Month: January 2023

Well-Defined NNS-Mn Complex Catalyzed Selective Synthesis of C-3 Alkylated Indoles and Bisindolylmethanes Using Alcohols was written by Mondal, Avijit;Sharma, Rahul;Dutta, Bishal;Pal, Debjyoti;Srimani, Dipankar. And the article was included in Journal of Organic Chemistry in 2022.Computed Properties of C7H7ClO This article mentions the following:

Herein, Mn-catalyzed selective C-3 functionalization of indoles with alcs was demonstrated. The developed catalyst can also furnish bis(indolyl)methanes from the same set of substrates under slightly modified reaction conditions. Mechanistic studies revealed that the C-3 functionalization of indoles was going via a borrowing hydrogen pathway. To highlight the practical utility, a diverse range of substrates including nine structurally important drug mols. were synthesized. Furthermore, a one-pot cascade strategy for synthesizing C-3 functionalized indoles directly from 2-aminophenyl ethanol and alc. was also introduced. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Computed Properties of C7H7ClO).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Computed Properties of C7H7ClO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Effectiveness and Clinical Performance of Erythritol Air-Polishing in Non-Surgical Periodontal Therapy: A Systematic Review of Randomized Clinical Trials. was written by Onisor, Florin;Mester, Alexandru;Mancini, Leonardo;Voina-Tonea, Andrada. And the article was included in Medicina (Kaunas, Lithuania) in 2022.Related Products of 149-32-6 This article mentions the following:

Background and objectives: The purpose of the present systematic review was to analyze the effectiveness of erythritol-based air-polishing in non-surgical periodontal therapy. Materials and methods: The protocol details were registered in the PROSPERO database (CRD42021267261). This review was conducted under the PRISMA guidelines. The electronic search was performed in PubMed, Scopus, and Web of Science databases to find relevant clinical trials published until January 2022. The inclusion criteria consisted of human clinical trials which reported the use of non-surgical periodontal treatment and erythritol air-polishing compared to non-surgical periodontal treatment alone in patients with good systemic health requiring treatment for periodontal disease. Results: 810 studies were imported into the Covidence Platform. Of these, seven clinical trials met the inclusion criteria. In active periodontal therapy, for PD (probing depth), CAL (clinical attachment level), and BOP (bleeding on probing), no statistical significance was achieved at 6 months follow-up. In supportive periodontal therapy for PD, CAL, and BOP, no statistical significance was achieved at 3 months follow-up. Conclusions: The findings suggest that erythritol air-polishing powder did not determine superior improvements of periodontal parameters compared to other non-surgical periodontal therapies. Future randomized clinical trials (RCTs) with calibrated protocols for diagnosis, therapeutic approaches, and longer follow-up are needed to draw a clear conclusion about the efficiency of erythritol air-polishing powder. In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6Related Products of 149-32-6).

(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Related Products of 149-32-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chemometric analysis of the seasonal variation in the essential oil composition and antioxidant activity of a new geraniol chemotype of Lippia alba (Mill.) N.E.Br. ex Britton & P. Wilson from the Brazilian Amazon was written by Barros, Luana de Sousa Peixoto;Santos da Cruz, Ellen de Nazare;de Araujo Guimaraes, Bruna;Setzer, William N.;Veras Mourao, Rosa Helena;do Rosario da Silva, Joyce Kelly;Silva da Costa, Jamile;Baia Figueiredo, Pablo Luis. And the article was included in Biochemical Systematics and Ecology in 2022.HPLC of Formula: 3391-86-4 This article mentions the following:

Lippia alba (Mill.) N.E.Br. ex Britton & P.Wilson is an aromatic shrub native and not endemic to Brazil, popularly known as lemon balm, and widely used throughout Brazil in folk medicine. This study aimed to evaluate the influence of climatic parameters on the yield, radical-scavenging, and chem. composition of the L. alba essential oil. The specimen was collected monthly from August/2021 to May/2022. Essential oils (EOs) were obtained by hydrodistillation, and GC-MS analyzed their chem. composition Chemometric analyses were performed to verify the climatic influences on the yields, chem. composition, and radical-scavenging apacity on L. alba EOs. The radical-scavenging capacity was performed by the DPPH radical-scavenging method. The lowest oil yield was obtained in Oct. (0.6%) and the highest in March (2.2%). The average yields in the dry season (August-Feb., 1.1 ± 0.3%) did not show a statistical difference with the rainy season (Apr.-May, 1.7 ± 0.5%). On the other hand, there was a strong and significant correlation between oil yields and humidity (r = 0.79), precipitation (r = 0.77) and insolation (r = -0.76). Oxygenated monoterpenoids (44.4-66.8%), followed by oxygenated sesquiterpenoids (11.1-26.4%) were predominant in the EOs. The major constituents in the EO were geraniol (21.0-46.9%, average 37.5 ± 8.0%) and elemol (9.0-22.2%). The average amounts of geraniol in the dry season (37.9 ± 5.8%) did not show statistical difference with the rainy season (36.5 ± 13.7%). Furthermore, there was no significant correlation between geraniol and elemol amounts with climatic parameters. The PCA anal. showed a separation between the samples from the dry and rainy seasons, and classified them into three groups: groups I and III (rainy season) and group II (dry season). Geraniol standard content showed a moderate correlation (r = 0.52) with antioxidant capacity. In the experiment, the researchers used many compounds, for example, Oct-1-en-3-ol (cas: 3391-86-4HPLC of Formula: 3391-86-4).

Oct-1-en-3-ol (cas: 3391-86-4) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.HPLC of Formula: 3391-86-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cheap and environmentally sustainable stereoselective arylketones reduction by Lactobacillus reuteri whole cells was written by Perna, F. M.;Ricci, M. A.;Scilimati, A.;Mena, M. C.;Pisano, I.;Palmieri, L.;Agrimi, G.;Vitale, P.. And the article was included in Journal of Molecular Catalysis B: Enzymatic in 2016.Category: alcohols-buliding-blocks This article mentions the following:

Various Lactobacillus reuteri strains were investigated as whole cell catalysts for the bioreduction of acetophenone into optically active (R)-1-phenylethanol. L. reuteri DSM 20016 strain gave an almost complete substrate conversion, in a short reaction time and enantiomeric excess up to 99%. The acetophenone bioreduction was used as a model reaction to optimize temperature and reducing equivalent source (glucose, lactose, cheese way and lignocellulosic hydrolyzates) to accomplish the biotransformation. The reduction of acetophenones into optically active (R)-1-arylethanols was also exploited to study L. reuteri DSM 20016 substrate specificity. In most of the cases, optically active (R)-1-arylethanols have been obtained with both excellent chem. and optical yields and with (R)-enantiopreference, through a cheap, simple and efficient process. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Category: alcohols-buliding-blocks).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nano-silica melamine trisulfonic acid as an efficient and reusable heterogeneous catalyst in esterification reactions was written by Javaherian, Mohammad;Latifi, Saeideh;Heidarizadeh, Fariba. And the article was included in Journal of the Iranian Chemical Society in 2022.COA of Formula: C4H10O3 This article mentions the following:

The use of nano-silica melamine trisulfonic acid as a reusable heterogeneous solid acid catalyst in the esterification reaction of carboxylic acids and alcs. is reported. The reaction conditions were optimized by testing temperature, each component of catalyst, feedstock ratios as well as load of catalyst. The synthesized catalyst was characterized by X-ray diffraction, SEM, Fourier transform IR spectroscopy, and thermogravimetric anal. techniques. The results showed that nano-silica melamine trisulfonic acid was an efficient dehydrating agent in the condensing reactions between different kinds of aliphatic and aromatic carboxylic acids and alcs. The method was simple, rapid, straightforward, catalyst reusability, and holds potential for further application in acid-catalyzed organic synthesis and industrial requirements. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6COA of Formula: C4H10O3).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.COA of Formula: C4H10O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Crosslinked films based on N-hydrophobic-O-hydrophilic chitosan derivatives: Preparation, properties and application in banana storage was written by Liu, Qun;Li, Bo;Li, Yan;Yang, Xiaodeng;Wang, Shoujuan;Qiao, Congde;Wang, Nianxing. And the article was included in Food Hydrocolloids in 2023.Application In Synthesis of Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate This article mentions the following:

Two kinds of N-hydrophobic-O-hydrophilic chitosan derivatives, N-2-hydroxypropyl-3-Bu ether-O-carboxymethyl chitosan (HBCC) and N-2-hydroxypropyl-3-(2-ethylhexyl glycidyl ether)-O-carboxymethyl chitosan (H2ECC) were synthesized and crosslinked with glutaraldehyde to prepare HBCC and H2ECC films. The properties of the crosslinked films, including microstructure, mech. properties, water vapor permeability, swelling property, light transmission, wettability, thermal stability, antibacterial property, and biocompatibility were characterized. The uncrosslinked HBCC and H2ECC films were used as controls. The results showed that the crosslinked films had tight structures, low water vapor permeability, strong water resistance, high UV light resistance, a slight decrease in visible light transmittance, and a small contact angle. The crosslinked films showed strong antibacterial activity against S. aureus and E. coli, non-toxicity to endothelial cells, and good biodegradability. Also, the crosslinked films can effectively prolong the fresh-keeping time of bananas by delaying the formation of soluble polysaccharides and malondialdehyde (MDA) in bananas. These results indicate that HBCC and H2ECC crosslinked films are potential biodegradable materials for fruit preservation. In the experiment, the researchers used many compounds, for example, Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6Application In Synthesis of Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate).

Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Application In Synthesis of Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reconstructing polyamide with nucleophilic catalyst for enhancing reverse osmosis membrane performance was written by Wu, Haowen;Liu, Yingying;Wang, Chong;Li, Xu;Wang, Zhi;Wang, Jixiao. And the article was included in Desalination in 2022.Related Products of 111-46-6 This article mentions the following:

In this work, the permselectivity of PA RO membrane was significantly improved by treating the PA layer with 4-dimethylaminopyridine (DMAP) aqueous solution With the assistance of DMAP, more residues in PA layer released during water soaking, unblocking the water channel in the PA layer. DMAP could also catalyze the reaction between the low activity amino groups and acyl chloride groups in PA, thereby reconstructing the resultant PA layer of RO membranes, generating a highly hydrophilic and neg. charged neonatal PA layer in-situ, and enhancing PA main part crosslinking. These factors were beneficial to membrane permselectivity. Consequently, the selectivity of the DMAP modified membrane could be increased by 62% at most (21594) with a 90% increase in permeance (3.37 L.m^-2.h^-1.bar^-1) compared with those of the virgin membrane (13,294, 1.78 L.m^-2.h^-1.bar^-1). This work provides a facile and low-cost strategy for preparing advanced RO membrane with outstanding permselectivity, exhibiting the potential for industrial application. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6Related Products of 111-46-6).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Related Products of 111-46-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Enhancing conformational flexibility of dendronized triphenylene via diethylene glycol linkers lowers transitions of helical columnar, Frank-Kasper, and quasicrystal phases was written by Imam, Mohammad R.;Peterca, Mihai;Xiao, Qi;Percec, Virgil. And the article was included in Giant in 2022.HPLC of Formula: 111-46-6 This article mentions the following:

A library of triphenylene (Tp) dendronized with self-assembling dendrons via a diethylene glycol linker was synthesized and the corresponding self-organizations were analyzed. They self-organize via a crown conformation in helical columns and spherical helixes that produce hexagonal columnar, Frank-Kasper and soft quasicrystal assemblies. The same self-organizations are produced in the absence of the diethylene glycol linker except that the phase transitions and isotropization temperatures occur at lower temperatures in the presence of the linker. The incorporation of the flexible diethylene glycol linker induces also strong π-π stacking in helical columns. Spherical helixes are spherical distorted short fragments of helical columns and therefore the same principles determine the thermal stability of the hexagonal columnar and of Frank-Kasper and quasicrystal assemblies except that the length of the supramol. backbone is much longer in helical columns. A comparison of these systems with side-chain liquid crystals indicates that supramol. dendrimers are stabilized by extended supramol. backbone conformations. This result suggests pathways to molecularly engineer phase transitions of supramol. dendrimers self-organized from crown conformations. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6HPLC of Formula: 111-46-6).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.HPLC of Formula: 111-46-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Comparison of Chirasil-DEX CB as gas chromatographic and ULMO as liquid chromatographic chiral stationary phase for enantioseparation of aryl- and heteroarylcarbinols was written by Uray, G.;Stampfer, W.;Fabian, W. M. F.. And the article was included in Journal of Chromatography, A in 2003.COA of Formula: C8H9ClO This article mentions the following:

For a broad spectrum of simple chiral alcs., incorporating a (substituted) (het)aryl building block, enantiomer separation characteristics are reported for both gas chromatog. on a Chirasil-DEX phase, and liquid chromatog. on an (S,S)-ULMO phase. On this chiral Pirkle-type phase, homochiral enantiomers (mostly R) are eluted 1st without exception. The elution order R before S appears conserved as a rule also for gas chromatog. separations on Chirasil-DEX, though with some remarkable exceptions indicating a change in the dominant discriminative mechanism. This was shown in the homologous series 1-phenylethanol to 1-phenylhexanol having the point of reversal at C4, while the o-methoxy analogs elute from C1 to C4 already in the reversed order. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9COA of Formula: C8H9ClO).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.COA of Formula: C8H9ClO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Exploration of key aroma active compounds in strong flavor Baijiu during the distillation by modern instrument detection technology combined with multivariate statistical analysis methods was written by He, Fei;Yang, Shiqi;Zhang, Guihu;Xu, Ling;Li, Hehe;Sun, Jinyuan;Huang, Mingquan;Zheng, Fuping;Sun, Baoguo. And the article was included in Journal of Food Composition and Analysis in 2022.Quality Control of Oct-1-en-3-ol This article mentions the following:

Liquid-liquid microextraction (LLME) combined with gas chromatog.-mass spectrometry (GC-MS) and headspace-gas chromatog.-ion mobility spectrometry (HS-GC-IMS) were used to detect the variations in volatile compounds during the distillation process of strong flavor raw Baijiu. The 3D fingerprint spectrum clearly showed a variation in volatile compounds from different distillation stages, and most alc.-soluble and low mol. weight compounds showed a downward trend with the extension of distillation time, but water-soluble, high mol. weight and high boiling compounds showed the opposite result. Then, 50 aroma compounds were sniffed and identified by gas chromatog.-olfactometry-mass spectrometry (GC-O-MS) and multivariate statistical anal. including principal component anal. (PCA) and partial least squares discriminant anal. (PLS-DA) confirmed four aroma active markers related to classification. Finally, the receiver operating characteristic (ROC) curve was further used to verify that Et butanoate and Et hexanoate were the most effective difference marker to distinguish the head Baijiu samples and butanoic acid was the most effective difference marker for distinguishing the heart Baijiu samples from the tail Baijiu samples. In the experiment, the researchers used many compounds, for example, Oct-1-en-3-ol (cas: 3391-86-4Quality Control of Oct-1-en-3-ol).

Oct-1-en-3-ol (cas: 3391-86-4) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Quality Control of Oct-1-en-3-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts