Month: December 2022

Jia, Kangle published the artcileThermal, light and pH triple stimulated changes in self-assembly of a novel small molecular weight amphiphile binary system, Application of 2-Hydroxy-4-(trifluoromethyl)benzoic acid, the publication is RSC Advances (2015), 5(1), 640-642, database is CAplus.

Novel multiple stimuli-responsive fluids based on an azobenzene-contained surfactant 1-[2-(4-decylphenylazo-phenoxy)-ethyl]-3-methylimidazolium bromide (C10AZOC2IMB) and a hydrotrope 4-(trifluoromethyl) salicylic acid (4FS) can be reversibly induced by temperature, light and pH from vesicles to wormlike micelles. UV-vis spectra, rheol. and cryo-TEM measurements were utilized to prove the self-assembly transitions.

RSC Advances published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Application of 2-Hydroxy-4-(trifluoromethyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Pengxin published the artcileDearomatization-rearomatization strategy of tyrosine for peptide/protein modification through thiol-addition reactions, Computed Properties of 4410-99-5, the publication is Chemical Communications (Cambridge, United Kingdom) (2021), 57(96), 12968-12971, database is CAplus and MEDLINE.

We have developed a dearomatization-rearomatization strategy for the modification of peptides/proteins through a thiol-Michael addition to the electrophilic cyclohexadienone intermediate that is generated in situ via the oxidation of tyrosine. This strategy enriches the conjugation toolbox and has great potential for applications in medicinal chem. and chem. biol.

Chemical Communications (Cambridge, United Kingdom) published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C9H8O4, Computed Properties of 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Feng, Yan published the artcileGas chromatography-mass spectrometry analysis of floral fragrance-related compounds in scented rose (Rosa hybrida) varieties and a subsequent evaluation on the basis of the analytical hierarchy process, Recommanded Product: cis-3,7-Dimethyl-2,6-Octadien-1-Ol, the publication is Plant Physiology and Biochemistry (Issy-les-Moulineaux, France) (2022), 368-377, database is CAplus and MEDLINE.

Scented rose (Rosa hybrida) varieties are valued as ornamentals, but they also contain volatile organic compounds (VOCs) that produce pleasant aromas. In plants, aromas are produced via metabolism during growth, and each aroma compound has a unique function. In this study, the floral aroma compounds of diverse scented rose varieties were analyzed and classified. The VOCs of different rose varieties were qual. and quant. analyzed via headspace solid-phase microextraction combined with gas chromatog. and mass spectrometry. The test materials were the mature flowers of 55 scented rose varieties that were cultivated under identical conditions. Seventeen important aroma compounds were selected and an anal. hierarchy process (AHP)-based method was developed to identify the most suitable essential oil resources, aromatherapy resources, and healthcare resources. A floral fragrance evaluation model was established for the comprehensive evaluation of the scented rose varieties. The 55 varieties were classified into three grades according to their suitability for each use. ′Soeur Emmanuelle′, ′Wollerton Old Hall′, ′Accademia′, and ′Tianmidemeng′ were revealed to be suitable essential oil, aromatherapy, and healthcare resources. On the basis of their aroma compound types, the fifty-five rose varieties were divided into eight groups. The results of this study provide the theor. basis for the classification of rose flower aromas as well as the rational use of diverse rose varieties to further develop the rose industry. nerol, geraniol, citronellol, phenethyl alc., trans-3-hexenyl acetate, 1,3,5-Trimethoxybenzene , phenylethanol acetate, vanillin ace-tate,citronellyl acetate, neryl acetate, hexyl acetate, 3,5-Dimethoxyben-zoic, α-elemene, β-elemene, γ-elemene and myrcene

Plant Physiology and Biochemistry (Issy-les-Moulineaux, France) published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, Recommanded Product: cis-3,7-Dimethyl-2,6-Octadien-1-Ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Zhan-Ku published the artcilePretreatment of sweet sorghum stalk with aqueous hydrogen peroxide for enhancing methanolysis and property of the bio-oil, Name: 4-Propylphenol, the publication is Renewable Energy (2021), 1127-1136, database is CAplus.

Alcoholysis is a promising approach for converting biomass into fuels and/or chems. under mild conditions. However, the effect of pretreatment on biomass alcoholysis was rarely reported. Herein, the effect of pretreatment with H₂O₂ on sweet sorghum stalk (SSS) methanolysis was examined The results show that the pretreatment could markedly improve the bio-oil (BO) yield and decrease the appropriate temperature for obtaining maximum BO yield. The appropriate temperature for pretreated SSS methanolysis was determined to be 280 °C and the maximum BO yield is 44 wt%. In addition, higher heating values of the BOs were also enhanced based on elemental anal. According to anal. with gas chromatograph/mass spectrometer, phenolic compounds, esters, and sugars are predominant in the BOs, and the yield of phenolic compounds significantly increased from 91.75 to 111.68 mg·g^-1 by the pretreatment. Moreover, polar species in the BOs decreased and deoxygenation occurred during pretreated SSS methanolysis. Analyses with scanning electron microscope and N₂ physisorption reveal that pretreated SSS has more grooves and higher sp. surface area and anomalous porosity than SSS. According to analyses with Fourier transform IR spectrometer and X-ray photoelectron spectrometer, oxygen functional groups mainly in the forms of C=O and COO were introduced into SSS by the pretreatment. The changes of phys. and chem. structures should be responsible for enhancing SSS methanolysis and property of the BO.

Renewable Energy published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Name: 4-Propylphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Wen-Pei published the artcileAcid-Free Copper-Catalyzed Electrophilic Nitration of Electron-Rich Arenes with Guanidine Nitrate, Safety of 4-Propylphenol, the publication is Journal of Organic Chemistry, database is CAplus and MEDLINE.

A practical copper-catalyzed nitration of electron-rich arenes with trimethylsilyl chloride and guanidine nitrate is reported. A variety of nitrated products were generated in moderate to excellent yields (32%-99%) at ambient temperature under acid free, open-flask and operationally simple conditions.

Journal of Organic Chemistry published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Safety of 4-Propylphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhao, Jian published the artcileDiscovery of substituted 3H-pyrido[2,3-d]pyrimidin-4-ones as potent, biased, and orally bioavailable sst2 agonist, Application In Synthesis of 1256345-79-5, the publication is Bioorganic & Medicinal Chemistry Letters (2020), 30(21), 127496, database is CAplus and MEDLINE.

The discovery of a novel 3H-pyrido[2,3-d]pyrimidin-4-one series as potent and biased sst2 agonists is described. This class of mols. exhibits excellent sst2 potency and selectivity against sst1, sst3, and sst5 receptors, and they are significantly more potent at inhibiting cAMP production than inducing internalization. The orally bioavailable 6-(3-chloro-5-methylphenyl)-3-(3-fluoro-5-hydroxyphenyl)-5-({methyl[(2S)-pyrrolidin-2-ylmethyl]amino}methyl)-3H,4H-pyrido[2,3-d]pyrimidin-4-one (36) also suppresses GH secretion in GHRH-challenged rats in a dose-dependent manner.

Bioorganic & Medicinal Chemistry Letters published new progress about 1256345-79-5. 1256345-79-5 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Benzene,Phenol,Boronic Acids,Boronic Acids,Boronic acid and ester, name is (3-Hydroxy-5-methylphenyl)boronic acid, and the molecular formula is C10H9NO4S, Application In Synthesis of 1256345-79-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shen, Lingyun published the artcileSelective Transformation of Vicinal Glycols to α-Hydroxy Acetates in Water via a Dehydrogenation and Oxidization Relay Process by a Self-Supported Single-Site Iridium Catalyst, HPLC of Formula: 90-64-2, the publication is ACS Catalysis (2021), 11(21), 12833-12839, database is CAplus.

α-Hydroxy acids have attracted broad attention because of their prevalence in bioactive mols. and biodegradable polymers, but their conventional syntheses are usually restricted to aromatic substrates, especially, in a stepwise manner. Herein, the transformation of alkyl and aryl vicinal glycols to α-hydroxy acetates in water under the air atm. with the solid self-supported NHC-Ir single-site catalyst is reported. Both aliphatic and aromatic glycols are compatible with a much higher catalytic efficiency in the presence of this solid single-site catalyst than other viable mol. catalysts (93% vs <35%) because of the “isolation effect”. Remarkably, this catalyst could be reused for 20 runs without an obvious loss in catalytic activity and selectivity. Control experiments and d. functional theory calculations reveal that the reaction firstly undergoes a dehydrogenation facilitated by the catalyst, and then it proceeds through an unexpected oxidization relay step by oxygen in the air, leading to the α-hydroxy acetate formation. This protocol can potentially contribute to the valorization of readily available and inexpensive diols.

ACS Catalysis published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C10H14N2O, HPLC of Formula: 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lin, Hanfeng published the artcileApplication of carboprost tromethamine in treatment of hypertension in pregnancy, Application In Synthesis of 58551-69-2, the publication is Fujian Yiyao Zazhi (2013), 35(5), 99-100, database is CAplus.

Objective: To investigate application of carboprost tromethamine in treatment of hypertension in pregnancy. Methods: 200 cases of patients with hypertension in pregnancy were selected as a treatment group, and 200 cases of normal pregnancy at the same period were selected as a control group. Two groups underwent lumbar epidural anesthesia for cesarean section surgery, the control group was instantly given oxytocin 20 IU injection for uterine wall after childbirth of fetus, the treatment group was one-time given carboprost tromethamine injection 250 μg after childbirth of fetus, and both groups were given 20 IU of oxytocin via continuous i.v. infusion for 6 h. The bleeding state, incidence of postpartum hemorrhage, Hb level, and blood pressure after childbirth were observed during surgery and after surgery within 2 h and 24 h. Results: Compared with the control group, the amount of bleeding within 2h, 24 h after surgery of the treatment group was lower, and incidence of postpartum hemorrhage was lower (P < 0.05). Blood pressure difference of the two groups was not statistically significant (P > 0.05) and the two groups had no significant adverse reactions. Conclusions: Carboprost tromethamine is an effective measure to prevent postpartum hemorrhage of hypertension in pregnancy.

Fujian Yiyao Zazhi published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Application In Synthesis of 58551-69-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Tsun-Ren published the artcileIridium/graphene nanostructured catalyst for the N-alkylation of amines to synthesize nitrogen-containing derivatives and heterocyclic compounds in a green process, Formula: C5H12O2, the publication is RSC Advances (2022), 12(8), 4760-4770, database is CAplus and MEDLINE.

A facile iridium/graphene-catalyzed methodol. providing an efficient synthetic route for C-N bond formation is reported. This catalyst can directly promote the formation of C-N bonds, without pre-activation steps, and without solvents, alkalis and other additives. This protocol provides a direct N-alkylation of amines using a variety of primary and secondary alcs. with good selectivity and excellent yields. Charmingly, the use of diols resulted in intermol. cyclization of amines, and such products are privileged structures in biol. active compounds Two examples illustrate the advantages of this catalyst in organic synthesis: the tandem catalysis to synthesize hydroxyzine, and the intermol. cyclization to synthesize cyclizine. Water is the only byproduct, which makes this catalytic process sustainable and environmentally friendly.

RSC Advances published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Formula: C5H12O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chang, Meng-Yang published the artcileCopper(II) Acetate Mediated Synthesis of 3-Sulfonyl-2-aryl-2H-chromenes, COA of Formula: C11H8O3, the publication is Synthesis (2019), 51(18), 3419-3430, database is CAplus.

This paper describes a concise, easy-operation, high-yielding method for the synthesis of 3-sulfonyl-2-aryl-2H-chromenes I [R = Me, n-Bu, 4-H₃CC₆H₄, etc.; R¹ = H; R² = H, OCH₃; R¹R² = -CH=CH-CH=CH-; R³ = H, Cl, Br; Ar = 2-furyl, 2-naphthyl, 3,4,5-(H₃CO)₃C₆H₂, etc.] by a one-pot, straightforward two-step synthetic route, which includes (i) Cu(OAc)₂/PyBOP-mediated intermol. [4+2] annulation of substituted salicylic acids 2-OH-3-R¹-4-R²-5-R³C₆HC(O)OH with β-sulfonylstyrenes ArCH=CHS(O)₂R in the presence of DMAP in refluxing DMF, and (ii) sequential O-alkylation of the resulting sulfonylflavanones II with Bu bromide. A plausible mechanism is proposed and discussed. This protocol provides a highly effective annulation via one carbon-oxygen (C-O) and one carbon-carbon (C-C) bond formations.

Synthesis published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, COA of Formula: C11H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts