Month: January 2023

Tolerant-to-methanol cathodic electrocatalysts based on organometallic clusters was written by Grinberg, V. A.;Pasynskii, A. A.;Kulova, T. L.;Maiorova, N. A.;Skundin, A. M.;Khazova, O. A.;Law, C. G.. And the article was included in Russian Journal of Electrochemistry in 2008.Application In Synthesis of Sodium 2-methyl-2-propanethiolate This article mentions the following:

A new approach to the fabrication of catalytic systems based on hetero- and homometal-chalcogenide clusters of Pt-M-X type (M = Fe, Mn; and X = S, Se, Te), which provides the reproducibility of catalyst composition and uniform distribution of catalyst over the carbon support, is proposed. Thus obtained catalysts are characterized using the XRD, TEM, and EDAX methods. The electrocatalytic activity of these systems in the oxygen reduction reaction, the role of the nature of chalcogenide atom and the atom of the second metal, which is the platinum partner, and the electrochem. behavior of nonplatinum chalcogenide systems are studied. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2Application In Synthesis of Sodium 2-methyl-2-propanethiolate).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Application In Synthesis of Sodium 2-methyl-2-propanethiolate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Volatile and glycosidically bound composition of Loureiro and Alvarinho wines was written by Oliveira, J. M.;Oliveira, P.;Baumes, R. L.;Maia, M. O.. And the article was included in Food Science and Technology International (London, United Kingdom) in 2008.Synthetic Route of C10H22O3 This article mentions the following:

Composition of Loureiro and Alvarinho wines from the Vinhos Verdes region, regarding free volatile compounds as well as glycosidically bound aroma precursors, was exhaustively determined by gas chromatog.-mass spectrometry after adsorption on XAD-2 resin. On the whole, were identified and quantified 120 volatile compounds in the free fraction and 77 glycosidically bound compounds, belonging to C₆-compounds, alcs., fatty acids Et esters, esters of organic acids, acetates, monoterpenic alcs., monoterpenic oxides and diols, C₁₃-norisoprenoids, volatile phenols, volatile fatty acids, and carbonyl compounds Globally, the wines of the two cultivars present similar composition on volatiles. However, regarding varietal compounds, Loureiro wines were richer than Alvarinho ones with respect to C₆-compounds and monoterpenic compounds, occurring the opposite for volatile phenols. It was also demonstrated that wines of both varieties might benefit the aroma reserve, present as glycoconjugates, as it is susceptible of being technol. explored. Linalool, Ho-trienol, (α-terpineol, contributing with fruity and floral notes, and (β-damascenone mostly for Alvarinho, confering tropical fruit notes, are the varietal compounds which may particularly influence the aroma of these wines. Respecting fermentative compounds, Alvarinho is also particularly rich in fatty acids Et esters related to lipid metabolism and acetates of fusel alcs., which can provide it a fruity character; Loureiro contains higher levels of esters of organic acids and 2-phenylethanol, conferring fruity and floral notes. Sensory anal. agreed with chem. analyses showing a pronounced tree and tropical fruit character for Alvarinho wines while Loureiro wines present more intense citrus fruit notes. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Synthetic Route of C10H22O3).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Synthetic Route of C10H22O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Asymmetric cross Rauhut-Currier reactions of vinyl ketones with carbonyl para-quinone methides via phosphine catalysis was written by Lu, Yue;He, Ningtao;Miao, Xiaohe;Wang, De. And the article was included in Organic Chemistry Frontiers in 2022.Safety of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol This article mentions the following:

Novel cross Rauhut-Currier reactions involving chiral phosphine catalysis between vinyl ketones and terminal-carbonyl-substituted para-quinone methides have been presented. This reaction approach showed broad substrate scope compatibility and moderate-to-excellent enantioselectivity control. The multifunctional products could be easily transformed to important and useful skeletons. Moreover, natural-product and drug derivatives were well tolerated in this methodol., exhibiting the promising applications of this reaction approach. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Safety of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Safety of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lithium bromide, an inexpensive and efficient catalyst for opening of epoxide rings by amines at room temperature under solvent-free condition was written by Chakraborti, Asit K.;Rudrawar, Santosh;Kondaskar, Atul. And the article was included in European Journal of Organic Chemistry in 2004.Electric Literature of C13H19NO This article mentions the following:

Lithium bromide has been found to be an inexpensive and efficient catalyst for the opening of epoxide rings by amines, and this provides an environmentally friendly method for the synthesis of β-amino alcs. Aromatic and aliphatic amines react with cycloalkene oxides to exclusively form trans-2-(aryl/alkylamino)cycloalkanols in high yields. A 98-100% selectivity in favor of nucleophilic attack at the benzylic carbon atom of styrene oxide is observed with aromatic amines. However, aliphatic amines exhibit a marginal preference for the reaction at the terminal carbon atom of the epoxide ring in styrene oxide. Non-styrenoidal, unsym. alkene oxides undergo selective nucleophilic attack at the sterically less hindered carbon atom by aniline. The chelation effect of the Li⁺ ion enables selective opening of the epoxide ring in 3-phenoxypropylene oxide in the presence of styrene oxide. In the experiment, the researchers used many compounds, for example, Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6Electric Literature of C13H19NO).

Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Electric Literature of C13H19NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Organosuperbase-Catalyzed 1,1-Diboration of Alkynes was written by Doan, Son H.;Ton, Nhan N. H.;Mai, Binh Khanh;Nguyen, Thanh Vinh. And the article was included in ACS Catalysis in 2022.Related Products of 1214264-88-6 This article mentions the following:

1,1-Diboryl alkenes are versatile building blocks in organic synthesis and medicinal chem. However, there have been only a small number of established methods to prepare this class of compounds, and most of them used transition-metal catalysts, which are undesirable in the preparation of biol. relevant compounds Herein, authors report an unprecedented application of P₁–^tBu phosphazene as a superbasic organocatalyst to promote 1,1-diboration reactions of unactivated aromatic and electron-deficient terminal alkynes. The dual Bronsted and Lewis basicity of this phosphazene enables the activation of reaction substrates and allows for high regio- and stereoselectivity to be obtained. A combination of thorough exptl. and computational studies suggests interesting mechanistic insights for these phosphazene-catalyzed diboration reactions, which are also discussed in detail. In the experiment, the researchers used many compounds, for example, 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-naphtho[1,8-de][1,3,2]diazaborinine (cas: 1214264-88-6Related Products of 1214264-88-6).

2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-naphtho[1,8-de][1,3,2]diazaborinine (cas: 1214264-88-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Related Products of 1214264-88-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Discovery of N²-(4-Amino-cyclohexyl)-9-cyclopentyl-N⁶-(4-morpholin-4-ylmethyl-phenyl)-9H-purine-2,6-diamine as a Potent FLT3 Kinase Inhibitor for Acute Myeloid Leukemia with FLT3 Mutations was written by Gucky, Tomas;Reznickova, Eva;Radosova Muchova, Tereza;Jorda, Radek;Klejova, Zuzana;Malinkova, Veronika;Berka, Karel;Bazgier, Vaclav;Ajani, Haresh;Lepsik, Martin;Divoky, Vladimir;Krystof, Vladimir. And the article was included in Journal of Medicinal Chemistry in 2018.Application In Synthesis of (R)-2-Aminobutan-1-ol This article mentions the following:

FLT3 tyrosine kinase is a potential drug target in acute myeloid leukemia (AML) because patients with FLT3-ITD mutations respond poorly to standard cytotoxic agents and there is a clear link between the disease and the oncogenic properties of FLT3. We present novel 2,6,9-trisubstituted purine derivatives with potent FLT3 inhibitory activity. The lead compound 7d displays nanomolar activity in biochem. assays and selectively blocks proliferation of AML cell lines harboring FLT3-ITD mutations, whereas other transformed and normal human cells are several orders of magnitude less sensitive. The MV4-11 cells treated with 7d suppressed the phosphorylation of FLT3 and its downstream signaling pathways, with subsequent G1 cell cycle arrest and apoptosis. Addnl., a single dose of 7d in mice with s.c. MV4-11 xenografts caused sustained inhibition of FLT3 and STAT5 phosphorylation over 48 h, in contrast to the shorter effect observed after administration of the reference FLT3 inhibitor quizartinib. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Application In Synthesis of (R)-2-Aminobutan-1-ol).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Application In Synthesis of (R)-2-Aminobutan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Characterization of Aminobenzylphenols as Protein Disulfide Isomerase Inhibitors in Glioblastoma Cell Lines was written by Shergalis, Andrea;Xue, Ding;Gharbia, Fatma Z.;Driks, Hannah;Shrestha, Binita;Tanweer, Amina;Cromer, Kirin;Ljungman, Mats;Neamati, Nouri. And the article was included in Journal of Medicinal Chemistry in 2020.Electric Literature of C7H6O3 This article mentions the following:

Disulfide bond formation is a critical post-translational modification of newly synthesized polypeptides in the oxidizing environment of the endoplasmic reticulum and is mediated by protein disulfide isomerase (PDIA1). In this study, we report a series of α-aminobenzylphenol analogs as potent PDI inhibitors. The lead compound, AS15, is a covalent nanomolar inhibitor of PDI, and the combination of AS15 analogs with glutathione synthesis inhibitor buthionine sulfoximine (BSO) leads to synergistic cell growth inhibition. Using nascent RNA sequencing, we show that an AS15 analog triggers the unfolded protein response in glioblastoma cells. A BODIPY-labeled analog binds proteins including PDIA1, suggesting that the compounds are cell-permeable and reach the intended target. Taken together, these findings demonstrate an extensive biochem. characterization of a novel series of highly potent reactive small mols. that covalently bind to PDI. In the experiment, the researchers used many compounds, for example, Benzo[d][1,3]dioxol-4-ol (cas: 69393-72-2Electric Literature of C7H6O3).

Benzo[d][1,3]dioxol-4-ol (cas: 69393-72-2) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Electric Literature of C7H6O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Natural deep eutectic solvent modified nanofiltration membranes with superior antifouling properties for pharmaceutical wastewater treatment was written by Moradi, Golshan;Rahimi, Masoud;Zinadini, Sirus;Shamsipur, Mojtaba;Babajani, Nasrin. And the article was included in Chemical Engineering Journal (Amsterdam, Netherlands) in 2022.HPLC of Formula: 2216-51-5 This article mentions the following:

Herein, the L-menthol/10-camphorsulfonic acid (L-M/CSA) natural deep eutectic solvent (NDES) was introduced as an innovative modifier for polyethersulfone (PES) nanofiltration (NF) membrane. Four membranes with different L-M/CSA NDES loadings (0, 0.2, 0.6, and 1 wt%) were prepared and characterized to evaluate the influence of L-M/CSA NDES on the properties of the membranes. The modified membrane with 0.2 wt% L-M/CSA NDES (M-0.2NDES) showed the pure water flux (PWF) of 111.5 L/m2h, which was about 7 times higher than that of the control membrane (M-0NDES). Meanwhile, the mean pore radius was increased from 0.7 nm for the M-0NDES membrane to 0.85 nm for the M-0.2NDES membrane, indicating the good pore forming capability of L-M/CSA NDES. Benefiting from L-M/CSA NDES blending, the modified membranes showed excellent removal efficiency to ceftriaxone (CTX) and amoxicillin (AMOX) solutions Particularly, the M-0.2NDES membrane possessed 99.6 and 99.2% rejection to CTX and AMOX, resp., with permeated flux up to about 111 L/m2h, which was far better than the data reported in the literature. M-0.2NDES membrane showed 89.1% COD (COD), 100% turbidity, and 51.6% total dissolved solids (TDS) removal from the industrial pharmaceutical wastewater. Blending with L-M/CSA NDES was also confirmed to be crucial to ameliorate the membrane antifouling properties. The related results revealed that the flux recovery ratio (FRR) of the M-0.2NDES membrane for milk solution reached 90.2%. The facile fabrication method of L-M/CSA NDES from green materials, good pore forming capability, enhanced antifouling properties, together with the efficient pharmaceuticals removal indicated the good prospect of L-M/CSA NDES for membrane separation applications. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5HPLC of Formula: 2216-51-5).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.HPLC of Formula: 2216-51-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A Catalytic Route to Ampakines and Their Derivatives was written by Mulzer, Michael;Coates, Geoffrey W.. And the article was included in Organic Letters in 2011.HPLC of Formula: 42514-50-1 This article mentions the following:

A catalytic domino reaction that efficiently provides access to an important class of heterocycles, the ampakines, e.g., I is reported. The current approach is based on the cobalt-catalyzed hydroformylation of dihydrooxazines and allows for the facile synthesis of the pharmaceutically interesting compound CX-614 and related substances. In the experiment, the researchers used many compounds, for example, 3-Amino-3-methylbutan-1-ol (cas: 42514-50-1HPLC of Formula: 42514-50-1).

3-Amino-3-methylbutan-1-ol (cas: 42514-50-1) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.HPLC of Formula: 42514-50-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A study of non-isothermal decomposition of calcium DL-lactate pentahydrate was written by Verma, B. P.;Verma, R. K.;Chandra, M.;Pandey, S.;Mallick, A. K.;Verma, Lata. And the article was included in Asian Journal of Chemistry in 1994.Quality Control of Calcium 2-hydroxypropanoate pentahydrate This article mentions the following:

The thermal decomposition of calcium DL-lactate pentahydrate has been studied under non-isothermal conditions in static air atm. with heating rate programmed at 1/6 Ks^-1. The thermogravimetric data thus obtained have been analyzed for the kinetic parameters of the two decomposition steps using Freeman-Carrol, Horowitz-Metzer, Coats Redfern, Fuoss, Karkhanawala-Dharwadkar and Zsako methods. Decomposition mechanisms have also been suggested. In the experiment, the researchers used many compounds, for example, Calcium 2-hydroxypropanoate pentahydrate (cas: 5743-47-5Quality Control of Calcium 2-hydroxypropanoate pentahydrate).

Calcium 2-hydroxypropanoate pentahydrate (cas: 5743-47-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Quality Control of Calcium 2-hydroxypropanoate pentahydrate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts