Month: January 2023

Highly dispersed palladium nanoparticles supported on an imidazolium-based ionic liquid polymer: an efficient catalyst for oxidation of alcohols was written by Karimi, Z.;Hassanpour, A.;Kangari, S.;Marjani, A.. And the article was included in Russian Chemical Bulletin in 2022.Synthetic Route of C7H7ClO This article mentions the following:

An efficient and stable nanocatalyst for selective oxidation of alcs. was developed. It contains palladium nanoparticles, which are well distributed throughout the network of a copolymer based on an ionic liquid The synthesized nanomaterials were characterized by various techniques such as nitrogen adsorption-desorption anal., thermal gravimetric anal., TEM, and FTIR spectroscopy. A high surface area and the appropriate pore size of the nanocatalyst make active metal sites accessible to reagents, whereas the presence of an ionic liquid in the network of the polymer structure creates a good environment for the leaching protection and stabilization of extremely dispersed palladium nanoparticles. The availability and abundance of active sites of highly dispersed palladium nanoparticles make the synthesized nanocatalyst very promising for oxidation of alcs. The nanocatalyst has a number of features such as a high surface area, an appropriate size of pores with high catalytic activity, high thermal stability of the nanostructures, and low amounts of the ionic liquid needed for its synthesis. Using this nanocatalyst, carbonyl compounds were prepared from the corresponding alcs. in high yields. Addnl., the prepared nanocatalyst can easily be recovered by centrifugation after completion of the reactions and was reused five times without a significant loss in its catalytic activity. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Synthetic Route of C7H7ClO).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Synthetic Route of C7H7ClO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Iron-Catalyzed Alkyne-Based Multicomponent Synthesis of Pyrimidines under Air was written by Mondal, Rakesh;Chakraborty, Gargi;Guin, Amit Kumar;Sarkar, Susmita;Paul, Nanda D.. And the article was included in Journal of Organic Chemistry in 2021.SDS of cas: 1777-82-8 This article mentions the following:

An iron-catalyzed sustainable, economically affordable, and eco-friendly synthetic protocol for the construction of various trisubstituted pyrimidines I (R = Ph, cyclopropyl, 2-thienyl, etc.; R¹ = Ph, cyclopropyl, 2-thienyl, etc.; R² = H, NH₂, Me, Ph, etc.) is described. A wide range of trisubstituted pyrimidines were prepared using a well-defined, easy to prepare, bench-stable, and phosphine-free iron catalyst featuring a redox non-innocent tridentate arylazo pincer under comparatively mild aerobic conditions via dehydrogenative functionalization of alcs. RCH₂OH with alkynes R¹CCH and amidines R²C(=NH)NH₂. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8SDS of cas: 1777-82-8).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.SDS of cas: 1777-82-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis of 45S5 Bioglass via a straightforward organic, nitrate-free sol-gel process was written by Rezabeigi, Ehsan;Wood-Adams, Paula M.;Drew, Robin A. L.. And the article was included in Materials Science & Engineering, C: Materials for Biological Applications in 2014.Electric Literature of C6H20CaO11 This article mentions the following:

More than four decades after the discovery of 45S5 Bioglass as the first bioactive material, this composition is still one of the most promising materials in the tissue engineering field. Sol-gel-derived bioactive glasses generally possess improved properties over other bioactive glasses, because of their highly porous microstructure and unique surface chem. which accelerate hydroxyapatite formation. In the current study, a new combination of precursors with lactic acid as the hydrolysis catalyst have been employed to design an organic, nitrate-free sol-gel procedure for synthesizing of 45S5 Bioglass_. This straightforward route is able to produce fully amorphous submicron particles of this glass with an appropriately high sp. surface area on the order of ten times higher than that of the melt-derived glasses. These characteristics are expected to lead to rapid hydroxyapatite formation and consequently more efficient bone bonding. In the experiment, the researchers used many compounds, for example, Calcium 2-hydroxypropanoate pentahydrate (cas: 5743-47-5Electric Literature of C6H20CaO11).

Calcium 2-hydroxypropanoate pentahydrate (cas: 5743-47-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Electric Literature of C6H20CaO11

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Analysis of the essential oil of magnolia and its effect on antioxidant enzyme activity, sCD40L and phosphorylate-activate Akt protein levels in gastric cancer mice was written by Li, Rui;Chen, Wei-chang;Wang, Wei-peng;Tian, Wen-yan;Zhang, Xue-guang. And the article was included in Medicinal Chemistry Research in 2010.Quality Control of rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate This article mentions the following:

The chem. composition of essential oil from magnolia collected in Suzhou city, China, was studied using gas chromatog.-mass spectroscopy. Fifty-four volatile compounds were identified in the essential oil, with eucalyptol (21.55%), β-Pinene(11.07%), D-Limonene (8.93%), 1R-α-Pinene (7.86%), Bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-, (1R)-(6.46%), Cyclohexene, 4-methylene-1-(1-methylethyl)- (5.30%), 1,4-Cyclohexadiene, 1-methyl-4-(1-methylethyl)- (5.10%), camphene (4.72%), being the major chem. constituents. In an in vivo approach, the protective effect of the essential oil against oxidative stress in gastric cancer (GC) mice was also investigated in terms of superoxide dismutase, CAT, and glutathione peroxidase activities. Our results indicate that the essential oil has an effective capability to enhance serum antioxidant enzyme activities and sCD40L, and decrease phosphorylate-activate Akt protein levels in a dose-dependent manner in gastric cancer mice. Overall, essential oil from magnolia appears to be an effective antioxidant and is quite suitable for further biol. evaluation. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Quality Control of rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Quality Control of rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The preparation and property of photo- and thermo-responsive hydrogels with a blending system was written by Shuai, Shirong;Zhou, Siyao;Liu, Yu;Huo, Weirong;Zhu, Hongyu;Li, Yang;Rao, Zikun;Zhao, Cong;Hao, Jianyuan. And the article was included in Journal of Materials Science in 2020.Category: alcohols-buliding-blocks This article mentions the following:

Hydrogels are the attractive biomaterials for biomedical applications. The dual-stimuli-responsive system, which is sensitive to both temperature and UV irradiation, was achieved through the self-assembly of amphiphilic block copolymers in aqueous solution and the cleavage of ο-nitrobenzyl (NB) ester groups under UV irradiation The copolymer of poly(ε-caprolactone)-b-ο-nitrobenzyl-poly(ethylene glycol)-ο-nitrobenzyl-b-poly(ε-caprolactone) (PCL-NB-PEG-NB-PCL) was prepared by ring-opening polymerization (ROP) and nucleophilic substitution reaction of ε-caprolactone (ε-CL) using photo-sensitized polyethylene glycol as an initiator. After blending with poly(ε-caprolactone)-b-poly(ethylene glycol)-b-poly(ε-caprolactone) (PCL-PEG-PCL), the system exhibited the promising dual sensitivity with wide gel-phase window and controllable sensitive properties. The structures and dual-responsive behaviors were characterized by ¹H-NMR, GPC, DMA, UV-Vis, DLS and SEM. The results demonstrated the temperature and photo-sensitivity of the synthesized hydrogel and indicated that the blending of these two copolymers can easily adjust the phase transition temperature and broaden the gel-phase window through the content of NB groups in PCL-NB-PEG-NB-PCL and the hydrophilic/hydrophobic balance of system. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Category: alcohols-buliding-blocks).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Volatile profiles of commercial vetch prepared via different processing methods was written by Riley, Samuel;Lale, Aneesh;Nguyen, Vy;Xi, Hangwei;Wilkinson, Kerry;Searle, Iain R.;Fisk, Ian. And the article was included in Food Chemistry in 2022.HPLC of Formula: 3391-86-4 This article mentions the following:

Vicia sativa (Common Vetch) is currently an underutilized leguminous crop species with high protein content and superior drought tolerance. This study aimed to understand the mechanisms behind vetch flavor development following processing to facilitate its uptake as a future source of dietary protein. A total of 95 volatile compounds were identified by solid-phase microextraction gas chromatog.-mass spectrometry (SPME GC-MS) for a range of vetches processed by dehulling, soaking, germination, microwaving, and fermentation 2-pentyl furan, benzyl alc., benzaldehyde, 1-octen-3-ol and 1-hexanol were found to be characteristic aroma compounds of V. sativa. Anal. of a V. sativa landrace demonstrated significant intraspecies variation in volatile abundance, three-fold that of com. varieties. Both natto and tempeh fermentation produced significant quantities of alcs., esters, and carboxylic acids with specifically natto generating significant pyrazines. Concentrations of 1-octen-3-ol significantly decreased after tempeh fermentation indicating its potential to reduce documented off flavor generating volatiles within V. sativa. In the experiment, the researchers used many compounds, for example, Oct-1-en-3-ol (cas: 3391-86-4HPLC of Formula: 3391-86-4).

Oct-1-en-3-ol (cas: 3391-86-4) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.HPLC of Formula: 3391-86-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Thermal conductivity performance in propylene glycol-based Darcy-Forchheimer nanofluid flow with entropy analysis was written by Wang, Fuzhang;Khan, Sohail A.;Khan, M. Ijaz;El-Zahar, Essam Roshdy;Yasir, M.;Nofal, Taher A.;Malik, M. Y.. And the article was included in Journal of Petroleum Science & Engineering in 2022.Quality Control of 1,2-Propanediol This article mentions the following:

Entropy generation is a novel prospective in many thermodn. processes and presents dynamic applications in heat polymer processing optimization. The significance of entropy generation is observed in heat exchangers, combustion, thermal systems, nuclear reactions, turbine systems, porous media and many others. In view of such thermal applications, the main objective of recent anal. is to analyze the entropy optimized anal. for dissipative flow of Darcy-Forchheimer nanofluid over a permeable medium. Flow is generated by stretching of surface. Thermal radiation and viscous dissipation are incorporated in heat expression. Boehmite (AlOOH) and silica (SiO₂) are considered as nanoparticles. Here propylene glycol (C₃H₈O₂) is considered as continuous phase fluid. Entropy features is discussed through thermodn. second law. Nonlinear ordinary dimensionless form is obtained through suitable dimensionless variables. The obtained dimensionless expressions are numerically solved by implementation of ND-solve method. Graphical feature of entropy rate, temperature, Bejan number and velocity profile against flow variables for both Boehmite (AlOOH) and silica (SiO₂) nanoparticles are discussed. Computational results of thermal transport rate and drag force vs. sundry variables for Boehmite and silica nanoparticles are studied. An increment in velocity profile is seen through volume fraction. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Quality Control of 1,2-Propanediol).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Quality Control of 1,2-Propanediol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Piceatannol alleviate ROS-mediated PC-12 cells damage and mitochondrial dysfunction through SIRT3/FOXO3a signaling pathway was written by Yang, Wei;Wang, Yu;Hao, Yiming;Wang, Ziyuan;Liu, Jie;Wang, Jing. And the article was included in Journal of Food Biochemistry in 2022.Synthetic Route of C14H12O4 This article mentions the following:

Oxidative stress-associated mitochondrial dysfunction has been identified as a major mechanism in multiple neurodegenerative diseases. This study aims to investigate the cytoprotective effects of piceatannol on ROS-mediated PC-12 cells damage and related mitochondrial dysfunction. Piceatannol treatment could significantly attenuate PC-12 cells oxidative damage and ROS-mediated cells apoptosis. Moreover, pretreatment with piceatannol effectively decreased mitochondrial membrane depolarization, cleaved-caspase 3, and increased Bcl-2 and Bcl-2/Bax compared with control H₂O₂ group. Meanwhile, piceatannol treatment improved mitochondrial respiration function which led to an enhancement in the maximal respiration and spare respiratory capacity. Further mechanisms anal. showed that the protein expression of SIRT3 and its downstream protein FOXO3a were significantly increased after piceatannol addition in a dose-dependent manner. Whereas the cytoprotective role of piceatannol was markedly abolished by the SIRT3 inhibitor 3-TYP, suggesting that SIRT3/FOXO3a signaling pathway played a vital role in mediating the neuronal cytoprotective effects of piceatannol. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Synthetic Route of C14H12O4).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Synthetic Route of C14H12O4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis and SAR of tolylamine 5-HT₆ antagonists was written by Singer, Jamie M.;Wilson, Michael W.;Johnson, Paul D.;Graham, Shelley R.;Cooke, Leonard W.;Roof, Robin L.;Boxer, Peter A.;Gold, Lisa H.;Meltzer, Leonard T.;Janssen, Ann;Roush, Nicole;Campbell, Jeffrey E.;Su, Ti-Zhi;Hurst, Susan I.;Stoner, Chad L.;Schwarz, Jacob B.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2009.Recommanded Product: 120121-01-9 This article mentions the following:

The synthesis and SAR of tolylamines with 5-HT₆ receptor antagonist activity was presented. The amine, core aromatic, peripheral aromatic, and ether linker moieties of an HTS hit were modulated and the effect on potency at 5-HT₆ examined Tolylpiperidine ether I was found to possess desirable pharmacokinetic properties, and was also shown to enhance cognition in the rat novel object recognition paradigm. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Recommanded Product: 120121-01-9).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Recommanded Product: 120121-01-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electrode-assisted desorption electrospray ionization mass spectrometry was written by Ozdemir, Abdil;Chen, Chung-Hsuan. And the article was included in Journal of Mass Spectrometry in 2010.Computed Properties of C10H22O3 This article mentions the following:

A new ion source has been developed for rapid, noncontact anal. of materials at ambient conditions. The method provides desorption of analytes under ambient conditions directly from different surfaces with little or no sample preparation The new method, termed electrode-assisted desorption electrospray ionization (EADESI), is on the basis of the ionization of mols. on different surfaces by highly charged droplets produced on a sharp-edged high voltage tip, and ions produced are introduced into the mass spectrometer through a capillary. The EADESI technique can be applied to various samples including amino acids, peptides, proteins, drugs and human fluids such as urine and blood. EADESI is promising for routine analyses in different fields such as forensic, environmental and material sciences. EADESI interface can be fit to a conventional ion-trap mass spectrometer. It can be used for various types of samples with a broad mass range. EADESI can also provide real-time anal. which is very valuable for biomedical applications. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Computed Properties of C10H22O3).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Computed Properties of C10H22O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts