Month: January 2023

A comprehensive chemical profiling of phytochemicals from Trachyspermum ammi and encapsulation for sustained release was written by Dutta, Shuvajit;Kundu, Aditi;Dutta, Anirban;Saha, Supradip;Banerjee, Kaushik. And the article was included in LWT–Food Science and Technology in 2021.Formula: C14H12O4 This article mentions the following:

Trachyspermum ammi (L.) Sprague, commonly called ‘Ajwain’ has been exploited for its huge ethonopharmacol. properties. Inspite of being extensively investigated, comprehensive studies on value addition for product development are lacking. Efforts have been made to identify suitable extraction technique for maximum extraction without hampering antioxidant potential. Effects of extraction techniques, conventional solid liquid extraction (CSLE), high speed homogenization extraction (HHE), ultra-sound assisted extraction (UAE) and microwave assisted extraction (MAE) on extraction yield, total phenolic content (TPC) and antioxidant activities were assessed. The study revealed highest extraction yield with methanol (100%) using MAE. However, the highest TPC (1860 ± 31.2 mg GAE 100g DW^-1) achieved extraction with methanol (100%) using UAE for 20.0 min. DPPH and ABTS assays showed excellent radical scavenging potential of methanolic concentrate with EC50 43.6 and 96.2, with reducing powder 157 Trolox Equivalent (μgmL^-1) in CUPRAC assay, resp. UPLC-QToF-ESI-MS anal. revealed putative characterization of thirty-seven phytochems. Rosmarinyl-3-O-glucoside (R₃Og) was isolated and characterized spectroscopically. Finally, R₃Og was encapsulated within WPI by heat gelation, characterized by FT-IR and SEM. Kinetics study of apparently pH independent release behavior of R₃Og from the WPI matrix suggested that the release was controlled by rapid relaxation of WPI aggregates and dominated at highly acidic pH. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Formula: C14H12O4).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Formula: C14H12O4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fusaric acid and analogous compounds. V. Syntheses of 3-alkylpicolinic acids and 5-methylpicolinic acid was written by Nakashima, Tatsumi. And the article was included in Yakugaku Zasshi in 1958.SDS of cas: 1122-71-0 This article mentions the following:

3,2-Me(H₂N)C₅H₃N b₆ 86-8°; picrate, m. 226°. 2,3-BrMeC₅H₃N b₆ 67-9°. 3,2-Me(HO₂C)C₅H₃N.H₂O (I) m. 113°. A solution of 1.6 g. AgNO₃ in 20% NH₄OH, 1.6 g. NaOH, and 16 ml. H₂O treated with 1 g. 3,2-Me(OHC)C₅H₃N, stirred 2 hrs., kept overnight, the solution filtered, the filtrate acidified with HCl, evaporated to dryness, the residue extracted with hot EtOH, the EtOH removed, the residue in H₂O adjusted to pH 3-4, the solution treated with (AcO)₂Cu, the Cu salt decomposed with H₂S, the solution filtered, the filtrate evaporated to dryness, and the residue extracted with EtOH gave 0.2 g. I, m. 113° (petr. ether). MeC(:NH)CH₂COR (R = Me) (16.3 g.) and 28.5 g. EtOCH:CHCH(OEt)₂ heated 2 days at 100°, the product in 10% HCl extracted with Et₂O, and distilled gave 12.5 g. 2,3-Me(RCO)C₅H₃N (II, R = Me), b₁₅ 102-3°; picrate, m. 171-3°. Similarly were prepared II (R, % yield, b.p/mm., and m.p. of picrate given): Et, 52.9, 108-10°/9, 145-7°; Pr, 73.4, 110-13°/8, 90-2°; Bu, 64.5, 123-6°/10, 93-4°. Wolff-Kishner reduction of II gave 2,3-Me(RCH₂)C₅H₃N (III) (R, % yield, b.p./mm., and m.p. of picrate given): Me, 76.5, 63-4°/13, 139-40°; Et, 76.2, 80-1°/14, 129-30°; Pr, 66.7, 96-9°/14, 130-1°; Bu, 63.6, 95-105°/8, 97-8°. III converted to their N-oxides, refluxed 2 hrs. with Ac₂O, and the product distilled gave 3,2-R(AcOCH₂)C₅H₃N (IV) (R, % yield, b.p./mm., and m.p. of picrate given): Et, 66.9, 131-2°/13, 156-7°; Pr, 60.8, 135-6°/9, 146-7°; Bu, 78.2, 150-2°/11, 105-6°; Am, 74.1, 158-9°/9, -. IV in HCl refluxed 10 hrs., the product concentrated, the residue made alk. with K₂CO₃, and extracted with CHCl₃ gave 3,2-R(HOCH₂)C₅H₃N (V), (R, % yield, b.p./mm., and m.p. of picrate given): Et, 53.1, 112-14°/8, 131-2°; Pr, 62.9, 130-2°/8, 174-5°; Bu, 61.6, 135-7°/8, 153-4°; Am, 55.2, 140-4°/8, 126-7°. V (R = Et) (2.6 g.) and 26 g. MnO₂ in Et₂O heated 2.5 hrs. at 35° and the product distilled gave 1.6 g. 3,2-R(OHC)C₅H₃N (VI, R = Et), b₈ 68-70°; semicarbazone, m. 177° (decomposition). Similarly were prepared VI (R, % yield, b.p./mm., and m.p. of semicarbazone given): Pr, 59.9, 63-5°/9, 182-3°; Bu, 60.7, 95-102°/8, 200-1°; Am, 54.6, 100-4°/9, 96-7°. Oxidation of VI with Ag₂O yielded 3,2-R(HO₂C)C₅H₃N (VII) (R, % yield, and m.p. given): Et, 19.5, 72-3°; Pr, 18.2, 67-8°; Bu, 17.5, 55-7°; Am, 13.8, 71-2°. 6,3-Me(MeO₂C)C₅H₃N (32 g.) added dropwise to 8.8 g. LiAlH₄ in 500 ml. Et₂O, refluxed 1 hr., the product poured in ice H₂O, the aqueous layer treated with K₂CO₃, and the precipitate taken up in CHCl₃ gave 15.1 g. 6,2-Me(HOCH₂)C₅H₃N (VII), b₈ 130-2°, m. 46°. SOCl₂ (100 ml.) at 0° treated portionwise with 15.1 g. VII, kept 30 min., refluxed 1 hr., the product conductivity in vacuo, the residue in ice H₂O made alk. with K₂CO₃, and extracted with Et₂O gave 6,3-Me(ClCH₂)C₅H₃N; this in 100 ml. MeOH reduced with 50% Pd-C and H, the MeOH removed, the residue in H₂O made alk. with Na₂CO₃, and extracted with Et₂O gave 6 g. 2,5-Me₂C₅H₃N (VII), b. 157-9°; picrate, m. 166-8°. VIII (6 g.) converted to its N-oxide and this and 6 ml. Ac₂O refluxed 1 hr. gave 5 g. 5,2-Me(AcOCH₂)C₅H₃N (IX), b₁₅ 124-4°; picrate, m. 130-1°. IX (5 g.) in 50 ml. HCl refluxed 10 hrs. gave 2.7 g. 5,2-Me(HOCH₂)C₅H₃N (X), b₈ 94-7°; picrate, m. 168°. Oxidation of 2.7 g. X with MnO₂ gave 1 g. 5,2-Me(OHC)C₅H₃N (XI), m. 35-6°. Oxidation of 1 g. XI with Ag₂O gave 0.2 g. 5,2-Me(HO₂C)C₅H₃N, m. 164-6°. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0SDS of cas: 1122-71-0).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.SDS of cas: 1122-71-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Iron(II/III) Halide Complexes Promote the Interconversion of Nitric Oxide and S-Nitrosothiols through Reversible Fe-S Interaction was written by Poptic, Anna L.;Zhang, Shiyu. And the article was included in Inorganic Chemistry in 2021.COA of Formula: C4H9NaS This article mentions the following:

Heme and non-heme iron in biol. mediate the storage/release of NO^• from S-nitrosothiols as a means to control the biol. concentration of NO^•. Despite their importance in many physiol. processes, the mechanisms of N-S bond formation/cleavage at Fe centers have been controversial. Herein, authors report the interconversion of NO^• and S-nitrosothiols mediated by Fe^II/Fe^III chloride complexes. The reaction of 2 equivalent of S-nitrosothiol (Ph₃CSNO) with [Cl₆Fe^II₂]^2- results in facile release of NO^• and formation of iron(III) halothiolate. Detailed spectroscopic studies, including in situ UV-vis, IR, and Moessbauer spectroscopy, support the interaction of the S atom with the Fe^II center. This is in contrast to the proposed mechanism of NO^• release from the well-studied “red product” κ¹-N bound S-nitrosothiol Fe^II complex, [(CN)₅Fe(κ¹-N-RSNO)]^3-. Addnl., Fe^III chloride can mediate NO^• storage through the formation of S-nitrosothiols. Treatment of iron(III) halothiolate with 2 equivalent of NO^• regenerates Ph₃CSNO with the Fe^II source trapped as the S = 3/2 {FeNO}⁷ species [Cl₃FeNO]^–, which is inert toward further coordination and activation of S-nitrosothiols. Their work demonstrates how labile iron can mediate the interconversion of NO^•/thiolate and S-nitrosothiol, which has important implications toward how Nature manages the biol. concentration of free NO^•. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2COA of Formula: C4H9NaS).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.COA of Formula: C4H9NaS

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ni-Catalyzed Reductive 1,2-Cross-Dialkylation of Unactivated Alkenes with Two Alkyl Bromides was written by Zhang, Jian-Xin;Shu, Wei. And the article was included in Organic Letters in 2022.Synthetic Route of C10H20O This article mentions the following:

Herein, a Ni-catalyzed reductive 1,2-dialkylation of unactivated aliphatic alkenes had been developed using two different alkyl bromides to gave (cyanoethyl)-alkyl-aryl-propanamides R¹CH₂CHR²CH₂C(O)NHAr [R¹ = cyanomethyl, H₂CCO₂Et, (2-oxotetrahydrofuran-3-yl); R² = Et, n-Pr, 3-phenylpropyl, etc.; Ar = Ph, 4-MeC₆H₄, 3-MeOC₆H₄, etc.]. The reaction proceeded smoothly under mild conditions to install two Csp³-Csp³ bonds onto directed aliphatic alkenes, demonstrating excellent chemo- and regioselectivity with good functional group tolerance. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Synthetic Route of C10H20O).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Synthetic Route of C10H20O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Discovery of 5-Chloro-4-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)oxy)-1-(2-fluoro-4-(methylsulfonyl)phenyl)pyridin-2(1H)-one (BMS-903452), an Antidiabetic Clinical Candidate Targeting GPR119 was written by Wacker, Dean A.;Wang, Ying;Broekema, Matthias;Rossi, Karen;O’Connor, Steven;Hong, Zhenqiu;Wu, Ginger;Malmstrom, Sarah E.;Hung, Chen-Pin;LaMarre, Linda;Chimalakonda, Anjaneya;Zhang, Lisa;Xin, Li;Cai, Hong;Chu, Cuixia;Boehm, Stephanie;Zalaznick, Jacob;Ponticiello, Randolph;Sereda, Larisa;Han, Song-Ping;Zebo, Rachel;Zinker, Bradley;Luk, Chiuwa Emily;Wong, Richard;Everlof, Gerry;Li, Yi-Xin;Wu, Chunyu K.;Lee, Michelle;Griffen, Steven;Miller, Keith J.;Krupinski, John;Robl, Jeffrey A.. And the article was included in Journal of Medicinal Chemistry in 2014.Reference of 142253-56-3 This article mentions the following:

G-protein-coupled receptor 119 (GPR119) is expressed predominantly in pancreatic β-cells and in enteroendocrine cells in the gastrointestinal tract. GPR119 agonists have been shown to stimulate glucose-dependent insulin release by direct action in the pancreas and to promote secretion of the incretin GLP-1 by action in the gastrointestinal tract. This dual mechanism of action has generated significant interest in the discovery of small mol. GPR119 agonists as a potential new treatment for type 2 diabetes. Herein, the authors describe the discovery and optimization of a new class of pyridone containing GPR119 agonists. The potent and selective BMS-903452 I was efficacious in both acute and chronic in vivo rodent models of diabetes. Dosing of I in a single ascending dose study in normal healthy humans showed a dose dependent increase in exposure and a trend toward increased total GLP-1 plasma levels. In the experiment, the researchers used many compounds, for example, 1-Boc-Azetidine-3-yl-methanol (cas: 142253-56-3Reference of 142253-56-3).

1-Boc-Azetidine-3-yl-methanol (cas: 142253-56-3) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Reference of 142253-56-3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Characterization and quantification of metabolites of racemic ketoprofen excreted in urine following oral administration to man by ¹H-NMR spectroscopy, directly coupled HPLC-MS and HPLC-NMR, and circular dichroism was written by Skordi, E.;Wilson, I. D.;Lindon, J. C.;Nicholson, J. K.. And the article was included in Xenobiotica in 2004.COA of Formula: C16H16O3 This article mentions the following:

The identity of the human metabolites of ketoprofen (2-(3-benzoylphenyl)-propanoic acid) excreted via urine was investigated after a single oral dose of the racemic drug. Drug metabolites were concentrated and partially purified from urine using solid-phase extraction chromatog. before separation and identification by directly coupled HPLC-MS and HPLC-NMR. The metabolites identified were the ester glucuronides of the parent drug and its phase I metabolites, 2-[3-(3-hydroxybenzoyl)phenyl]-propanoic acid, 2-[3-(4-hydroxybenzoyl)phenyl]-propanoic acid and 2-[3-(hydroxy(phenyl)methyl)phenyl]-propanoic acid, the latter formed by reduction of the ketone group of ketoprofen. In addition, two novel minor metabolites were identified as the ether glucuronides of 2-[3-(3-hydroxybenzoyl)phenyl]-propanoic acid and 2-[3-(4-hydroxybenzoyl)phenyl]-propanoic acid. These conjugates were all observed as diastereoisomeric pairs of unequal proportions. Purification of these metabolites by preparative chromatog. allowed stereochem. assignments. Metabolites were quantified by ¹H-NMR spectroscopy after spectral simplification achieved by hydrolysis of the conjugates. In the experiment, the researchers used many compounds, for example, 2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6COA of Formula: C16H16O3).

2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.COA of Formula: C16H16O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Replacing dietary fish meal improves ecosystem services of largemouth bass (Micropterus salmoides) farming was written by Cui, Zhenghe;Zhang, Jingya;Ren, Xing;Wang, Yan. And the article was included in Aquaculture in 2022.Synthetic Route of C18H32CaN2O10 This article mentions the following:

Sustainability of aquaculture industry depends on the value of ecosystem services (VES), which has been rarely quantified in aquaculture practices. The present study evaluated the impact of replacing dietary fish meal with soy protein concentrate (SPC) and cottonseed protein concentrate (CPC) on VES of largemouth bass Micropterus salmoides farming. A reference diet (RF) contained 400 g/kg fish meal, and 20%, 40% and 60% of the fish meal was replaced by either SPC (SPC20, SPC40, SPC60) or CPC (CPC20, CPC40, CPC60). Fish were fed with the test diets for eight weeks, and alternation in VES of three categories, including provision services, regulating services and cultural services, were calculated No significant differences were found in weight gain, retention efficiencies of nitrogen and carbon, condition factor, proximate composition of whole body and nitrogen waste between fish fed diet RF and diets CPC20, CPC40, CPC60, SPC20, SPC40 and SPC60. Fish fed diet RF exhibited lower feed intake and feed conversion ratio, but lower carbon waste relative to fish fed diet CPC60, and higher phosphorus waste relative to fish fed diet SPC60. These results reveal that fish meal level in largemouth bass diet could be reduced to 160 g/kg by using SPC or CPC as a fish meal alternate, and replacing dietary fish meal did not result in apparent neg. impact on regulating services of largemouth bass farming. The ratio of fish meal consumption to fish production declined with increasing fish meal replacement level, indicating provision services was improved by feeding diets CPC60 and SPC60. This study reveals, for the first time, that improvement of feeding management benefits to amplify VES of largemouth bass farming. In the experiment, the researchers used many compounds, for example, Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6Synthetic Route of C18H32CaN2O10).

Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Synthetic Route of C18H32CaN2O10

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Effects of broussonetia papyrifera-fermented feed on production performance, egg quality, and caecal microbiota of laying hens during the late laying period was written by Zhu, Yipu;Tao, Zhenyang;Chen, Xiaochen;Xiao, Jianshe;Zhang, Yanda;Wang, Zhanbin. And the article was included in Italian Journal of Animal Science in 2022.Electric Literature of C18H32CaN2O10 This article mentions the following:

This study was conducted to determine the effects of different proportions of Broussonetia papyrifera (BP)-fermented feed in the diet to replace part of soybean meal on the production performance, egg quality and caecal microbiota of laying hens in the late laying period. In the experiment, 360 Hy-line brown laying hens (67-wk-old) were randomly divided into 4 groups with 6 replicates in each group and 15 chickens in each replicate. The control group was fed with basic diets, and EG1, EG2 and EG3 groups were used in 1.5%, 3% and 4.5% BP-fermented feed to replace corn and soybean meal in the basic diet, resp. The pre-feeding period was 7 days, and the experiment period was 56 days. In terms of production performance, the average daily egg production in the EG3 decreased significantly compared with that in the control group (p < .05). In terms of caecal microorganisms, the abundance indexes of Sobs, Chao, and ACE community distribution in EG2 significantly increased compared with those in the control group (p < .05). At the phylum level, the abundance of WPS-2 in all exptl. groups significantly increased (p < .05). The abundance of Actinobacteria in EG1 increased significantly, and that of Campilobacterota and Elusimicrobiota in EG2 significantly increased (p < .05). At the genus level, Olsenella in EG1 increased significantly (p<.05) and UCG-008 in EG3 increased significantly (p < .05) with increasing replacement ratio of BP-fermented feed compared with the control group. The results suggest that based on the production performance, the recommended replacement amount is 3%. HighlightsBP-fermented feed can be used as a new protein feed in layers diet at late laying stages. BP-fermented feed had no significant impact on improved egg production performance and egg quality. Replacing part of soybean meal with BP-fermented feed can significantly increase the WPS-2 and Actinobacteria and other phyla, resulting in changes in the intestinal microbes of laying hens. In the experiment, the researchers used many compounds, for example, Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6Electric Literature of C18H32CaN2O10).

Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Electric Literature of C18H32CaN2O10

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Flavor characteristics of peanut butter pretreated by radio frequency heating, explosion puffing, microwave, and oven heating was written by Yang, Yini;Yuan, Binhong;Yu, Pei;Jia, Yimin;Zhou, Qi;Sun, Jinyuan. And the article was included in Food Chemistry in 2022.Formula: C8H16O This article mentions the following:

Currently, the effect of different pretreatments (i.e., radio frequency (RF), explosion puffing (EP), microwave (MW) and oven heating (OH)) on the flavor characteristics of peanut butter is unclear. Consequently, this study identified volatile aroma and non-volatile taste using HS-SPME/GC-MS combined with the use of an electronic nose, electronic tongue, and sniffing. 53 volatile compounds in four peanut butters were identified, MW-treated samples exhibited the most aroma-active compounds (43), followed by samples treated using OH (42), EP (38) and RF (21). Different pretreatment resulted in significant flavor differences in the aroma and taste. The peanut butter under MW pretreatment had a strongest nutty notes among the treatments. RF methods yielded smaller particle sizes and better texture compared to conventional OH. However, instantaneous heating using EP did not result in improvements to the aroma or taste. A combination of MW and RF may improve the flavor quality of peanut butter. In the experiment, the researchers used many compounds, for example, Oct-1-en-3-ol (cas: 3391-86-4Formula: C8H16O).

Oct-1-en-3-ol (cas: 3391-86-4) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Formula: C8H16O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of growth promoting hormones alters the composition and antioxidant potential of dill essential oil under salt stress was written by Ghassemi-Golezani, Kazem;Nikpour-Rashidabad, Neda;Samea-Andabjadid, Samira. And the article was included in Scientific Reports in 2022.Name: 5-Isopropyl-2-methylphenol This article mentions the following:

The performance of dill plant may be affected by adverse environments such as salinity. Thus, this research was designed to evaluate changes in chem. composition and antioxidant activity of seed essential oil of dill (Anethum graveolens L.) in response to salinity (0, 5, 10 and 15 dS/m) and 1 mM of each hormonal treatments (gibberellic acid, salicylic acid, and cytokinin). Salicylic acid (SA) reduced Na+ content of roots and leaves by 15.4%, 30.9% and 12.4%, 24.3%, but enhanced K+ content by 29.8%, 51.6% and 76.6%, 73.4% under moderate and severe salinities, resp. Essential oil yield was enhanced with progressing seed filling, despite decreasing essential oil percentage. Percentage of essential oil was increased under low and moderate salinities. Hormonal treatments, particularly SA enhanced seed mass and essential oil percentage, leading to enhanced essential oil yield. The amounts of most constituents were enhanced under moderate salinity. Foliar spray of SA and CK (cytokinin) increased almost all essential oil components, except dill ether and dill apiole, while the GA3 (gibberellic acid) treatment reduced most of the constituents. The α-fenchol was only induced by salt stress. The β-pinene, 1-terpineol, cryptone, oxypeucedanin hydrate, α-thujene and P-α-dimethylstyrene were also specifically synthesized in SA treated plants under salinity. The highest TPC (total phenolic content) and antioxidant activity were recorded for essential oil of SA treated plants at mass maturity under moderate salinity. In general, the SA spray was the most effective treatment for improving essential oil quantity and quality of dill plants. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Name: 5-Isopropyl-2-methylphenol).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Name: 5-Isopropyl-2-methylphenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts