Month: January 2023

Novel 1,4-dihydropyridine calcium antagonists. I. Synthesis and hypotensive activity of 4-(substituted pyridyl)-1,4-dihydropyridine derivatives was written by Ashimori, Atsuyuki;Ono, Taizo;Uchida, Takeshi;Ohtaki, Yutaka;Fukaya, Chikara;Watanabe, Masahiro;Yokoyama, Kazumasa. And the article was included in Chemical & Pharmaceutical Bulletin in 1990.Recommanded Product: 2-Bromopyridine-4-methanol This article mentions the following:

A series of 4-(substituted pyridyl)-1,4-dihydropyridine derivatives I (R = H, halo, CF₃, etc.) were synthesized and their hypotensive effects examined Several compounds have a hypotensive activity parallel to that of nicardipine; the 4-(3-trifluoromethyl-2-pyridyl) and 4-(2-trifluoromethyl-3-pyridyl) derivatives, in particular, had approx. twice the duration of nicardipine, and the 4-(4-cyano-2-pyridyl) derivative had the most potent hypotensive activity of all the derivatives synthesized. In the experiment, the researchers used many compounds, for example, 2-Bromopyridine-4-methanol (cas: 118289-16-0Recommanded Product: 2-Bromopyridine-4-methanol).

2-Bromopyridine-4-methanol (cas: 118289-16-0) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Recommanded Product: 2-Bromopyridine-4-methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Characterization and rheological behavior of asphalt binder modified by a novel cyclic borate ester additive was written by Oruc, Seref;Yilmaz, Bahadir;Sancak, Kemal. And the article was included in Construction and Building Materials in 2022.Related Products of 57-55-6 This article mentions the following:

In the current study, the synthesis of a novel additive containing boron and its inclusion in asphalt binder was completely achieved under chem. laboratory conditions. Following this objective, the structural analyses of the additive containing boron, namely Cyclic Borate Ester (CBE), and the modified asphalt binders were examined The asphalt binders were blended with CBE additive in 1%, 2%, 4%, and 6% (weight/weight) ratios at each stage of the experiment The elemental analyses of CBE were performed using the Fourier transform IR (FTIR) spectroscopy test, the thermogravimetry (TG), and the proton NMR (¹H NMR) spectroscopy test. The mechanisms of the modification in the modified asphalt binders were researched using FTIR while their microstructures and thermal degradation behaviors were analyzed via SEM (SEM) and TG tests. In the analyses the rheol. behaviors of the blends were investigated by the temperature-frequency-amplitude sweeps in dynamic shear rheometer (DSR) test. According to the exptl. results, it was seen that there was no phase separation between CBE and the asphalt matrix. There was an electrostatic interaction between asphalt and CBE ′s hydrocarbon chain. Accordingly, it was observed that the rutting resistance and elastic characteristics of the base asphalt binder investigated in the study were increased by including CBE. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Related Products of 57-55-6).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Related Products of 57-55-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ruthenium-Catalyzed (Z)-Selective Hydroboration of Terminal Alkynes with Naphthalene-1,8-diaminatoborane was written by Yamamoto, Kensuke;Mohara, Yusei;Mutoh, Yuichiro;Saito, Shinichi. And the article was included in Journal of the American Chemical Society in 2019.Formula: C16H20B2N2O2 This article mentions the following:

The metal-catalyzed (Z)-selective hydroboration of terminal alkynes is synthetically challenging due to the usually (E)-selective nature of the hydroboration and the formation of the thermodynamically unstable (Z)-isomer. Herein, the authors report that N-heterocyclic-carbene-ligated Ru complexes catalyze the (Z)-selective hydroboration of terminal alkynes with H-B(dan) (dan = naphthalene-1,8-diaminato), which generates a diverse range of synthetically valuable (Z)-alkenylboranes. Mechanistic studies, particularly the isolation of a catalytically relevant borylruthenium complex, revealed a mechanism that involves the insertion of the alkyne into a Ru-B bond, which provides a catalytic cycle that is distinctly different from that of previously reported (Z)-selective hydroborations. The direct cross-coupling of the obtained (Z)-alkenyl-B(dan) enables the rapid synthesis of biol. active Combretastatin A-4 analogs. In the experiment, the researchers used many compounds, for example, 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-naphtho[1,8-de][1,3,2]diazaborinine (cas: 1214264-88-6Formula: C16H20B2N2O2).

2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-naphtho[1,8-de][1,3,2]diazaborinine (cas: 1214264-88-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Formula: C16H20B2N2O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rh^III-Catalyzed C-H (Het)arylation/Vinylation of N-2,6-Difluoroaryl Acrylamides was written by Wang, Huai-Wei;Qiao, Yu-Han;Wu, Jia-Xue;Wang, Qiu-Ping;Tian, Meng-Xin;Li, Yong-Fei;Yao, Qing-Xia;Li, Da-Cheng;Dou, Jian-Min;Lu, Yi. And the article was included in Organic Letters in 2021.Safety of 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane This article mentions the following:

Rh^III-catalyzed sp² C-H cross-coupling of acrylamides with organoboron reactants was accomplished using a com.available N-2,6-difluoroaryl acrylamide auxiliary. A broad range of aryl and vinyl boronates as well as a variety of heterocyclic boronates with strong coordinating ability served as the coupling partners. This transformation proceeded under moderate reaction conditions with excellent functional group tolerance and high regioselectivity. In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4Safety of 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Safety of 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis of terpin hydrate from turpentine with ultrasound was written by Wang, Lin-lin;Chen, Xiao-peng;Wei, Xiao-jie;Zhu, Yuan-jiao. And the article was included in Tianranqi Huagong in 2003.Safety of rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate This article mentions the following:

The hydration reaction of turpentine catalyzed by sulfuric acid was studied. The non-homogeneous phase mass transfer has been enhanceed by ultrasound, and factors which influence the hydration reaction were optimized by the simplex search method. The optimum reaction conditions were as follows: reaction time = 17 h, H₂SO₄ concentration = 30% wt, turpentine/H₂SO₄ weight ratio = 1:1.72; under these conditions the yield of terpin hydrate was up to 94.82%. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Safety of rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Safety of rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Unified sensing of the concentration and enantiomeric composition of chiral compounds with an achiral probe was written by Sripada, Archita;Thanzeel, F. Yushra;Wolf, Christian. And the article was included in Chem in 2022.Name: (R)-2-Aminobutan-1-ol This article mentions the following:

Long-standing impracticalities with optical chiral compound sensing have limited the potential and acceptance of high-throughput experimentation technol. despite the introduction of com. available CD (CD) microplate readers. Chiroptical asym. reaction sensing typically requires UV or fluorescence measurements in combination with CD anal. to determine yield and enantiomeric ratio with two sep. calibration curves. Herein, we introduce a strategy that achieves both through the exclusive use of CD anal. with an achiral probe designed for quant. sensing of amines, amino alcs., and all standard chiral amino acids, thus eliminating the need for UV and fluorescence measurements. Unified CD sensing outperforms traditional optical, NMR, and chromatog. methods and offers speed, labor, and cost benefits at reduced chem. waste production It can be easily adapted by any laboratory, it can be applied in microscale asym. reaction screening without workup, and it is universally applicable and not restricted to the use of any particular optical probe. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Name: (R)-2-Aminobutan-1-ol).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Name: (R)-2-Aminobutan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Smart pH-Responsive Antimicrobial Hydrogel Scaffolds Prepared by Additive Manufacturing was written by Garcia, Carolina;Gallardo, Alberto;Lopez, Daniel;Elvira, Carlos;Azzahti, Asma;Lopez-Martinez, Elena;Cortajarena, Aitziber L.;Gonzalez-Henriquez, Carmen M.;Sarabia-Vallejos, Mauricio A.;Rodriguez-Hernandez, Juan. And the article was included in ACS Applied Bio Materials in 2018.Product Details of 109-17-1 This article mentions the following:

We report on the fabrication of 3D printed pH-responsive and antimicrobial hydrogels with a micrometer-scale resolution achieved by stereolithog. (SLA) 3D printing. The preparation of the hydrogels was optimized by selecting the most appropriate difunctional polyethylene glycol dimethacrylates (testing crosslinking agents with chain lengths ranging from 2 up to 14 units ethylene glycol) and introducing acrylic acid (AA) as a monofunctional monomer. As a result of the incorporation of AA, the hydrogels described are able to reversibly swell and shrink upon environmental changes on the pH, and the swelling extent is directly related to the amount of AA and can be thus finely tuned. More interestingly, upon optimization of the UV penetration depth employing a photoabsorber (Sudan I), a reliable procedure for the fabrication of 3D objects with a high model accuracy is shown. Finally, the antimicrobial properties of all of the hydrogels were demonstrated using Staphylococcus aureus as a bacterial model. We found that even those hydrogels with a low amount of AA monomeric units presented excellent antimicrobial properties against S. aureus. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Product Details of 109-17-1).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Product Details of 109-17-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Au-Pd alloy nanoparticles supported on layered double hydroxide for heterogeneously catalyzed aerobic oxidative dehydrogenation of cyclohexanols and cyclohexanones to phenols was written by Jin, Xiongjie;Taniguchi, Kento;Yamaguchi, Kazuya;Mizuno, Noritaka. And the article was included in Chemical Science in 2016.Safety of tert-Butyl (4-hydroxycyclohexyl)carbamate This article mentions the following:

Phenol, an important industrial chem., is widely produced using the well-developed cumene process. However, demand for the development of a novel alternative method for synthesizing phenol from benzene has been increasing. Herein, we report a novel system for the synthesis of phenols through aerobic oxidative dehydrogenation of cyclohexanols and cyclohexanones, catalyzed by Mg-Al-layered double hydroxide (LDH)-supported Au-Pd alloy nanoparticles (Au-Pd/LDH). Although monometallic Au/LDH, Pd/LDH, and their phys. mixture showed almost no catalytic activity, Au-Pd/LDH exhibited markedly high catalytic activity for the dehydrogenative phenol production Moreover, the effect of supports was critical; despite the high catalytic performance of Au-Pd/LDH, Au-Pd bimetallic nanoparticles supported on Al₂O₃, TiO₂, MgO, and CeO₂ were ineffective. Various substituted cyclohexanols and cyclohexanones were efficiently converted into the corresponding phenols, and N-substituted anilines. In addition, the observed catalysis was truly heterogeneous, and Au-Pd/LDH could be reused without substantial loss of its high performance. The present transformation is scalable, utilizes O₂ in air as the terminal oxidant, and generates water as the only byproduct. Dehydrogenative aromatization of cyclohexanols proceeds through (1) oxidation of cyclohexanols to cyclohexanones; (2) dehydrogenation of cyclohexanones to cyclohexenones; and (3) disproportionation of cyclohexenones to afford the desired phenols. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-hydroxycyclohexyl)carbamate (cas: 224309-64-2Safety of tert-Butyl (4-hydroxycyclohexyl)carbamate).

tert-Butyl (4-hydroxycyclohexyl)carbamate (cas: 224309-64-2) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Safety of tert-Butyl (4-hydroxycyclohexyl)carbamate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Possibility for the long-term storage of tableted drugs in plastic tubes was written by Malakhova, Z. N.;Artem’ev, A. I.. And the article was included in Farmatsiya (Moscow, Russian Federation) in 1976.HPLC of Formula: 2451-01-6 This article mentions the following:

Of the packaging materials tested, polyethylene [9002-88-4] and glass were the most effective, polystyrene [9003-53-6] was intermediate in effectiveness, and paper and cellophane were the least effective in controlling the moisture content of pharmaceutical tablets stored for 12 months. The relative effectiveness of each type of packaging material in controlling moisture varied somewhat with the drug tested. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6HPLC of Formula: 2451-01-6).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.HPLC of Formula: 2451-01-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Efficiently catalytic transfer hydrogenation of aryl and heteroaryl halides by ultrafine palladium nanoparticles confined into UiO-66 was written by Tong, Liangliang;Song, Xinluo;Jiang, Yuxin;Zhao, Bangyao;Li, Yafeng. And the article was included in International Journal of Hydrogen Energy in 2022.COA of Formula: C7H7ClO This article mentions the following:

The hydrodehalogenation of aryl and heteroaryl halides (AHHs) is very crucial for academic and industrial applications. Herein, ultrafine palladium nanoparticles (Pd NPs) with the size distribution about 1.77 ± 0.35 nm, were in-situ synthesized and confined into the metal-organic framework of UiO-66 (named as Pd@UiO-66) by impregnation reduction method without tedious post-reducing step. Pd@UiO-66 shows excellent activity with a high conversion (>90%) efficiency in the catalytic transfer hydrogenation (CTH) of AHHs under mild water systems utilizing ammonium formate as hydrogen donor. Furthermore, Pd@UiO-66 maintains highly excellent stability (conversion >95%) after 5 times reused cycles without losing catalytic activity and leaching Pd nanoparticles. This study supplies a new method for hybrid catalysts by immobilizing ultrafine Pd nanoparticles into crystalline MOFs, displaying efficient transform performance for halogen compounds by catalytic hydrogenation. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7COA of Formula: C7H7ClO).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.COA of Formula: C7H7ClO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts