIPs of [MeC(Ph)SO₂tBu]Li are significantly more reactive towards EtI than the corresponding O-Li contact ion pairs. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2Recommanded Product: Sodium 2-methyl-2-propanethiolate).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Recommanded Product: Sodium 2-methyl-2-propanethiolate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Facile synthesis of axially chiral styrene-type carboxylic acids via palladium-catalyzed asymmetric C-H activation was written by Yang, Chi;Wu, Tian-Rui;Li, Yan;Wu, Bing-Bing;Jin, Ruo-Xing;Hu, Duo-Duo;Li, Yuan-Bo;Bian, Kang-Jie;Wang, Xi-Sheng. And the article was included in Chemical Science in 2021.Reference of 68716-49-4 This article mentions the following:

A novel method by a one-step introduction of axial chirality and sterically hindered group were developed for facile synthesis of axially chiral styrene-type carboxylic acids. With the palladium-catalyzed C-H arylation and olefination of readily available cinnamic acid established, this transformation demonstrated excellent yield, excellent stereocontrol (up to 99% yield and 99% ee), and broad substrate scope under mild conditions. The axially chiral styrene-type carboxylic acids produced were successfully applied to Cp*Co(III)-catalyzed asym. C-H activation reactions, indicating their potential as chiral ligands or catalysts in asym. synthesis. In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4Reference of 68716-49-4).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Reference of 68716-49-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Highly Chemoselective Ni-Catalyzed Protecting-Group-Free 2,2′-Biphenol Synthesis and Mechanistic Insights was written by Long, Cheng-Yu;Chen, Hao;Ma, Cheng;Zhao, Bo-Wei;Li, Shen-Huan;Cui, Yue;Yang, Xinge;Ni, Shao-Fei;Wang, Xue-Qiang. And the article was included in Organic Letters in 2022.Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol This article mentions the following:

In this study, a Ni-catalyzed protecting-group-free C-C coupling protocol is described for the efficient synthesis of 2,2′-biphenol derivatives Its remarkable chemoselectivity control ability, wide substrate scope, and excellent functional group tolerance highlight this newly developed strategy. Detailed mechanistic studies have demonstrated that potassium tert-butoxide acts as a critical agent to prevent the occurrence of protonation events. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Search for chemotherapeutic amidines. XIII. α,ω-Bis(p-amidinophenoxy)alkenes and -alkynes was written by Ashley, J. N.;MacDonald, R. D.. And the article was included in Journal of the Chemical Society in 1957.Application In Synthesis of 4-Hydroxy-3-methylbenzonitrile This article mentions the following:

Some α,ω-bis(p-amidinophenoxy)alkenes and -alkynes and their nuclear substituted derivatives were prepared for comparison with the saturated analogs. They had no value as trypanocides. Concentrated H₂SO₄ (2.9 cc.) added in one portion to 498 g. 4-bromo-2-methylphenol in 325 cc. Ac₂O and the mixture refluxed 2 hrs. gave 562 g. 4-bromo-2-methylphenyl acetate (I), colorless oil, b₁₂ 132°. CuCN (145 g.) was added during 0.5 hr. to 100 cc. dry C₅H₅N at 90° (the internal temperature rose to 140°), the mixture stirred 10 min. longer and 275 g. I added, the bath temperature raised rapidly to 200° (an endothermic reaction occurred), and the mixture heated 3 hrs. at 228-30° and distilled at 60-170°/20-30 mm. This distillate poured on ice and concentrated HCl gave 177 g. 4-cyano-2-methylphenyl acetate (II), m. 75-6°. Hydrolysis of II gave 87% 4-cyano-2-methylphenol, m. 93-5°, b₁₂ 180-2°. 1,4-Dichloro-2-butyne (III) (70%), b₁₀ 52-2.5°, 1,4-dibromobut-2-yne (IV) (85%), and 1,6-dibromohexa-2,4-diyne (V) (79%), m. 18-19°, were prepared by recorded methods. cis-1,4-Dihydroxy-2-butene (b₁₅ 128-30°) gave 54% cis-dibromide (VI), b_0.8 33.5-4.0°. VI heated with a trace of iodine 1 hr. at 130-40° gave the trans isomer, plates, m. 52-3.5° (from ligroine). [2,4-R(NC)C₆H₃]₂X (VII) were prepared by the following methods: (A) an alc. solution of the cyanophenol (2.2 moles) followed by 1 mole IV added to 2.2 moles Na in dry alc. (20 cc. per g. of Na), the mixture refluxed overnight, cooled, and filtered, the residue washed with H₂O, and recrystallized gave VII; (B) 22 g. V was added to a stirred suspension of 17.2 g. NaHCO₃ in 24.3 g. p-cyanophenol in 100 cc. Me₂CO, the mixture refluxed overnight, cooled, filtered, and the residue washed with H₂O, and crystallized from AcOH; (C) 1 mole III refluxed overnight with 2.2 moles of the cyanophenol in 2.2 mole KOH and alc. gave VII (substituents X and R, method, % yield, m.p. given): (OCH₂C)₂, H, A, 60, 159-61°; (OCH₂C)₂, Me, A, 40, 166-7°; (OCH₂C)₂, Cl, C, 54, 224-6°; (OCH₂C)₂, Br, C, 50, 220-2°; (OCH₂C)₂, H, B, 49, 195-7°; trans-OCH₂CH:CHCH₂O, H, A, 70, 204-6°; trans-OCH₂CH:CHCH₂O, Cl, C, 61, 207-9°. VII suspended or dissolved in the appropriate alc., and the mixture saturated with HCl at 0-10°, the diimidoate di-HCl salts gradually formed, and after several days collected, dried, and heated 5-6 hrs. at 50-60° with saturated alt. NH₃ gave the following α,ω-bis(p-amidinophenoxy)alkenes and alkynes {4,2-R[H₂NC(:NH)]C₆H₃}₂X (substituents X and R, salt, alc. (and diluent) used in preparation of diimidoate, solvent for crystallization, m.p. given): (OCH₂C)₂, H, 2HCl.2H₂O, alc. (CHCl₃), MeOH-OCMe₂, 245-7°; (OCH₂C)₂, Me, 2Me₂SO₃H, alc. (CHCl₃), MeOH, 308-10°; (OCH₂C)₂, 2HO(CH₂)₂SO₃H.0.5H₂O, Cl, alc. (dioxane), MeOH-Et₂O, 243-5°; (OCH₂C)₂, Br, 2HO(CH₂)₂SO₃H, alc., MeOH, 253-5°; (OCH₂C)₂, H, 2HO(CH₂)₂SO₃H, alc., dilute HO(CH₂)₂SO₃H, 272-4°; trans-OCH₂CH:CHCH₂O, H, 2MeSO₃H, alc. dilute, MeSO₃H, 274-6°; trans-OCH₂CH:CHCH₂O, Cl, 2HO(CH₂)₂SO₃H, HO(CH₂)₂OEt, MeOH, 236-8°. 1,4-Bis(p-amidinophenoxy)-2-butyne di-HCl salt in MeOH was hydrogenated over 10% Pd-CaCO₃ at room temperature until 1 mole H was taken up and the diamidine di-HCl salt converted to the dimethanesulfonate in 70% yield, m. 232-4° (from MeOH). cis-1,4-Bis(4-amidino-2-chlorophenoxy)-2-butene was prepared similarly, and the gummy di-HCl salt which was precipitated by addition of Me₂CO as a powder after trituration with Me₂CO converted to the 2HO(CH₂)₂SO₃H salt, m. 218-20°. In the experiment, the researchers used many compounds, for example, 4-Hydroxy-3-methylbenzonitrile (cas: 15777-70-5Application In Synthesis of 4-Hydroxy-3-methylbenzonitrile).

4-Hydroxy-3-methylbenzonitrile (cas: 15777-70-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Application In Synthesis of 4-Hydroxy-3-methylbenzonitrile

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bench-stable potassium complexes for living and isoselective ring-opening polymerization of rac-lactide was written by Ren, Fangping;Li, Xinlei;Xian, Ji;Han, Xinning;Cao, Luya;Pan, Xiaobo;Wu, Jincai. And the article was included in Journal of Polymer Science (Hoboken, NJ, United States) in 2022.HPLC of Formula: 111-46-6 This article mentions the following:

To develop bench-stable and nontoxic catalysts for the ring-opening polymerization (ROP) of lactides is of importance with the aim of reducing costs in industrial production Although, recently, some potassium complexes have been reported for the living polymerization of rac-lactide (rac-LA), the moisture sensitivities of these complexes prevent their further applications in the mild polymerization condition. In this work, three bench-stable potassium phenolates as isoselective catalysts for the ROP of rac-LA were reported, and the moisture stability of these complexes does not inhibit their high activity under mild conditions even in the presence of trace water (2.0 equiv relative to the catalysts) or unpurified solvents. The controllable polymerization reactions can afford polylactides with desirable mol. weights, which can be high up to M_n = 80.0 kg/mol at an anhydrous condition and M_n = 54.3 kg/mol in presence of trace water. A best isoselectivity of P_m = 0.83 also can be achieved in this system at -70°C. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6HPLC of Formula: 111-46-6).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.HPLC of Formula: 111-46-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On the interactions of diols and DMPC monolayers was written by Rhys, Natasha H.;Barlow, David J.;Lawrence, M. Jayne;Lorenz, Christian D.. And the article was included in Journal of Molecular Liquids in 2022.Safety of 1,2-Propanediol This article mentions the following:

The interactions of lipid mols. with various solvent mols. is of utmost importance in the formulation of various drug delivery and personal care formulations. In this manuscript, a series of all-atom mol. dynamics simulations were used to investigate how the structural and interfacial properties of a DMPC (1,2-dimyristoyl-sn-glycero-3-phosphocholine) monolayer change when interacting with a range of diols that have varying carbon chain lengths and patterns of hydroxylation. In comparison to water, we find that all of the diols studied result in a more disordered and thinner monolayer. Addnl., we find that the shorter diols with the hydroxyl groups on neighboring carbons (1,2-ethanediol and 1,2-propanediol) are able to penetrate deeper into the head group region of the lipid monolayers and as a result significantly disorder and thin the monolayers. Like water, we find that the diols also form hydrogen-bonded networks that connect the DMPC head groups in neighboring mols. Interestingly, we find that the number of butanediol mols. that form these solvent-mediated interactions between the DMPC head groups is directly affected by the distribution of the hydroxyl groups within the diol mols. The results presented here provide a mechanistic description of how the chem. of diol solvent mols. will affect the structural and interfacial properties of lipid structures in solution In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Safety of 1,2-Propanediol).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Safety of 1,2-Propanediol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Directed β C-H Amination of Alcohols via Radical Relay Chaperones was written by Wappes, Ethan A.;Nakafuku, Kohki M.;Nagib, David A.. And the article was included in Journal of the American Chemical Society in 2017.Application of 94022-96-5 This article mentions the following:

A radical-mediated strategy for β C-H amination of alcs. has been developed. This approach employs a radical relay chaperone, which serves as a traceless director that facilitates selective C-H functionalization via 1,5-hydrogen atom transfer (HAT) and enables net incorporation of ammonia at the β carbon of alcs. The chaperones presented herein enable direct access to imidate radicals, allowing their first use for H atom abstraction. A streamlined protocol enables rapid conversion of alcs. to their β-amino analogs (via in situ conversion of alcs. to imidates, directed C-H amination, and hydrolysis to NH₂). Mechanistic experiments indicate HAT is rate-limiting, whereas intramol. amination is product- and stereo-determining In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5Application of 94022-96-5).

2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Application of 94022-96-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts